One-pot click synthesis of hybrid triazole-pyridine-functionalized polyphenol derivatives under ultrasound irradiation and their antimicrobial assays.

Συγγραφείς: Amariucai-Mantu D; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania., Marandis CG; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania., Diaconu D; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania., Antoci V; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania. vasilichia.antoci@uaic.ro., Mangalagiu II; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania. ionelm@uaic.ro.

Πηγή: Scientific reports [Sci Rep] 2026 Jun 05; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Triazoles*/chemistry , Click Chemistry*/methods , Polyphenols*/chemistry , Polyphenols*/pharmacology , Polyphenols*/chemical synthesis , Pyridines*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemical synthesis , Anti-Infective Agents*/chemistry, Gram-Negative Bacteria/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemical synthesis ; Microbial Sensitivity Tests ; Ultrasonic Waves ; Green Chemistry Technology

Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates.

Συγγραφείς: Cho YT; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA., Jao CY; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Xia Z; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA., White-Mathieu BM; Department of Chemistry, University of New Hampshire, Durham, New Hampshire, USA., Salic A; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Baskin JM; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA.; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.

Πηγή: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2026 Sep 28; Vol. 65 (40), pp. e1866870. Date of Electronic Publication: 2026 Aug 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ethanolamine*/chemistry , Ethanolamine*/metabolism , Phosphatidylethanolamines*/chemistry , Phosphatidylethanolamines*/metabolism, Alkynes/chemistry ; Azides/chemistry ; Glycosylphosphatidylinositols/chemistry ; Copper/chemistry ; Ubiquitin/chemistry ; Ubiquitin/metabolism ; Click Chemistry ; Cycloaddition Reaction

A facile synthesis, biological evaluation, ADMET profiling and computational insights of novel triazole-linked tetrahydrobenzo[b]thiophenes: A sonochemical click synthetic strategy in recyclable ionic liquid medium.

Συγγραφείς: Kurahatti S; Department of Chemistry, Karnatak University's Karnatak Science College, Dharwad, Karnataka 580001, India., Kalkhambkar RG; Department of Chemistry, Karnatak University's Karnatak Science College, Dharwad, Karnataka 580001, India. Electronic address: rgkalkhambkar2020@gmail.com., Dalbanjan NP; Dr. Prabhakar Kore Basic Science Research Centre, KLE Academy of Higher Education and Research (Deemed to be University), Nehru Nagar, Belagavi, Karnataka 590010, India.

Πηγή: Bioorganic chemistry [Bioorg Chem] 2026 Oct 05; Vol. 181, pp. 110286. Date of Electronic Publication: 2026 Jul 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ionic Liquids*/chemistry , Triazoles*/chemistry , Triazoles*/pharmacology , Thiophenes*/pharmacology , Thiophenes*/chemistry , Thiophenes*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Antifungal Agents*/pharmacology , Antifungal Agents*/chemical synthesis , Antifungal Agents*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemical synthesis , Antioxidants*/chemistry, Staphylococcus aureus/drug effects ; Candida albicans/drug effects ; Escherichia coli/drug effects ; Candida glabrata/drug effects ; Biphenyl Compounds/antagonists & inhibitors ; Microbial Sensitivity Tests ; Molecular Structure ; Click Chemistry ; Structure-Activity Relationship ; Molecular Docking Simulation ; Dose-Response Relationship, Drug

Organelle-Resolved Tetrazine-trans-Cyclooctene Click Chemistry for Cargo Delivery and Release.

Συγγραφείς: Durydivka O; Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Chovanec M; Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Dzijak R; Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Rahm M; Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Hrusak J; Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Reyes-Gutierrez PE; Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic., Vrabel M; Department of Bioorganic and Medicinal Chemistry, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.

Πηγή: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2026 Sep 19; Vol. 32 (35), pp. e71198. Date of Electronic Publication: 2026 Jun 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cyclooctanes*/chemistry , Doxorubicin*/chemistry , Prodrugs*/chemistry , Organelles*/chemistry , Organelles*/metabolism, Mitochondria/metabolism ; Mitochondria/chemistry ; Fluorescent Dyes/chemistry ; Click Chemistry ; Humans ; Cycloaddition Reaction ; Drug Delivery Systems ; Aza Compounds ; Benzene Derivatives

Peptide Thioester and Triazole Derivatives Through On-Resin Dual-Modification of Peptide Thiosulfonates.

