Cumulus cells enhance oocyte genomic quality control by promoting DNA damage-induced meiotic arrest.

Authors: Zhou C; Christopher Chen Oocyte Biology Research Laboratory, UQ Centre for Clinical Research, Building 71/918, Royal Brisbane & Women's Hospital Campus, Herston, Queensland 4029, Australia., McKinnon B; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4067, Australia., Homer H; Christopher Chen Oocyte Biology Research Laboratory, UQ Centre for Clinical Research, Building 71/918, Royal Brisbane & Women's Hospital Campus, Herston, Queensland 4029, Australia.

Source: Journal of cell science [J Cell Sci] 2026 Jul 15; Vol. 139 (14). Date of Electronic Publication: 2026 Jul 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

MeSH Terms: DNA Damage*/genetics , Oocytes*/metabolism , Oocytes*/cytology , Cumulus Cells*/metabolism , Cumulus Cells*/cytology , Meiosis*/genetics , Genome* , M Phase Cell Cycle Checkpoints*, Spindle Apparatus/metabolism ; Mad2 Proteins/metabolism ; Mad2 Proteins/genetics ; Gap Junctions/metabolism ; Animals ; Female ; Mice ; Signal Transduction ; Cell Cycle Checkpoints

Novel anticancer alkyl pyridinium derivative exhibits antiproliferative activity via G0/G1 cell cycle arrest and apoptosis activation in triple-negative breast cancer cells.

Authors: Rasafar N; Department of Chemistry and Biochemistry, The University of Texas at El Paso, USA., Sanchez-Michael LA; Department of Biological Sciences and the Border Biomedical Research Center, The University of Texas at El Paso, USA; The Cellular Characterization and Biorepository Core Facility and College of Science at the University of Texas at El Paso, El Paso, TX, USA., Torres A; Department of Biological Sciences and the Border Biomedical Research Center, The University of Texas at El Paso, USA., Andujo LA; Department of Chemistry and Biochemistry, The University of Texas at El Paso, USA., Gutierrez DA; Department of Biological Sciences and the Border Biomedical Research Center, The University of Texas at El Paso, USA; The Cellular Characterization and Biorepository Core Facility and College of Science at the University of Texas at El Paso, El Paso, TX, USA., Varela-Ramirez A; Department of Biological Sciences and the Border Biomedical Research Center, The University of Texas at El Paso, USA; The Cellular Characterization and Biorepository Core Facility and College of Science at the University of Texas at El Paso, El Paso, TX, USA., Aguilera RJ; Department of Biological Sciences and the Border Biomedical Research Center, The University of Texas at El Paso, USA; The Cellular Characterization and Biorepository Core Facility and College of Science at the University of Texas at El Paso, El Paso, TX, USA., Noveron JC; Department of Chemistry and Biochemistry, The University of Texas at El Paso, USA. Electronic address: jcnoveron@utep.edu.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Jun; Vol. 137, pp. 118638. Date of Electronic Publication: 2026 Mar 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH Terms: Apoptosis*/drug effects , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/metabolism , Pyridinium Compounds*/chemistry , Pyridinium Compounds*/pharmacology , Pyridinium Compounds*/chemical synthesis , G1 Phase Cell Cycle Checkpoints*/drug effects, Cell Proliferation/drug effects ; Reactive Oxygen Species/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Cell Cycle Checkpoints/drug effects ; Caspase 3/metabolism ; Humans ; MDA-MB-231 Cells ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Female ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Molecular Structure

Orally Bioavailable Cyclin A/B RxL Inhibitors: Optimization of a Novel Class of Macrocyclic Peptides That Target E2F-High and G1-S-Checkpoint-Compromised Cancers.

