In Vitro Generation of Brown and Beige Adipocytes via Cellular Reprogramming.

Authors: Toshihiro K; Department of Cellular Regenerative Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Harada Y; Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Dai P; Department of Cellular Regenerative Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Source: Cellular reprogramming [Cell Reprogram] 2025 Dec; Vol. 27 (6), pp. 216-227. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101528176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-4998 (Electronic) Linking ISSN: 21524971 NLM ISO Abbreviation: Cell Reprogram Subsets: MEDLINE

MeSH Terms: Adipocytes, Beige*/cytology , Adipocytes, Beige*/metabolism , Cellular Reprogramming* , Adipocytes, Brown*/cytology , Adipocytes, Brown*/metabolism , Cellular Reprogramming Techniques*/methods, Humans ; Animals ; Thermogenesis

Cellular Reprogramming and Microfluidics Enable Large-Scale Blastoid Production from Aged Donors.

Authors: Moura MT; Departamento de Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brasil.

Source: Cellular reprogramming [Cell Reprogram] 2025 Dec; Vol. 27 (6), pp. 213-215. Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article; News

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101528176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-4998 (Electronic) Linking ISSN: 21524971 NLM ISO Abbreviation: Cell Reprogram Subsets: MEDLINE

MeSH Terms: Microfluidics*/methods , Cellular Reprogramming* , Blastocyst*/cytology , Cellular Reprogramming Techniques*/methods , Aging*, Animals ; Macaca mulatta ; Humans

Establishment of human expanded potential stem cell lines via preimplantation embryo cultivation and somatic cell reprogramming.

Authors: Ruan D; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China.; Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China., Chen ACH; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China.; Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.; Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Tam TTKK; Stem Cell and Regenerative Medicine Consortium, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Huang W; Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Guo J; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China., Xu S; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China., Ruan H; Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Fong SW; Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Liu X; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China., Gao X; Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Yeung WSB; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China. wsbyeung@hku.hk.; Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. wsbyeung@hku.hk.; Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. wsbyeung@hku.hk., Lee YL; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China. cherielee@hku.hk.; Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. cherielee@hku.hk.; Department of Obstetrics and Gynaecology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. cherielee@hku.hk., Liu P; Center for Translational Stem Cell Biology, Science Park, Hong Kong Special Administrative Region, China. pliu88@hku.hk.; Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. pliu88@hku.hk.; Stem Cell and Regenerative Medicine Consortium, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. pliu88@hku.hk.

Source: Nature protocols [Nat Protoc] 2025 Oct; Vol. 20 (10), pp. 2698-2734. Date of Electronic Publication: 2025 Apr 29.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

MeSH Terms: Blastocyst*/cytology , Cellular Reprogramming* , Cell Culture Techniques*/methods , Embryo Culture Techniques*/methods , Cellular Reprogramming Techniques*/methods, Humans ; Cell Line ; Cell Differentiation ; Fibroblasts/cytology ; Trophoblasts/cytology

Cellular reprogramming during anti-PD-1 and chemotherapy treatment in early-stage primary hormone receptor-positive breast cancer.

Authors: Fu J; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waks AG; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pimenta E; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Titchen B; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Harvard Division of Medical Sciences PhD Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA, USA., Bi K; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Camp S; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Pappa T; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Keenan T; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shannon E; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Vigneau S; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bemus M; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nag A; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Thorner AR; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Park J; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., DiLullo M; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Wrabel E; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Jeselsohn R; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mittendorf EA; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.; Division of Breast Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA., Abravanel DL; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Tolaney SM; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Van Allen EM; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. eliezerm_vanallen@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. eliezerm_vanallen@dfci.harvard.edu.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eliezerm_vanallen@dfci.harvard.edu.; Parker Institute for Cancer Immunotherapy, Dana-Farber Cancer Institute, Boston, MA, USA. eliezerm_vanallen@dfci.harvard.edu.

Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10704. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Breast Neoplasms*/immunology , Cellular Reprogramming*/drug effects , Cellular Reprogramming*/genetics , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Female ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Paclitaxel/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Neoadjuvant Therapy ; Receptors, Estrogen/metabolism ; Macrophages/immunology ; Macrophages/drug effects ; Receptors, Progesterone/metabolism ; Middle Aged ; Gene Expression Regulation, Neoplastic/drug effects ; T-Lymphocytes/immunology ; Albumins

Light-Regulated Reprogramming in Moss: SHMT1 Mediates Blue Light Enhancement of Cell Regeneration.

Authors: Zhao M; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.; College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China., Huang X; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China., Lu W; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China., Wang S; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China., Zheng H; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China., Luo C; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China., Hu Z; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China., He Y; College of Life Sciences, Capital Normal University, Beijing, China., Li X; Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.

Source: Plant, cell & environment [Plant Cell Environ] 2025 Nov; Vol. 48 (11), pp. 7759-7774. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 9309004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3040 (Electronic) Linking ISSN: 01407791 NLM ISO Abbreviation: Plant Cell Environ Subsets: MEDLINE

MeSH Terms: Light* , Glycine Hydroxymethyltransferase*/metabolism , Glycine Hydroxymethyltransferase*/genetics , Glycine Hydroxymethyltransferase*/physiology , Cellular Reprogramming*/radiation effects , Cellular Reprogramming*/genetics , Plant Proteins*/metabolism , Plant Proteins*/genetics , Bryopsida*/radiation effects , Bryopsida*/physiology , Bryopsida*/genetics , Regeneration*/radiation effects, Protoplasts/radiation effects ; Protoplasts/metabolism ; Gene Expression Regulation, Plant/radiation effects ; Blue Light

Glioblastoma resistance to EGFR antibody-drug conjugate is driven by transcriptional reprogramming and TEK-induced EGFR suppression.

Authors: Blomquist MR; Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA.; Department of Neurological Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA.; Mayo Clinic Alix School of Medicine Arizona, Scottsdale, Arizona, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Noviello TMR; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Sereduk C; Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA.; Department of Neurological Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA., Grief D; Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA.; Department of Neurological Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Caruso FP; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy., Sharma R; Early Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.; Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, California, USA., Garcia-Mansfield K; Early Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, Arizona, USA., Pirrotte P; Early Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.; Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, California, USA., Kloss J; Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA., D'Angelo F; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Marin BM; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Porath K; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Jain S; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Rabichow B; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Ensign SPF; Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA.; Department of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, Arizona, USA., Iavarone A; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Paladino A; Institute of Biostructure and Bioimaging, Department of Biomedical Sciences, National Research Council (CNR), Naples, Italy., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Loftus JC; Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA., Ceccarelli M; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA. mxc2982@miami.edu.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. mxc2982@miami.edu., Tran NL; Department of Cancer Biology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA. tran.nhan@mayo.edu.; Department of Neurological Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., IERB-3-504A, Phoenix, Arizona, 85054, USA. tran.nhan@mayo.edu.

Source: Journal of translational medicine [J Transl Med] 2025 Oct 21; Vol. 23 (1), pp. 1153. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH Terms: Glioblastoma*/genetics , Glioblastoma*/drug therapy , Glioblastoma*/pathology , ErbB Receptors*/metabolism , ErbB Receptors*/antagonists & inhibitors , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Immunoconjugates*/therapeutic use , Immunoconjugates*/pharmacology , Brain Neoplasms*/genetics , Brain Neoplasms*/drug therapy , Transcription, Genetic*/drug effects , Cellular Reprogramming*/genetics , Cellular Reprogramming*/drug effects, Humans ; Animals ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Line, Tumor ; Mice ; Xenograft Model Antitumor Assays

Glial Cell Reprogramming in Ischemic Stroke: A Review of Recent Advancements and Translational Challenges.

