Wounding activates the HSFA1 transcription factors to promote cellular reprogramming in Arabidopsis.

Συγγραφείς: Coleman D; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Iwase A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; JST, PRESTO, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076Japan., Kawamura A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takebayashi A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Chen Y; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Minne M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Jager KE; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Peng M; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Kodama Y; Center for Bioscience Research and Education, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi 331-8505, Japan., Favero DS; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takahashi T; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Ikeuchi M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Division of Biological Sciences, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan., Suzuki T; Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan., Ohama N; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Yamaguchi-Shinozaki K; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Wigge PA; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany.; Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25 Haus 25, Raum B1.11-12, Potsdam 14476, Germany., De Veylder L; Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.; Center for Plant Systems Biology, VIB, Gent, Belgium., Sugimoto K; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Πηγή: The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis*/physiology , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Cellular Reprogramming*/genetics , Cellular Reprogramming*/physiology , Heat Shock Transcription Factors*/metabolism , Heat Shock Transcription Factors*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics, Gene Expression Regulation, Plant/genetics

Phospholipid remodeling interplays with auxin signaling to modulate cellular reprogramming in Arabidopsis regeneration.

Συγγραφείς: Chang P; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China., Yang X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Guo S; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhou J; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., He M; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Li Z; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Xu E; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Xin W; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Hu Y; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; National Center for Plant Gene Research, Beijing 100093, China., Xu C; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.

Πηγή: The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Indoleacetic Acids*/metabolism , Indoleacetic Acids*/pharmacology , Arabidopsis*/physiology , Arabidopsis*/metabolism , Arabidopsis*/genetics , Regeneration*/physiology , Phospholipids*/metabolism , Cellular Reprogramming*, Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/genetics ; Phosphatidic Acids/metabolism ; Plant Growth Regulators/metabolism ; Signal Transduction ; Gene Expression Regulation, Plant ; Plants, Genetically Modified

Protocol for identifying cellular reprogramming minimal networks using combinatorial transcription factor screening.

Συγγραφείς: Altman AR; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden., Pértiga-Cabral D; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden; CNC - Centre for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês Do Pombal, 3004-517 Coimbra, Portugal; CiBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Doctoral Programme in Experimental Biology and Biomedicine, University of Coimbra, Coimbra, Portugal., Pereira CF; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden; CNC - Centre for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês Do Pombal, 3004-517 Coimbra, Portugal; CiBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Asgard Therapeutics AB, Medicon Village, 223 81 Lund, Sweden., Kurochkin I; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden. Electronic address: ilia.kurochkin@med.lu.se.

Πηγή: STAR protocols [STAR Protoc] 2026 Jun 19; Vol. 7 (2), pp. 104527. Date of Electronic Publication: 2026 Apr 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Transcription Factors*/metabolism , Transcription Factors*/genetics , Cellular Reprogramming*/genetics, Fibroblasts/cytology ; Fibroblasts/metabolism ; Lentivirus/genetics ; Humans

A cross-talk between p16High senescence and cellular reprogramming.

Συγγραφείς: Emelyanov A; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, INSERM, CNRS, Nice, France., Bulavin DV; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, INSERM, CNRS, Nice, France.

Πηγή: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2026 Jun 10; Vol. 140 (6), pp. 1137-1147.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/genetics , Cellular Senescence*/physiology , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Cyclin-Dependent Kinase Inhibitor p16*/genetics , Cellular Reprogramming*, Fibroblasts/metabolism ; Humans ; Kruppel-Like Factor 4 ; Animals ; Epigenesis, Genetic ; Signal Transduction

Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming.

Συγγραφείς: Diak N; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Sieroń L; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Janelt K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Chajec L; Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Bankowa 9, 40-007, Katowice, Poland., Fus-Kujawa A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Dziedzic-Kowalska A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Trybus A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Raszczok K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland.; Students Scientific Society, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland., Bajdak-Rusinek K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland. kbajdak-rusinek@sum.edu.pl.

