Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas

Συγγραφείς: Chen, Jing, Sobecki, Michal, Krzywinska, Ewelina, Thierry, Kevin, Masmoudi, Mélissa, Nagarajan, Shunmugam, Fan, Zheng, He, Jingyi, Ferapontova, Irina, Nelius, Eric, Seehusen, Frauke, Gotthardt, Dagmar, Takeda, Norihiko, Sommer, Lukas, Sexl, Veronika, Münz, Christian, DeNardo, David, Hennino, Ana, Stockmann, Christian

Συνεισφορές: University of Zurich, Stockmann, Christian

Πηγή: EMBO Mol Med
EMBO Molecular Medicine, Vol 16, Iss 12, Pp 3033-3056 (2024)

Θεματικοί όροι: Cancer-Associated Fibroblasts Immunology, Medicine (General), Adenocarcinoma Immunology, 10017 Institute of Anatomy, Cancer-Associated Fibroblasts Pathology, 10184 Institute of Veterinary Pathology, ADAM12 Protein Metabolism, Pancreatic Neoplasms Prevention & Control, ADAM12 Protein, 610 Medicine & health, QH426-470, CD8-Positive T-Lymphocytes, Adenocarcinoma, 10263 Institute of Experimental Immunology, Cancer Vaccines, Mice, CD8-Positive T-Lymphocytes Immunology, R5-920, Cancer-Associated Fibroblasts, Report, Carcinoma, Pancreatic Ductal Pathology, Genetics, Mice Inbred C57BL, Adenocarcinoma Pathology, Animals, Humans, Cancer Vaccines Immunology, Pancreatic Adenocarcinoma, Cancer Vaccines Administration & Dosage, Cancer-Associated Fibroblasts Metabolism, Disease Models Animal, Vaccination, Fibrosis, Pancreatic Neoplasms, Mice, Inbred C57BL, Disease Models, Animal, Pancreatic Neoplasms Immunology, 1313 Molecular Medicine, 11401 Comprehensive Cancer Center Zurich, Pancreatic Neoplasms Pathology, Carcinoma Pancreatic Ductal Therapy, Adenocarcinoma Therapy, 570 Life sciences, biology, Immunotherapy, Carcinoma Pancreatic Ductal Immunology, Carcinoma, Pancreatic Ductal

Περιγραφή αρχείου: application/pdf; chen_et_al_2024_fibrolytic_vaccination_against_adam12_reduces_desmoplasia_in_preclinical_pancreatic_adenocarcinomas.pdf - application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39478152
https://doaj.org/article/32a6bfacd9884de49c5ed19adffba64c
https://phaidra.vetmeduni.ac.at/o:3794
https://doi.org/10.1038/s44321-024-00157-4

COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma

Συγγραφείς: Esposito, Mauro, Yerly, Laura, Shukla, Prachi, Hermes, Victoria, Sella, Federica, Balazs, Zsolt, Lattmann, Evelyn, Tastanova, Aizhan, Turko, Patrick, Lang, Ramon, Kolm, Isabel, Staeger, Ramon, Kuonen, François, Krauthammer, Michael, Hafner, Juerg, Levesque, Mitchell P, Restivo, Gaetana

Συνεισφορές: University of Zurich, Restivo, Gaetana

Πηγή: The British journal of dermatology, vol. 191, no. 5, pp. 775-790

Θεματικοί όροι: Male, 0301 basic medicine, 0303 health sciences, Skin Neoplasms, LMZ Competence Centre Language and Medicine Zurich, Humans, Carcinoma, Basal Cell/pathology, Carcinoma, Basal Cell/genetics, Carcinoma, Basal Cell/metabolism, Skin Neoplasms/pathology, Skin Neoplasms/genetics, Skin Neoplasms/metabolism, Cancer-Associated Fibroblasts/pathology, Cancer-Associated Fibroblasts/metabolism, Tumor Microenvironment, Laser Capture Microdissection, Female, Single-Cell Analysis, Aged, Middle Aged, Skin/pathology, RNA-Seq, 10177 Dermatology Clinic, 610 Medicine & health, 2708 Dermatology, 03 medical and health sciences, Cancer-Associated Fibroblasts, Carcinoma, Basal Cell, Biomarkers, Tumor, 11493 Department of Quantitative Biomedicine, Skin

Περιγραφή αρχείου: application/pdf; ZORA_ljae258.pdf - application/pdf; ZORA_264519.pdf - application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38916477
https://serval.unil.ch/notice/serval:BIB_41ED2ED028E5
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_41ED2ED028E53
https://serval.unil.ch/resource/serval:BIB_41ED2ED028E5.P001/REF.pdf