Authors: Greșiță A; Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania.; Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, 11568, USA., Hermann DM; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, 45147, Essen, Germany.; Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania., Boboc IKS; Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania., Doeppner TR; Department of Neurology, University Medical Center Göttingen, 37075, Göttingen, Germany.; Department of Neurology, University of Giessen Medical School, 35392, Giessen, Germany., Petcu E; Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, 11568, USA.; Department of Biological & Chemical Sciences, New York Institute of Technology, Old Westbury, NY, 11568, USA., Semida GF; Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania. semida.flavia@yahoo.com., Popa-Wagner A; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, 45147, Essen, Germany. aurel.popa-wagner@geriatrics-healthyageing.com.; Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania. aurel.popa-wagner@geriatrics-healthyageing.com.

Source: Translational stroke research [Transl Stroke Res] 2025 Oct; Vol. 16 (5), pp. 1811-1835. Date of Electronic Publication: 2025 Feb 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE

MeSH Terms: Cellular Reprogramming*/physiology , Ischemic Stroke*/therapy , Ischemic Stroke*/pathology , Neuroglia*/physiology , Translational Research, Biomedical*, Humans ; Animals

Ascl1 in Retinal Regeneration: From Neuronal Fate Determination to Reprogramming Mechanisms.

Authors: Yan L; Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, China.; College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China., Sun B; Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, China.; College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China., Li N; Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, China.; College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China., Yang Y; Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, China.; College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China., Qin H; Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, China.; College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China., Yao K; Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, China.; College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71261.

Publication Type: Journal Article; Review

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Basic Helix-Loop-Helix Transcription Factors*/metabolism , Basic Helix-Loop-Helix Transcription Factors*/genetics , Retina*/physiology , Retina*/metabolism , Cellular Reprogramming* , Nerve Regeneration* , Retinal Neurons*/metabolism , Regeneration*, Animals ; Humans ; Neurogenesis/physiology ; Zebrafish ; Ependymoglial Cells/metabolism

FOXO1-driven metabolic reprogramming of hematomal CD8 ⁺ T cells drives the expansion of perihematomal edema following intracerebral hemorrhage.

Authors: Lin J; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Ren H; Department of Neurology, Tianjin Neurological Institute, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, International Joint Laboratory of Ocular Diseases, Ministry of Education, Haihe Laboratory of Cell Ecosystem, Tianjin Medical University General Hospital, Tianjin, 300052, China., Wang Y; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Yu H; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.; Department of Oncology, 363 Hospital, Chengdu, Sichuan, China., Chen Z; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Yu X; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Gao Z; Department of Neurosurgery of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China., Zheng Y; Department of Neurosurgery of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China., Wu Q; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Zhang Y; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Lin Q; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Li R; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China., Tian D; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China., Cai Z; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China., Liu Q; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China. qliu@tmu.edu.cn.; Department of Neurology, Tianjin Neurological Institute, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, International Joint Laboratory of Ocular Diseases, Ministry of Education, Haihe Laboratory of Cell Ecosystem, Tianjin Medical University General Hospital, Tianjin, 300052, China. qliu@tmu.edu.cn., Fu Y; Department of Neurology of First Affiliated Hospital, Institute of Neurology, Fujian Medical University, Fuzhou, 350000, China. fuying@fjmu.edu.cn.

Source: Cellular & molecular immunology [Cell Mol Immunol] 2025 Dec; Vol. 22 (12), pp. 1629-1641. Date of Electronic Publication: 2025 Nov 14.

Publication Type: Journal Article

Journal Info: Publisher: Chinese Society of Immunology;; _b Nature Pub. Group Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-0226 (Electronic) Linking ISSN: 16727681 NLM ISO Abbreviation: Cell Mol Immunol Subsets: MEDLINE

MeSH Terms: Cerebral Hemorrhage*/complications , Cerebral Hemorrhage*/immunology , Cerebral Hemorrhage*/pathology , Cerebral Hemorrhage*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Forkhead Box Protein O1*/metabolism , Hematoma*/immunology , Hematoma*/pathology , Hematoma*/metabolism , Brain Edema*/pathology , Brain Edema*/immunology , Brain Edema*/etiology , Brain Edema*/metabolism , Cellular Reprogramming*, Animals ; Humans ; Mice, Inbred C57BL ; Mice ; Male ; Interferon-gamma/metabolism ; Microglia/metabolism ; Female ; Metabolic Reprogramming

Hydrogen enhanced photothermal therapy for redox-regulated tumor apoptosis and immune reprogramming.