Πηγή: Histochemistry and cell biology [Histochem Cell Biol] 2026 Apr 20; Vol. 164 (1). Date of Electronic Publication: 2026 Apr 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Mitochondria*/metabolism , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Cellular Reprogramming*, Fibroblasts/metabolism ; Fibroblasts/cytology ; Reactive Oxygen Species/metabolism ; Humans ; Cells, Cultured ; Membrane Potential, Mitochondrial

Redefining cellular reprogramming with advanced genomic technologies.

Συγγραφείς: Morris SA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.

Πηγή: Nature reviews. Genetics [Nat Rev Genet] 2026 Mar; Vol. 27 (3), pp. 193-211. Date of Electronic Publication: 2025 Oct 17.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962779 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0064 (Electronic) Linking ISSN: 14710056 NLM ISO Abbreviation: Nat Rev Genet Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Genomics*/methods , Cellular Reprogramming Techniques*/methods, Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Cell Differentiation/genetics ; Regenerative Medicine/methods ; Humans ; Animals ; Single-Cell Analysis

Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis.

Συγγραφείς: Liu YW; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Zou JT; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Gong JS; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Jin L; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Cao J; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China., He ZH; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Qian YX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Wang X; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Wan MD; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Hu XY; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China., Hong CG; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Du W; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Chen CY; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Liu HJ; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. liuhongji@hnu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. liuhongji@hnu.edu.cn., Xie H; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. huixie@csu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. huixie@csu.edu.cn.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China. huixie@csu.edu.cn., Wang ZX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. wangzx@csu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. wangzx@csu.edu.cn.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China. wangzx@csu.edu.cn.

Πηγή: Experimental & molecular medicine [Exp Mol Med] 2026 Mar; Vol. 58 (3), pp. 782-797. Date of Electronic Publication: 2026 Mar 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Osteoarthritis*/therapy , Osteoarthritis*/pathology , Osteoarthritis*/metabolism , Osteoarthritis*/genetics , Osteoarthritis*/etiology , Cellular Reprogramming*/genetics , Kruppel-Like Transcription Factors*/genetics , Kruppel-Like Transcription Factors*/metabolism , SOXB1 Transcription Factors*/genetics , SOXB1 Transcription Factors*/metabolism , Cartilage*/pathology , Cartilage*/metabolism, Chondrocytes/metabolism ; Dependovirus/genetics ; Genetic Vectors/genetics ; Genetic Vectors/administration & dosage ; Animals ; Mice ; Kruppel-Like Factor 4 ; Fibrosis ; Humans ; Male ; Disease Models, Animal ; Cell Differentiation

Proteomic Signatures of Cellular Reprogramming in Bladder Cancer: Insights into the Acquisition of Cancer Stem-like States and Phenotypic Plasticity.

Συγγραφείς: Barlak BSR; Protein Research and Proteomics Laboratory, Department of Medical Biology, Faculty of Medicine, Kocaeli University, Izmit, Türkiye., Iskender B; Protein Research and Proteomics Laboratory, Department of Medical Biology, Faculty of Medicine, Kocaeli University, Izmit, Türkiye banu.iskender@kocaeli.edu.tr.

Πηγή: Cancer genomics & proteomics [Cancer Genomics Proteomics] 2026 Mar-Apr; Vol. 23 (2), pp. 300-321.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 101188791 Publication Model: Print Cited Medium: Internet ISSN: 1790-6245 (Electronic) Linking ISSN: 11096535 NLM ISO Abbreviation: Cancer Genomics Proteomics Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Urinary Bladder Neoplasms*/pathology , Urinary Bladder Neoplasms*/metabolism , Urinary Bladder Neoplasms*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Proteomics*/methods , Cellular Reprogramming*, Humans ; Cell Line, Tumor ; Phenotype ; Epithelial-Mesenchymal Transition ; Cell Plasticity

Navigating the landscape of direct cellular reprogramming with DiReG.

