Functional validation of driver mutation-specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity.

Authors: van den Bosch Q; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC Cancer Institute University Medical Center, Rotterdam, The Netherlands., Verdijk RM; Department of Pathology, Erasmus MC Cancer Institute University Medical Center, Rotterdam, The Netherlands., Fadlelseed H; National Ophthalmic Pathology Laboratory, Royal Victoria Eye and Ear Hospital and Research Foundation, Dublin, Ireland., van den Bosch T; Department of Pathology, Erasmus MC Cancer Institute University Medical Center, Rotterdam, The Netherlands., Owens S; National Ophthalmic Pathology Laboratory, Royal Victoria Eye and Ear Hospital and Research Foundation, Dublin, Ireland., Kennedy S; National Ophthalmic Pathology Laboratory, Royal Victoria Eye and Ear Hospital and Research Foundation, Dublin, Ireland., Kilic E; Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands., Brosens E; Department of Clinical Genetics, Erasmus MC Cancer Institute University Medical Center, Rotterdam, The Netherlands.

Source: The Journal of pathology [J Pathol] 2026 Oct; Vol. 270 (2), pp. 226-240. Date of Electronic Publication: 2026 Jul 21.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE

MeSH Terms: Uveal Neoplasms*/genetics , Uveal Neoplasms*/pathology , Uveal Neoplasms*/metabolism , Melanoma*/genetics , Melanoma*/pathology , Melanoma*/metabolism , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Mutation* , Cell Plasticity*, Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; Eukaryotic Initiation Factor-1/genetics ; Eukaryotic Initiation Factor-1/metabolism ; Humans ; Uveal Melanoma ; Animals ; Zebrafish ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Female

Beyond Foxp3 and TSDR: a dual epigenetic lock framework for treg stability and plasticity.

Authors: Wang F; Huzhou Central Blood Station, Huzhou, China., Yang H; Huzhou Central Blood Station, Huzhou, China., Xu Z; Huzhou College of Life and Health, Huzhou, China., Song J; Huzhou Central Blood Station, Huzhou, China., Wang Z; Zhejiang Chinese Medical University, Hangzhou, China., Wang L; Huzhou Central Blood Station, Huzhou, China.

Source: Frontiers in immunology [Front Immunol] 2026 Sep 22; Vol. 17, pp. 1952451. Date of Electronic Publication: 2026 Sep 22 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/metabolism , Forkhead Transcription Factors*/genetics , Forkhead Transcription Factors*/immunology , Cell Plasticity*/genetics , Cell Plasticity*/immunology , Epigenesis, Genetic*, Humans ; Animals ; Super Enhancers ; Immune Tolerance ; DNA Methylation

MAP2-mediated integrin dysregulation reprograms cancer cell plasticity in hepatocellular carcinoma.

Authors: Lou UK; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Wong TL; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; The University of Hong Kong - Shenzhen Hospital, Shenzhen, China., Huang IB; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Lam KH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Yu H; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Man KF; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Loh JJ; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Zhou L; Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Gao Y; State Key Laboratory of Cancer Biology, Biotechnology Centre, School of Pharmacy, Fourth Military Medical University, Xi'an, China., Yu CH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. chyu1@hku.hk.; The University of Hong Kong - Shenzhen Hospital, Shenzhen, China. chyu1@hku.hk., Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. stefma@hku.hk.; The University of Hong Kong - Shenzhen Hospital, Shenzhen, China. stefma@hku.hk.; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China. stefma@hku.hk.; Laboratory for Synthetic Chemistry and Chemical Biology, Hong Kong Science and Technology Park, Hong Kong, China. stefma@hku.hk.

Source: Nature communications [Nat Commun] 2026 Sep 16; Vol. 17 (1). Date of Electronic Publication: 2026 Sep 16.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/drug therapy , Cell Plasticity*/drug effects , Cell Plasticity*/genetics , Integrins*/metabolism , Integrins*/genetics, Gene Expression Regulation, Neoplastic/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; AC133 Antigen/metabolism ; Sorafenib/pharmacology ; Transcription Factors/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Humans ; Cell Line, Tumor ; Animals ; YAP-Signaling Proteins

IL-1β signaling as a molecular arbiter of stem cell plasticity: orchestrating the niches of repair, fibrosis, and cancer.