Transcriptional landscape of the interaction of human Mesenchymal Stem Cells with Glioblastoma in bioprinted co-cultures

Συγγραφείς: Oliver, Lisa, Landais, Yuna, Gratas, Catherine, Cartron, Pierre-François, Paris, François, Heymann, Dominique, Vallette, François, Serandour, Aurelien

Συνεισφορές: KERANDEL-DION, Céline, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers (CRCI2NA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), One Biosciences, Plasticity of Ecosystem from the Tumor after RadiotherapY - PETRY (CRCI2NA / Eq 10), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ), Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO), UNICANCER, Cancéropôle Grand-Ouest Bretagne-Centre-Pays de Loire, University of Sheffield Sheffield, Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), NANTES UNIVERSITÉ - École Centrale de Nantes (Nantes Univ - ECN), Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis (Team 6 - U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE)

Πηγή: Stem Cell Res Ther
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)

Θεματικοί όροι: 0301 basic medicine, MESH: Brain Neoplasms / genetics, MESH: Temozolomide / therapeutic use, Medicine (General), 3D tumor model, [SDV]Life Sciences [q-bio], Response to treatment, QD415-436, Cell Communication, MESH: Brain Neoplasms / metabolism, Biochemistry, MESH: Coculture Techniques, MESH: Glioblastoma / pathology, 03 medical and health sciences, R5-920, MESH: Brain Neoplasms / pathology, Cancer-Associated Fibroblasts, MESH: Glioblastoma / metabolism, MESH: Tumor Microenvironment, MESH: Cell Communication, MESH: Bioprinting / methods, Tumor Microenvironment, Temozolomide, Humans, MESH: Glioblastoma / genetics, 0303 health sciences, MESH: Humans, Brain Neoplasms, MESH: Mesenchymal Stem Cells / cytology, Research, Bioprinting, Mesenchymal Stem Cells, Coculture Techniques, [SDV] Life Sciences [q-bio], MESH: Mesenchymal Stem Cells / metabolism, MESH: Cancer-Associated Fibroblasts / pathology, MESH: Cancer-Associated Fibroblasts / metabolism, Mesenchymal stromal/stem cell, Co-culture, Glioblastoma, MESH: Temozolomide / pharmacology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39538257
https://doaj.org/article/6c267ab48d44485a92ba4348d55c821e

Targeting cancer-associated fibroblasts/tumor cells cross-talk inhibits intrahepatic cholangiocarcinoma progression via cell-cycle arrest

Συγγραφείς: Mancarella, Serena, Gigante, Isabella, Pizzuto, Elena, Serino, Grazia, Terzi, Alberta, Dituri, Francesco, Maiorano, Eugenio, Vincenti, Leonardo, De Bellis, Mario, Ardito, Francesco, Calvisi, Diego F, Giannelli, Gianluigi

Πηγή: J Exp Clin Cancer Res
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)

Θεματικοί όροι: Cholangiocarcinoma progression, Gamma secretase inhibitor, Liver cancer, Tumor microenvironment, Tumor stroma, Research, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell Cycle Checkpoints, Xenograft Model Antitumor Assays, Cholangiocarcinoma, Mice, Cancer-Associated Fibroblasts, Bile Duct Neoplasms, Cell Line, Tumor [MeSH], Disease Progression [MeSH], Cancer-Associated Fibroblasts/pathology [MeSH], Humans [MeSH], Bile Duct Neoplasms/metabolism [MeSH], Cell Cycle Checkpoints/drug effects [MeSH], Cholangiocarcinoma/drug therapy [MeSH], Bile Duct Neoplasms/pathology [MeSH], Animals [MeSH], Cholangiocarcinoma/metabolism [MeSH], Cancer-Associated Fibroblasts/metabolism [MeSH], Mice [MeSH], Cholangiocarcinoma/pathology [MeSH], Xenograft Model Antitumor Assays [MeSH], Bile Duct Neoplasms/drug therapy [MeSH], Cholangiocarcinoma/genetics [MeSH], Bile Duct Neoplasms/genetics [MeSH], Cell Line, Tumor, Disease Progression, Humans, Animals, RC254-282

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39415286
https://doaj.org/article/f7201f2a93ed4fb2bd5f4cc907746a8b
https://hdl.handle.net/11562/1143928
https://doi.org/10.1186/s13046-024-03210-9
https://repository.publisso.de/resource/frl:6519211

Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation

Συγγραφείς: Soumitra Ghosh, Jovan Isma, Paola Ostano, Luigi Mazzeo, Annagiada Toniolo, Monalisa Das, Joni R. White, Christian Simon, G. Paolo Dotto

Πηγή: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Nature communications, vol. 15, no. 1, pp. 7984

Θεματικοί όροι: Cell Nucleus, Male, Nuclear Envelope, Science, Fibroblasts, Lamin Type A, Article, Cancer-Associated Fibroblasts, Receptors, Androgen, Protein Phosphatase 1, Humans, Receptors, Androgen/metabolism, Receptors, Androgen/genetics, Lamin Type A/metabolism, Lamin Type A/genetics, Phosphorylation, Cancer-Associated Fibroblasts/metabolism, Cancer-Associated Fibroblasts/pathology, Cell Nucleus/metabolism, Protein Phosphatase 1/metabolism, Protein Phosphatase 1/genetics, Fibroblasts/metabolism, Nuclear Envelope/metabolism, Tumor Microenvironment

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39266569
https://doaj.org/article/ecacd5c27cbc40799626a289a8be3460
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_39467E97F3A55
https://serval.unil.ch/resource/serval:BIB_39467E97F3A5.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_39467E97F3A5

Exploring the Onset and Progression of Prostate Cancer through a Multicellular Agent-based Model

Συγγραφείς: Margot Passier, Maisa N.G. van Genderen, Anniek Zaalberg, Jeroen Kneppers, Elise M. Bekers, Andries M. Bergman, Wilbert Zwart, Federica Eduati

Πηγή: Cancer Res Commun
Passier, M, van Genderen, M N G, Zaalberg, A, Kneppers, J, Bekers, E, Bergman, A, Zwart, W & Eduati, F 2023, 'Exploring the Onset and Progression of Prostate Cancer through a Multicellular Agent-based Model', Cancer Research Communications, pp. 1473.

Θεματικοί όροι: Male, 0301 basic medicine, Prostate/pathology, 0303 health sciences, Prostatic Neoplasms/genetics, Prostate, Prostatic Neoplasms, SDG 3 – Goede gezondheid en welzijn, 3. Good health, Cancer-Associated Fibroblasts/pathology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Cancer-Associated Fibroblasts, Tumor Microenvironment, Humans, Research Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37554550
https://research.tue.nl/en/publications/98edbab5-9ffa-497e-8902-b476977c421d
https://doi.org/10.1158/2767-9764.CRC-23-0097
https://research.vumc.nl/en/publications/21444a84-8e14-4e4a-b5ea-c7d4d022fbb0

Implication of IL6-positive Cancer-associated Fibroblasts in Merkel Cell Carcinoma Pathogenesis: A Possible Modulator of Immune Microenvironment

Συγγραφείς: Zhenlong, Zheng, Dae San, Yoo, Shanshan, Li, Meiling, Pei, Sang Gyun, Lee, Ji Young, Kim, Kee Yang, Chung, Mi Ryung, Roh

Συνεισφορές: Zhenlong Zheng, Dae San Yoo, Shanshan Li, Meiling Pei, Sang Gyun Lee, Ji Young Kim, Kee Yang Chung, Mi Ryung Roh, Roh, Mi Ryung

Πηγή: Anticancer Research. 42:4359-4369

Θεματικοί όροι: Skin Neoplasms, Interleukin-6, Carcinoma, Merkel Cell* / pathology, Cancer-Associated Fibroblasts* / pathology, CD8-Positive T-Lymphocytes, Prognosis, 3. Good health, Carcinoma, Merkel Cell, 03 medical and health sciences, Merkel cell carcinoma, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Cancer-Associated Fibroblasts, tumor infiltrating lymphocytes, Skin Neoplasms* / pathology, Tumor Microenvironment, Humans, Lymphocytes, Tumor-Infiltrating, cancer-associated fibroblasts

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36039447

Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort

Συγγραφείς: Christoph Arolt, Franziska Hoffmann, Lisa Nachtsheim, Philipp Wolber, Orlando Guntinas-Lichius, Reinhard Buettner, Ferdinand von Eggeling, Alexander Quaas, Jens Peter Klußmann

