Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples.

Συγγραφείς: Art J; Center for Molecular Medicine, University of Georgia; Interdisciplinary Neuroscience, University of Georgia; js.esquibel@yahoo.com., James C; Center for Molecular Medicine, University of Georgia; Department of Biochemistry and Molecular Biology, University of Georgia., Dalal B; Center for Molecular Medicine, University of Georgia; Department of Biochemistry and Molecular Biology, University of Georgia., Fantone K; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia., Rada B; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia., Felner EI; Division of Pediatric Endocrinology, Emory University School of Medicine., Gonzalez-Duarte A; Dysautonomia Center, New York University Langone Health., Michopoulos V; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine., Corneo B; Stem Cell Core, Columbia Stem Cell Initiative, Columbia University., Zeltner N; Center for Molecular Medicine, University of Georgia; Department of Biochemistry and Molecular Biology, University of Georgia; Department of Cellular Biology, University of Georgia.

Πηγή: Journal of visualized experiments : JoVE [J Vis Exp] 2026 Apr 10 (230). Date of Electronic Publication: 2026 Apr 10.

Τύπος έκδοσης: Journal Article; Video-Audio Media; Research Support, N.I.H., Extramural

Στοιχεία περιοδικού: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Induced Pluripotent Stem Cells*/cytology , Blood Buffy Coat*/cytology , Cellular Reprogramming Techniques*/methods, Leukocytes, Mononuclear/cytology ; Humans ; Cryopreservation ; Cellular Reprogramming

Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines.

Συγγραφείς: Kuebler B; Barcelona Stem Cell Bank, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L´Hospitalet de Llobregat, Spain.; Program for Clinical Translation of Regenerative Medicine in Catalonia (P-[CMRC]), L´Hospitalet de Llobregat, Spain., Selvitella S; Barcelona Stem Cell Bank, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L´Hospitalet de Llobregat, Spain.; Program for Clinical Translation of Regenerative Medicine in Catalonia (P-[CMRC]), L´Hospitalet de Llobregat, Spain., Aran B; Barcelona Stem Cell Bank, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L´Hospitalet de Llobregat, Spain.; Program for Clinical Translation of Regenerative Medicine in Catalonia (P-[CMRC]), L´Hospitalet de Llobregat, Spain., Raya A; Program for Clinical Translation of Regenerative Medicine in Catalonia (P-[CMRC]), L´Hospitalet de Llobregat, Spain.; Stem Cell Potency Group, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L´Hospitalet de Llobregat, Spain.; Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; Physiological Sciences Department, Faculty of Medicine and Health Sciences, University of Barcelona, L´Hospitalet de Llobregat, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Veiga A; Barcelona Stem Cell Bank, Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L´Hospitalet de Llobregat, Spain.; Program for Clinical Translation of Regenerative Medicine in Catalonia (P-[CMRC]), L´Hospitalet de Llobregat, Spain.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jan 13; Vol. 16, pp. 1719056. Date of Electronic Publication: 2026 Jan 13 (Print Publication: 2025).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Induced Pluripotent Stem Cells*/cytology , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/physiology , Cellular Reprogramming*/genetics, Humans ; Cell Line ; Cell Differentiation ; Cellular Reprogramming Techniques

Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain.

Συγγραφείς: Wang J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Chen S; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Liu X; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Neurology, Jingzhou Hospital, Yangtze University, Jingzhou, China., Wang J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China., Huang L; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Nie L; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wu X; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Feng Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Liu N; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Tang Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhu L; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Qin C; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li G; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lgghuster@163.com., Tang Z; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ddjtzp@163.com.; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, China. ddjtzp@163.com.; National Center for Major Public Health Events, Wuhan, China. ddjtzp@163.com.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan, China. ddjtzp@163.com.

Πηγή: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jul 29; Vol. 11 (1). Date of Electronic Publication: 2026 Jul 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Astrocytes*/metabolism , Astrocytes*/pathology , Astrocytes*/drug effects , Neurons*/metabolism , Neurons*/pathology , Neurons*/drug effects , Ferroptosis*/drug effects , Ferroptosis*/genetics , Cerebral Hemorrhage*/pathology , Cerebral Hemorrhage*/genetics , Cerebral Hemorrhage*/drug therapy , Cerebral Hemorrhage*/metabolism , Cellular Reprogramming*/drug effects , Cellular Reprogramming*/genetics, Brain/pathology ; Brain/metabolism ; Brain/drug effects ; Animals ; Mice ; Humans

Wounding activates the HSFA1 transcription factors to promote cellular reprogramming in Arabidopsis.