Authors: Shapiro JA; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Dupper NJ; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Fraga-Walton B; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Bockus AT; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Leung SSF; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Yang K; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Bhatt C; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., DeMart MK; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Baldomero MP; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Hernandez L; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Fung G; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Metobo S; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Xie S; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Lent BM; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Spellmeyer DC; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Luna J; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Hoang D; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Chand M; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Gritsenko Y; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Gleason CE; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Hamkins-Indik F; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Zheng J; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Odeh R; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Nosrati M; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., He D; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Bambal R; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Cremin P; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Fang J; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Levin B; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Wang EW; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Evangelista M; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Earp D; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Kreatsoulas C; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Singh R; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Garcia PD; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States., Aggen JB; Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Mar 12; Vol. 69 (5), pp. 5441-5460. Date of Electronic Publication: 2026 Feb 21.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH Terms: Cyclin A*/antagonists & inhibitors , Cyclin A*/metabolism , Cyclin B*/antagonists & inhibitors , Cyclin B*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/chemistry , E2F Transcription Factors*/metabolism , G1 Phase Cell Cycle Checkpoints*/drug effects , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/pharmacokinetics , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/administration & dosage , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacokinetics, S Phase Cell Cycle Checkpoints/drug effects ; Humans ; Animals ; Administration, Oral ; Biological Availability ; Mice ; Cell Line, Tumor ; Structure-Activity Relationship

DNA damage checkpoints balance a tradeoff between diploid- and polyploid-derived arrest failures.

Authors: Fujimaki K; Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115, USA. Electronic address: kotaro_fujimaki@hms.harvard.edu., Jambhekar A; Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA., Lahav G; Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA. Electronic address: galit@hms.harvard.edu.

Source: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116348. Date of Electronic Publication: 2025 Sep 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: DNA Damage* , Polyploidy* , Diploidy* , Cell Cycle Checkpoints*, Humans ; G2 Phase Cell Cycle Checkpoints ; Mitosis

Exploring the effects of roscovitine, serum starvation, and contact inhibition at G0/G1 arrest in northern tiger cat dermal fibroblasts.

Authors: Viana JVDS; Laboratory of Animal Biotechnology, Federal Rural University of Semi-Arid, Av. Francisco Mota, Mossoró, RN, 59625-900, Brazil., Barbosa BS; Laboratory of Animal Biotechnology, Federal Rural University of Semi-Arid, Av. Francisco Mota, Mossoró, RN, 59625-900, Brazil., Rodrigues LLV; Laboratory of Animal Biotechnology, Federal Rural University of Semi-Arid, Av. Francisco Mota, Mossoró, RN, 59625-900, Brazil., Pereira ABM; Laboratory of Animal Biotechnology, Federal Rural University of Semi-Arid, Av. Francisco Mota, Mossoró, RN, 59625-900, Brazil., Alves PV; Sargento Prata Municipal Zoo, Fortaleza, CE, Brazil., Silva HVR; Laboratory of Carnivores Reproduction, University of Ceara State, Fortaleza, CE, Brazil., Maranhão SS; Laboratory of Experimental Oncology, Center for Research and Drug Development, Federal University of Ceará, Fortaleza, CE, Brazil., Paier CRK; Laboratory of Experimental Oncology, Center for Research and Drug Development, Federal University of Ceará, Fortaleza, CE, Brazil., Luciano MCDS; Laboratory of Experimental Oncology, Center for Research and Drug Development, Federal University of Ceará, Fortaleza, CE, Brazil., Pessoa C; Laboratory of Experimental Oncology, Center for Research and Drug Development, Federal University of Ceará, Fortaleza, CE, Brazil., Pereira AF; Laboratory of Animal Biotechnology, Federal Rural University of Semi-Arid, Av. Francisco Mota, Mossoró, RN, 59625-900, Brazil. alexsandra.pereira@ufersa.edu.br.

Source: In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 2025 Sep; Vol. 61 (8), pp. 899-908. Date of Electronic Publication: 2025 Jul 30.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-706X (Electronic) Linking ISSN: 10712690 NLM ISO Abbreviation: In Vitro Cell Dev Biol Anim Subsets: MEDLINE

MeSH Terms: Fibroblasts*/drug effects , Fibroblasts*/cytology , Roscovitine*/pharmacology , Resting Phase, Cell Cycle*/drug effects , G1 Phase Cell Cycle Checkpoints*/drug effects , Dermis*/cytology, Apoptosis/drug effects ; Culture Media, Serum-Free/pharmacology ; Cell Survival/drug effects ; G1 Phase/drug effects ; Cell Cycle Checkpoints/drug effects ; Animals ; Cats ; Tigers

Isoquinocycline B induces G0/G1 cell cycle arrest and apoptosis in MDA-MB-231 cancer cells.

