Mechanistic reprogramming of the mtDNA-cGAS-STING axis in cellular senescence: from mitochondrial homeostatic disruption to inflammatory and immune outcomes.

Authors: Zhang Y; School of Traditional Chinese Medicine, Yangzhou University, Yangzhou, 225003, China., Zhu J; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, 200032, China., Cui L; Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China., Chen S; Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China., Li X; Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China., Gao L; Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China., Chen X; Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China., Wen K; Faculty of Medicine, Yangzhou University, Yangzhou, 225009, China., Zeng B; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. zbb020708@163.com., Qian Y; School of Traditional Chinese Medicine, Yangzhou University, Yangzhou, 225003, China. yyqian@yzu.edu.cn.; NATCM Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer, Yangzhou, China. yyqian@yzu.edu.cn.

Source: Biogerontology [Biogerontology] 2026 Oct 03; Vol. 27 (5). Date of Electronic Publication: 2026 Oct 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE

MeSH Terms: DNA, Mitochondrial*/metabolism , DNA, Mitochondrial*/genetics , Cellular Senescence*/immunology , Cellular Senescence*/physiology , Mitochondria*/metabolism , Mitochondria*/immunology , Membrane Proteins*/metabolism , Nucleotidyltransferases*/metabolism, Inflammation/immunology ; Humans ; cGAS-STING Signaling Pathway ; STING Protein ; Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase ; Animals ; Homeostasis ; Signal Transduction

Evaluation the role of quinoa seeds in attenuation the brain cellular senescence and aging induced by D-galactose and γ-radiation in rats: insights into autophagy, telomerase activity, amyloid-β and tau proteins.

Authors: Mohamed MA; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt. merehanfahem@sci.asu.edu.eg., Elbakry MMM; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.; Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Cairo, Egypt., Elbakary NM; Radiation Biology Department, National Centre for Radiation Research & Technology, Egyptian Atomic-Energy Authority, Cairo, Egypt., Moselhy SS; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt., Said YA; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Source: Inflammopharmacology [Inflammopharmacology] 2026 Oct; Vol. 34 (10), pp. 6819-6838. Date of Electronic Publication: 2026 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE

MeSH Terms: Brain*/drug effects , Brain*/metabolism , Seeds*/chemistry , Aging*/drug effects , Aging*/metabolism , Chenopodium quinoa*/chemistry , Cellular Senescence*/drug effects , Cellular Senescence*/radiation effects , Plant Extracts*/pharmacology, Autophagy/drug effects ; Galactose/toxicity ; Telomerase/metabolism ; Amyloid beta-Peptides/metabolism ; Oxidative Stress/drug effects ; tau Proteins/metabolism ; Gamma Rays/adverse effects ; Antioxidants/pharmacology ; Animals ; Male ; Rats ; Molecular Docking Simulation

HMGCR-Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence.

Authors: Zhang X; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Zhou S; War Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center, Daping Hospital, Army Medical University, Chongqing, China., Liu X; Department of Otorhinolaryngology and Maxillofacial Surgery, The 988th Hospital of the Joint Logistics Support Force, Zhengzhou, China., Xiang W; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Peng X; Metabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Tian Y; Metabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Li S; Metabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Wang H; Metabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Liao B; Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Fang S; Department of Emergency Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Jin R; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Wu J; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Bai C; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Zhang W; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Huang B; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Li B; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Chen L; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Chen L; Metabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China., Zhang B; Metabolism and Repair, Laboratory For Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.; Rehabilitation Center, Key Specialty of Neck and Low Back Pain Rehabilitation, Xingcheng Special Duty Sanatorium, Xingcheng, China., Ni Z; Department of Rehabilitation Medicine, Army Medical Center, Daping Hospital, Army Medical University of PLA, Chongqing, China.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Oct; Vol. 13 (55), pp. e76498. Date of Electronic Publication: 2026 Jul 13.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/genetics , Cellular Senescence*/physiology , Fibroblasts*/metabolism , Fibroblasts*/pathology , Synovial Membrane*/metabolism , Synovial Membrane*/pathology , Cholesterol*/metabolism , Hydroxymethylglutaryl CoA Reductases*/metabolism , Hydroxymethylglutaryl CoA Reductases*/genetics , Osteoarthritis*/metabolism , Osteoarthritis*/pathology , Osteoarthritis*/genetics, Animals ; Humans ; Mice ; Disease Progression ; Male ; Disease Models, Animal

Targeting cellular senescence in dermatology: senolytic and senomorphic strategies.