Συγγραφείς: Coleman D; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Iwase A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; JST, PRESTO, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076Japan., Kawamura A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takebayashi A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Chen Y; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Minne M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Jager KE; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Peng M; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Kodama Y; Center for Bioscience Research and Education, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi 331-8505, Japan., Favero DS; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takahashi T; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Ikeuchi M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Division of Biological Sciences, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan., Suzuki T; Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan., Ohama N; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Yamaguchi-Shinozaki K; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Wigge PA; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany.; Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25 Haus 25, Raum B1.11-12, Potsdam 14476, Germany., De Veylder L; Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.; Center for Plant Systems Biology, VIB, Gent, Belgium., Sugimoto K; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Πηγή: The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis*/physiology , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Cellular Reprogramming*/genetics , Cellular Reprogramming*/physiology , Heat Shock Transcription Factors*/metabolism , Heat Shock Transcription Factors*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics, Gene Expression Regulation, Plant/genetics

Advances in nanodelivery systems based on tumor-associated cell reprogramming strategies for enhanced tumor therapy.

Συγγραφείς: Liu L; Department of Oncology and Hematology, Renshou County People's Hospital, The Second People's Hospital of Meishan City, Meishan, Sichuan, 620500, China., Liu Y; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Tan X; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Ding K; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Li Q; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Zhao T; Analysis and Testing Center, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., He X; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Liu Z; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Yang H; Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China., Wu M; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China; Chinese Pharmacy Laboratory, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: 379103530@qq.com., Li C; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China. Electronic address: lispringhong@126.com.

Πηγή: Acta biomaterialia [Acta Biomater] 2026 Jun; Vol. 216, pp. 51-66. Date of Electronic Publication: 2026 Apr 28.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/therapy , Neoplasms*/pathology , Neoplasms*/immunology , Tumor Microenvironment* , Cellular Reprogramming* , Nanomedicine*, Stromal Cells/pathology ; Humans ; Animals

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-synergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Συγγραφείς: Xu J; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Xu J; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Shu Y; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Huangfu Q; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Shen L; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Wei J; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., He X; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Sun C; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Chen J; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Tang L; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Meng L; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Wang W; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China., Cai M; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. Electronic address: caiming@zju.edu.cn., Wang B; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. Electronic address: wangbohan@zju.edu.cn., Wen J; Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. Electronic address: wenjiaming@zju.edu.cn.

Πηγή: Acta biomaterialia [Acta Biomater] 2026 Aug; Vol. 219, pp. 278-294. Date of Electronic Publication: 2026 Jul 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Sunitinib*/pharmacology , Sunitinib*/therapeutic use , Sunitinib*/chemistry , Carcinoma, Renal Cell*/drug therapy , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/immunology , Gelatin*/chemistry , Gelatin*/pharmacology , Hydrogels*/chemistry , Hydrogels*/pharmacology , Kidney Neoplasms*/drug therapy , Kidney Neoplasms*/immunology , Kidney Neoplasms*/pathology , Copper*/chemistry , Copper*/pharmacology , Cellular Reprogramming*/drug effects, Tumor Microenvironment/drug effects ; Cuproptosis ; Animals ; Humans ; Hydrogen-Ion Concentration ; Cell Line, Tumor ; Mice ; Drug Synergism

Next-Generation Hepatocyte Expansion: Bridging Molecular Reprogramming with Multicellular Organoids for Clinical Translation.

Συγγραφείς: Zhou Y; Department of Hepatobiliary Surgery II, Guangdong Engineering Technology Research Center of Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Zeng M; Department of Hepatobiliary Surgery II, Guangdong Engineering Technology Research Center of Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Fu G; Department of Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China. mhksfgb@126.com., Gao Y; Department of Hepatobiliary Surgery II, Guangdong Engineering Technology Research Center of Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. gaoyi6146@163.com.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Southern Medical University, Guangzhou, China. gaoyi6146@163.com.; Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases, Southern Medical University, Guangzhou, China. gaoyi6146@163.com.