Authors: Jeong GH; Research division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea., Lee H; Research division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea., Cho JY; Prokaryote Research Division, Nakdonggang National Institute of Biological Resources (NNIBR), Sangju, 37242, Republic of Korea., Rho JR; Department of Oceanography, Kunsan National University, Gunsan 54150, Republic of Korea., Chung BY; Research division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea., Park S; Bio-resources Bank Division, Nakdonggang National Institute of Biological Resources (NNIBR), Sangju, 37242, Republic of Korea. Electronic address: psh214@nnibr.re.kr., Bai HW; Research division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup 56212, Republic of Korea; Radiation Biotechnology and Applied Radioisotope Science, University of Science and Technology (UST), Daejeon, 34113, Republic of Korea. Electronic address: hbai@kaeri.re.kr.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Aug 15; Vol. 124, pp. 130244. Date of Electronic Publication: 2025 Apr 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH Terms: Apoptosis*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Anthraquinones*/pharmacology , Anthraquinones*/chemistry , G1 Phase Cell Cycle Checkpoints*/drug effects, Reactive Oxygen Species/metabolism ; Cell Proliferation/drug effects ; Cell Cycle Checkpoints/drug effects ; Humans ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Female

Cyprinid herpesvirus 3 does not replicate productively in EPC cells but induces S-phase cell cycle arrest.

Authors: Ouyang P; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: Ouyang.ping@live.cn., Zhou Y; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: 13980759644@163.com., Chen F; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: fchen0617@163.com., Zhu Y; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: lszhuyubing@163.com., Li X; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: 13088092064@163.com., Liu B; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: 15183932987@163.com., Chen D; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: chendf_sicau@126.com., Geng Y; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: gengyisicau@126.com., Song K; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: 14986@sicau.edu.cn., Huang X; Department of Aquatic Medicine, Fisheries College, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China; Sichuan Aquatic Animal Disease Surveillance and Control Center, Chengdu, Sichuan, 611130, China. Electronic address: hxlscau@126.com.

Source: Microbial pathogenesis [Microb Pathog] 2026 Sep; Vol. 218, pp. 108636. Date of Electronic Publication: 2026 Jun 15.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: Herpesviridae*/physiology , Herpesviridae*/genetics , Virus Replication* , S Phase Cell Cycle Checkpoints* , Cell Cycle Checkpoints*, Herpesviridae Infections/virology ; Herpesviridae Infections/veterinary ; Fish Diseases/virology ; Virion/ultrastructure ; Animals ; Cell Line ; DNA, Viral ; Cytopathogenic Effect, Viral ; Gene Expression Profiling ; Viral Load ; Microscopy, Electron, Transmission

SCR Organism: Cyprinid herpesvirus 3

10-HDA Suppresses the Growth of Gastric Cancer Cells Through Inducing Apoptosis and G0/G1 Cell Cycle Arrest.

Authors: Huang L; College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Lin T; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Jiang S; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Lin A; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Zhu Y; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Lin Z; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Lin Y; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Su S; College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Source: Nutrients [Nutrients] 2026 Aug 15; Vol. 18 (16). Date of Electronic Publication: 2026 Aug 15.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

MeSH Terms: Apoptosis*/drug effects , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism , Cell Proliferation*/drug effects , Fatty Acids, Monounsaturated*/pharmacology , G1 Phase Cell Cycle Checkpoints*/drug effects , Antineoplastic Agents*/pharmacology , Cell Cycle Checkpoints*/drug effects , Resting Phase, Cell Cycle*/drug effects, Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Cell Line, Tumor ; Royal Jelly

Characterization of the ribosomal stress response pathway leading to cell cycle arrest in Arabidopsis thaliana.