Authors: Haykal D; Centre Laser Palaiseau, 49 Ter Rue de Paris, 91120, Palaiseau, France. docteur.haykal@gmail.com., Flament F; L'Oreal Research & Innovation, Clichy, France., Garibyan L; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Dermatology, Harvard Medical School, Boston, MA, USA., Lee K; Department of Dermatology, Temple University, Philadelphia, PA, USA., Escot J; Helena Rubinstein, L'Oreal Luxury Division, Levallois, France., Gueniche A; Helena Rubinstein, L'Oreal Luxury Division, Levallois, France., Kirkland J; Center for Advanced Gerotherapeutics, Department of Medicine, Pacific Design Center, Cedars-Sinai Health Sciences University, Suite B223.14, 8687 Melrose Avenue, West Hollywood, CA, 90069, USA.

Source: GeroScience [Geroscience] 2026 Oct; Vol. 48 (5), pp. 6343-6352. Date of Electronic Publication: 2026 Jul 08.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Senotherapeutics*/pharmacology , Senotherapeutics*/therapeutic use , Skin Aging*/physiology , Skin Aging*/drug effects , Dermatology*/methods, Geroscience/methods ; Humans ; Senescence-Associated Secretory Phenotype

Targeting Cellular Senescence Enhances Post-Burn Wound Healing in Aged Mice.

Authors: Faour S; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada., Khalaf F; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; Centre for Metabolism, Obesity, and Diabetes Research, McMaster University, Hamilton, Ontario, Canada., Chen Y; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Bieerkehazhi S; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., de Brito Monteiro L; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Aijaz A; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Abdulkareem N; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Matveev A; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Hinz B; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Laboratory of Tissue Repair and Regeneration, Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, Toronto, Ontario, Canada., Jeschke MG; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.; David Braley Research Institute, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; Centre for Metabolism, Obesity, and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Source: Shock (Augusta, Ga.) [Shock] 2026 Oct 01; Vol. 66 (4), pp. 918-929. Date of Electronic Publication: 2026 Jun 22.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-0514 (Electronic) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE

MeSH Terms: Wound Healing*/drug effects , Wound Healing*/physiology , Burns*/pathology , Burns*/drug therapy , Burns*/metabolism , Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Aging*, Quercetin/pharmacology ; Quercetin/therapeutic use ; Dasatinib/therapeutic use ; Dasatinib/pharmacology ; Senotherapeutics/pharmacology ; beta-Galactosidase/metabolism ; Animals ; Mice ; Male ; Mice, Inbred C57BL

Role of the GAPDH-mediated glycolysis-senescence axis in osteoarthritis chondrocytes and its modulation by semaglutide.

Authors: Liu D; Department of Orthopedics, The Second Affiliated Hospital of Bengbu Medical University, No. 633 Longhua Road, Huaishang District, Bengbu, 233000 Anhui, China; Anhui Key Laboratory of Computational Medicine and Intelligent Health, Bengbu Medical University, No. 2600 Donghai Avenue, Bengbu, 233000 Anhui, China. Electronic address: m18297312520@163.com., Wang L; Department of Urology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu, 233004 Anhui, China., Zhu L; School of Basic Medical Sciences, Bengbu Medical University, No. 2600 Donghai Avenue, Bengbu, 233030 Anhui, China., Wang Y; School of Basic Medical Sciences, Bengbu Medical University, No. 2600 Donghai Avenue, Bengbu, 233030 Anhui, China., Pei L; Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical University, 233004 Anhui, China.

Source: Joint bone spine [Joint Bone Spine] 2026 Oct; Vol. 93 (5), pp. 106072. Date of Electronic Publication: 2026 May 08.

Publication Type: Journal Article

Journal Info: Publisher: Editions Elsevier Country of Publication: France NLM ID: 100938016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1778-7254 (Electronic) Linking ISSN: 1297319X NLM ISO Abbreviation: Joint Bone Spine Subsets: MEDLINE

MeSH Terms: Chondrocytes*/metabolism , Chondrocytes*/drug effects , Osteoarthritis*/metabolism , Osteoarthritis*/genetics , Osteoarthritis*/pathology , Osteoarthritis*/drug therapy , Cellular Senescence*/drug effects , Cellular Senescence*/genetics , Glycolysis*/drug effects , Glycolysis*/genetics , Glucagon-Like Peptides*/pharmacology , Glyceraldehyde-3-Phosphate Dehydrogenases*/genetics, Cell Proliferation/drug effects ; Semaglutide ; Humans ; Cells, Cultured ; Oxidative Stress

Communication breakdown: senescent cells in interorgan communication of aging.