Πηγή: Stem cell reviews and reports [Stem Cell Rev Rep] 2026 Aug; Vol. 22 (6), pp. 2752-2767. Date of Electronic Publication: 2026 Jun 16.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hepatocytes*/cytology , Hepatocytes*/metabolism , Hepatocytes*/transplantation , Organoids*/cytology , Organoids*/metabolism , Translational Research, Biomedical* , Cellular Reprogramming*, Humans ; Animals ; Cell Proliferation

Aging-driven reprogramming of CD34⁺ hematopoietic stem cells in leukemogenesis: Mechanisms and therapeutic implications.

Συγγραφείς: Pandey SN; Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh 244001, India., Afzal M; Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia., Rekha A; Dr DY Patil Medical College, Hospital and Research Centre, Pimpri, Pune, India., Vijayan MP; Faculty of Health Sciences, Villa College, Maldives., Uniyal P; Faculty of Pharmacy, Graphic Era Hill University, Dehradun, India; Centre for Promotion of Research, Graphic Era Deemed University, Dehradun, India., Maji C; Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park 2, Greater Noida, India., Khan A; Center For Health Research, Northern Border University, Arar 73213, Saudi Arabia., Thangavelu L; Faculty of Health Sciences, Villa College, Maldives., Nagaraj K; Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Nagar, Thandalam, Kanchipuram - Chennai Rd., Chennai, Tamil Nadu 602105, India. Electronic address: nagarajk.smc@saveetha.com.

Πηγή: Mechanisms of ageing and development [Mech Ageing Dev] 2026 Aug; Vol. 232, pp. 112212. Date of Electronic Publication: 2026 Jun 11.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0347227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6216 (Electronic) Linking ISSN: 00476374 NLM ISO Abbreviation: Mech Ageing Dev Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hematopoietic Stem Cells*/metabolism , Hematopoietic Stem Cells*/pathology , Antigens, CD34*/metabolism , Aging*/pathology , Aging*/metabolism , Leukemia*/pathology , Leukemia*/metabolism , Leukemia*/therapy , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/metabolism , Cell Transformation, Neoplastic*/metabolism , Cell Transformation, Neoplastic*/pathology , Cellular Senescence* , Cellular Reprogramming*, Humans ; Animals

Efficient induction of EPSCs via episomal reprogramming: a functionally equivalent yet transcriptionally specialized alternative to EPSCs.

Συγγραφείς: Zheng R; Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted Delivery Proof-of-Concept Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, No. 1068 Xueyuan Avenue, Shenzhen University Town, Xili, Nanshan District, Shenzhen, China; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Zhang M; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Science, Hangzhou 310024, China; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Cheng Y; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Wen J; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Zhao X; Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted Delivery Proof-of-Concept Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, No. 1068 Xueyuan Avenue, Shenzhen University Town, Xili, Nanshan District, Shenzhen, China., Xiao D; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Xu J; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Pei K; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Wang L; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China., Xu J; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Science, Hangzhou 310024, China., Zhang J; Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted Delivery Proof-of-Concept Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, No. 1068 Xueyuan Avenue, Shenzhen University Town, Xili, Nanshan District, Shenzhen, China; Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China; Sino-European Center of Biomedicine and Health, No. 7, Qingshuihe 3rd Road, Luohu District, Shenzhen, China. Electronic address: jian.zhang@siat.ac.cn., Cai C; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Science, Hangzhou 310024, China; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China. Electronic address: cheguo_cai@ucas.ac.cn., Gao Y; Shenzhen Beike Biotechnology Co., Ltd., Shenzhen 518054, China; Shenzhen Beikeyuan Cell Technology Co., Ltd., Shenzhen 518054, China. Electronic address: yunfeng@beike.cc.

Πηγή: Stem cell research [Stem Cell Res] 2026 Aug; Vol. 94, pp. 104027. Date of Electronic Publication: 2026 Jun 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Plasmids*/metabolism , Plasmids*/genetics , Pluripotent Stem Cells*/metabolism , Pluripotent Stem Cells*/cytology, Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Humans ; Cell Differentiation

Oxidative stress drives liver failure during in vivo partial reprogramming.

Συγγραφείς: Eom HJ; College of Pharmacy, Seoul National University, Seoul, Republic of Korea., Jo BK; College of Pharmacy, Seoul National University, Seoul, Republic of Korea., Kim J; College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea., Cha HJ; College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. Electronic address: hjcha93@snu.ac.kr.