Συγγραφείς: Werner M; Institute of Organic Chemistry, Heidelberg University, Heidelberg, Germany.; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Heidelberg, Germany., Bergmann A; Institute of Organic Chemistry, Heidelberg University, Heidelberg, Germany., Liu C; Institute of Organic Chemistry, Heidelberg University, Heidelberg, Germany., Behnam M; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Heidelberg, Germany., Klein C; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Heidelberg, Germany., Thomas F; Institute of Organic Chemistry, Heidelberg University, Heidelberg, Germany.

Πηγή: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2026 Sep 14; Vol. 65 (38), pp. e8315692. Date of Electronic Publication: 2026 Jul 13.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Peptides*/chemistry , Peptides*/chemical synthesis , Triazoles*/chemistry , Esters*/chemistry , Sulfhydryl Compounds*/chemistry, Azides/chemistry ; Alkynes/chemistry ; Click Chemistry ; Molecular Structure ; Catalysis

Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy.

Συγγραφείς: Alqahtani AA; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia., Saeed AM; Medical Education Department, College of Medicine, Najran University, Najran, Saudi Arabia., Alam A; Subhwanti Institute of Professional Education Bettiah, Bettiah, India.; International Institute of Pharmaceutical Science and Research, Kalyani Nadia, India., Pathak K; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India., Sahariah JJ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India., Elnoubi OA; Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia., A Abdel-Wahab B; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia.; Department of Pharmacology, College of Medicine, Assiut University, Assiut, Egypt., Alqahtani S; Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia.; Comparative Pathobiology Department, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA., Alshiban NM; Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia., Bakir MB; Medical Education Department, College of Medicine, Najran University, Najran, Najran, Saudi Arabia., Ahmad MZ; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.

Πηγή: Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2026 Sep; Vol. 52 (9), pp. 1750-1767. Date of Electronic Publication: 2026 Jul 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Zinc Oxide*/chemistry , Zinc Oxide*/pharmacology , Zinc Oxide*/chemical synthesis , Wound Healing*/drug effects , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Fruit*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry, Green Chemistry Technology/methods ; Plant Extracts/chemistry ; Staphylococcus aureus/drug effects ; Metal Nanoparticles/chemistry ; Pseudomonas aeruginosa/drug effects ; Anti-Bacterial Agents/pharmacology ; Nanoparticles/chemistry ; Humans ; A549 Cells ; Animals ; Microbial Sensitivity Tests

Genetic Code Expansion Enables Oriented, Site-Specific Conjugation of DARPins to Lipid Nanoparticles for Selective mRNA Delivery to CD8⁺ T Cells.

Συγγραφείς: Dakhnevich A; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Pateev I; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Skvortsov IA; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Yarmachkova S; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Shevyrev D; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Chubarova A; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Gasina M; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Cherepanova N; Medicinal Chemistry Core Facility, Sirius University of Science and Technology, 354349 Sirius, Russia., Siaglova ED; Biomaterials Core Facility, Sirius University of Science and Technology, 354349 Sirius, Russia., Reshetnikov V; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Baranov MV; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia., Ivanov RA; Biotechnology Department, Sirius University of Science and Technology, 354349 Sirius, Russia.

Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Aug 29; Vol. 27 (17). Date of Electronic Publication: 2026 Aug 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Nanoparticles*/chemistry , CD8-Positive T-Lymphocytes*/metabolism , RNA, Messenger*/genetics , RNA, Messenger*/administration & dosage , RNA, Messenger*/chemistry , Lipids*/chemistry , Genetic Code*, Phenylalanine/chemistry ; Animals ; Mice ; Click Chemistry ; Liposomes

Systematic optimization and comparative evaluation of exosome fluorescence labeling workflows based on cholesterol anchoring and copper-free click chemistry.

Συγγραφείς: Li C; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China., Zeng Y; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China., Wei K; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China., Li X; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. lixy@sjtu.edu.cn., Wang Y; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. wangyan11@sjtu.edu.cn.

Πηγή: Mikrochimica acta [Mikrochim Acta] 2026 Aug 21; Vol. 193 (9). Date of Electronic Publication: 2026 Aug 21.

