SGLT2i-Triggered hyperglycosuria Unveils CDKN2A-Driven distal tubular senescence and EMT, Fueling renal fibrosis.

Συγγραφείς: Chen Y; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Zheng SC; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Bai YF; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Deng WZ; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Gong N; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Fu YF; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Zhang ZY; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Chen XM; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China., Hong Q; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China. Electronic address: hongquan@301hospital.com.cn., Sun XF; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing 100853, China; Medical School of Chinese PLA, Beijing 100853, China. Electronic address: xfssun@126.com.

Πηγή: Biochemical pharmacology [Biochem Pharmacol] 2026 Aug; Vol. 250 (Pt 1), pp. 117942. Date of Electronic Publication: 2026 Mar 31.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Sodium-Glucose Transporter 2 Inhibitors*/toxicity , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Kidney Tubules, Distal*/drug effects , Kidney Tubules, Distal*/metabolism , Kidney Tubules, Distal*/pathology, Fibrosis/metabolism ; Fibrosis/chemically induced ; Benzhydryl Compounds/toxicity ; Glucosides/toxicity ; Glucosides/pharmacology ; Animals ; Mice, Inbred C57BL ; Mice ; Male ; Sodium-Glucose Transporter 2

Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition.

Συγγραφείς: Wang X; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Yang J; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Jin C; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Wang X; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Contreras D; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Devos M; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Kane MM; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032., Rosenfeld MG; Department of Medicine, University of California San Diego, La Jolla, CA 92093., Suh Y; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032.

Πηγή: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jul 28; Vol. 123 (30), pp. e2600323123. Date of Electronic Publication: 2026 Jul 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ovary*/metabolism , Ovary*/cytology , Ovary*/physiology , Cellular Senescence*/genetics , Cellular Senescence*/physiology , Aging*/genetics , Aging*/physiology , Aging*/metabolism , Estrous Cycle*/physiology, Granulosa Cells/metabolism ; Animals ; Female ; Mice ; Single-Cell Analysis ; Transcriptome ; Single-Cell Gene Expression Analysis

Cellular senescence and inflammageing: from mechanisms to senotherapeutic interventions.

Συγγραφείς: Chmielewski PP; Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 6a Chałubińskiego Street, 50-368, Wrocław, Poland. piotr.chmielewski@umw.edu.pl.

Πηγή: Biogerontology [Biogerontology] 2026 Jul 23; Vol. 27 (4). Date of Electronic Publication: 2026 Jul 23.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Senotherapeutics*/therapeutic use , Senotherapeutics*/pharmacology , Inflammation*/pathology , Inflammation*/drug therapy , Aging*/pathology, Humans ; Animals ; Senescence-Associated Secretory Phenotype

Protective effects of circPVT1 against D-galactose-induced senescence in HEI-OC1 auditory cells.

Συγγραφείς: Liu H; Department of Otolaryngology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China., Qian M; Department of Otolaryngology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China., Li L; Department of Rheumatology and Immunology, The First Affiliated Hospital of Jinzhou Medical University, 121000, Jinzhou, China., Gong L; Department of Otolaryngology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China. gongliang202105@163.com.

Πηγή: Molecular biology reports [Mol Biol Rep] 2026 Jul 21; Vol. 53 (1). Date of Electronic Publication: 2026 Jul 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Galactose*/pharmacology , Galactose*/metabolism , Cellular Senescence*/drug effects , Cellular Senescence*/genetics , RNA, Circular*/genetics , RNA, Circular*/metabolism , Hair Cells, Auditory*/metabolism , Hair Cells, Auditory*/drug effects , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism, Apoptosis/drug effects ; Apoptosis/genetics ; Reactive Oxygen Species/metabolism ; Cell Survival/drug effects ; Cell Survival/genetics ; Oxidative Stress/drug effects ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/metabolism ; Presbycusis/genetics ; Presbycusis/metabolism ; Animals ; Cell Line ; Humans

Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases.

Συγγραφείς: Ran S; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Zhou S; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Ma H; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Zhang F; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Yang Y; Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China., Abulajiang M; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Yang X; Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China., Li S; College of Pharmacy and Food, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China., Zhang Q; Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.; Department of Pharmacy, Sichuan Provincial People's Hospital East Sichuan Hospital & Dazhou First People's Hospital, Dazhou, 635000, China.