Πηγή: Molecules and cells [Mol Cells] 2026 Aug; Vol. 49 (8), pp. 100378. Date of Electronic Publication: 2026 Jun 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 9610936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0219-1032 (Electronic) Linking ISSN: 10168478 NLM ISO Abbreviation: Mol Cells Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Oxidative Stress*/drug effects , Liver Failure*/metabolism , Liver Failure*/pathology , Liver Failure*/genetics , Cellular Reprogramming*, Hepatocytes/metabolism ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Reactive Oxygen Species/metabolism ; Acetylcysteine/pharmacology ; NF-E2-Related Factor 2/metabolism ; Antioxidants/pharmacology ; Animals ; Kruppel-Like Factor 4 ; Mice ; Female ; Male ; Signal Transduction

Promises of reprogramming-induced rejuvenation.

Συγγραφείς: Simpson DJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. Electronic address: https://twitter.com/@DanielJSimpson4., Arif N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA., Suwanlikit Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA; Department of Pharmacology, Faculty of Science, Mahidol University, Thailand., Kirschner K; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: kirschner.kristina@mayo.edu., Chandra T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: chandra.tamir@mayo.edu.

Πηγή: Current opinion in genetics & development [Curr Opin Genet Dev] 2026 Aug; Vol. 99, pp. 102484. Date of Electronic Publication: 2026 May 20.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 9111375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0380 (Electronic) Linking ISSN: 0959437X NLM ISO Abbreviation: Curr Opin Genet Dev Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Rejuvenation*/physiology , Cellular Senescence*/genetics, Epigenesis, Genetic/genetics ; Humans ; Animals

Conjugated polymer intrachain donor-acceptor reconfiguration-tailored off-on NIR-II photoacoustic probes with ultralow background for high-fidelity imaging of immunotherapy-associated macrophage reprogramming.

Συγγραφείς: Li X; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) and School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, 211800, China., He C; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China., Lu X; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) and School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, 211800, China. Electronic address: iamxmlu@njtech.edu.cn., Fan Q; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China., Tang Y; Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China. Electronic address: iamyftang@njupt.edu.cn., Huang W; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) and School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, 211800, China; Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an, 710072, China.

Πηγή: Biomaterials [Biomaterials] 2026 Aug; Vol. 331, pp. 124126. Date of Electronic Publication: 2026 Mar 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Photoacoustic Techniques*/methods , Polymers*/chemistry , Immunotherapy* , Macrophages* , Cellular Reprogramming*, Animals ; Mice ; Humans ; Cell Line, Tumor

PRKCI-ECT2 copy number gain promotes developmental reprogramming and metastatic competence in lung adenocarcinoma.

Συγγραφείς: Nguyen DT; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA., Meneses KM; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA., Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA., Prieto LI; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA; Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN, USA., Weems C; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Jamieson L; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA., Baker DJ; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA; Department of Pediatrics, Mayo Clinic College of Medicine, Rochester, MN, USA; Paul F. Glenn Center for Biology of Aging Research, Mayo Clinic College of Medicine, Rochester, MN, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA., Khoor A; Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Murray NR; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA., Justilien V; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Fields AP; Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address: fields.alan@mayo.edu.

Πηγή: Cell reports [Cell Rep] 2026 Jul 28; Vol. 45 (7), pp. 117697. Date of Electronic Publication: 2026 Jul 18.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Kinase C*/metabolism , Protein Kinase C*/genetics , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/pathology , Proto-Oncogene Proteins*/genetics , Proto-Oncogene Proteins*/metabolism , Cellular Reprogramming*/genetics , DNA Copy Number Variations*/genetics, Isoenzymes/metabolism ; Isoenzymes/genetics ; SOX9 Transcription Factor/metabolism ; Animals ; Protein Kinase C-lambda ; Humans ; Mice ; Neoplasm Metastasis ; Signal Transduction

Epigenetic and 3D genome reprogramming during the aging of the human hippocampus.

