ACYP2 Induces Temozolomide Resistance in Glioblastoma by Promoting PARP1-Mediated DNA Damage Repair

Συγγραφείς: Mengjun Sui, Qing Cai, Zhiwei Sun, Jinjin Li, Yiyang Zhang, Mengdan Li, Penggao Dai, Gang Li

Πηγή: Mol Cancer Res

Θεματικοί όροι: DNA Repair, Brain Neoplasms, Poly (ADP-Ribose) Polymerase-1, Mice, Nude, Cancer Genes and Networks, Xenograft Model Antitumor Assays, Acid Anhydride Hydrolases, Mice, Drug Resistance, Neoplasm, Cell Line, Tumor, Temozolomide, Humans, Animals, Glioblastoma, Antineoplastic Agents, Alkylating, DNA Damage

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41003719
https://pubmed.ncbi.nlm.nih.gov/41003719/
https://doi.org/10.1158/1541-7786.MCR-25-0423
https://pmc.ncbi.nlm.nih.gov/articles/PMC12757725/

Cancer Genomic Alterations and Microenvironmental Features Encode Synergistic Interactions with Disease Outcomes

Συγγραφείς: Masroor Bayati, Zoe P. Klein, Alexander T. Bahcheli, Mykhaylo Slobodyanyuk, Jeffrey To, Kevin C.L. Cheng, Jigyansa Mishra, Diogo Pellegrina, Kissy Guevara-Hoyer, Chris McIntosh, Mamatha Bhat, Jüri Reimand

Πηγή: Mol Cancer Res

Θεματικοί όροι: Neoplasms, Tumor Microenvironment, Humans, Female, Genomics, Cancer Genes and Networks

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40900635
https://pubmed.ncbi.nlm.nih.gov/40900635/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12670080/
https://doi.org/10.1158/1541-7786.MCR-25-0475

The LINC00519/hsa- miR- 22- 3p/MECOM Axis Accelerates Intrahepatic Cholangiocarcinoma Progression through PI3K/AKT Signaling

Συγγραφείς: Zhuxin Gu, Yanjun Sun, Fajing Chen, Weiwei Gu, Xiaohua Lu, Suming Zhao, Qinan Geng, Yang Yang

Πηγή: Mol Cancer Res

Θεματικοί όροι: Male, Apoptosis, Cancer Genes and Networks, Cholangiocarcinoma, Gene Expression Regulation, Neoplastic, MicroRNAs, Phosphatidylinositol 3-Kinases, Bile Duct Neoplasms, Cell Movement, Cell Line, Tumor, Disease Progression, Humans, RNA, Long Noncoding, Female, Proto-Oncogene Proteins c-akt, Signal Transduction, Cell Proliferation

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40748321
https://pubmed.ncbi.nlm.nih.gov/40748321/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12580760/
https://doi.org/10.1158/1541-7786.MCR-25-0207

Coevolution of Atypical BRAF and KRAS Mutations in Colorectal Tumorigenesis

Συγγραφείς: Woolley, C.E., Domingo, E., Fernandez-Tajes, J., Pennel, K.A.F., Roxburgh, P., Edwards, J., Richman, S.D., Maughan, T.S., Kerr, D.J., Soriano, I., Tomlinson, I.P.M.

Πηγή: Mol Cancer Res

Θεματικοί όροι: Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), Male, Carcinogenesis, Mutation, Humans, Female, Cancer Genes and Networks, Colorectal Neoplasms, Prognosis

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39751654
https://eprints.whiterose.ac.uk/id/eprint/221347/

METTL3-Mediated m6A Modification Regulates the Polycomb Repressive Complex 1 Components BMI1 and RNF2 in Hepatocellular Carcinoma Cells

Συγγραφείς: Weina Chen, Jinqiang Zhang, Wenbo Ma, Nianli Liu, Tong Wu

Πηγή: Mol Cancer Res

Θεματικοί όροι: Polycomb Repressive Complex 1, Carcinoma, Hepatocellular, Adenosine, Ubiquitin-Protein Ligases, Liver Neoplasms, Methyltransferases, Mice, SCID, Cancer Genes and Networks, Gene Expression Regulation, Neoplastic, Mice, Cell Line, Tumor, Humans, Animals, Cell Proliferation

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39625677

ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity

Συγγραφείς: Katie E. Hebron, Olivia L. Perkins, Angela Kim, Xiaoying Jian, Sofia A. Girald-Berlingeri, Haiyan Lei, Jack F. Shern, Elizabeth A. Conner, Paul A. Randazzo, Marielle E. Yohe

Πηγή: Mol Cancer Res

Θεματικοί όροι: Mice, Cell Line, Tumor, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Rhabdomyosarcoma, Humans, Animals, Cell Differentiation, ADP-Ribosylation Factor 1, Cancer Genes and Networks, Muscle Development, Adaptor Proteins, Signal Transducing

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39495123

Ruthenium Drug BOLD-100 Regulates BRAF MT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation

Συγγραφείς: Daryl Griffin, Robbie Carson, Debbie Moss, Tamas Sessler, Deborah Lavin, Vijay K. Tiwari, Shivaali Karelia, Richard Kennedy, Kienan I. Savage, Simon McDade, Adam Carie, Jim Pankovich, Mark Bazett, Sandra Van Schaeybroeck

Πηγή: Mol Cancer Res
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium drug BOLD-100 regulates BRAFmt colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V K, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151

Θεματικοί όροι: Proto-Oncogene Proteins B-raf, Basic Helix-Loop-Helix Proteins, Ataxia Telangiectasia Mutated Proteins/metabolism, name=Oncology, name=Cancer Research, colorectal cancer, Apoptosis, Ataxia Telangiectasia Mutated Proteins, Cancer Genes and Networks, Receptors, Aryl Hydrocarbon/metabolism, Cell Line, ruthenium drug, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects, Cell Line, Tumor, Proto-Oncogene Proteins B-raf/genetics, Receptors, Basic Helix-Loop-Helix Transcription Factors, Humans, name=SDG 3 - Good Health and Well-being, Tumor, cell apoptosis, Apoptosis/drug effects, Colorectal Neoplasms/drug therapy, 3. Good health, Receptors, Aryl Hydrocarbon, Aryl Hydrocarbon/metabolism, BOLD-100, BRAFMT, Colorectal Neoplasms, Reactive Oxygen Species, Signal Transduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39083088
https://pure.qub.ac.uk/en/publications/357b4c8d-d077-4033-8c9a-433d6c961788
https://doi.org/10.1158/1541-7786.MCR-24-0151
https://pureadmin.qub.ac.uk/ws/files/611793665/Ruthenium_drug.pdf
https://findresearcher.sdu.dk/ws/files/279240332/mcr-24-0151.pdf
https://doi.org/10.1158/1541-7786.MCR-24-0151
https://portal.findresearcher.sdu.dk/da/publications/3d27516f-a3d5-4134-9523-74594c733a9f

USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming

Συγγραφείς: Thomas L. Ekstrom, Sajjad Hussain, Tibor Bedekovics, Asma Ali, Lucia Paolini, Hina Mahmood, Raya M. Rosok, Jan Koster, Steven A. Johnsen, Paul J. Galardy

Πηγή: Mol Cancer Res

Θεματικοί όροι: Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Neuroblastoma, Mice, Cell Line, Tumor, Humans, Animals, Cancer Genes and Networks, Ubiquitin Thiolesterase, Epigenesis, Genetic, Cell Proliferation

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38775808

MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV075) in Small-Cell Lung Cancer

Συγγραφείς: Joshua P. Plotnik, Zheng Zha, Weiguo Feng, Irene Lee, Jacob Riehm, Ryan A. McClure, Stephanie Sandoval, Tamar Uziel, Erin Murphy, Xin Lu, Lloyd T. Lam

Πηγή: Mol Cancer Res

Θεματικοί όροι: 0301 basic medicine, N-Myc Proto-Oncogene Protein, Sulfonamides, 0303 health sciences, Lung Neoplasms, Pyridones, Gene Amplification, Proteins, Cancer Genes and Networks, Small Cell Lung Carcinoma, Proto-Oncogene Proteins c-myc, Bromodomain Containing Proteins, 03 medical and health sciences, Cell Line, Tumor, Humans

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38747975

NSCLC Extracellular Vesicles Containing miR-374a-5p Promote Leptomeningeal Metastasis by Influencing Blood‒Brain Barrier Permeability

Συγγραφείς: Jie Jin, Yumeng Cui, Huicong Niu, Yanli Lin, Xiaojie Wu, Xuejiao Qi, Kaixuan Bai, Yu Zhang, Youliang Wang, Hui Bu

Πηγή: Mol Cancer Res

Θεματικοί όροι: Male, 0301 basic medicine, 0303 health sciences, Lung Neoplasms, Mice, Nude, Cancer Genes and Networks, Middle Aged, Permeability, MicroRNAs, Extracellular Vesicles, Mice, 03 medical and health sciences, Blood-Brain Barrier, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Meningeal Neoplasms, Humans, Animals, Female

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38639925

Distinct Regulation of ASCL1 by the Cell Cycle and Chemotherapy in Small Cell Lung Cancer

Συγγραφείς: Yuning Liu, Qingzhe Wu, Bin Jiang, Tingting Hou, Chuanqiang Wu, Ming Wu, Hai Song

Πηγή: Mol Cancer Res

Θεματικοί όροι: Basic Helix-Loop-Helix Proteins, 0301 basic medicine, 0303 health sciences, Lung Neoplasms, Cell Cycle, Antineoplastic Agents, Cancer Genes and Networks, Small Cell Lung Carcinoma, Gene Expression Regulation, Neoplastic, Mice, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38512021

Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis

Συγγραφείς: Sehong Kim, Thomas T.Y. Lau, Man Kit Liao, Hoi Tang Ma, Randy Y.C. Poon

Πηγή: Mol Cancer Res

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Mitosis, Nuclear Proteins, Cell Cycle Proteins, Spindle Apparatus, Cancer Genes and Networks, Cytoskeletal Proteins, Protein Subunits, 03 medical and health sciences, Humans, M Phase Cell Cycle Checkpoints, Kinetochores, Microtubule-Associated Proteins, HeLa Cells