Authors: Yu S; Department of Life Sciences, Integrated Institute of Biomedical Research, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea., Lee SH; Department of Life Sciences, Integrated Institute of Biomedical Research, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea., Choi MS; Department of Life Sciences, Integrated Institute of Biomedical Research, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea., Choi J; Department of Life Sciences, Integrated Institute of Biomedical Research, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. Electronic address: jinchoi@gist.ac.kr.

Source: Seminars in immunology [Semin Immunol] 2026 Sep; Vol. 83, pp. 102050. Date of Electronic Publication: 2026 Jul 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9009458 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3618 (Electronic) Linking ISSN: 10445323 NLM ISO Abbreviation: Semin Immunol Subsets: MEDLINE

MeSH Terms: Interleukin-1beta*/metabolism , Stem Cells*/metabolism , Neoplasms*/metabolism , Neoplasms*/pathology , Neoplasms*/immunology , Stem Cell Niche*/immunology , Signal Transduction* , Cell Plasticity*, Humans ; Animals ; Fibrosis ; Wound Healing ; Regeneration

Macrophage programming in systemic sclerosis: Niches, networks, and translational horizons.

Authors: Luo H; Guangxi Medical University, Nanning, Guangxi, China. 202310072@sr.gxmu.edu.cn.; Department of Rheumatology and Immunology, The First Affiliated Hospital of University of South China, 69 Chuanshan Road, Hengyang, Hunan, 421001, China. 202310072@sr.gxmu.edu.cn., Hu D; Department of Neonatology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Source: Seminars in immunopathology [Semin Immunopathol] 2026 Aug 27; Vol. 48 (1). Date of Electronic Publication: 2026 Aug 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 101308769 Publication Model: Electronic Cited Medium: Internet ISSN: 1863-2300 (Electronic) Linking ISSN: 18632297 NLM ISO Abbreviation: Semin Immunopathol Subsets: MEDLINE

MeSH Terms: Scleroderma, Systemic*/metabolism , Scleroderma, Systemic*/etiology , Scleroderma, Systemic*/pathology , Scleroderma, Systemic*/therapy , Scleroderma, Systemic*/immunology , Macrophages*/metabolism , Macrophages*/immunology , Macrophage Activation*/immunology , Macrophage Activation*/genetics , Cell Plasticity*/genetics , Cell Plasticity*/immunology , Cellular Microenvironment*/immunology, Humans ; Animals ; Signal Transduction ; Translational Research, Biomedical ; Autoimmunity ; Disease Susceptibility ; Biomarkers ; Fibrosis

PDCD10-Deficient Tumor Cells Reprogram Angiogenesis Through Paracrine Endothelial Activation and GSC-like Plasticity in GBM.

Authors: Chen ZR; Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany., Chen Z; Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany., Wan XY; Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany., Busch MA; Department of Neuroanatomy, Medical Faculty, Institute of Anatomy II, University of Duisburg-Essen, 45147 Essen, Germany., Dünker N; Department of Neuroanatomy, Medical Faculty, Institute of Anatomy II, University of Duisburg-Essen, 45147 Essen, Germany., Rauschenbach L; Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany., Sure U; Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany., Zhu Y; Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Source: Cells [Cells] 2026 Aug 25; Vol. 15 (17). Date of Electronic Publication: 2026 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: Neovascularization, Pathologic*/metabolism , Neovascularization, Pathologic*/pathology , Glioblastoma*/pathology , Glioblastoma*/metabolism , Glioblastoma*/blood supply , Glioblastoma*/genetics , Apoptosis Regulatory Proteins*/metabolism , Apoptosis Regulatory Proteins*/deficiency , Apoptosis Regulatory Proteins*/genetics , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/metabolism , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , Brain Neoplasms*/blood supply , Endothelial Cells*/metabolism , Endothelial Cells*/pathology , Paracrine Communication* , Cell Plasticity*, Culture Media, Conditioned/pharmacology ; Humans ; Animals ; Cell Line, Tumor ; Kruppel-Like Factor 4 ; Mice ; Membrane Proteins ; Proto-Oncogene Proteins

Reprogramming of Cellular Plasticity via ETS and MYC Core-Regulatory Circuits during Response to MAPK Inhibition in BRAF-Mutant Colorectal Cancer.