Authors: Chu H; Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China; Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China., Wu Q; Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China., Xu Z; Department of Breast Surgery, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China., Cao J; Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, No.1558, Sanhuan North Road, Wuxing District, Huzhou 313000 Zhejiang Province, China., Zheng H; Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China., Wu J; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Central Laboratory, the First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001 Heilongjiang, China., Liu Q; Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China., Ruan X; School of Energy and Environment, City University of Hong Kong, Hong Kong 999077, China., Fang X; Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China., Cui X; State Key Laboratory of Automotive Simulation and Control, Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun 130012, China., Ravi SK; School of Energy and Environment, City University of Hong Kong, Hong Kong 999077, China., Chen F; Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, 126 Sendai Street, Changchun 130033 Jilin, China. Electronic address: cff@jlu.edu.cn.

Source: Acta biomaterialia [Acta Biomater] 2025 Dec; Vol. 208, pp. 496-509. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH Terms: Hydrogen*/pharmacology , Hydrogen*/chemistry , Photothermal Therapy* , Apoptosis*/drug effects , Cellular Reprogramming*/drug effects, Animals ; Oxidation-Reduction/drug effects ; Tumor Microenvironment/drug effects ; Cell Line, Tumor ; Mice ; Humans ; Reactive Oxygen Species/metabolism ; Palladium/chemistry ; Palladium/pharmacology ; Rhodium/chemistry ; Rhodium/pharmacology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Macrophages

RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility.

Authors: He C; Hainan Academy of Sciences, School of Life Sciences and Medical Technology, Hainan Medical University, 352 Yehai Road, Longhua Distr, Haikou, 571199, China.; Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Hunan Normal University School of Medicine, Changsha, 410013, China.; The Affiliated Hosptial of Hunan University, Xiangtan Central Hospital, Xiangtan, 411100, China., Cui Y; Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Hunan Normal University School of Medicine, Changsha, 410013, China., Chen W; Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Hunan Normal University School of Medicine, Changsha, 410013, China., Li C; Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Hunan Normal University School of Medicine, Changsha, 410013, China., He Z; Hainan Academy of Sciences, School of Life Sciences and Medical Technology, Hainan Medical University, 352 Yehai Road, Longhua Distr, Haikou, 571199, China.; Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Hunan Normal University School of Medicine, Changsha, 410013, China.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e17491. Date of Electronic Publication: 2025 Oct 16.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Sertoli Cells*/metabolism , Sertoli Cells*/cytology , DNA Methylation*/genetics , Cellular Reprogramming*/genetics , Spermatogonia*/metabolism , Fertility*/genetics , Infertility, Male*/genetics , Infertility, Male*/metabolism , Adult Germline Stem Cells*/metabolism, Male ; Humans ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; Azoospermia/genetics

N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.

Authors: Tang H; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Zhong Y; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Wang J; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Meng S; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Yu D; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Fan B; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Dong X; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Wang M; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Fu M; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Qian Y; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Zhang X; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Ji R; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China., Zhang X; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China. Electronic address: xuzhang@ujs.edu.cn., Fang X; Department of Oncology, Affiliated Gaochun Hospital of Jiangsu University, 211300 Nanjing, China. Electronic address: lygfxj@126.com., Zhang J; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China. Electronic address: jiahui.zhang@ujs.edu.cn.

