YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

Authors: Rahil Noorizadeh, Barbara Sax, Tahereh Javaheri, Branka Radic-Sarikas, Valerie Fock, Veveeyan Suresh, Maximilian Kauer, Aleksandr Bykov, Danijela Kurija, Michaela Schlederer, Lukas Kenner, Gerhard Weber, Wolfgang Mikulits, Florian Halbritter, Richard Moriggl, Heinrich Kovar

Source: Cell Reports ; issn:1746-6148

Subject Terms: Animals, Mesenchymal Stem Cells Metabolism, YAP-Signaling Proteins Metabolism, RNA-Binding Protein EWS Metabolism, RNA-Binding Protein EWS Genetics, Humans, Mice, Cell Transformation, Neoplastic Metabolism, Neoplastic Genetics, Proto-Oncogene Protein c-fli-1Metabolism, Proto-Oncogene Protein c-fli-1Genetics, Adaptor Proteins, Signal Transducing Metabolism, Insulin-Like Growth Factor I Metabolism, Transcription Factors Metabolism, Sarcoma, Ewing Metabolism, Ewing Pathology, Ewing Genetics, Cellular Reprogramming Drug Effects, Oncogene Proteins, Fusion Metabolism, Fusion Genetics, Receptor, IGF Type 1 Metabolism, Bone and Bones Metabolism, Bone and Bones Pathology

File Description: application/pdf

Relation: isPartOf:https://phaidra.vetmeduni.ac.at/o:605[Open Access Publikationen]; https://phaidra.vetmeduni.ac.at/o:4046

Availability: https://doi.org/10.1016/j.celrep.2025.115381
https://phaidra.vetmeduni.ac.at/o:4046

Functional Gene Restoration and Cancer Stem Cell Eradication in a Treatment-Resistant TNBC Case: A First-in-Human Paradigm Shift

Authors: Malone, Marc, orcid:0009-0004-8968-

Contributors: Greer, Erin, Wimbs, Trisha

Subject Terms: Epigenetics, Epigenetic Memory, Epigenetic Repression, Metabolic Reprogramming/drug effects, Cellular Reprogramming/drug effects, Cellular Reprogramming/genetics, Cellular Reprogramming Techniques/methods, Metabolic Reprogramming, Metabolic Reprogramming/genetics, Triple-Negative Breast Cancer, Breast cancer, Signal processing, Signal Transduction, Signal Transduction/genetics, cancer stem cells, metastatic, tumor reduction

Relation: https://zenodo.org/records/15278175; oai:zenodo.org:15278175; https://doi.org/10.5281/zenodo.15278175

Availability: https://doi.org/10.5281/zenodo.15278175
https://zenodo.org/records/15278175

First Human Epigenetic Reprogramming Case: ESR1/PGR Gene Restoration, Tumor Reduction, and CSC/CTC Suppression in Advanced TNBC

Authors: Malone, Marc, orcid:0009-0004-8968-

Contributors: Greer, Erin, Wimbs, Trisha

Subject Terms: Epigenetics, Epigenetic Memory, Epigenetic Repression, Metabolic Reprogramming/drug effects, Cellular Reprogramming/drug effects, Cellular Reprogramming/genetics, Cellular Reprogramming Techniques/methods, Metabolic Reprogramming, Metabolic Reprogramming/genetics, Triple-Negative Breast Cancer, Breast cancer, Signal processing, Signal Transduction, Signal Transduction/genetics

Relation: https://zenodo.org/records/15277781; oai:zenodo.org:15277781; https://doi.org/10.5281/zenodo.15277781

Availability: https://doi.org/10.5281/zenodo.15277781
https://zenodo.org/records/15277781

Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts

Authors: Sang Wook Lee, Patrick Tae Joon Hwang, Eric Shin, Yoshiaki Tanaka, Ho-Wook Jun, Hong Yi, Woongchan Rah, Sangsung Kim, Kyuwon Cho, Seongho Bae, Nam Kyun Kim, Young Sup Yoon, Jae kyung Jung, Dong Hoon Shin, Min Goo Lee, Richard P. Harvey, Rebecca D. Levit, Mark A. Sussman, Hun-Jun Park, In-Hyun Park, Ji Woong Han, Hyein Lee, Jaeyeaon Cho, Hee Cheol Cho