Authors: Ghosh R; Columbia Center for Translational Immunology and Burch-Lodge Center for Human Longevity, Department of Medicine, Columbia University Medical Center, New York, NY, USA., Dipali SS; Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA., Desdín-Míco G; Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Electronic address: gabriela.desdin@unil.ch., Yousefzadeh MJ; Columbia Center for Translational Immunology and Burch-Lodge Center for Human Longevity, Department of Medicine, Columbia University Medical Center, New York, NY, USA. Electronic address: mjy2118@cumc.columbia.edu.

Source: Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2026 Oct; Vol. 37 (10), pp. 918-926. Date of Electronic Publication: 2026 Mar 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9001516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3061 (Electronic) Linking ISSN: 10432760 NLM ISO Abbreviation: Trends Endocrinol Metab Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/physiology , Cellular Senescence*/genetics , Aging*/physiology , Cell Communication*/physiology, Inflammation/metabolism ; Humans ; Animals

Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation.

Authors: Bahraminasab M; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Al-Rashdi JS; Animal and Veterinary sciences, Sultan Qaboos University, Muscat, Muscat Governorate, Oman., Darweesh M; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Mohammadi S; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Al-Amri IS; Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa, 616, Oman., Al-Harrasi A; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Al-Roshdi MR; Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa, 616, Oman. m.alroshdi@unizwa.edu.om.

Source: Molecular biology reports [Mol Biol Rep] 2026 Sep 25; Vol. 53 (1). Date of Electronic Publication: 2026 Sep 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH Terms: Stress Granules*/metabolism , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Cellular Senescence*/physiology , Cellular Senescence*/genetics , Inflammation*/metabolism , Inflammation*/genetics , Stress, Physiological*, Humans ; Signal Transduction ; Animals ; cGAS-STING Signaling Pathway ; Senescence-Associated Secretory Phenotype

Manganese overload as a previously underappreciated trigger of cellular senescence: Unraveling mechanisms and therapeutic rescue by the senolytic quercetin.

Authors: Tao Z; Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China., Guo C; Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China., Xu S; Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China., Xiao X; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China., Yang B; Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China., Wang S; Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China., Skalny AV; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl 150000, Russia; Center of Bioelementology and Human Ecology, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow 119146, Russia., Tinkov AA; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl 150000, Russia; Center of Bioelementology and Human Ecology, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow 119146, Russia., Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Lu R; Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Clinical Experimental Research Center, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Suzhou, Jiangsu 215300, China. Electronic address: lurz@ujs.edu.cn.

Source: Neurotoxicology [Neurotoxicology] 2026 Sep; Vol. 116, pp. 103528. Date of Electronic Publication: 2026 Jul 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE

MeSH Terms: Quercetin*/pharmacology , Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Senotherapeutics*/pharmacology , Manganese*/toxicity, Oxidative Stress/drug effects ; Signal Transduction/drug effects ; DNA Damage/drug effects ; beta-Galactosidase/metabolism ; Animals ; Caenorhabditis elegans ; PC12 Cells ; cGAS-STING Signaling Pathway

Semaglutide exerts anti-pulmonary fibrosis effects by inhibiting cellular senescence through activation of the Sirt1/HSF1/HSPs pathway.

Authors: Qian Z; Xiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, Hunan, China., Shuang L; Xiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, Hunan, China., Yu-Yang L; Xiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, Hunan, China., Min-Lin L; Xiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, Hunan, China., Chong-Mei H; School of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750003, Ningxia, China., Min-Hui L; School of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750003, Ningxia, China., Wei L; Xiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha 410013, Hunan, China. Electronic address: liuw079@csu.edu.cn., Si-Yuan T; School of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750003, Ningxia, China. Electronic address: sytang263@csu.edu.cn.