Source: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112085. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , MicroRNAs*/metabolism , MicroRNAs*/genetics , Exosomes*/metabolism , Exosomes*/genetics , Neutrophils*/metabolism , Neutrophils*/pathology , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Cellular Reprogramming*, Humans ; Animals ; Disease Progression ; Cell Line, Tumor ; Mice ; Cell Proliferation ; PTEN Phosphohydrolase/metabolism ; PTEN Phosphohydrolase/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Forkhead Box Protein O3/metabolism ; Forkhead Box Protein O3/genetics ; Signal Transduction ; Phosphatidylinositol 3-Kinases/metabolism ; Oxaliplatin/pharmacology ; Gene Expression Regulation, Neoplastic ; Male ; Mice, Nude

Regulated cell death environments drive fibroinflammatory reprogramming in surviving adipose-derived stem cells.

Authors: Oliva-Olivera W; Biomedical Research Institute of Málaga and Nanotechnology Platform - IBIMA BIONAND Platform, 29590, Málaga, Spain. wolivaolivera@ibima.eu.; CIBER of Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III Health Institute, 28029, Madrid, Spain. wolivaolivera@ibima.eu., Ravnsborg T; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230, Odense, Denmark., Le Boiteux E; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230, Odense, Denmark., García-Fuentes E; Clinical Management Unit of Digestive System, Virgen de la Victoria University Hospital, 29010, Málaga, Spain.; CIBER of Liver and Digestive Diseases (CIBERehd), Carlos III Health Institute, 28029, Madrid, Spain., Garrido-Sánchez L; Biomedical Research Institute of Málaga and Nanotechnology Platform - IBIMA BIONAND Platform, 29590, Málaga, Spain. lourgarrido@gmail.com.; CIBER of Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III Health Institute, 28029, Madrid, Spain. lourgarrido@gmail.com.; Clinical Management Unit of Endocrinology and Nutrition, Virgen de La Victoria University Hospital, 29010, Málaga, Spain. lourgarrido@gmail.com., Jensen ON; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230, Odense, Denmark., Tinahones FJ; Biomedical Research Institute of Málaga and Nanotechnology Platform - IBIMA BIONAND Platform, 29590, Málaga, Spain.; CIBER of Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III Health Institute, 28029, Madrid, Spain.; Clinical Management Unit of Endocrinology and Nutrition, Virgen de La Victoria University Hospital, 29010, Málaga, Spain.; Department of Medicine and Dermatology, Faculty of Medicine, University of Málaga, 29010, Málaga, Spain.

Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2025 Dec; Vol. 30 (11-12), pp. 2800-2809. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

MeSH Terms: Adipose Tissue*/cytology , Stem Cells*/metabolism , Stem Cells*/cytology , Inflammation*/genetics , Inflammation*/metabolism , Cellular Reprogramming*, Humans ; Tumor Necrosis Factor-alpha/pharmacology ; Histones/metabolism ; Cell Death ; Cells, Cultured ; Cell Survival ; Protein Processing, Post-Translational

Role of macrophages reprogramming in pathogenesis of gestational diabetes mellitus.

Authors: Milan KL; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India., Shree RA; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India., Nandana N; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India., Leela R; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India., Ramkumar KM; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India. Electronic address: ramkumak@srmist.edu.in.

Source: Cytokine [Cytokine] 2025 Dec; Vol. 196, pp. 157041. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE

MeSH Terms: Diabetes, Gestational*/immunology , Diabetes, Gestational*/pathology , Diabetes, Gestational*/metabolism , Macrophages*/immunology , Macrophages*/metabolism , Macrophages*/pathology , Cellular Reprogramming*, Humans ; Pregnancy ; Female ; Animals ; Placenta/immunology ; Placenta/metabolism ; Insulin Resistance ; Macrophage Activation ; Inflammation

Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs.

Authors: Ward TR; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Qu PP; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Leung LC; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Stanford Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Zhou B; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Muench KL; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA., Khechaduri A; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Plastini MJ; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Charlton CA; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA., Pattni R; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Ho S; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Ho M; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Huang Y; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Zhou P; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Hallmayer JF; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Mourrain P; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Stanford Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Palmer TD; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA., Zhang X; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA. xianglongruoying@gmail.com.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA. xianglongruoying@gmail.com., Urban AE; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA. aeurban@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA. aeurban@stanford.edu.