Συγγραφείς: Lauber M; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., List M; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. markus.list@tum.de.; Munich Data Science Institute (MDSI), Technical University of Munich, Garching, Germany. markus.list@tum.de.

Πηγή: NPJ systems biology and applications [NPJ Syst Biol Appl] 2026 Feb 06; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7189 (Electronic) Linking ISSN: 20567189 NLM ISO Abbreviation: NPJ Syst Biol Appl Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Cellular Reprogramming*/physiology , Computational Biology*/methods, Transcription Factors/metabolism ; Transcription Factors/genetics ; Regenerative Medicine/methods ; Humans ; Animals ; Software

Hepatocyte-specific partial cellular reprogramming via selective OSK mRNA lipid nanoparticle attenuates liver fibrosis.

Συγγραφείς: Zhang C; Human Phenome Institute, Fudan University, Shanghai 201203, China., Bai Y; Human Phenome Institute, Fudan University, Shanghai 201203, China., Yin Q; Human Phenome Institute, Fudan University, Shanghai 201203, China., Li J; Human Phenome Institute, Fudan University, Shanghai 201203, China., Huang K; Human Phenome Institute, Fudan University, Shanghai 201203, China., Qiu M; Human Phenome Institute, Fudan University, Shanghai 201203, China; Center for mRNA Translational Research, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Shanghai 201203, China. Electronic address: mqiu@fudan.edu.cn.

Πηγή: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 Feb 10; Vol. 390, pp. 114569. Date of Electronic Publication: 2025 Dec 22.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Nanoparticles*/administration & dosage , Nanoparticles*/chemistry , RNA, Messenger*/administration & dosage , Hepatocytes*/metabolism , Liver Cirrhosis*/therapy , Liver Cirrhosis*/genetics , Liver Cirrhosis*/pathology , Octamer Transcription Factor-3*/genetics , Lipids*/chemistry , Lipids*/administration & dosage , SOXB1 Transcription Factors*/genetics , Kruppel-Like Transcription Factors*/genetics , Cellular Reprogramming*, Animals ; Kruppel-Like Factor 4 ; Mice, Inbred C57BL ; Male ; Mice ; Humans ; Liposomes

In Vitro Generation of Brown and Beige Adipocytes via Cellular Reprogramming.

Συγγραφείς: Toshihiro K; Department of Cellular Regenerative Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Harada Y; Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Dai P; Department of Cellular Regenerative Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Πηγή: Cellular reprogramming [Cell Reprogram] 2025 Dec; Vol. 27 (6), pp. 216-227. Date of Electronic Publication: 2025 Nov 18.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101528176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-4998 (Electronic) Linking ISSN: 21524971 NLM ISO Abbreviation: Cell Reprogram Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Adipocytes, Beige*/cytology , Adipocytes, Beige*/metabolism , Adipocytes, Brown*/cytology , Adipocytes, Brown*/metabolism , Cellular Reprogramming Techniques*/methods , Cellular Reprogramming*, Humans ; Animals ; Thermogenesis

Cellular Reprogramming and Microfluidics Enable Large-Scale Blastoid Production from Aged Donors.

Συγγραφείς: Moura MT; Departamento de Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brasil.

Πηγή: Cellular reprogramming [Cell Reprogram] 2025 Dec; Vol. 27 (6), pp. 213-215. Date of Electronic Publication: 2025 Oct 22.

Τύπος έκδοσης: News

Στοιχεία περιοδικού: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101528176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-4998 (Electronic) Linking ISSN: 21524971 NLM ISO Abbreviation: Cell Reprogram Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Microfluidics*/methods , Blastocyst*/cytology , Cellular Reprogramming Techniques*/methods , Cellular Reprogramming* , Aging*, Animals ; Macaca mulatta ; Humans

Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.