Τύπος έκδοσης: Journal Article; Comparative Study; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Exosomes*/chemistry , Exosomes*/metabolism , Cholesterol*/chemistry , Fluorescent Dyes*/chemistry, Azides/chemistry ; Copper/chemistry ; Click Chemistry ; Humans ; A549 Cells

Correlation between protein-polydimethylsiloxane visible particle formation and computationally derived antibody surface properties.

Συγγραφείς: Hirayama K; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, Japan. Electronic address: hirayama.kazunori24@chugai-pharm.co.jp., Arai K; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, Japan., Fukuda M; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, Japan. Electronic address: fukuda.masakazu43@chugai-pharm.co.jp., Saitoh S; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, Japan., Hashimoto D; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, Japan., Aiba Y; Formulation Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo, Japan.

Πηγή: Journal of pharmaceutical sciences [J Pharm Sci] 2026 Aug; Vol. 115 (8), pp. 104364. Date of Electronic Publication: 2026 Jun 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Antibodies, Monoclonal*/chemistry , Dimethylpolysiloxanes*/chemistry, Poloxamer/chemistry ; Computational Chemistry/methods ; Surface Properties ; Hydrophobic and Hydrophilic Interactions ; Adsorption

NADES-assisted sustainable extraction of total protein content from Achyranthes bidentata seeds and their biochemical characterization.

Συγγραφείς: Salunkhe PK; Department of Technology, Shivaji University, Kolhapur, 416004, Maharashtra, India. Electronic address: premrajsalunkhe09@gmail.com.

Πηγή: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2026 Aug; Vol. 140, pp. 108429. Date of Electronic Publication: 2026 Jun 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 9206091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-488X (Electronic) Linking ISSN: 10568719 NLM ISO Abbreviation: J Pharmacol Toxicol Methods Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Seeds*/chemistry , Achyranthes*/chemistry , Plant Proteins*/isolation & purification , Plant Proteins*/chemistry , Deep Eutectic Solvents*/chemistry , Plant Extracts*/chemistry, Flavonoids/chemistry ; Flavonoids/isolation & purification ; Phenols/chemistry ; Green Chemistry Technology/methods ; Lactic Acid/chemistry ; Solvents/chemistry ; Glycerol/chemistry

Low-viscosity ternary NADES for green extraction and UHPLC-DAD determination of potential endocrine-disrupting contaminants in wastewater.

Συγγραφείς: Luna-Díaz JM; Environmental Analytical Chemistry Group, University of Balearic Islands, Cra. Valldemossa km 7.5, 07122, Palma de Mallorca, Spain; Centro de Investigación en Materiales Avanzados, S.C. (CIMAV), Miguel de Cervantes 120, Chihuahua, 31136, Mexico., Leal-Quezada LO; Centro de Investigación en Materiales Avanzados, S.C. (CIMAV), Miguel de Cervantes 120, Chihuahua, 31136, Mexico., Ferrer L; Environmental Analytical Chemistry Group, University of Balearic Islands, Cra. Valldemossa km 7.5, 07122, Palma de Mallorca, Spain., Palacio E; Environmental Analytical Chemistry Group, University of Balearic Islands, Cra. Valldemossa km 7.5, 07122, Palma de Mallorca, Spain. Electronic address: edwin.palacio@uib.es.

Πηγή: Talanta [Talanta] 2026 Aug 01; Vol. 305, pp. 129654. Date of Electronic Publication: 2026 Mar 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Water Pollutants, Chemical*/analysis , Water Pollutants, Chemical*/isolation & purification , Wastewater*/analysis , Wastewater*/chemistry , Deep Eutectic Solvents*/chemistry , Endocrine Disruptors*/analysis , Endocrine Disruptors*/isolation & purification, Chromatography, High Pressure Liquid/methods ; Green Chemistry Technology/methods ; Menthol/chemistry ; Camphor/chemistry ; Thymol/chemistry ; Parabens/analysis ; Triclosan/analysis ; Viscosity

Metal-free deformylation strategy enables sustainable Hantzsch-type pyridine synthesis in neat water.

Συγγραφείς: Yang XY; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Li X; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Xu J; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Liao HM; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Xu ZG; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Lei J; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China. jlei0916@163.com., Chen ZZ; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China. 18883138277@163.com.