Συγγραφείς: Zemke NR; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA., Lee S; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA., Mamde S; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA., Yang B; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA., Berchtold N; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.; Immunis Inc., Irvine, CA, USA., Garduño BM; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA., Indralingam HS; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA., Bartosik WM; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA., Lau PK; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA., Dong K; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA., Hsu E; Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Yang A; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA., Tani Y; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA., Chen C; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA., Zeng Q; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA., Ajith V; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA., Tong L; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA., Seng C; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Li D; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Wang T; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Zhou J; Arc Institute, Palo Alto, CA, USA.; Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA., Ecker JR; Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA., Glass CK; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; Department of Medicine, University of California, School of Medicine, La Jolla, CA, USA., Cotman CW; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Department of Neurology, University of California, Irvine School of Medicine, Irvine, CA, USA., Xu X; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.; The Center for Neural Circuit Mapping, University of California, Irvine, CA, USA., Ren B; Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.

Πηγή: Science (New York, N.Y.) [Science] 2026 Jul 23; Vol. 393 (6809), pp. eadt8307. Date of Electronic Publication: 2026 Jul 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Aging*/genetics , Cellular Reprogramming*/genetics , Hippocampus*/metabolism , Hippocampus*/cytology , Hippocampus*/physiology , Epigenesis, Genetic* , Genome, Human*, Astrocytes/metabolism ; Astrocytes/physiology ; Chromatin/ultrastructure ; Microglia/metabolism ; Microglia/physiology ; Aged ; Humans ; Middle Aged ; DNA Methylation ; Gene Expression Regulation

Immunological Reprogramming in Cardiomyopathies: From Cardiomyocyte Injury to Disease of the Cardiac Immune Ecosystem.

Συγγραφείς: Urbanowicz T; Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, ½ Długa, 61-848 Poznań, Poland., Filipiak KJ; The Centre of Postgraduate Medical Education, 99/103 Marymoncka Street, 01-813 Warsaw, Poland.

Πηγή: Cells [Cells] 2026 Jul 22; Vol. 15 (14). Date of Electronic Publication: 2026 Jul 22.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cardiomyopathies*/immunology , Cardiomyopathies*/pathology , Myocytes, Cardiac*/immunology , Myocytes, Cardiac*/pathology , Cellular Reprogramming*/immunology, Humans ; Animals

Reprogramming the wound microenvironment: identity remodeling strategies for fibroblasts, keratinocytes, and macrophages.

Συγγραφείς: Wang J; Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Hand surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Pediatric Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China., Chen M; Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Hand surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Pediatric Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China., Wei J; Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Hand surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Pediatric Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China., Chen X; Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Hand surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Pediatric Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Luzhou Key Laboratory for Prevention and Treatment of Orthopedic Diseases Through Integrated Traditional Chinese and Western Medicine, Luzhou, Sichuan, China., Wang C; Mianyang Orthopaedic Hospital, Mianyang, Sichuan, China., Feng H; Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Hand surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.; Department of Pediatric Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jul 20; Vol. 17, pp. 1892931. Date of Electronic Publication: 2026 Jul 20 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Macrophages*/metabolism , Macrophages*/physiology , Keratinocytes*/metabolism , Keratinocytes*/physiology , Fibroblasts*/metabolism , Fibroblasts*/physiology , Cellular Reprogramming* , Wound Healing* , Cellular Microenvironment*, Humans ; Animals

Case Report: Schwann cell reprogramming and PDGF-driven nerve hypertrophy in an NF1 patient with CIDP-like autoimmunity.

Συγγραφείς: Wang F; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Cao W; Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China., Lu J; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Huang R; Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China., Bai Y; Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China., Zhang Y; Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China., Wang Z; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Chen Z; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Wang Z; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jul 17; Vol. 17, pp. 1862732. Date of Electronic Publication: 2026 Jul 17 (Print Publication: 2026).

Τύπος έκδοσης: Case Reports; Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Schwann Cells*/metabolism , Schwann Cells*/pathology , Schwann Cells*/immunology , Platelet-Derived Growth Factor*/metabolism , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating*/immunology , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating*/pathology , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating*/genetics , Neurofibromatosis 1*/immunology , Neurofibromatosis 1*/genetics , Neurofibromatosis 1*/pathology , Autoimmunity* , Cellular Reprogramming*, Neurofibromin 1/genetics ; Fibroblasts/metabolism ; Humans ; Hypertrophy ; Signal Transduction ; Female ; Male

Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming.