Πηγή: International journal of biological sciences [Int J Biol Sci] 2026 Jul 20; Vol. 22 (12), pp. 6767-6789. Date of Electronic Publication: 2026 Jul 20 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Aging*/physiology , Cellular Senescence*/physiology , Cellular Senescence*/drug effects , Senotherapeutics*/therapeutic use, Humans ; Animals ; Epigenesis, Genetic ; Apoptosis

Emodin alleviates radiation-induced pulmonary fibrosis by targeting cellular senescence via the mtDNA-cGAS-STING axis.

Συγγραφείς: Duan W; Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People's Republic of China., Sha Y; 920th Hospital of Joint Logistics Support Force, PLA, Kunming, Yunnan, People's Republic of China., Tang X; Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People's Republic of China., Liu R; Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People's Republic of China., Su B; 920th Hospital of Joint Logistics Support Force, PLA, Kunming, Yunnan, People's Republic of China., Huang M; 920th Hospital of Joint Logistics Support Force, PLA, Kunming, Yunnan, People's Republic of China., Xun X; 920th Hospital of Joint Logistics Support Force, PLA, Kunming, Yunnan, People's Republic of China., Ye Y; 920th Hospital of Joint Logistics Support Force, PLA, Kunming, Yunnan, People's Republic of China. ye_yfei@163.com.

Πηγή: Biogerontology [Biogerontology] 2026 Jul 06; Vol. 27 (4). Date of Electronic Publication: 2026 Jul 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/drug effects , Cellular Senescence*/radiation effects , Emodin*/pharmacology , DNA, Mitochondrial*/metabolism , Membrane Proteins*/metabolism , Nucleotidyltransferases*/metabolism , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/etiology , Pulmonary Fibrosis*/metabolism , Radiation Pneumonitis*/pathology , Radiation Pneumonitis*/metabolism , Radiation Pneumonitis*/drug therapy, Signal Transduction/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Animals ; cGAS-STING Signaling Pathway ; STING Protein ; Mice ; Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase ; Mice, Inbred C57BL ; Male

Epigenetic dynamics of cellular senescence: From mechanistic insights to precision senotherapy.

Συγγραφείς: Hu X; Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.; West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China., Lai W; Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, China., Liu M; Department of Anesthesiology, Air Force Hospital of Western Theater Command, PLA, Chengdu, Sichuan 610011, China., Wang B; Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.; West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China.

Πηγή: Chinese medical journal [Chin Med J (Engl)] 2026 Jul 05; Vol. 139 (13), pp. 1913-1942. Date of Electronic Publication: 2026 Mar 17.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Chinese Medical Association ; produced by Wolters Kluwer Country of Publication: China NLM ID: 7513795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2542-5641 (Electronic) Linking ISSN: 03666999 NLM ISO Abbreviation: Chin Med J (Engl) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/genetics , Cellular Senescence*/physiology , Epigenesis, Genetic*/genetics , Senotherapeutics*, DNA Methylation/genetics ; Humans ; Animals

Senolytic therapy ameliorates high-fat diet-induced hippocampal senescence and cognitive decline in mice.

Συγγραφείς: Xia X; Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; National Demonstration Center for Experimental Basic Medical Science Education (Xuzhou Medical University), Xuzhou 221004, China; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Yi F; Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China., Zhang R; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Wu R; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Zhang X; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Zhang Y; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Liu J; The First Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Qin H; National Demonstration Center for Experimental Basic Medical Science Education (Xuzhou Medical University), Xuzhou 221004, China; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., He B; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Duan Y; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Xu Y; The Second Clinical Medical College, Xuzhou Medical University, Xuzhou 221004, China., Huang XF; Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address: xhuang@uow.edu.au., Yu Y; Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address: yinghuayu@xzhmu.edu.cn., Hu M; Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address: huminmin@xzhmu.edu.cn.