Source: European journal of human genetics : EJHG [Eur J Hum Genet] 2025 Dec; Vol. 33 (12), pp. 1698-1707. Date of Electronic Publication: 2025 May 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

MeSH Terms: DNA Copy Number Variations* , Neurons*/metabolism , Neurons*/cytology , Epigenome* , Transcriptome* , Cellular Reprogramming*, Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Chromosomes, Human, Pair 16/genetics ; DNA Methylation ; Intellectual Disability/genetics ; Autism Spectrum Disorder/genetics ; Chromosome Deletion ; Autistic Disorder ; Chromosome Disorders

SCR Disease Name: 16p11.2 Deletion Syndrome

Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration.

Authors: Tang LP; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China; Joint Center for Single Cell Biology, Shandong Agricultural University and Radboud University, Nijmegen, the Netherlands., Zhai LM; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China., Li J; BGI Research, Beijing 102601, China., Gao Y; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China., Ma QL; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China., Li R; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China., Liu QF; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China., Zhang WJ; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China., Yao WJ; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China., Mu B; BGI Research, Beijing 102601, China., Qin C; BGI Research, Beijing 102601, China., Tian X; Joint Center for Single Cell Biology, Shandong Agricultural University and Radboud University, Nijmegen, the Netherlands; Plant Systems Physiology, Department of Plant and Animal Biology, Radboud Institute for Biological and Environmental Sciences, Radboud University, 6500 AJ Nijmegen, the Netherlands., Shaw R; Joint Center for Single Cell Biology, Shandong Agricultural University and Radboud University, Nijmegen, the Netherlands; Plant Systems Physiology, Department of Plant and Animal Biology, Radboud Institute for Biological and Environmental Sciences, Radboud University, 6500 AJ Nijmegen, the Netherlands; Department of Bio-Sciences, School of Bio Sciences & Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India., Xia K; BGI Research, Beijing 102601, China. Electronic address: xiakeke@genomics.cn., Xu J; Joint Center for Single Cell Biology, Shandong Agricultural University and Radboud University, Nijmegen, the Netherlands; Plant Systems Physiology, Department of Plant and Animal Biology, Radboud Institute for Biological and Environmental Sciences, Radboud University, 6500 AJ Nijmegen, the Netherlands. Electronic address: jian.xu@ru.nl., Su YH; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China; Joint Center for Single Cell Biology, Shandong Agricultural University and Radboud University, Nijmegen, the Netherlands. Electronic address: suyh@sdau.edu.cn., Zhang XS; State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China; Joint Center for Single Cell Biology, Shandong Agricultural University and Radboud University, Nijmegen, the Netherlands. Electronic address: zhangxs@sdau.edu.cn.

Source: Cell [Cell] 2025 Nov 26; Vol. 188 (24), pp. 6923-6938.e18. Date of Electronic Publication: 2025 Sep 16.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH Terms: Arabidopsis*/genetics , Arabidopsis*/cytology , Arabidopsis*/metabolism , Arabidopsis*/physiology , Cellular Reprogramming* , Regeneration*, Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/genetics ; Indoleacetic Acids/metabolism ; Gene Expression Regulation, Plant ; Cotyledon/metabolism ; Cotyledon/cytology ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Oxygenases/metabolism ; Oxygenases/genetics ; Meristem/metabolism ; Meristem/cytology ; Mixed Function Oxygenases/metabolism ; Mixed Function Oxygenases/genetics ; Basic Helix-Loop-Helix Transcription Factors

TLR2 agonism suppresses myeloid leukemogenesis by reprogramming leukemia stem cells.