Authors: Ohbayashi I; Department of Life Sciences, National Cheng Kung University, No. 1, University Road, East District, Tainan 701, Taiwan  R.O.C.; Institute of Tropical Plant Sciences and Microbiology, National Cheng Kung University, No. 1, University Road, East District, Tainan 701, Taiwan  R.O.C., Hsu TY; Department of Life Sciences, National Cheng Kung University, No. 1, University Road, East District, Tainan 701, Taiwan  R.O.C., Faustine J; Department of Life Sciences, National Cheng Kung University, No. 1, University Road, East District, Tainan 701, Taiwan  R.O.C., Chiang PC; Department of Life Sciences, National Cheng Kung University, No. 1, University Road, East District, Tainan 701, Taiwan  R.O.C., Miyashita T; Department of Biological Sciences, Graduate School of Sciences, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan., Yonekura T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Iwamoto A; Department of Biological Sciences, Graduate School of Sciences, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.; Department of Biological Sciences, Faculty of Science, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan., Furutani M; Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan., Sugiyama M; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.; Department of Biochemistry and Biotechnology, Faculty of Chemistry and Biochemistry, 3-27-1 Rokkakubashi, Kanagawa-ku, Kanagawa University, Yokohama 221-8686, Japan.

Source: Plant & cell physiology [Plant Cell Physiol] 2026 Sep 29; Vol. 67 (9), pp. 1642-1659.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: Japan NLM ID: 9430925 Publication Model: Print Cited Medium: Internet ISSN: 1471-9053 (Electronic) Linking ISSN: 00320781 NLM ISO Abbreviation: Plant Cell Physiol Subsets: MEDLINE

MeSH Terms: Arabidopsis*/genetics , Arabidopsis*/physiology , Arabidopsis*/cytology , Arabidopsis*/metabolism , Arabidopsis*/drug effects , Ribosomes*/metabolism , Ribosomes*/drug effects , Stress, Physiological*/drug effects , Stress, Physiological*/genetics , Cell Cycle Checkpoints*/genetics , Cell Cycle Checkpoints*/drug effects, Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/genetics ; Gene Expression Regulation, Plant/drug effects ; Mutation/genetics ; Endoreduplication ; DNA Damage

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.

Authors: Tabe C; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Kumar R; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Huang Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Kruhlak MJ; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Sharma AK; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Shrestha RL; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Source: Cancer research communications [Cancer Res Commun] 2026 Sep 01; Vol. 6 (9), pp. 2110-2125.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE

MeSH Terms: Kinesins*/antagonists & inhibitors , Kinesins*/genetics , Kinesins*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Small Cell Lung Carcinoma*/genetics , Small Cell Lung Carcinoma*/drug therapy , Small Cell Lung Carcinoma*/pathology , Small Cell Lung Carcinoma*/metabolism , M Phase Cell Cycle Checkpoints*/drug effects , M Phase Cell Cycle Checkpoints*/genetics, Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Cell Line, Tumor ; Chromosomal Instability ; Mitosis

Targeting CDK4 with repurposing perphenazine inhibited the growth of gastric cancer AGS and HGC27 cells by arresting cell cycle.

Authors: Ma Y; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China., Tian Y; Faculty of Applied Sciences, Macao Polytechnic University, Macao, SAR, PR China., Wang H; College of Pastoral Agriculture Science and Technology, Lanzhou University, No. 768 West Jiayuguan Road, Lanzhou 730020, PR China., Zhang H; Department of Gastroenterology, Sanaitang Hospital, No. 72 Jingning Road, Lanzhou 730030, PR China., Li Y; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China., Zhou Z; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China., Si Z; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China., Zhao Y; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China., Jin Y; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China., Zhang B; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China., Fang H; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China., Liu H; Faculty of Applied Sciences, Macao Polytechnic University, Macao, SAR, PR China., Zhu H; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China., Liu Y; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China. Electronic address: yqliu@lzu.edu.cn., Chen P; School of Pharmacy, Lanzhou University, No. 199 Donggang West Road, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, No. 222 South Tianshui Road, Lanzhou 730000, PR China. Electronic address: chenpeng@lzu.edu.cn.