Authors: Lee HM; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas., Zheng Z; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Sorokin A; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wong CW; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Napolitano S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Chowdhury S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kanikarla Marie P; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Singh AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kochat V; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Bristow CA; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas., Srinivasan S; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas., Peoples M; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas., Arslan E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Alshenaifi JY; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas., Villarreal OE; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas., Morris VK; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Shen JP; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Meric-Bernstam F; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jain AK; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas., Fowlkes NW; Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Anderson A; Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Menter DG; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Saw AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rai K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kopetz S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Aug 03; Vol. 32 (15), pp. 3309-3324.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

MeSH Terms: Proto-Oncogene Proteins B-raf*/genetics , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Protein Kinase Inhibitors*/pharmacology , Cell Plasticity*/genetics , Cell Plasticity*/drug effects , Proto-Oncogene Proteins c-ets*/genetics , Proto-Oncogene Proteins c-ets*/metabolism , Mutation*, Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Animals ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Epigenesis, Genetic

Metabolic-epigenetic crosstalk in innate immune cell plasticity within the tumor microenvironment.

Authors: Noh J; Department of Biological Sciences and Biotechnology, Chungbuk National University, Cheongju, Korea., Lee J; Department of Biological Sciences and Biotechnology, Chungbuk National University, Cheongju, Korea., You C; Department of Biological Sciences and Biotechnology, Chungbuk National University, Cheongju, Korea., Kang K; Department of Biological Sciences and Biotechnology, Chungbuk National University, Cheongju, Korea. kangk@cbnu.ac.kr.

Source: Experimental & molecular medicine [Exp Mol Med] 2026 Aug; Vol. 58 (8), pp. 2491-2506. Date of Electronic Publication: 2026 Aug 06.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , Neoplasms*/metabolism , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/genetics , Neoplasms*/etiology , Cell Plasticity*/immunology , Cell Plasticity*/genetics , Immunity, Innate* , Epigenesis, Genetic*, Humans ; Animals ; Metabolic Reprogramming ; Trained Immunity

IRAK4 constrains cellular plasticity during chemically-induced cell fate reprogramming into multiple lineages.

Authors: Huang C; Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China. huangchuanshu@ojlab.AC.cn.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325035, China. huangchuanshu@ojlab.AC.cn., Han X; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325035, China., Wang T; Key Laboratory of Laboratory Medicine, Ministry of Education, Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China., Zhao Y; State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, Peking University, Beijing, 100871, China. yangzhao@pku.edu.cn., Li J; Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China. jun.li@wmu.edu.cn.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325035, China. jun.li@wmu.edu.cn.

Source: EMBO reports [EMBO Rep] 2026 Aug; Vol. 27 (16), pp. 4903-4934. Date of Electronic Publication: 2026 Jul 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

MeSH Terms: Cellular Reprogramming*/drug effects , Cellular Reprogramming*/genetics , Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Interleukin-1 Receptor-Associated Kinases*/antagonists & inhibitors , Cell Lineage*/drug effects , Cell Plasticity*/genetics , Cell Plasticity*/drug effects, Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibroblasts/drug effects ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Endoderm/cytology ; Endoderm/metabolism ; Neurons/cytology ; Neurons/metabolism ; Animals ; Mice ; Cell Cycle ; Cell Differentiation

Harnessing neutrophil plasticity: From mechanistic insights to oncology therapeutics.

Authors: Zhang AQ; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, China., Wang J; Army 953rd Hospital (Shigatse Branch, Xinqiao Hospital), Army Medical University, Shigatse, China., Chung JY; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, China., Zhou J; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, China., Tang PC; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, China., Liu X; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China., Zhang Q; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China., To KF; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, China., Li Y; Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, China. Electronic address: lys@cqu.edu.cn., Tang PM; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong; Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong; CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Guangdong, China. Electronic address: patrick.tang@cuhk.edu.hk.

Source: Cancer letters [Cancer Lett] 2026 Oct 10; Vol. 658, pp. 218730. Date of Electronic Publication: 2026 Jul 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

MeSH Terms: Neutrophils*/immunology , Neutrophils*/metabolism , Neutrophils*/drug effects , Tumor Microenvironment*/immunology , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/therapy , Cell Plasticity*, Extracellular Traps/immunology ; Extracellular Traps/metabolism ; Humans ; Animals ; Signal Transduction

Organ-specific transcriptional programs regulate cellular plasticity in lymphatic endothelial cells.