Πηγή: Experimental neurology [Exp Neurol] 2026 Jul; Vol. 401, pp. 115745. Date of Electronic Publication: 2026 Mar 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Diet, High-Fat*/adverse effects , Hippocampus*/drug effects , Hippocampus*/pathology , Hippocampus*/metabolism , Senotherapeutics*/pharmacology , Senotherapeutics*/therapeutic use , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/pathology , Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Dasatinib*/pharmacology , Dasatinib*/therapeutic use, Quercetin/pharmacology ; Quercetin/therapeutic use ; Animals ; Mice ; Male ; Mice, Inbred C57BL

The telomerase reverse transcriptase-derived peptide GN11 alleviates glycolysis and cellular senescence in the fibrotic kidney by inhibiting the TGF-β1/Smad3/lncRNA Oip5-os1/miR-30c-5p/Rock2 axis.

Συγγραφείς: Yang R; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Zhang J; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Feng X; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Huang R; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Wang W; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Chen W; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Liu Y; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Chen T; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Bai J; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Lei H; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Zhang J; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Rao S; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China., Zhang B; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Science, Lanzhou University, Lanzhou 730000, China. Electronic address: zhangbz@lzu.edu.cn.

Πηγή: Biochemical pharmacology [Biochem Pharmacol] 2026 Jul; Vol. 249, pp. 117902. Date of Electronic Publication: 2026 Mar 14.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): MicroRNAs*/metabolism , MicroRNAs*/antagonists & inhibitors , MicroRNAs*/genetics , RNA, Long Noncoding*/metabolism , RNA, Long Noncoding*/antagonists & inhibitors , RNA, Long Noncoding*/genetics , Cellular Senescence*/drug effects , Cellular Senescence*/physiology , rho-Associated Kinases*/metabolism , rho-Associated Kinases*/antagonists & inhibitors , rho-Associated Kinases*/genetics , Telomerase*/chemistry , Telomerase*/metabolism , Telomerase*/pharmacology , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/antagonists & inhibitors , Glycolysis*/drug effects , Glycolysis*/physiology , Kidney*/drug effects , Kidney*/pathology , Kidney*/metabolism , Peptide Fragments*/pharmacology, Signal Transduction/drug effects ; Animals ; Humans ; Fibrosis ; Mice ; Male ; Mice, Inbred C57BL

Regulatory mechanisms of age-related degenerative diseases: Insights from the gut microbiota-cellular senescence interaction network.

Συγγραφείς: Sun P; College of Physical Education and Health, East China Normal University, Shanghai 200241, PR China; The key Laboratory of Adolescent Health Assessment and Exercise Intervention of the Ministry of Education, East China Normal University, Shanghai 200241, PR China. Electronic address: psun@tyxx.ecnu.edu.cn., Chen G; College of Physical Education and Health, East China Normal University, Shanghai 200241, PR China., Guo Y; College of Physical Education and Health, East China Normal University, Shanghai 200241, PR China.

Πηγή: Ageing research reviews [Ageing Res Rev] 2026 Jul; Vol. 119, pp. 103152. Date of Electronic Publication: 2026 Apr 29.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/physiology , Gastrointestinal Microbiome*/physiology , Aging*/metabolism , Aging*/pathology , Neurodegenerative Diseases*/microbiology , Neurodegenerative Diseases*/metabolism, Humans ; Animals ; Intestinal Barrier Function ; Senescence-Associated Secretory Phenotype

Senescence-circadian interplay stratifies patient prognosis and reveals immune remodeling heterogeneity in colorectal cancer.

Συγγραφείς: Luo LZ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhan Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Bioinformatics, Sun Yat-sen University Cancer Center, Guangzhou, China., Bao RX; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Bioinformatics, Sun Yat-sen University Cancer Center, Guangzhou, China., Zheng YQ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Wu QN; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Xi SY; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu ZX; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Bioinformatics, Sun Yat-sen University Cancer Center, Guangzhou, China., Li T; Department of Gastroenterology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China., Zhao Q; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Bioinformatics, Sun Yat-sen University Cancer Center, Guangzhou, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jun 03; Vol. 17, pp. 1804974. Date of Electronic Publication: 2026 Jun 03 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/mortality , Colorectal Neoplasms*/pathology , Cellular Senescence*/genetics , Cellular Senescence*/immunology , Circadian Rhythm*/genetics , Circadian Rhythm*/immunology, NADPH Oxidase 4/genetics ; NADPH Oxidase 4/metabolism ; Biomarkers, Tumor/genetics ; Tumor Microenvironment/immunology ; Tumor Microenvironment/genetics ; Lymphocytes, Tumor-Infiltrating/immunology ; Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Gene Expression Profiling ; Transcriptome ; Female

A conserved regulatory architecture stabilizes cellular senescence across distinct triggers in human fibroblasts.