Source: Biochemical pharmacology [Biochem Pharmacol] 2026 Sep; Vol. 251 (Pt 1), pp. 118133. Date of Electronic Publication: 2026 Jun 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/metabolism , Stomach Neoplasms*/pathology , Cyclin-Dependent Kinase 4*/antagonists & inhibitors , Cyclin-Dependent Kinase 4*/metabolism , Cyclin-Dependent Kinase 4*/genetics , Drug Repositioning*/methods , Perphenazine*/pharmacology , Perphenazine*/administration & dosage , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/administration & dosage , Cell Cycle Checkpoints*/drug effects , Cell Cycle Checkpoints*/physiology, Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Xenograft Model Antitumor Assays/methods ; Humans ; Animals ; Cell Line, Tumor ; Mice ; Mice, Nude ; Mice, Inbred BALB C ; Female

Polyphyllin I inhibits ovarian cancer growth by inducing G0/G1 phase arrest and inhibiting the c-Myc signaling pathway.

Authors: Tang Q; Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China., Huang K; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China., Li M; College of Pharmacy, Qinghai University for Nationalities, Xining, China., Zhao Z; Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China., Deng Y; Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China., Zuo Y; Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China., Wang N; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China., Zhu Y; Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. yongxia_zhu0409@uestc.edu.cn.

Source: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Jun 12; Vol. 42 (7), pp. 254. Date of Electronic Publication: 2025 Jun 12.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

MeSH Terms: Diosgenin*/analogs & derivatives , Diosgenin*/pharmacology , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Proto-Oncogene Proteins c-myc*/metabolism , G1 Phase Cell Cycle Checkpoints*/drug effects, Signal Transduction/drug effects ; Cell Proliferation/drug effects ; Resting Phase, Cell Cycle/drug effects ; Apoptosis/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Cycle Checkpoints/drug effects ; Humans ; Female ; Cell Line, Tumor

RIPK3 promotes G2/M cell cycle arrest in renal tubular epithelial cells for maladaptive kidney repair.

Authors: Xie Z; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Li L; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Liang H; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Chen Y; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Li Z; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Zhang L; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Luo J; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Zhao X; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Chen Y; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Dong W; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China., Liang X; Division of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.

Source: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2026 Oct 14; Vol. 140 (10), pp. 2107-2126.

Publication Type: Journal Article

Journal Info: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

MeSH Terms: Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism , Receptor-Interacting Protein Serine-Threonine Kinases*/genetics , Receptor-Interacting Protein Serine-Threonine Kinases*/antagonists & inhibitors , Epithelial Cells*/pathology , Epithelial Cells*/metabolism , Epithelial Cells*/enzymology , Acute Kidney Injury*/pathology , Acute Kidney Injury*/genetics , Acute Kidney Injury*/metabolism , Kidney Tubules*/pathology , Kidney Tubules*/metabolism , Renal Insufficiency, Chronic*/pathology , Renal Insufficiency, Chronic*/etiology , Renal Insufficiency, Chronic*/genetics , Renal Insufficiency, Chronic*/metabolism , Renal Insufficiency, Chronic*/enzymology , G2 Phase Cell Cycle Checkpoints*, Reperfusion Injury/pathology ; CDC2 Protein Kinase/metabolism ; CDC2 Protein Kinase/genetics ; Animals ; Humans ; Male ; Mice, Inbred C57BL ; Phosphorylation ; Mice ; Fibrosis ; Disease Models, Animal ; Mice, Knockout

Prenylated 4-Hydroxycoumarin derivatives as inducers of CDK4/6-mediated cell cycle arrest: From design and synthesis to in vitro and in vivo evaluation of their anti-breast Cancer activity.

Authors: Pan X; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China., Wang S; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China., Lai K; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China., Dong H; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China., Zheng K; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China., Shen Y; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China., Yu A; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China., Lin C; Department of Pharmaceutics, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China. Electronic address: congconglin@hrbmu.edu.cn., Gan C; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, PR China. Electronic address: chunligan@126.com.