Συγγραφείς: Uthamacumaran A; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Horth C; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Bareke E; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Gravel M; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada., Majewski J; Department of Human Genetics, McGill University, 740 Dr Penfield Ave, Montreal, QC, H3A 2T8, Canada. jacek.majewski@mcgill.ca.

Πηγή: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Dec 30; Vol. 14 (1), pp. 30. Date of Electronic Publication: 2025 Dec 30.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Glioma*/pathology , Glioma*/genetics , Neurons*/pathology , Neurons*/metabolism , Neurons*/drug effects , Neurons*/physiology , Cellular Reprogramming*/physiology , Cellular Reprogramming*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Histones*/genetics, Humans ; Cell Line, Tumor ; Child ; Cell Differentiation ; Gene Expression Regulation, Neoplastic

Interleukin-4-mediated Pro-Regenerative Cellular Reprogramming in 3-dimensional Liver Culture.

Συγγραφείς: Camat D; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada. Electronic address: damra.camat@mail.utoronto.ca., Nakib D; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada. Electronic address: diana.nakib@mail.utoronto.ca., Chung SW; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Sekhon M; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Liu Y; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Lumanto P; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada., Hyduk SJ; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada., Perciani CT; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Bartczak AM; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Cheng ML; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Pezzutti OI; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Kaltagian M; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada., Altaf F; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada., Jafari SM; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada., Manuel J; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada., Thoeni C; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Ogawa S; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; McEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada., Ma XZ; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada., McGilvray ID; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada. Electronic address: ian.mcgilvray@uhn.ca., MacParland SA; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address: sonya.macparland@uhn.ca.

Πηγή: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2026; Vol. 20 (2), pp. 101626. Date of Electronic Publication: 2025 Sep 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Gastroenterological Association Country of Publication: United States NLM ID: 101648302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-345X (Electronic) Linking ISSN: 2352345X NLM ISO Abbreviation: Cell Mol Gastroenterol Hepatol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Interleukin-4*/pharmacology , Interleukin-4*/metabolism , Liver Regeneration*/drug effects , Cellular Reprogramming*/drug effects , Liver*/cytology , Liver*/drug effects , Liver*/pathology , Liver*/metabolism, Hepatocytes/metabolism ; Hepatocytes/drug effects ; Cell Proliferation/drug effects ; Thioacetamide/toxicity ; Adenosine Triphosphate/metabolism ; Animals ; Mice ; Mice, Inbred C57BL ; Male

Multifaceted controls on auxin metabolism during cellular reprogramming and organ regeneration in plants.

Συγγραφείς: Maruyama K; Division of Biological Sciences, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan., Ikeuchi M; Division of Biological Sciences, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan.

Πηγή: Journal of experimental botany [J Exp Bot] 2025 Dec 16; Vol. 77 (1), pp. 141-148.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9882906 Publication Model: Print Cited Medium: Internet ISSN: 1460-2431 (Electronic) Linking ISSN: 00220957 NLM ISO Abbreviation: J Exp Bot Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Indoleacetic Acids*/metabolism , Plant Growth Regulators*/metabolism , Regeneration* , Cellular Reprogramming*, Plant Roots/physiology

Targeted neuronal reprogramming rescues memory and neural synchrony in Alzheimer's disease.

Συγγραφείς: Galán-Ganga M; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Rodríguez-Navarro I; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Zaballa S; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Ramón-Lainez A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Gómez-Rivada N; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Peters C; Department of Molecules-Signaling-Development, Max-Planck Institute for Biological Intelligence, Martinsried, 82152, Germany., Fernández-Irigoyen J; Proteomics Platform, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra UPNA, IdiSNA, Pamplona, 31008, Spain., Santamaría E; Proteomics Platform, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra UPNA, IdiSNA, Pamplona, 31008, Spain., Rabadán MÁ; ZeClinics SL. and ZeNeuroid SL., Barcelona, Spain., Alberch J; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain.; Production and Validation Centre of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036, Spain., Rodríguez MJ; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Del Toro D; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain. danieldeltoro@ub.edu.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain. danieldeltoro@ub.edu.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain. danieldeltoro@ub.edu.; Production and Validation Centre of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036, Spain. danieldeltoro@ub.edu., Giralt A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain. albertgiralt@ub.edu.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain. albertgiralt@ub.edu.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain. albertgiralt@ub.edu.; Production and Validation Centre of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036, Spain. albertgiralt@ub.edu.