Συγγραφείς: Shahzaib M; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Luigi Vanvitelli Campania University, 80138, Naples, Italy., Aprile D; Department of Life Sciences, Health and Health Professions, Link Campus University, 00165, Rome, Italy., Squillaro T; Department of Life Sciences, Health and Health Professions, Link Campus University, 00165, Rome, Italy., Alessio N; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Luigi Vanvitelli Campania University, 80138, Naples, Italy., Peluso G; Faculty of Medicine and Surgery, Saint Camillus International, University of Health Sciences, Rome, Italy., Di Bernardo G; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Luigi Vanvitelli Campania University, 80138, Naples, Italy. gianni.dibernardo@unicampania.it., Galderisi U; Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Luigi Vanvitelli Campania University, 80138, Naples, Italy. umberto.galderisi@unicampania.it.; Sbarro Health Research Organization, Temple University, Philadelphia, PA, 19122, USA. umberto.galderisi@unicampania.it.; Genome and Stem Cell Center (GENKÖK), Erciyes University, Kayseri, Turkey. umberto.galderisi@unicampania.it.

Πηγή: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 3511-3529. Date of Electronic Publication: 2026 May 07.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/genetics , Cellular Senescence*/physiology , Fibroblasts*/metabolism , Fibroblasts*/physiology, Humans ; Protein Interaction Maps

Cellular senescence as a therapeutic target for aging intervention.

Συγγραφείς: Bi Y; Henan Academy of Sciences, Zhengzhou, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: youkunbi@ibp.ac.cn., Ji G; Henan Academy of Sciences, Zhengzhou, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: gj28@ibp.ac.cn.

Πηγή: Biomedical journal [Biomed J] 2026 Jun; Vol. 49 (3), pp. 100948. Date of Electronic Publication: 2026 Jan 17.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 101599820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2320-2890 (Electronic) Linking ISSN: 23194170 NLM ISO Abbreviation: Biomed J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/physiology , Cellular Senescence*/drug effects , Aging*/physiology , Aging*/drug effects, Immunotherapy/methods ; Senotherapeutics/therapeutic use ; Humans ; Animals

Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload.

Συγγραφείς: Ávila-Galicia KE; Posgrado en Biología Experimental, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico; Laboratorio de Bioenergética y Envejecimiento Celular, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico., Alarcón-Aguilar A; Laboratorio de Bioenergética y Envejecimiento Celular, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico., Soto-Reyes E; Departamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Ciudad de México, Mexico., Königsberg M; Laboratorio de Bioenergética y Envejecimiento Celular, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad-Iztapalapa (UAM-I), Ciudad de México, Mexico. Electronic address: mkf@xanum.uam.mx.

Πηγή: Ageing research reviews [Ageing Res Rev] 2026 Jun; Vol. 118, pp. 103115. Date of Electronic Publication: 2026 Mar 27.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/physiology , Cellular Senescence*/genetics , Epigenesis, Genetic*/physiology , Fatty Acids*/metabolism , Chromatin Assembly and Disassembly*/physiology , Aging*/genetics , Aging*/metabolism , Chromatin*/metabolism, Obesity/metabolism ; Obesity/genetics ; Humans ; Animals

Loss of sirtuin 3 disrupts cellular senescence signaling pathways.