Πηγή: Molecular diversity [Mol Divers] 2026 Aug; Vol. 30 (4), pp. 5439-5447. Date of Electronic Publication: 2026 Jan 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Pyridines*/chemical synthesis , Pyridines*/chemistry , Water*/chemistry, Metals/chemistry ; Chemistry Techniques, Synthetic ; Green Chemistry Technology

Sustainable green extraction of polysaccharides from Caryophylli Flos using ultrasound-assisted DES: Process optimization, structural identification, and bioactivity.

Συγγραφείς: Shu P; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China; School of Life Sciences, Henan University, Kaifeng 475004, Henan, China. Electronic address: shupenghua@yeah.net., Yang H; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China., Yin H; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China., Zhang Z; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; School of Life Sciences, Henan University, Kaifeng 475004, Henan, China., Chen Y; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China., Chen S; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China., Guo S; College of Chemical and Materials Engineering, Xuchang University, Xuchang 461000, Henan, China., Zheng J; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China., Wei X; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China., Lv C; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China., Zhou J; Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, Chin. Electronic address: zhoujingbo@gdaas.cn., Huang J; Food and Pharmacy College, Xuchang University, Xuchang 461000, Henan, China; Collaborative Innovation Center of Functional Food by Green Manufacturing, Xuchang 461000, Henan, China. Electronic address: huangjih1216@126.com.

Πηγή: Food chemistry [Food Chem] 2026 Oct 30; Vol. 527, pp. 150901. Date of Electronic Publication: 2026 Aug 27.

Τύπος έκδοσης: Journal Article; Evaluation Study

Στοιχεία περιοδικού: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Polysaccharides*/isolation & purification , Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Plant Extracts*/isolation & purification , Plant Extracts*/chemistry , Ultrasonics*/methods , Green Chemistry Technology*/methods , Green Chemistry Technology*/instrumentation , Chemical Fractionation*/methods , Chemical Fractionation*/instrumentation, Flowers/chemistry ; Antioxidants/isolation & purification ; Antioxidants/chemistry ; Glycoside Hydrolase Inhibitors/isolation & purification ; Glycoside Hydrolase Inhibitors/chemistry ; Deep Eutectic Solvents/chemistry ; Syzygium

Green valorization of avocado pits waste via intermittent pressurized liquid extraction: Phenolic profiling, antioxidant activity, and pH-dependent color stability of six Brazilian cultivars.

Συγγραφείς: García-Ramón DF; Laboratory for High-Pressure Technology and Natural Products (LTAPPN), Faculty of Animal Science and Food Engineering, University of São Paulo, Av. Duque De Caxias Norte 225, Pirassununga 13635-900, SP, Brazil., de Sant'Ana JPF; Laboratory for High-Pressure Technology and Natural Products (LTAPPN), Faculty of Animal Science and Food Engineering, University of São Paulo, Av. Duque De Caxias Norte 225, Pirassununga 13635-900, SP, Brazil., Fougère L; Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, CNRS UMR 7311; Pôle De Chimie Rue De Chartres - BP 6759 45067, Orléans Cedex 2, France., Destandau E; Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, CNRS UMR 7311; Pôle De Chimie Rue De Chartres - BP 6759 45067, Orléans Cedex 2, France., West C; Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, CNRS UMR 7311; Pôle De Chimie Rue De Chartres - BP 6759 45067, Orléans Cedex 2, France., de Oliveira AL; Laboratory for High-Pressure Technology and Natural Products (LTAPPN), Faculty of Animal Science and Food Engineering, University of São Paulo, Av. Duque De Caxias Norte 225, Pirassununga 13635-900, SP, Brazil. Electronic address: alelopes@usp.br.

Πηγή: Food chemistry [Food Chem] 2026 Oct 30; Vol. 527, pp. 150821. Date of Electronic Publication: 2026 Aug 20.