Πηγή: Head Neck Pathol

Θεματικοί όροι: Original Paper, Cancer-Associated Fibroblasts, Carcinoma, Biomarkers, Tumor, Humans, Cancer-Associated Fibroblasts/pathology [MeSH], Collagen Type XI/genetics [MeSH], Humans [MeSH], RNA-ISH, Cancer-Associated Fibroblasts/metabolism [MeSH], Carcinoma/pathology [MeSH], Salivary Glands/pathology [MeSH], CAFs, Biomarkers, Tumor/metabolism [MeSH], Extracellular matrix, Collagen Type XI/metabolism [MeSH], Salivary gland carcinoma, Salivary Gland Neoplasms/pathology [MeSH], Salivary Glands/metabolism [MeSH], Tumour microenvironment, Collagen Type XI, Salivary Gland Neoplasms, Salivary Glands, 3. Good health

Σύνδεσμος πρόσβασης: https://link.springer.com/content/pdf/10.1007/s12105-021-01370-0.pdf
https://pubmed.ncbi.nlm.nih.gov/34378164
https://pubmed.ncbi.nlm.nih.gov/34378164/
https://link.springer.com/article/10.1007/s12105-021-01370-0
https://link.springer.com/content/pdf/10.1007/s12105-021-01370-0.pdf
https://www.ncbi.nlm.nih.gov/pubmed/34378164
https://repository.publisso.de/resource/frl:6445588

Cancer‐associated fibroblasts induce an aggressive phenotypic shift in non‐malignant breast epithelial cells via interleukin‐8 and S100A8

Συγγραφείς: Nam Hoon Cho, Minsoo Koh, Seung Yeon Lee, Hyun Jeong Kim, Aree Moon, Hoe Suk Kim, Sejin Hwang, Hyesol Lim, Kyoung Mee Kim, Joohee Jung, So Yeon Park, Mijeong Bae, Hao Jin, Woo Kyung Moon

Συνεισφορές: Hyesol Lim, Minsoo Koh, Hao Jin, Mijeong Bae, Seung-Yeon Lee, Kyoung Mee Kim, Joohee Jung, Hyun Jeong Kim, So Yeon Park, Hoe Suk Kim, Woo Kyung Moon, Sejin Hwang, Nam Hoon Cho, Aree Moon, Cho, Nam Hoon

Πηγή: Journal of Cellular Physiology. 236:7014-7032

Θεματικοί όροι: 0301 basic medicine, Breast Neoplasms / drug therapy, Nude, Calgranulin A / genetics, Paracrine Communication, Mice, Cancer-Associated Fibroblasts, Cell Movement, CCAAT-Enhancer-Binding Protein-beta / genetics, S100A8, Inbred BALB C, Mice, Inbred BALB C, Sulfonamides, 0303 health sciences, Tumor, Cultured, Transcription Factor RelA / genetics, invasion, Tumor Cells, 3. Good health, Cancer-Associated Fibroblasts / metabolism, Phenotype, Interleukin-8 / genetics, Cancer-Associated Fibroblasts / pathology, Breast Neoplasms / pathology, Female, Interleukin-8 / metabolism, cancer-associated fibroblasts, Cancer-Associated Fibroblasts / drug effects, Signal Transduction, Epithelial-Mesenchymal Transition, Mice, Nude, Breast Neoplasms, Epithelial Cells / pathology, Cell Line, 03 medical and health sciences, breast cancer, Cell Line, Tumor, Animals, Humans, Transcription Factor RelA / metabolism, Calgranulin A, Neoplasm Invasiveness, Sulfonamides / pharmacology, CCAAT-Enhancer-Binding Protein-beta, Interleukin-8, Epithelial Cells / metabolism, interleukin-8, Breast Neoplasms / metabolism, Calgranulin A / metabolism, Epithelial Cells, Xenograft Model Antitumor Assays, Coculture Techniques, Breast Neoplasms / genetics, CCAAT-Enhancer-Binding Protein-beta / metabolism

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/33748944
https://www.ncbi.nlm.nih.gov/pubmed/33748944
https://europepmc.org/article/MED/33748944
https://snucm.elsevierpure.com/en/publications/cancer-associated-fibroblasts-induce-an-aggressive-phenotypic-shi
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.30364
https://pubmed.ncbi.nlm.nih.gov/33748944/

Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis

Συγγραφείς: Chih Min Tang, Jorge I. de la Torre, Adam M. Burgoyne, Olivier Harismendy, Hyunho Yoon, Sudeep Banerjee, Lillian R. Klug, J. Silvio Gutkind, Mojgan Hosseini, Jason K. Sicklick, Alfredo A. Molinolo, Antonio L. Delgado, Mayra Yebra, Ronald P. DeMatteo, Martina De Siena, Mengyuan Liu, Yoon Young Choi, Andrew M. Lowy, Zhiyong Wang, Randall French, Sangkyu Noh, Michael Heinrich