Contributors: Jaeyeaon Cho, Sangsung Kim, Hyein Lee, Woongchan Rah, Hee Cheol Cho, Nam Kyun Kim, Seongho Bae, Dong Hoon Shin, Min Goo Lee, In-Hyun Park, Yoshiaki Tanaka, Eric Shin, Hong Yi, Ji Woong Han, Patrick Tae Joon Hwang, Ho-Wook Jun, Hun-Jun Park, Kyuwon Cho, Sang Wook Lee, Jae Kyung Jung, Rebecca D Levit, Mark A Sussman, Richard P Harvey, Young-Sup Yoon, Yoon, Young Sup

Source: Nature Biomedical Engineering. 5:880-896

Subject Terms: 0301 basic medicine, Myocardium / metabolism, Myocytes, Smooth Muscle, Myocardial Infarction, Neovascularization, Physiologic, Ascorbic Acid, Bone Morphogenetic Protein 4, Myosin Heavy Chains / genetics, Gap Junctions / physiology, Inbred C57BL, Fibroblasts / metabolism, Mice, 03 medical and health sciences, Bone Morphogenetic Protein 4 / pharmacology, Animals, Regeneration, Smooth Muscle / transplantation, Physiologic, Neovascularization, Myocytes, 0303 health sciences, Endothelial Cells / transplantation, Myosin Heavy Chains, Endothelial Cells / metabolism, Myosin Heavy Chains / metabolism, Myocardium, Fibroblasts / cytology, Endothelial Cells, Gap Junctions, Heart, Smooth Muscle / cytology, Fibroblasts, Smooth Muscle / metabolism, Cellular Reprogramming, MicroRNAs / metabolism, Cellular Reprogramming / drug effects, Mice, Inbred C57BL, MicroRNAs, Ascorbic Acid / pharmacology, Myocardium / pathology, Heart / physiology, Myocardial Infarction / therapy, Myocardium / cytology, Transcriptome, Endothelial Cells / cytology

Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809198
https://pubmed.ncbi.nlm.nih.gov/34426676
https://www.nature.com/articles/s41551-021-00783-0
https://www.nature.com/articles/s41551-021-00783-0.pdf
https://pubmed.ncbi.nlm.nih.gov/34426676/
https://europepmc.org/article/MED/34426676

Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy

Authors: Elodie Renaude, Marie Kroemer, Christophe Borg, Paul Peixoto, Eric Hervouet, Romain Loyon, Olivier Adotévi

Contributors: INSERM - Institut National de la Santé et de la Recherche Médicale, EFS - Etablissement Français du Sang, Université de Franche-Comté

Source: Front Immunol
Frontiers in Immunology, Vol 12 (2021)

Subject Terms: 0301 basic medicine, Immunology, Antineoplastic Agents, Epigenesis, Genetic/drug effects, Biochimie, biophysique & biologie moléculaire, Immunotherapy, Adoptive, Epigenesis, Genetic, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Cellular Reprogramming/drug effects, Neoplasms, Tumor Microenvironment, tumor microenvironment, Animals, Humans, Lymphocytes, Tumor-Infiltrating/immunology, CD4+ helper T cells, 0303 health sciences, Lymphocytes, Tumor-Infiltrating/metabolism, epigenetics, Cell Differentiation, T-Lymphocytes, Helper-Inducer, RC581-607, Cellular Reprogramming, Life sciences, 3. Good health, Treatment Outcome, plasticity, Sciences du vivant, immunotherapy, Immunologic diseases. Allergy, Biochemistry, biophysics & molecular biology

Access URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.669992/pdf
https://pubmed.ncbi.nlm.nih.gov/34262562
https://doaj.org/article/291928e2de864f3b876293c40387eabb
https://pubmed.ncbi.nlm.nih.gov/34262562/
https://www.frontiersin.org/articles/10.3389/fimmu.2021.669992/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273698
https://europepmc.org/article/PMC/PMC8273698

DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells

Authors: Bruyer, Angelique, Maes, Ken, Herviou, Laurie, Kassambara, Alboukadel, Seckinger, Anja, Cartron, Guillaume, Reme, Thierry, Robert, Nicolas, Requirand, Guilhem, Boireau, Stéphanie, Müller-Tidow, Carsten, Veyrune, Jean-Luc, Vincent, Laure, Bouhya, Salahedine, Goldschmidt, Hartmut, Vanderkerken, Karin, Hose, Dirk, Klein, Bernard, De Bruyne, Elke, Moreaux, Jerome

Contributors: Basic (bio-) Medical Sciences, FORMER_Hematology, Translational Oncology Research Center

Source: Br J Cancer

Subject Terms: 0301 basic medicine, mice, Plasma Cells, Multiple Myeloma/drug therapy, Epigenesis, Genetic/drug effects, Article, Epigenesis, Genetic, Mice, 03 medical and health sciences, Cellular Reprogramming/drug effects, Antineoplastic Combined Chemotherapy Protocols, Tumor Cells, Cultured, Animals, Humans, Molecular Targeted Therapy, 0303 health sciences, Histone Deacetylase Inhibitors/administration & dosage, Gene Expression Profiling, Cell Differentiation, Cellular Reprogramming, Microarray Analysis, 3. Good health, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, Plasma Cells/drug effects, Research Design, Cell Differentiation/drug effects, Gene Expression Regulation, Neoplastic/drug effects, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, microarray analysis, Multiple Myeloma, Transcriptome, Molecular Targeted Therapy/methods

Access URL: https://www.nature.com/articles/s41416-018-0025-x.pdf
https://pubmed.ncbi.nlm.nih.gov/29500406
https://europepmc.org/article/PMC/PMC5931098
https://www.nature.com/articles/s41416-018-0025-x
https://pubmed.ncbi.nlm.nih.gov/29500406/
https://paperity.org/p/136374428/dnmti-hdaci-combined-epigenetic-targeted-treatment-induces-reprogramming-of-myeloma-cells
https://www.ncbi.nlm.nih.gov/pubmed/29500406
https://researchportal.vub.be/en/publications/dnmtihdaci-combined-epigenetic-targeted-treatment-induces-reprogr
https://biblio.vub.ac.be/vubir/dnmtihdaci-combined-epigenetic-targeted-treatment-induces-reprogramming-of-myeloma-cells-in-the-direction-of-normal-plasma-cells(3bb55fec-a3b0-484c-83f0-895a06cb08d8).html

Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.

Authors: Renaude, Elodie, Kroemer, Marie, Borg, Christophe, Peixoto, Paul, Hervouet, Eric, Loyon, Romain, Adotévi, Olivier

Source: Frontiers in Immunology, 12, 669992 (2021)

Subject Terms: CD4+ helper T cells, epigenetics, immunotherapy, plasticity, tumor microenvironment, Cellular Reprogramming/drug effects, Epigenesis, Genetic/drug effects, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Tumor Microenvironment, Cellular Reprogramming, Neoplasms, Immunology, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.669992/full; urn:issn:1664-3224

Access URL: https://orbi.uliege.be/handle/2268/330764

Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But not Angiogenesis of Human Pancreatic Duct Cells

Authors: Ding, Lei, Heremans, Yves, Pipeleers, Daniel, Ling, Zhidong, Heimberg, Harry, Gysemans, Conny, Mathieu, Chantal

Contributors: Faculty of Engineering, Pathology/molecular and cellular medicine, Vriendenkring VUB, Diabetes Pathology & Therapy, Clinical Biology, FORMER_Beta Cell Neogenesis, Basic (bio-) Medical Sciences

Source: Cell Transplantation, Vol 24 (2015)