Source: Bioorganic chemistry [Bioorg Chem] 2026 Oct 05; Vol. 181, pp. 110344. Date of Electronic Publication: 2026 Aug 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Cyclin-Dependent Kinase 4*/metabolism , Cyclin-Dependent Kinase 4*/antagonists & inhibitors , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Cell Cycle Checkpoints*/drug effects , Cyclin-Dependent Kinase 6*/metabolism , Cyclin-Dependent Kinase 6*/antagonists & inhibitors , 4-Hydroxycoumarins*/pharmacology , 4-Hydroxycoumarins*/chemistry , 4-Hydroxycoumarins*/chemical synthesis , Drug Design*, Cell Proliferation/drug effects ; Apoptosis/drug effects ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/pathology ; Mammary Neoplasms, Experimental/metabolism ; Humans ; Female ; Animals ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Mice ; Molecular Docking Simulation

[Expression of Concern] Inhibition of TMEM45A suppresses proliferation, induces cell cycle arrest and reduces cell invasion in human ovarian cancer cells.

Authors: Guo J; Department of Gynecology and Obstetrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China., Chen L; Department of Gynecology and Obstetrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China., Luo N; Department of Gynecology and Obstetrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China., Yang W; Department of Gynecology and Obstetrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China., Qu X; Department of Gynecology and Obstetrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China., Cheng Z; Department of Gynecology and Obstetrics, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China.

Source: Oncology reports [Oncol Rep] 2026 Oct; Vol. 56 (4). Date of Electronic Publication: 2026 Aug 28.

Publication Type: Journal Article; Expression of Concern

Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE

MeSH Terms: Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/metabolism , Cell Proliferation*/genetics , Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/antagonists & inhibitors , Cell Cycle Checkpoints*/genetics, Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Humans ; Female ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Movement

Cepharanthine suppresses LMBV replication via cell cycle arrest and immunomodulation.

Authors: Liu B; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China., Wang M; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China., Zhang Z; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China., Yang B; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China., Lian S; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China., Jiang H; Hainan Institute of Northwest A&F University, Sanya, Hainan Province, 572024, China; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China., Ling F; Hainan Institute of Northwest A&F University, Sanya, Hainan Province, 572024, China; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China. Electronic address: feiling@nwsuaf.edu.cn., Wang G; Hainan Institute of Northwest A&F University, Sanya, Hainan Province, 572024, China; College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, 712100, China. Electronic address: wanggaoxue@126.com.

Source: Fish & shellfish immunology [Fish Shellfish Immunol] 2026 Oct; Vol. 177, pp. 111592. Date of Electronic Publication: 2026 Jul 14.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH Terms: Benzylisoquinolines*/pharmacology , Virus Replication*/drug effects , Fish Diseases*/immunology , Fish Diseases*/virology , Fish Diseases*/drug therapy , Cell Cycle Checkpoints*/drug effects , Ranavirus*/physiology , Ranavirus*/drug effects , DNA Virus Infections*/veterinary , DNA Virus Infections*/immunology , DNA Virus Infections*/drug therapy , DNA Virus Infections*/virology , Antiviral Agents*/pharmacology , Immunomodulation*/drug effects, Animals ; Benzodioxoles

PLK1 inhibition enhances Brentuximab vedotin efficacy in CD30-positive T-cell lymphoma via spindle assembly checkpoint activation.

Authors: Mori Y; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Suto K; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Takei N; Institute for Animal Experimentation, Hokkaido University Faculty of Medicine, Sapporo, Japan., Yokoyama K; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Chiba M; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Ishio T; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Goto H; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Endo T; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.; Department of Infection Control and Prevention, Hokkaido University Hospital, Sapporo, Japan., Hasegawa H; Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki, 852-8501, Japan., Maeda M; Institute for Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan., Otsuguro S; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, 060 0812, Japan., Maenaka K; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, 060 0812, Japan.; Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo, 060 0812, Japan.; Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, 001-0020, Japan.; Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan., Teshima T; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan., Yang Y; Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Nakagawa M; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan. nakagawam@med.hokudai.ac.jp.; Department of Hematology, Hokkaido University Hospital, Sapporo, Japan. nakagawam@med.hokudai.ac.jp.