Τύπος έκδοσης: Journal Article; Evaluation Study

Στοιχεία περιοδικού: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Phenols*/isolation & purification , Phenols*/chemistry , Persea*/chemistry , Persea*/classification , Antioxidants*/isolation & purification , Antioxidants*/chemistry , Plant Extracts*/isolation & purification , Plant Extracts*/chemistry , Waste Products*/analysis , Chemical Fractionation*/methods, Green Chemistry Technology/methods ; Fruit/chemistry ; Fruit/classification ; Brazil ; Hydrogen-Ion Concentration ; Color ; Chromatography, High Pressure Liquid

A comparative QbD-driven optimization of solid lipid nanoparticles and nanostructured lipid carriers for enhanced drug delivery.

Συγγραφείς: K K SP; Department of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India., N D; Department of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, India. Electronic address: damodhan@srmist.edu.in.

Πηγή: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2026 Oct 29; Vol. 837, pp. 154599. Date of Electronic Publication: 2026 Sep 17.

Τύπος έκδοσης: Journal Article; Comparative Study

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Drug Carriers*/chemistry , Nanoparticles*/chemistry , Lipids*/chemistry , Trimipramine*/administration & dosage , Trimipramine*/chemistry , Trimipramine*/pharmacokinetics , Nanostructures*/chemistry , Drug Delivery Systems*, Antidepressive Agents, Tricyclic/administration & dosage ; Antidepressive Agents, Tricyclic/chemistry ; Particle Size ; Biological Availability ; Solubility ; Chemistry, Pharmaceutical ; Liposomes

New oxa/thiadiazole-chalcone hybrids linked via a clickable 1,2,3-triazole bridge with dual EGFR/VEGFR-2 kinase inhibitory activity and antiproliferative effects.

Συγγραφείς: El-Qommos M; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Assiut (BUA), Assiut 71511, Egypt. Electronic address: merit.nashaat@bua.edu.eg., Morsy RMI; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: rana.morsy@aun.edu.eg., Abdel-Rahman HM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Assiut (BUA), Assiut 71511, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: hamdy.abdelrahman@bua.edu.eg., Hussein MA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: mhussein63@aun.edu.eg., Mostafa YA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Assiut (BUA), Assiut 71511, Egypt. Electronic address: yaabdelkarem@pharm.aun.edu.eg.

Πηγή: Bioorganic chemistry [Bioorg Chem] 2026 Oct 15; Vol. 182, pp. 110453. Date of Electronic Publication: 2026 Aug 31.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Triazoles*/chemistry , Triazoles*/pharmacology , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Chalcone*/chemistry , Chalcone*/pharmacology , Thiadiazoles*/chemistry , Thiadiazoles*/pharmacology , Chalcones*/chemistry , Chalcones*/pharmacology, ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Cell Proliferation/drug effects ; Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Click Chemistry

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV-1 Reverse Transcriptase.

Συγγραφείς: da Silva Moura JA; Center of Research in Therapeutic Innovation Suely Galdino (NUPIT SG), Biosciences Center, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., de Melo MVG; Center of Research in Therapeutic Innovation Suely Galdino (NUPIT SG), Biosciences Center, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., do Nascimento DRS; Center of Research in Therapeutic Innovation Suely Galdino (NUPIT SG), Biosciences Center, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., Bezerra TPW; Center of Research in Therapeutic Innovation Suely Galdino (NUPIT SG), Biosciences Center, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., Métifiot M; UMR 5234, Microbiologie Fondamentale et Pathogénicité, Université de Bordeaux, CNRS, Bordeaux, France., Recordon-Pinson P; UMR 5234, Microbiologie Fondamentale et Pathogénicité, Université de Bordeaux, CNRS, Bordeaux, France., da Rocha Pitta MG; Center of Research in Therapeutic Innovation Suely Galdino (NUPIT SG), Biosciences Center, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., da Rocha Pitta MG; Center of Research in Therapeutic Innovation Suely Galdino (NUPIT SG), Biosciences Center, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., Pereira MC; Center of Research in Therapeutic Innovation Suely Galdino (NUPIT SG), Biosciences Center, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil., Andreola ML; UMR 5234, Microbiologie Fondamentale et Pathogénicité, Université de Bordeaux, CNRS, Bordeaux, France.