Συγγραφείς: Kura N; Jean Mayer USDA Human Nutrition Research On Aging at Tufts University, Boston, MA, 02111, USA.; Graduate School of Biological Sciences, Tufts University, Boston, MA, 02111, USA., Mogck BA; Jean Mayer USDA Human Nutrition Research On Aging at Tufts University, Boston, MA, 02111, USA., Jezak ST; Jean Mayer USDA Human Nutrition Research On Aging at Tufts University, Boston, MA, 02111, USA.; Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA, 02111, USA., Velarde MC; Institute of Biology, College of Science, University of the Philippines, 1101, Quezon City, Philippines., Wiley CD; Jean Mayer USDA Human Nutrition Research On Aging at Tufts University, Boston, MA, 02111, USA. christopher.wiley@tufts.edu.; Graduate School of Biological Sciences, Tufts University, Boston, MA, 02111, USA. christopher.wiley@tufts.edu.; Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA, 02111, USA. christopher.wiley@tufts.edu.; Department of Medicine, School of Medicine, Tufts University, Boston, MA, 02111, USA. christopher.wiley@tufts.edu.

Πηγή: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 3483-3495. Date of Electronic Publication: 2026 May 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Sirtuin 3*/genetics , Sirtuin 3*/deficiency , Sirtuin 3*/metabolism , Cellular Senescence*/physiology , Cellular Senescence*/genetics , Signal Transduction* , Senescence-Associated Secretory Phenotype*, Fibroblasts/metabolism ; Wound Healing/physiology ; Tumor Suppressor Protein p53/metabolism ; Animals ; Mice, Knockout ; Mice ; Aging

Human Islet miR-199a-5p and miR-214-3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet-Derived Cells.

Συγγραφείς: Wong WKM; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., El-Azzi I; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Nachanekar A; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Alvandi E; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Pham NHT; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Hardikar HP; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Polkamp M; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Saini V; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Cheng F; Health Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Jiang G; Department of Medicine and Therapeutics, And Hong Kong Institute of Diabetes and Obesity, and Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong (Special Administrative Region), China.; School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, China., Sørensen AE; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Chew YV; Centre for Transplant and Renal Research, Westmead Institute for Medical Research (WIMR), University of Sydney, Westmead, New South Wales, Australia., Thomas HE; Immunology and Diabetes Group, St. Vincent's Institute (SVI) for Medical Research, Fitzroy, Victoria, Australia., Loudovaris T; Immunology and Diabetes Group, St. Vincent's Institute (SVI) for Medical Research, Fitzroy, Victoria, Australia., Ma RCW; Department of Medicine and Therapeutics, And Hong Kong Institute of Diabetes and Obesity, and Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong (Special Administrative Region), China., Hawthorne WJ; Centre for Transplant and Renal Research, Westmead Institute for Medical Research (WIMR), University of Sydney, Westmead, New South Wales, Australia., Dalgaard LT; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Joglekar MV; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Hardikar AA; Diabetes & Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia.; Department of Science and Environment, Roskilde University, Roskilde, Denmark.

Πηγή: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2026 Aug; Vol. 242 (8), pp. e70277.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262545 Publication Model: Print Cited Medium: Internet ISSN: 1748-1716 (Electronic) Linking ISSN: 17481708 NLM ISO Abbreviation: Acta Physiol (Oxf) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): MicroRNAs*/metabolism , MicroRNAs*/genetics , Islets of Langerhans*/metabolism , Islets of Langerhans*/cytology , Cellular Senescence*/physiology , Cellular Senescence*/genetics , Body Mass Index*, Humans ; Female ; Male ; Adult ; Middle Aged ; Aged ; Age Factors ; Sex Factors ; Tissue Donors

Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury.

Συγγραφείς: Keeble AR; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Owen AM; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States., Gonzalez-Velez S; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Thomas NT; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States., Brightwell CR; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States., Balawender PJ; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., O'Daniel MG; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Weiss HC; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Noehren H; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Thompson H; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, Kentucky, United States., Zuluaga-Osorio KS; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Bates ZT; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Gottlieb L; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Long DE; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States., Harrison DA; Department of Biology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky, United States., Kern PA; Division of Endocrinology, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Conley CE; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Samaan MA; Department of Kinesiology and Health Promotion, College of Education, University of Kentucky, Lexington, Kentucky, United States., Duncan ST; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Stone AV; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Johnson DL; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Wen Y; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Noehren B; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States., Dungan CM; Department of Health, Human Performance, and Recreation, College of Health and Human Sciences, Baylor University, Waco, Texas, United States., Fry CS; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, United States.