Συνεισφορές: Hyunho Yoon, Chih-Min Tang, Sudeep Banerjee, Mayra Yebra, Sangkyu Noh, Adam M Burgoyne, Jorge De la Torre, Martina De Siena, Mengyuan Liu, Lillian R Klug, Yoon Young Choi, Mojgan Hosseini, Antonio L Delgado, Zhiyong Wang, Randall P French, Andrew Lowy, Ronald P DeMatteo, Michael C Heinrich, Alfredo A Molinolo, J Silvio Gutkind, Olivier Harismendy, Jason K Sicklick, Choi, Yoon Young

Πηγή: Oncogene
Oncogene, vol 40, iss 11

Θεματικοί όροι: Tumor Microenvironment / drug effects, 0301 basic medicine, Gastrointestinal Stromal Tumors / pathology, Receptor, Platelet-Derived Growth Factor alpha, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Cancer-Associated Fibroblasts, Epithelial-Mesenchymal Transition / genetics, Tumor Microenvironment, 2.1 Biological and endogenous factors, Neoplasm Metastasis, Signal Transduction / drug effects, Cancer, Platelet-Derived Growth Factor, Lymphokines, Tumor, TOR Serine-Threonine Kinases, Platelet-Derived Growth Factor / genetics, Biological Sciences, TOR Serine-Threonine Kinases / antagonists & inhibitors, 3. Good health, Cancer-Associated Fibroblasts / pathology, Paracrine Communication / drug effects, Cancer-Associated Fibroblasts / drug effects, Receptor, Signal Transduction, Epithelial-Mesenchymal Transition, Gastrointestinal Stromal Tumors, Oncology and Carcinogenesis, Clinical Sciences, Gastrointestinal Stromal Tumors / genetics, Article, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Paracrine Communication, Humans, Oncology & Carcinogenesis, Protein Kinase Inhibitors, Phosphatidylinositol 3-Kinases / drug effects, Platelet-Derived Growth Factor alpha / genetics, Snail Family Transcription Factors / genetics, Biomedical and Clinical Sciences, Protein Kinase Inhibitors / pharmacology, Platelet-Derived Growth Factor alpha, TOR Serine-Threonine Kinases / genetics, Oncology and carcinogenesis, Gastrointestinal Stromal Tumors / drug therapy, Lymphokines / genetics, Biochemistry and cell biology, Biochemistry and Cell Biology, Snail Family Transcription Factors, Digestive Diseases

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41388-021-01685-w.pdf
https://pubmed.ncbi.nlm.nih.gov/33603171
https://europepmc.org/article/PMC/PMC7979540
https://www.nature.com/articles/s41388-021-01685-w.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33603171
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979540
https://www.nature.com/articles/s41388-021-01685-w
https://www.mendeley.com/catalogue/597df1f6-5666-35ef-b090-44766dd80108/
https://escholarship.org/content/qt92q03395/qt92q03395.pdf
https://escholarship.org/uc/item/92q03395

Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Συγγραφείς: Jürgen C. Becker, Kaiji Fan, Kai Horny, Ivelina Spassova, Thilo Gambichler, Dirk Schadendorf, Cathrin Ritter, Niels Ødum, David Schrama, Jan Gravemeyer, Selma Ugurel, Anja Lange

Πηγή: Oncogene
Fan, K, Spassova, I, Gravemeyer, J, Ritter, C, Horny, K, Lange, A, Gambichler, T, Ødum, N, Schrama, D, Schadendorf, D, Ugurel, S & Becker, J C 2021, ' Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53 ', Oncogene, vol. 40, pp. 980–996 . https://doi.org/10.1038/s41388-020-01576-6