Authors: Tsuyama Y; Department of Oral and Maxillofacial Surgical Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan., Takahashi K; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan., Kobayashi M; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan. Electronic address: kobayashi.m.0fde@m.isct.ac.jp., Benzemam Suzuki L; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan., Akagi H; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan., Yokozawa M; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Japan., Imafuku T; Department of Molecular Pathophysiology, Wakayama Medical University, Japan., Hashimoto S; Department of Molecular Pathophysiology, Wakayama Medical University, Japan., Matsunaga Y; Institute of Industrial Science, The University of Tokyo, Japan., Itoh F; Institute of Liberal Arts and Sciences, University of Toyama, Japan., Harada H; Department of Oral and Maxillofacial Surgical Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan., Hong YK; Division of Surgical Sciences, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, USA., Watabe T; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Japan; Oral Science Center, Institute of Biomedical Engineering, Institute of Science Tokyo, Japan. Electronic address: t-watabe.bch@tmd.ac.jp.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2026 Oct 08; Vol. 834, pp. 154315. Date of Electronic Publication: 2026 Jul 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Endothelial Cells*/metabolism , Endothelial Cells*/cytology , Cell Plasticity*/genetics , Lymphatic Vessels*/cytology , Lymphatic Vessels*/metabolism , Transcription, Genetic*, Lung/cytology ; Lung/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Transforming Growth Factor beta/metabolism ; Myocardium/cytology ; Myocardium/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Animals ; Mice ; Endothelial-Mesenchymal Transition ; Prospero-Related Homeobox 1 Protein ; Organ Specificity ; Cells, Cultured ; Signal Transduction ; Gene Expression Profiling

Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses.

Authors: Sajiki Y; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Ando S; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Perkins CM; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Huang YC; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Immunology Graduate Program, University of Cincinnati College of Medicine , Cincinnati, OH, USA., Smith KE; Comparative Medicine Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Doerning CM; Comparative Medicine Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Hildeman DA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Araki K; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Source: The Journal of experimental medicine [J Exp Med] 2026 Oct 05; Vol. 223 (10). Date of Electronic Publication: 2026 Aug 31.

Publication Type: Journal Article

Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

MeSH Terms: CD8-Positive T-Lymphocytes*/immunology , Memory T Cells*/immunology , T-Lymphocyte Subsets*/immunology , Cell Plasticity*/immunology , Immunologic Memory*, Antigens, Ly/immunology ; Antigens, Ly/metabolism ; Receptors, CXCR3/immunology ; Animals ; Mice ; Mice, Inbred C57BL ; Signal Transduction

Immune cell fibrotic plasticity: mesenchymal-like reprogramming of macrophages, neutrophils and T cells.

Authors: Long X; Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, China., Yuan S; Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, China., Luo Z; Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, China., Chen Y; Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, China., Xiao S; Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, China., Deng C; Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, China., Chen J; Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, China.

Source: Frontiers in immunology [Front Immunol] 2026 Oct 02; Vol. 17, pp. 1904807. Date of Electronic Publication: 2026 Oct 02 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Macrophages*/immunology , Macrophages*/pathology , Macrophages*/metabolism , Neutrophils*/immunology , Neutrophils*/pathology , Neutrophils*/metabolism , T-Lymphocytes*/immunology , T-Lymphocytes*/pathology , T-Lymphocytes*/metabolism , Cell Plasticity*/immunology , Cellular Reprogramming*/immunology, Humans ; Animals ; Fibrosis ; Signal Transduction

PGE2 Enhances Human ILC3 Function but Constrains ILC2-to-ILC3 Plasticity.

Authors: Wirth L; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.; Mechanistic Biology & Profiling, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.; Clinical Lung- and Allergy Research Unit, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Weigel W; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.; Clinical Lung- and Allergy Research Unit, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Kokkinou E; Department of Oncology, Bloomberg Kimmel Institute of Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Kolmert J; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Johnsson AK; Division of Immunology and Allergy, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden., Quaranta A; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Wheelock C; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Jangard M; ENT Unit, Sophiahemmet University and Sophiahemmet Hospital, Stockholm, Sweden., Pandey RV; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Dahlén SE; Clinical Lung- and Allergy Research Unit, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Tibbitt CA; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.; Clinical Lung- and Allergy Research Unit, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Hochdörfer T; Mechanistic Biology & Profiling, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Mjösberg J; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.; Clinical Lung- and Allergy Research Unit, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Source: European journal of immunology [Eur J Immunol] 2026 Oct; Vol. 56 (10), pp. e70296.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

MeSH Terms: Dinoprostone*/immunology , Dinoprostone*/metabolism , Lymphocytes*/immunology , Immunity, Innate*/immunology , Cell Plasticity*/immunology , Asthma*/immunology, Prostaglandin D2/metabolism ; Humans ; Cells, Cultured

Spatiotemporal single-cell profiling reveals T cell clonal dynamics and phenotypic plasticity in human graft-versus-host disease.