Πηγή: Molecular biomedicine [Mol Biomed] 2026 Jun 10; Vol. 7 (1). Date of Electronic Publication: 2026 Jun 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Alzheimer Disease*/physiopathology , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Alzheimer Disease*/genetics , Neurons*/metabolism , Neurons*/pathology , Memory* , Cellular Reprogramming*, Receptors, N-Methyl-D-Aspartate/metabolism ; Hippocampus/metabolism ; Hippocampus/pathology ; Focal Adhesion Kinase 2/metabolism ; tau Proteins/metabolism ; Animals ; Male ; Mice ; Female ; Disease Models, Animal ; Mice, Transgenic ; Humans

Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain.

Συγγραφείς: Wang J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Chen S; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Liu X; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Neurology, Jingzhou Hospital, Yangtze University, Jingzhou, China., Wang J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China., Huang L; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Nie L; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wu X; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Feng Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Liu N; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Tang Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhu L; Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Qin C; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li G; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lgghuster@163.com., Tang Z; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ddjtzp@163.com.; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, China. ddjtzp@163.com.; National Center for Major Public Health Events, Wuhan, China. ddjtzp@163.com.; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan, China. ddjtzp@163.com.

Πηγή: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jul 29; Vol. 11 (1). Date of Electronic Publication: 2026 Jul 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Astrocytes*/metabolism , Astrocytes*/pathology , Astrocytes*/drug effects , Neurons*/metabolism , Neurons*/pathology , Neurons*/drug effects , Ferroptosis*/drug effects , Ferroptosis*/genetics , Cerebral Hemorrhage*/pathology , Cerebral Hemorrhage*/genetics , Cerebral Hemorrhage*/drug therapy , Cerebral Hemorrhage*/metabolism , Cellular Reprogramming*/drug effects , Cellular Reprogramming*/genetics, Brain/pathology ; Brain/metabolism ; Brain/drug effects ; Animals ; Mice ; Humans

Cellular reprogramming during anti-PD-1 and chemotherapy treatment in early-stage primary hormone receptor-positive breast cancer.

Συγγραφείς: Fu J; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waks AG; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pimenta E; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Titchen B; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Harvard Division of Medical Sciences PhD Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA, USA., Bi K; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Camp S; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Pappa T; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Keenan T; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shannon E; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Vigneau S; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bemus M; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nag A; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Thorner AR; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Park J; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., DiLullo M; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Wrabel E; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Jeselsohn R; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mittendorf EA; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.; Division of Breast Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA., Abravanel DL; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Tolaney SM; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Van Allen EM; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. eliezerm_vanallen@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. eliezerm_vanallen@dfci.harvard.edu.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eliezerm_vanallen@dfci.harvard.edu.; Parker Institute for Cancer Immunotherapy, Dana-Farber Cancer Institute, Boston, MA, USA. eliezerm_vanallen@dfci.harvard.edu.

Πηγή: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10704. Date of Electronic Publication: 2025 Nov 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Breast Neoplasms*/immunology , Cellular Reprogramming*/drug effects , Cellular Reprogramming*/genetics , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Paclitaxel/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Receptors, Estrogen/metabolism ; Macrophages/immunology ; Macrophages/drug effects ; Receptors, Progesterone/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; T-Lymphocytes/immunology ; Humans ; Female ; Neoadjuvant Therapy ; Middle Aged ; Albumins

Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction.