Θεματικοί όροι: 0301 basic medicine, Carcinogenesis, Chemokine CXCL2, Interleukin-1beta, Medizin, Exosomes, Article, 03 medical and health sciences, Cancer-Associated Fibroblasts, Signal Transduction/genetics [MeSH], Tumor Suppressor Protein p53/antagonists, Actins/genetics [MeSH], Single-Cell Analysis [MeSH], Immunoglobulin J Recombination Signal Sequence-Binding Protein/antagonists, MicroRNAs/genetics [MeSH], RNA-Seq [MeSH], Skin cancer, Interleukin-1beta/genetics [MeSH], Antagomirs/pharmacology [MeSH], Cell Polarity/genetics [MeSH], Cancer-Associated Fibroblasts/pathology [MeSH], Humans [MeSH], Tumor Suppressor Protein p53/genetics [MeSH], Cancer-Associated Fibroblasts/metabolism [MeSH], Carcinoma, Merkel Cell/genetics [MeSH], Carcinoma, Merkel Cell/pathology [MeSH], Chemokine CXCL2/genetics [MeSH], Exosomes/genetics [MeSH], Tumor Microenvironment/genetics [MeSH], Carcinogenesis/genetics [MeSH], Gene Expression Regulation, Neoplastic/genetics [MeSH], Cancer microenvironment, Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics [MeSH], Tumor Microenvironment, Humans, RNA-Seq, 0303 health sciences, Antagomirs, Cell Polarity, Actins, 3. Good health, Carcinoma, Merkel Cell, Gene Expression Regulation, Neoplastic, MicroRNAs, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Single-Cell Analysis, Tumor Suppressor Protein p53, Biologie, Signal Transduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41388-020-01576-6.pdf
https://pubmed.ncbi.nlm.nih.gov/33311552
https://www.nature.com/articles/s41388-020-01576-6.pdf
https://europepmc.org/article/PMC/PMC7862059
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862059
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862059
https://www.nature.com/articles/s41388-020-01576-6
https://www.ncbi.nlm.nih.gov/pubmed/33311552
https://curis.ku.dk/ws/files/273653643/s41388_020_01576_6_1_.pdf
https://repository.publisso.de/resource/frl:6471344
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85097379123
https://doi.org/10.1038/s41388-020-01576-6
https://www.ncbi.nlm.nih.gov/pubmed/33311552

Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages.

Συγγραφείς: Li, X., Møller, S.H., Park, J., Chuang, Y.M., Hsueh, P.C., Chang, T.H., Kao, K.C., Gallart-Ayala, H., Wang, Y.H., Peng, J.J., Bevilacqua, A., Yu, Y.R., Li, Z., Kieffer, Y., Peigney, D., Croizer, H., Xu, Y., Zippelius, A., Lopez-Mejia, I.C., Fajas, L., Mechta-Grigoriou, F., Ivanisevic, J., Xiao, Z., Ho, M.C., Shen, Y.C., Ho, P.C.

Θεματικοί όροι: Glutamine/biosynthesis, Glutamine/metabolism, Cancer-Associated Fibroblasts/metabolism, Cancer-Associated Fibroblasts/pathology, Animals, Tumor Microenvironment/immunology, Mice, Tumor-Associated Macrophages/metabolism, Tumor-Associated Macrophages/pathology, Tumor-Associated Macrophages/immunology, Humans, Signal Transduction, Macrophages/metabolism, Cell Line, Tumor, Neoplasms/pathology, Neoplasms/metabolism, Inbred C57BL, NF-kappa B/metabolism, Interleukin-6/metabolism, Toll-Like Receptor 4/metabolism, Syk Kinase/metabolism

Relation: Journal of Experimental Medicine; https://iris.unil.ch/handle/iris/273631; serval:BIB_2960BA83F45B; 001530056700001

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/273631
https://doi.org/10.1084/jem.20241426

Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation.

Συγγραφείς: Clocchiatti, A., Ghosh, S., Procopio, M.G., Mazzeo, L., Bordignon, P., Ostano, P., Goruppi, S., Bottoni, G., Katarkar, A., Levesque, M., Kölblinger, P., Dummer, R., Neel, V., Özdemir, B.C., Dotto, G.P.

Θεματικοί όροι: Animals, Cancer-Associated Fibroblasts/metabolism, Cancer-Associated Fibroblasts/pathology, Cell Line, Tumor, Female, Humans, Mice, Inbred NOD, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Receptors, Androgen/genetics, Androgen/metabolism, Repressor Proteins/genetics, Repressor Proteins/metabolism, Skin Neoplasms/genetics, Skin Neoplasms/metabolism, Skin Neoplasms/pathology, Transcriptional Activation, Cancer, Dermatology, Oncology, Sex hormones, Skin cancer

Relation: The Journal of Clinical Investigation; https://iris.unil.ch/handle/iris/246595; serval:BIB_DB6A4F3B1607; 000452071300035

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/246595
https://doi.org/10.1172/JCI99159

Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy

Συγγραφείς: Vienot, Angélique, Pallandre, Jean-René, Renaude, Elodie, Viot, Julien, Bouard, Adeline, Spehner, Laurie, Kroemer, Marie, Abdeljaoued, Syrine, van der Woning, Bas, de Haard, Hans, Loyon, Romain, Hervouet, Eric, Peixoto, Paul, Borg, Christophe