Authors: Shi L; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Uzuni A; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Wang XK; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Pressler M; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Harle DW; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.; Columbia Institute of Human Nutrition, Columbia University, New York, NY, USA., Chakrabarti S; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Macedo R; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Belay K; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Gordillo CA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., McMahon-Skates T; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Raps E; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Zhang JYA; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Nazaret A; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.; Department of Computer Science, Columbia University, New York, NY, USA., Fan JL; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Jin Y; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Shen X; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Fuller JS; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Azad T; Department of Computer Science, Columbia University, New York, NY, USA., Huang J; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Chainani P; Department Statistics and Data Science, Yale University, New Haven, CT, USA., Nima JP; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Abrams JA; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Del Portillo A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Mapara MY; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Alhamar M; Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA., Sykes M; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., McFaline-Figueroa JL; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Azizi E; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA. elham@azizilab.com.; Department of Biomedical Engineering, Columbia University, New York, NY, USA. elham@azizilab.com.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. elham@azizilab.com.; Department of Computer Science, Columbia University, New York, NY, USA. elham@azizilab.com.; Data Science Institute, Columbia University, New York, NY, USA. elham@azizilab.com., Reshef R; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA. ran.reshef@columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. ran.reshef@columbia.edu.

Source: Nature immunology [Nat Immunol] 2026 Oct; Vol. 27 (10), pp. 2156-2171. Date of Electronic Publication: 2026 Sep 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

MeSH Terms: Graft vs Host Disease*/immunology , Graft vs Host Disease*/genetics , Hematopoietic Stem Cell Transplantation*/adverse effects , CD8-Positive T-Lymphocytes*/immunology , Memory T Cells*/immunology , Cell Plasticity*/immunology, Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Clone Cells/immunology ; Humans ; Single-Cell Analysis ; Female ; Phenotype ; Male ; Adult ; Middle Aged ; Single-Cell Gene Expression Analysis ; Spatial Transcriptomics ; Immunologic Memory

A biphasic effect of alcohol on endothelial plasticity through regulation of endothelial-to-mesenchymal transition.

Authors: Liu W; Department of Surgery, University of Rochester Medical Center, Rochester, New York, United States., Gusti Y; Department of Surgery, University of Rochester Medical Center, Rochester, New York, United States., Athar F; Department of Surgery, University of Rochester Medical Center, Rochester, New York, United States., Rajendran NK; Department of Surgery, University of Rochester Medical Center, Rochester, New York, United States., Cahill PA; Vascular Biology and Therapeutics Laboratory, School of Biotechnology, Dublin City University, Dublin, Ireland., Redmond EM; Department of Surgery, University of Rochester Medical Center, Rochester, New York, United States.

Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2026 Oct 01; Vol. 331 (4), pp. H1363-H1376. Date of Electronic Publication: 2026 Sep 15.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

MeSH Terms: Endothelial-Mesenchymal Transition*/drug effects , Ethanol*/pharmacology , Ethanol*/toxicity , Endothelial Cells*/drug effects , Endothelial Cells*/metabolism , Endothelial Cells*/pathology , Cell Plasticity*/drug effects , Carotid Artery Injuries*/pathology , Carotid Artery Injuries*/metabolism, Signal Transduction/drug effects ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Cell Movement/drug effects ; Cadherins/metabolism ; Coronary Vessels/drug effects ; Coronary Vessels/metabolism ; Coronary Vessels/pathology ; Cytokines/pharmacology ; Carotid Arteries/pathology ; Carotid Arteries/drug effects ; Carotid Arteries/metabolism ; Animals ; Humans ; Male ; Cells, Cultured ; Mice, Inbred C57BL ; Neointima ; Dose-Response Relationship, Drug ; Disease Models, Animal ; Cell Hypoxia ; Mice

Metabolic regulation of stem cell plasticity.