Συγγραφείς: Murano T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Hagihara H; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Tajinda K; Astellas Research Institute of America, San Diego, CA, USA., Takao K; Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, Toyama, Japan.; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan., Takamiya Y; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Katoh K; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Ph.D. Program in Humanics, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Japan.; The Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases (NIID), Tokyo, Japan., Robison AJ; Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI, USA., Matsumoto M; Astellas Research Institute of America, San Diego, CA, USA.; Arialys Therapeutics Inc., La Jolla, CA, USA., Namihira M; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Laboratory of Neural Regeneration and Brain Repair, Division of Biological Science, Graduate School of Science andTechnology, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, Japan., Miyakawa T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan. miyakawa@fujita-hu.ac.jp.

Πηγή: Nature communications [Nat Commun] 2026 Jul 17; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 17.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neurons*/physiology , Neurons*/metabolism , Neurons*/cytology , Dentate Gyrus*/cytology , Dentate Gyrus*/physiology , Dentate Gyrus*/metabolism , Cellular Reprogramming*/physiology, Animals ; Mice ; Optogenetics ; Male ; Mice, Inbred C57BL ; Mice, Knockout

Efficient chemical reprogramming of human T cells into functional megakaryocytes and platelets.

Συγγραφείς: Qin J; Beijing Institute of Radiation Medicine, Beijing 100850, China., Hua Z; Beijing Institute of Radiation Medicine, Beijing 100850, China.; College of Life Science, Hebei University, Baoding 071002, China., Zhao X; Beijing Institute of Radiation Medicine, Beijing 100850, China.; College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China., Jiang J; Beijing Institute of Radiation Medicine, Beijing 100850, China., Li J; Beijing Institute of Radiation Medicine, Beijing 100850, China., Wang S; Beijing Institute of Radiation Medicine, Beijing 100850, China., Pan Y; Beijing Institute of Radiation Medicine, Beijing 100850, China., Zhang B; Beijing Institute of Radiation Medicine, Beijing 100850, China., Li Y; Beijing Institute of Radiation Medicine, Beijing 100850, China., Zhou Q; Institute of Health Service and Transfusion Medicine, Beijing 100850, China., Zhang Y; Beijing Institute of Radiation Medicine, Beijing 100850, China., Chen Y; Beijing Institute of Radiation Medicine, Beijing 100850, China., Liu Y; Beijing Institute of Radiation Medicine, Beijing 100850, China., Xu C; Beijing Institute of Radiation Medicine, Beijing 100850, China.; Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China., Fan T; Beijing Institute of Radiation Medicine, Beijing 100850, China., Lv Y; Beijing Institute of Radiation Medicine, Beijing 100850, China., Yan X; College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China., Yue W; Beijing Institute of Radiation Medicine, Beijing 100850, China., Pei X; Beijing Institute of Radiation Medicine, Beijing 100850, China., Li Y; Beijing Institute of Radiation Medicine, Beijing 100850, China.; College of Life Science, Hebei University, Baoding 071002, China.; Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.

Πηγή: Science advances [Sci Adv] 2026 Jul 17; Vol. 12 (29), pp. eaeb3177. Date of Electronic Publication: 2026 Jul 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Megakaryocytes*/cytology , Megakaryocytes*/metabolism , Megakaryocytes*/drug effects , Blood Platelets*/cytology , Blood Platelets*/metabolism , Blood Platelets*/drug effects , T-Lymphocytes*/cytology , T-Lymphocytes*/drug effects , T-Lymphocytes*/metabolism , Cellular Reprogramming*/drug effects, Cell Differentiation/drug effects ; Humans

Single-cell transcriptomic unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis.

Συγγραφείς: Putzbach W; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Zappia MP; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Magdy A; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Li J; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Nogueira V; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Lou K; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Islam ABMMK; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Frolov M; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA., Hay N; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.; Research and Development Section, Jesse Brown VA Medical Center, Chicago, IL 60612, USA.; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.

Πηγή: Science advances [Sci Adv] 2026 Jul 17; Vol. 12 (29), pp. eaee9308. Date of Electronic Publication: 2026 Jul 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neutrophils*/metabolism , Neutrophils*/pathology , Neutrophils*/drug effects , Cellular Reprogramming*/genetics , Transcriptome*, Tumor Microenvironment/genetics ; Animals ; Mice ; Neoplasm Metastasis ; Single-Cell Gene Expression Analysis ; Single-Cell Analysis ; Female ; Gene Expression Regulation, Neoplastic ; Granulocyte Colony-Stimulating Factor