Authors: Lawler ME; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia, PA., Romer-Seibert JS; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia, PA., Bowman MS; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA., Mitra R; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia, PA., Eischen CM; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia, PA., Bowman RL; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA., Meyer SE; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia, PA.; Department of Medical Oncology, Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia, PA.

Source: Blood advances [Blood Adv] 2025 Nov 25; Vol. 9 (22), pp. 5888-5901.

Publication Type: Journal Article

Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

MeSH Terms: Toll-Like Receptor 2*/agonists , Toll-Like Receptor 2*/metabolism , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/mortality , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/drug effects , Cellular Reprogramming*, Animals ; Humans ; Mice ; Signal Transduction ; Disease Models, Animal

In vivo differentiation of embryonic cells devoid of key reprogramming factors.

Authors: Youlten SE; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Miao L; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Hoppe C; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Boswell CW; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Musaev D; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Abdelmessih M; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Olowookere D; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Weiss LA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Krishnaswamy S; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Computer Science, Yale University, New Haven, CT 06510, USA., Giraldez AJ; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: antonio.giraldez@yale.edu., Tornini VA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Institute for Society and Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Electronic address: vtornini@ucla.edu.

Source: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116498. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: Zebrafish*/embryology , Zebrafish*/genetics , Cell Differentiation*/genetics , Cellular Reprogramming*/genetics , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics, Animals ; Gene Expression Regulation, Developmental ; Octamer Transcription Factor-3/metabolism ; Octamer Transcription Factor-3/genetics ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/metabolism ; Nanog Homeobox Protein/metabolism ; Nanog Homeobox Protein/genetics

Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy.

Authors: Frlic T; Institute of Biophysics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Pavlin M; Institute of Biophysics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Source: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1688995. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Immunotherapy, Adoptive*/methods , Neoplasms*/therapy , Neoplasms*/immunology , Neoplasms*/metabolism , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , Cellular Reprogramming* , T-Lymphocytes*/metabolism , T-Lymphocytes*/immunology, Humans ; Tumor Microenvironment/immunology ; Animals ; Epigenesis, Genetic ; Cell Differentiation ; Immunologic Memory ; Metabolic Reprogramming

Myogenic enhancer snatching promotes adipogenic differentiation during epigenetic reprogramming mediated by lineage-specific transcription factors.

Authors: Hu M; Yazhouwan National Laboratory, Sanya, 572000, China., Xu Z; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China., Sun J; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China., Li L; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China., Liu P; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China., Zhou H; Yazhouwan National Laboratory, Sanya, 572000, China., Qi X; Yazhouwan National Laboratory, Sanya, 572000, China., Ren W; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China., Liu Y; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China., Chen S; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China., Kuang R; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China., Wang D; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China., Guo Y; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China., Sun G; Hainan Research Institute of Huazhong Agricultural University, Sanya, 572000, China., Zhao S; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.; Yazhouwan National Laboratory, Sanya, 572000, China., Zhu M; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China. zhumengjin@mail.hzau.edu.cn.; Hainan Research Institute of Huazhong Agricultural University, Sanya, 572000, China. zhumengjin@mail.hzau.edu.cn., Li L; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China. l.li@mail.hzau.edu.cn., Zhao Y; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China. yxzhao@mail.hzau.edu.cn.; Yazhouwan National Laboratory, Sanya, 572000, China. yxzhao@mail.hzau.edu.cn.

Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Nov 19; Vol. 82 (1), pp. 412. Date of Electronic Publication: 2025 Nov 19.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

MeSH Terms: Adipogenesis*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Epigenesis, Genetic* , Muscle Development*/genetics , Enhancer Elements, Genetic*/genetics , Cellular Reprogramming*/genetics, Animals ; Mice ; Myoblasts/metabolism ; Myoblasts/cytology ; Cell Lineage/genetics ; Cell Differentiation/genetics ; Chromatin/metabolism ; Chromatin/genetics ; Cell Line ; Adipocytes/cytology ; Adipocytes/metabolism