Authors: Kuuluvainen E; Faculty of Biological and Environmental Sciences and Institute of Biotechnology, HiLIFE, University of Helsinki, Finland. Electronic address: https://twitter.com/@EmiliaKuul., Gopalakrishnan S; Faculty of Biological and Environmental Sciences and Institute of Biotechnology, HiLIFE, University of Helsinki, Finland. Electronic address: https://twitter.com/@SwethaGopalakr2., Katajisto P; Faculty of Biological and Environmental Sciences and Institute of Biotechnology, HiLIFE, University of Helsinki, Finland; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address: pekka.katajisto@helsinki.fi.

Source: Current opinion in genetics & development [Curr Opin Genet Dev] 2026 Oct; Vol. 100, pp. 102530. Date of Electronic Publication: 2026 Aug 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9111375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0380 (Electronic) Linking ISSN: 0959437X NLM ISO Abbreviation: Curr Opin Genet Dev Subsets: MEDLINE

MeSH Terms: Cell Plasticity*/genetics , Cell Differentiation*/genetics , Stem Cells*/metabolism , Stem Cells*/cytology, Cell Lineage/genetics ; Animals ; Humans

Harnessing Endogenous Plasticity Rather than Reprogramming of Mature Cells Will Advance Regenerative Medicine, Cancer Treatment and Rejuvenation.

Authors: Bhartiya D; TZAR Genomics India Pvt Ltd, Todi Mill Compound, Senapati Bapat Marg, Lower Parel, Mumbai, 400013, India. deepa.bhartiya@tzarlabs.com., Sharma N; TZAR Genomics India Pvt Ltd, Todi Mill Compound, Senapati Bapat Marg, Lower Parel, Mumbai, 400013, India., Tripathi A; Epigeneres Biotech Pvt Ltd, Todi Mill Compound, Senapati Bapat Marg, Lower Parel, Mumbai, 400013, India., Tripathi A; TZAR Genomics India Pvt Ltd, Todi Mill Compound, Senapati Bapat Marg, Lower Parel, Mumbai, 400013, India.; 23Ikigai Pte Ltd, 137 Telok Ayer Street, Singapore, #05-02, 068602, Singapore.

Source: Stem cell reviews and reports [Stem Cell Rev Rep] 2026 Oct; Vol. 22 (7), pp. 3417-3438. Date of Electronic Publication: 2026 Jul 29.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE

MeSH Terms: Regenerative Medicine*/methods , Neoplasms*/therapy , Neoplasms*/pathology , Rejuvenation*/physiology , Cellular Reprogramming* , Cell Plasticity*, Induced Pluripotent Stem Cells/cytology ; Embryonic Stem Cells/cytology ; Humans ; Animals ; Cell Differentiation ; Cell Dedifferentiation

Developmentally constrained plasticity as a therapeutic vulnerability in cancer.

Authors: Xian JS; The First Clinical School of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 511436, China., Yang YX; Department of Obstetrics, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Li WL; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China., Liu M; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China; Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, 510095, China. Electronic address: liuming@gzhmu.edu.cn., Zhang XF; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, China; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, 511436, China; Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, 510095, China. Electronic address: cheungXF@gzhmu.edu.cn.

Source: Neoplasia (New York, N.Y.) [Neoplasia] 2026 Oct; Vol. 80, pp. 101344. Date of Electronic Publication: 2026 Jul 29.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE

MeSH Terms: Neoplasms*/pathology , Neoplasms*/etiology , Neoplasms*/therapy , Neoplasms*/drug therapy , Neoplasms*/metabolism , Cell Plasticity*, Drug Resistance, Neoplasm/genetics ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Humans ; Animals ; Cell Lineage ; Cellular Reprogramming

Mammary adipocyte plasticity and epithelial crosstalk: roles in development, remodeling, and disease.

Authors: Chen P; Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Liao Y; Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. yunjun1000@sina.com., Cai J; Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. drjunrongcai@outlook.com.

Source: Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2026 Oct; Vol. 27 (5), pp. 1023-1040. Date of Electronic Publication: 2026 Jul 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 100940588 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2606 (Electronic) Linking ISSN: 13899155 NLM ISO Abbreviation: Rev Endocr Metab Disord Subsets: MEDLINE

MeSH Terms: Adipocytes*/physiology , Adipocytes*/metabolism , Mammary Glands, Human*/metabolism , Mammary Glands, Human*/cytology , Mammary Glands, Human*/growth & development , Mammary Glands, Human*/physiology , Cell Plasticity*/physiology , Epithelial Cells*/physiology , Mammary Glands, Animal*, Humans ; Animals ; Female