Πηγή: ChemMedChem [ChemMedChem] 2026 Oct 14; Vol. 21 (19), pp. e70494.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): HIV Reverse Transcriptase*/antagonists & inhibitors , HIV Reverse Transcriptase*/metabolism , Reverse Transcriptase Inhibitors*/chemistry , Reverse Transcriptase Inhibitors*/pharmacology , Reverse Transcriptase Inhibitors*/chemical synthesis , Thiazoles*/chemistry , Thiazoles*/pharmacology , Thiazoles*/chemical synthesis , HIV-1*/drug effects , HIV-1*/enzymology , Thiazolidines*/chemistry , Thiazolidines*/pharmacology , Thiazolidines*/chemical synthesis , Anti-HIV Agents*/chemistry , Anti-HIV Agents*/pharmacology , Anti-HIV Agents*/chemical synthesis , Drug Design*, Humans ; Structure-Activity Relationship ; Chemistry, Pharmaceutical

Using mixtures of linoleic acid, a long-chain polyunsaturated fatty acid, and its monoglyceride in lipid-based formulations to increase drug loading and enhance aqueous microemulsification.

Συγγραφείς: Kandagatla HP; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, NY 11439, USA., Chowdhury N; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, NY 11439, USA., Verbić TŽ; University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, the Republic of Serbia., Avdeef A; in-ADME Research, Walnut Creek, CA 94595, USA., Savoy A; School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, CH 4132 Muttenz, Switzerland., Kuentz M; School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, CH 4132 Muttenz, Switzerland., Serajuddin ATM; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, NY 11439, USA. Electronic address: serajuda@stjohns.edu.

Πηγή: International journal of pharmaceutics [Int J Pharm] 2026 Oct 05; Vol. 703, pp. 127369. Date of Electronic Publication: 2026 Sep 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Monoglycerides*/chemistry , Linoleic Acid*/chemistry, Emulsions/chemistry ; Water/chemistry ; Lipids/chemistry ; Chemistry, Pharmaceutical/methods ; Solubility ; Drug Delivery Systems ; Drug Compounding ; Glycerides

Effect of thin-film freezing process parameters and excipient composition on mRNA lipid nanoparticles in inhalable powders.

Συγγραφείς: Sandoval MA; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States., Li Q; University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Philadelphia, PA 19104, United States., Shi R; University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Philadelphia, PA 19104, United States., Giri BR; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States., Yanwinitchai S; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States., Southard B; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States., Ni H; University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Philadelphia, PA 19104, United States., Owens DE 3rd; TFF Pharmaceuticals, Inc., Fort Worth, TX 76107, United States., Williams RO 3rd; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States., Weissman D; University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Philadelphia, PA 19104, United States. Electronic address: Dreww@pennmedicine.upenn.edu., Cui Z; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States. Electronic address: Zhengrong.Cui@austin.utexas.edu.

Πηγή: International journal of pharmaceutics [Int J Pharm] 2026 Oct 05; Vol. 703, pp. 127318. Date of Electronic Publication: 2026 Aug 18.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Ιατρικοί όροι (MeSH): RNA, Messenger*/chemistry , RNA, Messenger*/administration & dosage , Nanoparticles*/chemistry , Excipients*/chemistry , Lipids*/chemistry, Chemistry, Pharmaceutical/methods ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Powders ; Administration, Inhalation ; Particle Size ; Freeze Drying ; Aerosols ; Freezing ; Dry Powder Inhalers ; Drug Compounding ; Liposomes

Applicability of the Vreeman-Sun equation - power law mixing rule (VS-PL) model for predicting tabletability of mixtures.

Συγγραφείς: Wang Z; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA; Bristol Myers Squibb, 1 Squibb Dr, New Brunswick, NJ 08901, USA., Bhagali V; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA; Serán BioScience, 63040 Lower Meadow Dr, Bend, OR 97701, USA., Vreeman G; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA., Hasabnis A; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA., Sun CC; Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, MN 55455, USA; Department of Industrial and Molecular Pharmaceutics, Purdue University, Robert E. Heine Pharmacy Building, 124C, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address: sun1456@purdue.edu.

Πηγή: International journal of pharmaceutics [Int J Pharm] 2026 Oct 05; Vol. 703, pp. 127314. Date of Electronic Publication: 2026 Aug 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Tablets*/chemistry , Excipients*/chemistry , Models, Theoretical*, Stearic Acids/chemistry ; Powders/chemistry ; Chemistry, Pharmaceutical/methods ; Drug Compounding/methods ; Particle Size ; Bulk Drugs