Πηγή: Oncoimmunology
OncoImmunology, Vol 11, Iss 1 (2022)

Θεματικοί όροι: TGF-β, 0301 basic medicine, Immunology, CD8-Positive T-Lymphocytes, Biochimie, biophysique & biologie moléculaire, fibroblast, Cancer-Associated Fibroblasts/pathology, Mice, 03 medical and health sciences, Cancer-Associated Fibroblasts, Neoplasms, Tumor Microenvironment, Immunology and Allergy, cancer, Animals, RC254-282, Original Research, Chemokines/therapeutic use, chemokine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC581-607, Life sciences, microenvironment, Neoplasms/drug therapy, 3. Good health, Oncology, Immunotherapy/methods, Sciences du vivant, chemo-immunotherapy, Immunotherapy, Immunologic diseases. Allergy, Chemokines, Biochemistry, biophysics & molecular biology

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36387055
https://doaj.org/article/baa9317abb2648f583e8924e70d7f5b7
https://hdl.handle.net/2268/330763
https://doi.org/10.1080/2162402X.2022.2144669

Differential Expression of Cancer-Associated Fibroblast-Related Proteins in Ductal Carcinoma in situ According to Molecular Subtype and Stromal Histology

Συγγραφείς: Hye Min Kim, Ji Hee Lee, Ja Seung Koo

Συνεισφορές: Lee J.H., Kim H.M., Koo J.S., Koo, Ja Seung

Πηγή: Pathobiology. 85:311-321

Θεματικοί όροι: 0301 basic medicine, Cancer-associated fibroblast, Receptor, ErbB-2, Intraductal, Triple Negative Breast Neoplasms/pathology, Triple Negative Breast Neoplasms, Stroma, Triple Negative Breast Neoplasms/metabolism, Noninfiltrating/metabolism, Noninfiltrating/pathology, Cancer-Associated Fibroblasts/pathology, 03 medical and health sciences, Cancer-Associated Fibroblasts, Ductal, Breast/metabolism, Receptors, Tumor/metabolism, Breast/diagnosis, Biomarkers, Tumor, Humans, Breast, 0303 health sciences, Carcinoma, Carcinoma, Ductal, Breast, Ductal carcinoma in situ, Cancer-Associated Fibroblasts/metabolism, Neoplastic/genetics, Middle Aged, 3. Good health, Gene Expression Regulation, Neoplastic, Carcinoma, Intraductal, Noninfiltrating, Gene Expression Regulation, Receptors, Estrogen, Breast/pathology, Progesterone/genetics, ErbB-2/metabolism, Progesterone/metabolism, Female, Estrogen/metabolism, Triple Negative Breast Neoplasms/genetics, Receptors, Progesterone, Biomarkers, Receptor

Σύνδεσμος πρόσβασης: https://www.karger.com/Article/Pdf/492392
https://pubmed.ncbi.nlm.nih.gov/30223270
https://pubmed.ncbi.nlm.nih.gov/30223270/
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166684
https://yonsei.pure.elsevier.com/en/publications/differential-expression-of-cancer-associated-fibroblast-related-p-2
https://www.ncbi.nlm.nih.gov/pubmed/30223270

Pathogenic role and regulatory mechanism of tumor-associated macrophage to cancer-associated fibroblast transition during cancer progression

Συνεισφορές: Tang, Chiu Tsun Philip (author.), Lan, Hui-Yao (thesis advisor.), Chinese University of Hong Kong Graduate School. Division of Medical Sciences. (degree granting institution.)

Θεματικοί όροι: Fibroblasts--pathology, Macrophages, Neoplastic Processes, Cancer-Associated Fibroblasts--pathology, Neoplasms--pathology, Tumor-Associated Macrophages

Περιγραφή αρχείου: electronic resource; remote; 1 online resource (xxii, 166 leaves) : illustrations (some color); computer; online resource

Relation: cuhk:2399010; local: ETD920201249; local: AAI28176474; local: 991039875429203407

Διαθεσιμότητα: https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991039875429203407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_US
https://repository.lib.cuhk.edu.hk/en/item/cuhk-2399010

Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma

Συγγραφείς: Cheol Keun Park, Woo Hee Jung, Ja Seung Koo

Συνεισφορές: College of Medicine, Dept. of Pathology, Cheol Keun Park, Woo Hee Jung, Ja Seung Koo, Koo, Ja Seung, Jung, Woo Hee