Subject Terms: Vascular Endothelial Growth Factor A, Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Chorioallantoic Membrane/blood supply, Apoptosis, Chick Embryo, Mice, SCID, Research & Experimental Medicine, Chorioallantoic Membrane, Cell Proliferation/drug effects, Mice, Mice, Inbred NOD, 10 Technology, Islet transplantation, Child, MYCOPHENOLATE-MOFETIL, 11 Medical and Health Sciences, Immunosuppressant, 0303 health sciences, Cytokines/genetics, Tacrolimus/pharmacology, Middle Aged, Cellular Reprogramming, 3. Good health, Interleukin-8/blood, Medicine, Research & Experimental, Human pancreatic duct cell, young adult, Medicine, Cytokines, Female, Dedifferentiation, Chemokines, Life Sciences & Biomedicine, Immunosuppressive Agents, HUMAN ISLET PREPARATIONS, Adult, mice, Adolescent, Neovascularization, Physiologic, Tacrolimus, Young Adult, 03 medical and health sciences, Chemokines/genetics, BETA-CELLS, Cellular Reprogramming/drug effects, Cell & Tissue Engineering, Animals, Humans, Cell Proliferation, Sirolimus, Transplantation, Science & Technology, Cytoldnes, Neurology & Neurosurgery, Immunosuppressive Agents/pharmacology, TRANSPLANTATION, Pancreatic Ducts/cytology, Vascular Endothelial Growth Factor A/blood, 31 Biological sciences, Apoptosis/drug effects, EDMONTON PROTOCOL, Interleukin-8, GRAFT, Pancreatic Ducts, Sirolimus/pharmacology, DIABETES-MELLITUS, Cell Biology, 06 Biological Sciences, ENDOTHELIAL GROWTH-FACTOR, RAT, Angiogenesis, RAPAMYCIN, Chickens

Access URL: https://lirias.kuleuven.be/bitstream/123456789/469022/3/Ding%20et%20al.%20Cell%20Transplant%202015.pdf
https://pubmed.ncbi.nlm.nih.gov/25198311
https://doaj.org/article/f61e82c0b6c84bf6bfd755feab98ab91
https://www.ncbi.nlm.nih.gov/pubmed/25198311
https://journals.sagepub.com/doi/10.3727/096368914X682819
https://journals.sagepub.com/doi/pdf/10.3727/096368914X682819
https://researchportal.vub.be/en/publications/clinical-immunosuppressants-inhibit-inflammatory-proliferative-an-2
http://journals.sagepub.com/doi/10.3727/096368914X682819
https://lirias.kuleuven.be/handle/123456789/469022
https://doi.org/10.3727/096368914x682819
https://biblio.vub.ac.be/vubir/clinical-immunosuppressants-inhibit-inflammatory-proliferative-and-reprogramming-potential-but-not-angiogenesis-of-human-pancreatic-duct-cells(838ca2d3-223f-4f44-87ef-270b152e1a7f).html
https://doi.org/10.3727/096368914x682819
https://biblio.vub.ac.be/vubir/clinical-immunosuppressants-inhibit-inflammatory-proliferative-and-reprogramming-potential-but-not-angiogenesis-of-human-pancreatic-duct-cells(5dc3b7c4-9bc4-4de6-a52d-79c2645a0a96).html
https://hdl.handle.net/20.500.14017/5dc3b7c4-9bc4-4de6-a52d-79c2645a0a96
https://doi.org/10.3727/096368914x682819

Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?

Authors: Escoll, Pedro, Buchrieser, Carmen

Contributors: Biologie des Bactéries intracellulaires - Biology of Intracellular Bacteria, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), The Institut Pasteur, the French Region Ile de France (DIM Malinf), the grant no. ANR-10-LABX-62-IBEID and the Fondation pour la Recherche Médicale (FRM), grant No. DEQ20120323697., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)

Source: ISSN: 1742-464X.

Subject Terms: Bacterial infection, Glycolysis, Mitochondria, OXPHOS, Warburg-like metabolism, MESH: Animals, MESH: Bacteria/growth & development, MESH: Cell Differentiation, MESH: Cell Proliferation, MESH: Interleukin-1beta/immunology, MESH: Cellular Reprogramming/drug effects, MESH: Glycolysis/genetics, MESH: Host-Pathogen Interactions, MESH: Humans, MESH: Interleukin-1beta/biosynthesis, MESH: Lipopolysaccharides/pharmacology, MESH: Macrophages/drug effects, MESH: Mitochondria/metabolism, MESH: Macrophages/immunology, MESH: Macrophages/metabolism, MESH: Macrophages/microbiology, MESH: Mitochondria/drug effects, MESH: Mitochondria/immunology, MESH: Mitochondria/microbiology, MESH: Bacteria/pathogenicity, MESH: Oxidative Phosphorylation/drug effects, MESH: T-Lymphocytes/drug effects, MESH: T-Lymphocytes/immunology, MESH: T-Lymphocytes/metabolism, MESH: T-Lymphocytes/microbiology

