Functional Gene Restoration and Cancer Stem Cell Eradication in a Treatment-Resistant TNBC Case: A First-in-Human Paradigm Shift

Authors: Malone, Marc, orcid:0009-0004-8968-

Contributors: Greer, Erin, Wimbs, Trisha

Subject Terms: Epigenetics, Epigenetic Memory, Epigenetic Repression, Metabolic Reprogramming/drug effects, Cellular Reprogramming/drug effects, Cellular Reprogramming/genetics, Cellular Reprogramming Techniques/methods, Metabolic Reprogramming, Metabolic Reprogramming/genetics, Triple-Negative Breast Cancer, Breast cancer, Signal processing, Signal Transduction, Signal Transduction/genetics, cancer stem cells, metastatic, tumor reduction

Relation: https://zenodo.org/records/15278175; oai:zenodo.org:15278175; https://doi.org/10.5281/zenodo.15278175

Availability: https://doi.org/10.5281/zenodo.15278175
https://zenodo.org/records/15278175

First Human Epigenetic Reprogramming Case: ESR1/PGR Gene Restoration, Tumor Reduction, and CSC/CTC Suppression in Advanced TNBC

Authors: Malone, Marc, orcid:0009-0004-8968-

Contributors: Greer, Erin, Wimbs, Trisha

Subject Terms: Epigenetics, Epigenetic Memory, Epigenetic Repression, Metabolic Reprogramming/drug effects, Cellular Reprogramming/drug effects, Cellular Reprogramming/genetics, Cellular Reprogramming Techniques/methods, Metabolic Reprogramming, Metabolic Reprogramming/genetics, Triple-Negative Breast Cancer, Breast cancer, Signal processing, Signal Transduction, Signal Transduction/genetics

Relation: https://zenodo.org/records/15277781; oai:zenodo.org:15277781; https://doi.org/10.5281/zenodo.15277781

Availability: https://doi.org/10.5281/zenodo.15277781
https://zenodo.org/records/15277781

Genome-wide DNA methylation profiling is able to identify prefibrotic PMF cases at risk for progression to myelofibrosis

Authors: Lehmann, Ulrich, Stark, Helge, Bartels, Stephan, Schlue, Jerome, Büsche, Guntram, Kreipe, Hans

Source: http://lobid.org/resources/99370675582406441#!, 13(1):28.

Subject Terms: Embryonic Germ Cells/metabolism [MeSH], Animal Experimentation [MeSH], Disease Progression [MeSH], Fibrosis/pathology [MeSH], Risk Factors [MeSH], Gene Ontology [MeSH], 850 k EPIC array, Genome-Wide Association Study/methods [MeSH], Male [MeSH], DNA methylation, Primary Myelofibrosis/genetics [MeSH], DNA Fingerprinting/methods [MeSH], Fusion Proteins, bcr-abl/genetics [MeSH], Female [MeSH], Humans [MeSH], Bone Marrow/metabolism [MeSH], Predictive Value of Tests [MeSH], Prefibrotic PMF, Cellular Reprogramming Techniques/methods [MeSH], Epigenomics/methods [MeSH], Fibrosis/genetics [MeSH], Cell Competition/genetics [MeSH], CpG Islands/genetics [MeSH], Cancer epigenetics and diagnostics, DNA Methylation [MeSH], Research, Prognosis [MeSH], Primary Myelofibrosis/pathology [MeSH], Myelofibrosis

Relation: https://repository.publisso.de/resource/frl:6463989; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860011/

Availability: https://repository.publisso.de/resource/frl:6463989
https://doi.org/10.1186/s13148-021-01010-y
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860011/

Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2

Authors: Shraya Sharma, Shin Jeong Lee, Young Sup Yoon, Claire Min Shin, Ju Young Kim, Changwon Park, Yoshiaki Tanaka, In-Hyun Park, Kyuwon Cho, Eun Jae Kim, Hyo Jae An, Sangsung Kim, Sangho Lee, Ji Woong Han, Se Yeong Oh

Contributors: College of Medicine, Dept. of Life Science, Sangho Lee, Changwon Park, Ji Woong Han, Ju Young Kim, Kyuwon Cho, Eun Jae Kim, Sangsung Kim, Shin-Jeong Lee, Se Yeong Oh, Yoshiaki Tanaka, In-Hyun Park, Hyo Jae An, Claire Min Sin, Shraya Sharma, Young-sup Yoon, Yoon, Young Sup, Lee, Shin-Jeong

Source: Circulation Research. 120:848-861

Subject Terms: Male, 0301 basic medicine, Hindlimb/physiology, Cells, Nude, Transcription Factors/genetics, regenerative medicine, Mice, Nude, Neovascularization, Physiologic, ischemia, Mice, 03 medical and health sciences, Ischemia, fibroblasts, Human Umbilical Vein Endothelial Cells, Cell Differentiation/physiology, Animals, Humans, Cellular Reprogramming Techniques, Neovascularization, Cells, Cultured, Cultured, Endothelial Cells, Cell Differentiation, Fibroblasts, Transcription Factors/biosynthesis, Ischemia/metabolism, endothelial cells, Cellular Reprogramming Techniques/methods, Hindlimb/blood supply, Hindlimb, 3. Good health, Endothelial Cells/physiology, Physiologic/physiology, cell therapy, Fibroblasts/physiology, Transcription Factors

Access URL: https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.309833
https://pubmed.ncbi.nlm.nih.gov/28003219
https://open.library.emory.edu/publications/emory:s8k5s/
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.309833
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336520
https://pubmed.ncbi.nlm.nih.gov/28003219/
http://europepmc.org/articles/PMC5336520
https://yonsei.pure.elsevier.com/en/publications/direct-reprogramming-of-human-dermal-fibroblasts-into-endothelial

Turning tumors from cold to inflamed to improve immunotherapy response.

Authors: Gerard, C.L., Delyon, J., Wicky, A., Homicsko, K., Cuendet, M.A., Michielin, O.

Subject Terms: Antineoplastic Agents, Immunological/pharmacology, Cellular Reprogramming Techniques/methods, Combined Modality Therapy, Humans, Immune Checkpoint Inhibitors/pharmacology, Immunotherapy/methods, Immunotherapy/trends, Neoplasms/drug therapy, Neoplasms/genetics, Neoplasms/immunology, Tumor Microenvironment/drug effects, Tumor Microenvironment/immunology, Cold tumors, Hot tumors, Immunotherapy, Inflamed tumors, Tumor microenvironment

Relation: Cancer Treatment Reviews; https://iris.unil.ch/handle/iris/38788; serval:BIB_4AB33FCA1873; 000708666700001

Availability: https://iris.unil.ch/handle/iris/38788
https://doi.org/10.1016/j.ctrv.2021.102227