Source: Leukemia [Leukemia] 2026 Oct; Vol. 40 (10), pp. 2133-2142. Date of Electronic Publication: 2026 Jul 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

MeSH Terms: Proto-Oncogene Proteins*/antagonists & inhibitors , Cell Cycle Proteins*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Ki-1 Antigen*/metabolism , Brentuximab Vedotin*/pharmacology , M Phase Cell Cycle Checkpoints*/drug effects , Lymphoma, T-Cell*/drug therapy , Lymphoma, T-Cell*/pathology , Lymphoma, T-Cell*/metabolism , Protein Kinase Inhibitors*/pharmacology, Apoptosis/drug effects ; Humans ; Polo-Like Kinase 1 ; Animals ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Drug Synergism

D430-2307 inhibits breast cancer cell growth by dual induction of apoptosis and G0/G1 arrest via phosphatidylinositol 3-kinase/protein kinase B signaling.

Authors: Xu J; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University.; College of Basic Medical Science, China Three Gorges University, Yichang, Hubei Province, China., Ni S; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University.; College of Basic Medical Science, China Three Gorges University, Yichang, Hubei Province, China., Yang Y; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University.; College of Basic Medical Science, China Three Gorges University, Yichang, Hubei Province, China., Sheng D; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University.; College of Basic Medical Science, China Three Gorges University, Yichang, Hubei Province, China., Liu Y; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University.; College of Basic Medical Science, China Three Gorges University, Yichang, Hubei Province, China.

Source: Anti-cancer drugs [Anticancer Drugs] 2026 Oct 01; Vol. 37 (9), pp. 554-569. Date of Electronic Publication: 2026 Mar 04.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100823 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5741 (Electronic) Linking ISSN: 09594973 NLM ISO Abbreviation: Anticancer Drugs Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Apoptosis*/drug effects , Proto-Oncogene Proteins c-akt*/metabolism , Phosphatidylinositol 3-Kinase*/metabolism , G1 Phase Cell Cycle Checkpoints*/drug effects , Antineoplastic Agents*/pharmacology, Cell Proliferation/drug effects ; Signal Transduction/drug effects ; Cell Movement/drug effects ; Reactive Oxygen Species/metabolism ; Resting Phase, Cell Cycle/drug effects ; Phosphatidylinositol 3-Kinases/metabolism ; Humans ; Female ; MDA-MB-231 Cells ; MCF-7 Cells ; Molecular Docking Simulation

Melanoma Cells Exposed to Clomiphene Citrate Respond With Cell Cycle Arrest and Reduced Invasiveness.

Authors: Ribeiro TS; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Silva FHS; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Miranda APGS; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Borges IT; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Prazeres PHDM; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Ferreira MCF; Department of Obstetrics and Gynecology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Ferreira E; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Reis FM; Department of Obstetrics and Gynecology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Del Puerto HL; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Source: Journal of applied toxicology : JAT [J Appl Toxicol] 2026 Oct; Vol. 46 (10), pp. 3675-3679. Date of Electronic Publication: 2026 Apr 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE

MeSH Terms: Melanoma*/pathology , Melanoma*/metabolism , Clomiphene*/pharmacology , Clomiphene*/toxicity , Cell Cycle Checkpoints*/drug effects, Cell Movement/drug effects ; Cell Survival/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Oxidative Stress/drug effects ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Cadherins/genetics ; Cadherins/metabolism ; Humans ; Cell Line, Tumor ; Neoplasm Invasiveness ; Superoxide Dismutase 2 ; Dose-Response Relationship, Drug

Network topology creates independent control of multiple checkpoints in the cell cycle system.

Authors: Yamauchi Y; Laboratory of Mathematical Biology, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287., Sugiyama H; Earth Life Science Institute, Institute of Science Tokyo, Tokyo 152-8550, Japan., Goto Y; Laboratory of Quantitative Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8315, Japan.; Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8315, Japan., Aoki K; Laboratory of Quantitative Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8315, Japan.; Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8315, Japan., Mochizuki A; Laboratory of Mathematical Biology, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Sep 29; Vol. 123 (39), pp. e2537815123. Date of Electronic Publication: 2026 Sep 23.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Cell Cycle*/physiology , Cell Cycle Checkpoints*/physiology , Models, Biological*