Πηγή: Function (Oxford, England) [Function (Oxf)] 2026 Aug 01; Vol. 7 (4), pp. e0172026. Date of Electronic Publication: 2026 Jun 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: United States NLM ID: 101770668 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2633-8823 (Electronic) Linking ISSN: 26338823 NLM ISO Abbreviation: Function (Oxf) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Anterior Cruciate Ligament Injuries*/complications , Anterior Cruciate Ligament Injuries*/pathology , Muscular Atrophy*/etiology , Muscular Atrophy*/pathology , Osteoarthritis, Knee*/etiology , Osteoarthritis, Knee*/pathology , Osteoarthritis*/etiology , Osteoarthritis*/pathology, Quercetin/pharmacology ; Macrophages/pathology ; Macrophages/metabolism ; Dasatinib/pharmacology ; Dasatinib/therapeutic use ; Senotherapeutics/pharmacology ; Muscle, Skeletal/pathology ; Animals ; Humans ; Male ; Female ; Disease Models, Animal ; Mice

Dermal Interstitial Glycogenosis and Stromal Senescence-Associated Marker Expression in Fibrofolliculomas: Implications for Pathogenesis and mTOR-Targeted Therapy.

Συγγραφείς: Nazarian RM; Department of Dermatology, Boston University School of Medicine, Boston, MA., Miyagi Y; Molecular Pathology & Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan ; and., Nakatani Y; Department of Pathology, Yokosuka Kyosai Hospital, Yokosuka, Japan .

Πηγή: The American Journal of dermatopathology [Am J Dermatopathol] 2026 Aug 01; Vol. 48 (8), pp. 617-621. Date of Electronic Publication: 2026 Jun 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7911005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-0311 (Electronic) Linking ISSN: 01931091 NLM ISO Abbreviation: Am J Dermatopathol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Skin Neoplasms*/pathology , Skin Neoplasms*/drug therapy , Skin Neoplasms*/metabolism , Stromal Cells*/pathology , Cellular Senescence*, TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Biomarkers, Tumor/analysis ; MTOR Inhibitors/therapeutic use ; Humans ; Female ; Male ; Middle Aged ; Adult ; Aged

Senescence as a regulatory mechanism in skeletal muscle repair in young mice.

Συγγραφείς: Johnson AL; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., Bevington RT; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., Parise G; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.

Πηγή: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 Aug 01; Vol. 331 (2), pp. C316-C327. Date of Electronic Publication: 2026 Jun 18.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Muscle, Skeletal*/drug effects , Muscle, Skeletal*/pathology , Muscle, Skeletal*/metabolism , Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Regeneration*/drug effects , Regeneration*/physiology , Wound Healing*/drug effects , Aging*, Macrophages/drug effects ; Macrophages/metabolism ; Satellite Cells, Skeletal Muscle/drug effects ; Satellite Cells, Skeletal Muscle/metabolism ; Satellite Cells, Skeletal Muscle/pathology ; Senotherapeutics/pharmacology ; Quercetin/pharmacology ; Animals ; Mice ; Mice, Inbred C57BL ; Male

Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions.

Συγγραφείς: Liu X; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Guo Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Popa-Wagner A; Center for Normal and Pathological Ageing, University of Medicine and Pharmacy, Craiova, Romania., Lämmermann I; Rockfish Bio AG, Vienna, Austria., Grillari J; Ludwig Boltzmann Institute for Traumatology, the Research Center in Cooperation with AUVA, Vienna, Austria; Institute of Molecular Biotechnology, BOKU University, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria. Electronic address: johannes.grillari@boku.ac.at., Hermann DM; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: dirk.hermann@uk-essen.de.

Πηγή: Ageing research reviews [Ageing Res Rev] 2026 Aug; Vol. 120, pp. 103206. Date of Electronic Publication: 2026 Jun 14.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/physiology , Ischemic Stroke*/pathology , Ischemic Stroke*/metabolism , Ischemic Stroke*/therapy , Brain*/pathology , Brain*/metabolism , Brain Ischemia*/pathology , Stroke*/pathology, Humans ; Animals ; Senescence-Associated Secretory Phenotype