Relation: info:eu-repo/semantics/altIdentifier/pmid/29603622; PUBMED: 29603622

Availability: https://pasteur.hal.science/pasteur-02437195
https://pasteur.hal.science/pasteur-02437195v1/document
https://pasteur.hal.science/pasteur-02437195v1/file/2018%20FEBS_Escoll.pdf
https://doi.org/10.1111/febs.14446

Temporal Perturbation of the Wnt Signaling Pathway in the Control of Cell Reprogramming Is Modulated by TCF1

Authors: Aulicino, Francesco, Theka, Ilda, Ombrato, Luigi, Lluis, Frederic, Cosma, Maria Pia

Source: Stem Cell Reports
Stem Cell Reports, Vol 2, Iss 5, Pp 707-720 (2014)

Subject Terms: 0301 basic medicine, Medicine (General), Epithelial-Mesenchymal Transition, beta Catenin/genetics, Small Interfering/metabolism, QH301-705.5, Induced Pluripotent Stem Cells, Transcription Factors/genetics, Doxorubicin/pharmacology, Article, Cell Line, Mice, 03 medical and health sciences, R5-920, Cellular Reprogramming/drug effects, Induced Pluripotent Stem Cells/cytology, Antibiotics, Animals, Hepatocyte Nuclear Factor 1-alpha, Biology (General), RNA, Small Interfering, Wnt Signaling Pathway, Wnt Proteins/genetics, beta Catenin, Homeodomain Proteins, Antineoplastic/pharmacology, 0303 health sciences, Antibiotics, Antineoplastic, Cèl·lules mare embrionàries, Genètica animal, Hepatocyte Nuclear Factor 1-alpha/antagonists & inhibitors, Cellular Reprogramming, Wnt Proteins, Doxorubicin, RNA, RNA Interference, Homeodomain Proteins/genetics, Cèl·lules mare, Transcription Factors

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/24936456
https://doaj.org/article/0d2d95e62ca24034b60319aa17fcb1b8
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050487/
http://www.cell.com/stem-cell-reports/abstract/S2213-6711(14)00108-8
https://www.sciencedirect.com/science/article/pii/S2213671114001088
http://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2814%2900108-8
https://core.ac.uk/display/90932314
http://europepmc.org/articles/PMC4050487

Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma.

Contributors: College of Medicine, Dept. of Neurosurgery, Jinsoo Oh, Yongbo Kim, Lihua Che, Jeong Beom Kim, Gyeong Eon Chang, Eunji Cheong, Seok-Gu Kang, Yoon Ha, Kang, Seok Gu, Ha, Yoon

Subject Terms: Animals, Cell Differentiation/drug effects, Cell Line, Tumor, Cell Proliferation/drug effects, Cellular Reprogramming/drug effects, Colforsin/administration & dosage, Cyclic AMP/antagonists & inhibitors, Cyclic AMP/genetics, Gene Expression Regulation, Neoplastic/drug effects, Glioma/drug therapy, Glioma/genetics, Glioma/pathology, Glycogen Synthase Kinase 3/antagonists & inhibitors, Glycogen Synthase Kinase 3/genetics, Humans, Mice, Neurons/drug effects, Neurons/metabolism, Optical Imaging, Pyridines/administration & dosage, Pyrimidines/administration & dosage, Rats, Signal Transduction/drug effects, Small Molecule Libraries/administration & dosage, Xenograft Model Antitumor Assays

Relation: PLOS ONE; J02540; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161495; T201704959; PLOS ONE, Vol.12(11) : e0178881, 2017; 61402

Availability: https://ir.ymlib.yonsei.ac.kr/handle/22282913/161495
https://doi.org/10.1371/journal.pone.0178881