Συγγραφείς: Bann GG; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.).; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B.)., Dos Santos M; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.)., Chen K; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX (K.C., L.X.)., Tan W; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.)., Bezprozvannaya S; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.)., Gan P, Xu L; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX (K.C., L.X.)., Liu N; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.)., Bassel-Duby R; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.)., Olson EN; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX (G.G.B., M.D.S., W.T., S.B., P.C., N.L., R.B.-D., E.N.O.).

Πηγή: Circulation [Circulation] 2025 Sep 02; Vol. 152 (9), pp. 616-629. Date of Electronic Publication: 2025 Jul 09.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Myocardial Infarction*/metabolism , Myocardial Infarction*/genetics , Myocardial Infarction*/pathology , Myocardial Infarction*/physiopathology , Myocardial Infarction*/therapy , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Transcription Factors*/genetics , Transcription Factors*/metabolism , Cellular Reprogramming*, Fibroblasts/metabolism ; MEF2 Transcription Factors/genetics ; MEF2 Transcription Factors/metabolism ; Animals ; Mice ; Humans ; Disease Models, Animal ; Mice, Inbred C57BL ; Cells, Cultured ; Male ; T-Box Domain Proteins

Tumor necrosis factor promotes doublecortin-like kinase 1 expression and cellular reprogramming in intestinal epithelial cells leading to neoplastic transformation.

Συγγραφείς: Huang L; Department of Gastroenterology, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China.; Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China.; Nantong Key Laboratory of Genetics and Reproductive Medicine, Nantong, 226018, Jiangsu, China., Li T; Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China.; Nantong Key Laboratory of Genetics and Reproductive Medicine, Nantong, 226018, Jiangsu, China., Huang X; Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China.; Nantong Key Laboratory of Genetics and Reproductive Medicine, Nantong, 226018, Jiangsu, China., Chen X; Department of Gastroenterology, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China., Ju Y; Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China.; Nantong Key Laboratory of Genetics and Reproductive Medicine, Nantong, 226018, Jiangsu, China., Xu L; Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China.; Nantong Key Laboratory of Genetics and Reproductive Medicine, Nantong, 226018, Jiangsu, China., Ma C; Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China.; Nantong Key Laboratory of Genetics and Reproductive Medicine, Nantong, 226018, Jiangsu, China., Tao Y; Department of Pathology, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China., Yang Y; Department of Nephrology, Rheumatology, and Immunology, Nantong Children's Hospital, Nantong, 226018, Jiangsu, China., Bian X; Department of Gastroenterology, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China., Huycke MM; Department of Radiation Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Wang X; Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, 226018, Jiangsu, China. xingmin-wang@ntu.edu.cn.; Nantong Key Laboratory of Genetics and Reproductive Medicine, Nantong, 226018, Jiangsu, China. xingmin-wang@ntu.edu.cn.; Nantong Maternity and Child Healthcare Hospital, 399 Century Ave, Nantong, 226018, Jiangsu, China. xingmin-wang@ntu.edu.cn.

Πηγή: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Oct 02; Vol. 23 (1), pp. 415. Date of Electronic Publication: 2025 Oct 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cell Transformation, Neoplastic*/pathology , Cell Transformation, Neoplastic*/metabolism , Cell Transformation, Neoplastic*/genetics , Cell Transformation, Neoplastic*/drug effects , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Tumor Necrosis Factor-alpha*/metabolism , Tumor Necrosis Factor-alpha*/pharmacology , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Epithelial Cells*/drug effects , Cellular Reprogramming*/drug effects , Intracellular Signaling Peptides and Proteins*/metabolism , Intracellular Signaling Peptides and Proteins*/genetics , Intestinal Mucosa*/pathology, Receptors, Tumor Necrosis Factor, Type I/metabolism ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Intestines/pathology ; Animals ; Doublecortin-Like Kinases ; Humans ; Mice ; Mice, Transgenic ; Mice, Inbred C57BL