Source: Biochemical pharmacology [Biochem Pharmacol] 2026 Sep; Vol. 251 (Pt 2), pp. 118172. Date of Electronic Publication: 2026 Jun 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Sirtuin 1*/metabolism , Heat Shock Transcription Factors*/metabolism , Heat Shock Transcription Factors*/genetics , Glucagon-Like Peptides*/pharmacology , Glucagon-Like Peptides*/therapeutic use , Pulmonary Fibrosis*/metabolism , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/chemically induced , Heat-Shock Proteins*/metabolism, Signal Transduction/drug effects ; Signal Transduction/physiology ; Animals ; Semaglutide ; Mice ; Male ; Mice, Inbred C57BL

Cellular Senescence in Human Chondrocytes in Relation to Osteoarthritis.

Authors: Qiang Y; Center for Single-Cell Omics, School of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Zheng C; Center for Single-Cell Omics, School of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Maslov AY; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Lu Z; Center for Single-Cell Omics, School of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Zhou M; Center for Single-Cell Omics, School of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Gao J; Department of Orthopaedics, Shanghai Sixth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Ren P; Center for Single-Cell Omics, School of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Pang Y; Department of Orthopaedics, Shanghai Sixth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Vijg J; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.

Source: Cartilage [Cartilage] 2026 Sep; Vol. 17 (3), pp. 762-770. Date of Electronic Publication: 2025 Jun 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Sage Country of Publication: United States NLM ID: 101518378 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1947-6043 (Electronic) Linking ISSN: 19476035 NLM ISO Abbreviation: Cartilage Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/physiology , Cellular Senescence*/drug effects , Chondrocytes*/drug effects , Chondrocytes*/pathology , Chondrocytes*/metabolism , Cartilage, Articular*/pathology , Cartilage, Articular*/cytology , Cartilage, Articular*/metabolism , Osteoarthritis*/pathology, Apoptosis/drug effects ; bcl-2-Associated X Protein/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; beta-Galactosidase/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Humans ; Female ; Cells, Cultured ; Aged ; Middle Aged ; Male

Assessing mechanisms and evidence of a causal role for cellular senescence and somatic mutations in aging.

Authors: Trastus LA; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan 20139, Italy., d'Adda di Fagagna F; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan 20139, Italy.; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Pavia 27100, Italy.

Source: Aging [Aging (Albany NY)] 2026 Aug 26; Vol. 18 (1), pp. 1066-1076. Date of Electronic Publication: 2026 Aug 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/genetics , Cellular Senescence*/physiology , Aging*/genetics , Mutation*, Humans ; Animals ; DNA Damage ; Senescence-Associated Secretory Phenotype

Targeting cellular senescence with Traditional Chinese Medicine: advances in neurodegenerative disorder treatment.

Authors: Hai H; Department of Rheumatology and Immunology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., Li M; Department of Rheumatology and Immunology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., Hu X; Department of Oncology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., Peng J; Department of Oncology, General Hospital of Western Theater Command, Chengdu, Sichuan, China., He Z; Department of Rheumatology and Immunology, General Hospital of Western Theater Command, Chengdu, Sichuan, China.

Source: Frontiers in neurology [Front Neurol] 2026 Aug 19; Vol. 17, pp. 1875385. Date of Electronic Publication: 2026 Aug 19 (Print Publication: 2026).

Publication Type: Journal Article; Review; Systematic Review

Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-2295 (Electronic) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Neurodegenerative Diseases*/drug therapy , Neurodegenerative Diseases*/metabolism , Medicine, Chinese Traditional*/methods , Drugs, Chinese Herbal*/therapeutic use , Drugs, Chinese Herbal*/pharmacology, Signal Transduction/drug effects ; Humans ; Animals

Coal Dust-Mimetic Carbon Nanoparticles Induce Colonic Epithelial Cell Senescence via p16/p21 Dual Pathways and Promote Colonic Inflammatory Response.

Authors: Wang Y; The First Hospital of Anhui University of Science and Technology, Huainan, China., Zhang C; Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, China., Li X; The First Hospital of Anhui University of Science and Technology, Huainan, China., Li S; The First Hospital of Anhui University of Science and Technology, Huainan, China., Jiang W; The First Hospital of Anhui University of Science and Technology, Huainan, China., Duan B; The First Hospital of Anhui University of Science and Technology, Huainan, China., Liu X; The First Hospital of Anhui University of Science and Technology, Huainan, China., Zhou S; The First Hospital of Anhui University of Science and Technology, Huainan, China., Zhang Y; The First Hospital of Anhui University of Science and Technology, Huainan, China.