Πηγή: Breast Cancer Research and Treatment. 159:55-69

Θεματικοί όροι: Receptor, Platelet-Derived Growth Factor alpha, Lobular/pathology, Breast cancer, 0302 clinical medicine, Cancer-Associated Fibroblasts, Ductal, Breast/metabolism, Gelatinases/metabolism, Membrane Glycoproteins, Breast Neoplasms/pathology, Carcinoma, Ductal, Breast, Serine Endopeptidases, Membrane Glycoproteins/metabolism, Invasive lobular carcinoma, 3. Good health, Platelet-Derived Growth Factor alpha/metabolism, Gelatinases, Prolyl Hydroxylases/metabolism, Female, Proteoglycans, Cancer-Associated Fibroblasts/pathology, Receptor, Invasive ductal carcinoma, Cancer-associated fibroblast, S100 Calcium-Binding Protein A4/metabolism, Breast Neoplasms, Prolyl Hydroxylases, Receptor, Platelet-Derived Growth Factor beta, Serine Endopeptidases/metabolism, 03 medical and health sciences, Endopeptidases, Biomarkers, Tumor, Humans, S100 Calcium-Binding Protein A4, Tumor stroma, Antigens, Cancer-Associated Fibroblasts/metabolism, Carcinoma, Lobular/metabolism, Platelet-Derived Growth Factor beta/metabolism, Membrane Proteins, Proteoglycans/metabolism, Carcinoma, Lobular, Breast Neoplasms/metabolism, Tissue Array Analysis, Breast/pathology, Tumor/metabolism, Membrane Proteins/metabolism, Antigens/metabolism, Biomarkers

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/27469595
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151955?mode=simple
http://europepmc.org/abstract/MED/27469595
http://cancerres.aacrjournals.org/content/77/6_Supplement/A40
https://pubmed.ncbi.nlm.nih.gov/27469595/
https://link.springer.com/article/10.1007/s10549-016-3929-2/fulltext.html
https://yonsei.pure.elsevier.com/en/publications/expression-of-cancer-associated-fibroblast-related-proteins-diffe

Heterogeneity of CAFfeinated Tumors: Sweet Targeting Perspectives: Sweet Targeting Perspectives

Συγγραφείς: Olivier De Wever

Συνεισφορές: Clinical sciences

Πηγή: Cancer Research. 82:537-538

Θεματικοί όροι: 0301 basic medicine, Cancer-Associated Fibroblasts/pathology, 03 medical and health sciences, Cancer-Associated Fibroblasts, Neoplasms, Tumor Microenvironment, Humans, Neoplasms/genetics, TUMOR MICROENVIRONMENT, 3. Good health

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35180304
https://biblio.vub.ac.be/vubir/(e39195c0-72cb-476f-9b81-e5a3f8073661).html

Cytoskeletal alteration modulates cancer cell invasion through RhoA-YAP signaling in stromal fibroblasts

Συνεισφορές: Do Kyeong Kim, Eun Kyoung Kim, Da-Woon Jung, Jin Kim, Kim, Jin

Θεματικοί όροι: Adaptor Proteins, Signal Transducing / metabolism, Cancer-Associated Fibroblasts / pathology, Carcinoma, Squamous Cell / pathology, Cell Line, Tumor, Coculture Techniques, Cytoskeleton / metabolism, Cytoskeleton / pathology, Gene Expression Regulation, Neoplastic, Humans, Mouth Neoplasms / pathology, Neoplasm Invasiveness, Signal Transduction, Transcription Factors / metabolism, YAP-Signaling Proteins, rhoA GTP-Binding Protein / metabolism

Relation: PLOS ONE; J02540; https://ir.ymlib.yonsei.ac.kr/handle/22282913/189227; T9992019225

Διαθεσιμότητα: https://ir.ymlib.yonsei.ac.kr/handle/22282913/189227
https://doi.org/10.1371/journal.pone.0214553

Activin A-Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer.

Συγγραφείς: Pich-Bavastro, C., Yerly, L., Di Domizio, J., Tissot-Renaud, S., Gilliet, M., Kuonen, F.

Θεματικοί όροι: Humans, Cancer-Associated Fibroblasts/pathology, Skin Neoplasms/drug therapy, Skin Neoplasms/genetics, Carcinoma, Basal Cell/pathology, Macrophages/pathology, Immunotherapy, Tumor Microenvironment

Περιγραφή αρχείου: application/pdf

Relation: Clinical Cancer Research; https://iris.unil.ch/handle/iris/237540; serval:BIB_ED6EC1F62C5D; 001088433400001

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/237540
https://doi.org/10.1158/1078-0432.CCR-23-0219