Source: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2026 Aug; Vol. 41 (8), pp. 2374-2392. Date of Electronic Publication: 2026 Jun 25.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Scientific Publications Country of Publication: Australia NLM ID: 8607909 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1746 (Electronic) Linking ISSN: 08159319 NLM ISO Abbreviation: J Gastroenterol Hepatol Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/drug effects , Cellular Senescence*/genetics , Nanoparticles*/adverse effects , Nanoparticles*/toxicity , Carbon*/toxicity , Carbon*/adverse effects , Signal Transduction*/genetics , Signal Transduction*/physiology , Signal Transduction*/drug effects , Cyclin-Dependent Kinase Inhibitor p21*/metabolism , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Coal*/adverse effects , Coal*/toxicity , Epithelial Cells*/pathology , Colon*/pathology , Colon*/cytology , Inflammatory Bowel Diseases*/etiology , Inflammatory Bowel Diseases*/pathology , Dust*, Mitochondria/pathology ; Reactive Oxygen Species/metabolism ; Animals ; Male ; Intestinal Barrier Function ; Disease Models, Animal ; Carbon Nanomaterials ; Gastrointestinal Microbiome

Amino acid metabolism at the senescence-cancer interface.

Authors: Lori G; Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, Florence 50134, Italy., Mancini C; Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, Florence 50134, Italy., Pranzini E; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, Florence 50134, Italy. Electronic address: erica.pranzini@unifi.it., Magherini F; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, Florence 50134, Italy. Electronic address: francesca.magherini@unifi.it., Taddei ML; Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, Florence 50134, Italy.

Source: Trends in cancer [Trends Cancer] 2026 Aug; Vol. 12 (8), pp. 741-754. Date of Electronic Publication: 2026 May 14.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101665956 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-8025 (Electronic) Linking ISSN: 24058025 NLM ISO Abbreviation: Trends Cancer Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/immunology , Cellular Senescence*/drug effects , Amino Acids*/metabolism , Neoplasms*/pathology , Neoplasms*/metabolism , Neoplasms*/immunology , Neoplasms*/drug therapy, Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Stromal Cells/metabolism ; Stromal Cells/pathology ; Humans ; Metabolic Reprogramming ; Animals

SGLT2i-Triggered hyperglycosuria Unveils CDKN2A-Driven distal tubular senescence and EMT, Fueling renal fibrosis.

Authors: Chen Y; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Zheng SC; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Bai YF; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Deng WZ; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Gong N; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Fu YF; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Zhang ZY; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Chen XM; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Hong Q; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China. Electronic address: hongquan@301hospital.com.cn., Sun XF; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China. Electronic address: xfssun@126.com.

Source: Biochemical pharmacology [Biochem Pharmacol] 2026 Aug; Vol. 250 (Pt 1), pp. 117942. Date of Electronic Publication: 2026 Mar 31.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Sodium-Glucose Transporter 2 Inhibitors*/toxicity , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Kidney Tubules, Distal*/drug effects , Kidney Tubules, Distal*/metabolism , Kidney Tubules, Distal*/pathology, Fibrosis/metabolism ; Fibrosis/chemically induced ; Benzhydryl Compounds/toxicity ; Glucosides/toxicity ; Glucosides/pharmacology ; Animals ; Mice, Inbred C57BL ; Mice ; Male ; Sodium-Glucose Transporter 2

Endothelial Matrin-3 Limits Cellular Senescence and Lipid Dysregulation to Protect Against Murine Atherosclerosis.

Authors: Cheng X; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Tanni FY; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Zoni RN; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Abdollahi E; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Childs E; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Sun X; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Nebraska Center for the Prevention of Obesity Diseases Through Dietary Molecules, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2026 Oct 31; Vol. 40 (20), pp. e72396.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Atherosclerosis*/metabolism , Atherosclerosis*/pathology , Atherosclerosis*/prevention & control , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Nuclear Matrix-Associated Proteins*/metabolism , Nuclear Matrix-Associated Proteins*/genetics , Endothelial Cells*/metabolism , Cellular Senescence* , Lipid Metabolism*, Animals ; Mice ; Humans ; Mice, Knockout ; Mice, Inbred C57BL

Cellular senescence is an early feature and therapeutic target in amyotrophic lateral sclerosis TDP-43^Q331K mice.

Authors: Viteri JA; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Kerr NR; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Brennan CD; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Kick GR; Department of Ophthalmology, University of Missouri-Columbia, Columbia, MO, USA., Wang M; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Ketabforoush A; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Snyder HJ; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Moore PJ; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Darvishi FB; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Dashtmian AR; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Ayyagari SN; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Rich K; Department of Genetics, Harvard Medical School, Boston, MA, USA., Zhu Y; Department of Physiology and Biomedical Engineering, Robert & Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; The Sam and Ann Barshop Institute for Longevity and Aging Studies; Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA., Nishimune H; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA., Arnold WD; Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, Columbia, MO, USA; NextGen Precision Health, University of Missouri-Columbia, Columbia, MO, USA. Electronic address: wdavidarnold@health.missouri.edu.

Source: Neurobiology of disease [Neurobiol Dis] 2026 Oct 15; Vol. 229, pp. 107610. Date of Electronic Publication: 2026 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/physiopathology , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Cellular Senescence*/drug effects , Cellular Senescence*/physiology, Spinal Cord/pathology ; Spinal Cord/metabolism ; Spinal Cord/drug effects ; Dasatinib/pharmacology ; Senotherapeutics/pharmacology ; Motor Cortex/pathology ; Motor Cortex/drug effects ; Motor Cortex/metabolism ; Quercetin/pharmacology ; Motor Neurons/pathology ; Motor Neurons/drug effects ; Motor Neurons/metabolism ; Microglia/metabolism ; Microglia/pathology ; Microglia/drug effects ; Animals ; Mice ; Mice, Transgenic ; Disease Models, Animal

Mangiferin attenuates UV-B-induced premature senescence through suppression of mitochondrial ROS and restoration of mitochondrial dynamics in human dermal fibroblasts and BALB/c mice.

Authors: Ragni G; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Mushtaq MA; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Irshad BA; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Farhat KN; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Kaiser P; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Zabeer A; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Tasduq SA; Experimental Toxicology Lab, Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: stabdullah@iiim.res.in.

Source: Bioorganic chemistry [Bioorg Chem] 2026 Oct 15; Vol. 182, pp. 110454. Date of Electronic Publication: 2026 Aug 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Ultraviolet Rays*/adverse effects , Reactive Oxygen Species*/metabolism , Reactive Oxygen Species*/antagonists & inhibitors , Mitochondria*/drug effects , Mitochondria*/metabolism , Fibroblasts*/drug effects , Fibroblasts*/metabolism , Cellular Senescence*/drug effects , Cellular Senescence*/radiation effects , Xanthones*/pharmacology , Xanthones*/chemistry , Mitochondrial Dynamics*/drug effects, Skin Aging/drug effects ; Skin/drug effects ; Humans ; Animals ; Mice ; Mice, Inbred BALB C ; Dose-Response Relationship, Drug ; Cells, Cultured ; Molecular Structure ; Structure-Activity Relationship

Is Cellular Senescence a Biological Feature of Long COVID? A Transcriptomic Analysis Across Comparative Postacute Sequelae Phenotypes.

Authors: Epsi NJ; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Richard SA; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Morris MJ; Joint Base San Antonio-Fort Sam, Brooke Army Medical Center, Houston, Texas, USA., Lindholm DA; Joint Base San Antonio-Fort Sam, Brooke Army Medical Center, Houston, Texas, USA.; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Ganesan A; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.; Division of Infectious Diseases, Walter Reed National Military Medical Center, Bethesda, Maryland, USA., Colombo RE; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; Division of Infectious Diseases, Madigan Army Medical Center, Joint Base Lewis McChord, Fort Lewis, Washington, USA., Mende K; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.; Joint Base San Antonio-Fort Sam, Brooke Army Medical Center, Houston, Texas, USA., Jones MU; Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Malloy AMW; Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Rubin LH; Department of Neurology, Psychiatry and Behavioral Sciences, Molecular and Cellular Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Agan BK; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA., Tribble DR; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Burgess TH; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Dalgard C; Department of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA., Puskarich MA; Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Pollett SD; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.

Source: The Journal of infectious diseases [J Infect Dis] 2026 Oct 15; Vol. 234 (4), pp. e869-e880.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

MeSH Terms: COVID-19*/genetics , COVID-19*/complications , COVID-19*/pathology , Cellular Senescence*/genetics, Humans ; Post-Acute COVID-19 Syndrome ; Phenotype ; Female ; Gene Expression Profiling ; Male ; Middle Aged ; SARS-CoV-2 ; Aged ; Transcriptome ; Cohort Studies ; Cognitive Dysfunction