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38324016

ORAOV1 , CCND1 , and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma

Συγγραφείς: Céline I. Mahieu, Andrew G. Mancini, Ellee P. Vikram, Vicente Planells-Palop, Nancy M. Joseph, Aaron D. Tward

Πηγή: Mol Cancer Res
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol 22, iss 2

Θεματικοί όροι: Tumor, Carcinoma, Cell Cycle, Gene Amplification, Oncogenes, Cancer Genes and Networks, 3. Good health, Cell Line, Neoplasm Proteins, MicroRNAs, Squamous Cell, Cell Line, Tumor, Carcinoma, Squamous Cell, Humans, Cyclin D1

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37930255
https://escholarship.org/content/qt0r43g3gc/qt0r43g3gc.pdf
https://escholarship.org/uc/item/0r43g3gc

Integrating Clinical Cancer and PTM Proteomics Data Identifies a Mechanism of ACK1 Kinase Activation

Συγγραφείς: Eranga R. Balasooriya, Deshan Madhusanka, Tania P. López-Palacios, Riley J. Eastmond, Dasun Jayatunge, Jake J. Owen, Jack S. Gashler, Christina M. Egbert, Chanaka Bulathsinghalage, Lu Liu, Stephen R. Piccolo, Joshua L. Andersen

Πηγή: Mol Cancer Res

Θεματικοί όροι: Proteomics, Fetal Proteins, Ubiquitin, Neoplasms, Humans, Cancer Genes and Networks, Protein-Tyrosine Kinases, Protein Processing, Post-Translational, Cells, Cultured, 3. Good health

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37847650

SP4 Facilitates Esophageal Squamous Cell Carcinoma Progression by Activating PHF14 Transcription and Wnt/Β-Catenin Signaling

Συγγραφείς: Li Wei, Chaowei Deng, Bo Zhang, Guanghui Wang, Yan Meng, Hao Qin

Πηγή: Mol Cancer Res

Θεματικοί όροι: Esophageal Neoplasms, Nuclear Proteins, Sp4 Transcription Factor, Cancer Genes and Networks, Gene Expression Regulation, Neoplastic, Cell Movement, Cell Line, Tumor, Humans, Esophageal Squamous Cell Carcinoma, Prospective Studies, Wnt Signaling Pathway, beta Catenin, Cell Proliferation, Transcription Factors

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37768180

AMPK Associates with Chromatin and Phosphorylates the TAF-1 Subunit of the Transcription Initiation Complex to Regulate Histone Gene Expression in ALL Cells

Συγγραφείς: Guangyan Sun, Guy J. Leclerc, Sanjay Chahar, Julio C. Barredo

Πηγή: Mol Cancer Res

Θεματικοί όροι: Histones, Proteomics, Mice, Animals, Gene Expression, Cancer Genes and Networks, AMP-Activated Protein Kinases, Chromatin

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37682252

Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer

Συγγραφείς: Yonghong Chen, Catherine R. Dufour, Lingwei Han, Ting Li, Hui Xia, Vincent Giguère

Πηγή: Mol Cancer Res

Θεματικοί όροι: Male, Homeodomain Proteins, Mice, Cell Line, Tumor, TOR Serine-Threonine Kinases, Humans, Animals, Prostatic Neoplasms, Cancer Genes and Networks, Phosphorylation, 3. Good health, Cell Proliferation

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37409967

ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis

Συγγραφείς: Mabel Perez-Oquendo, Roxsan Manshouri, Yanhua Tian, Jared J. Fradette, B. Leticia Rodriguez, Samrat T. Kundu, Don L. Gibbons

Πηγή: Mol Cancer Res

Θεματικοί όροι: Lung Neoplasms, Epithelial-Mesenchymal Transition, Zinc Finger E-box-Binding Homeobox 1, Membrane Proteins, Acetylation, Adenocarcinoma of Lung, Nerve Tissue Proteins, Cancer Genes and Networks, Gene Expression Regulation, Neoplastic, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Humans, Protein Processing, Post-Translational, Mi-2 Nucleosome Remodeling and Deacetylase Complex

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37255406

Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation

Συγγραφείς: Seemon Coomar, Pedro Mota, Alexander Penson, Jürg Schwaller, Omar Abdel-Wahab, Dennis Gillingham

Πηγή: Mol Cancer Res
Molecular Cancer Research

Θεματικοί όροι: Proteome, Humans, Kinesins, RNA-Binding Proteins, RNA Splicing Factors, Cancer Genes and Networks, Protein Binding

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37255411

Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer

Συγγραφείς: Neng-Yu Lin, Jian-Jr Lee, Syue-Ting Chen, Jung-An Lin, Chia-Hsuan Lin, Hsuan-Yu Lin, Yong-Han Su, Cheng-Chang Chen, Mei-Chun Lin, Ching-Ying Kuo, Min-Chuan Huang

Πηγή: Mol Cancer Res

Θεματικοί όροι: Glycosylation, Hyaluronan Receptors, Osteogenesis, Polysaccharides, Humans, Female, Breast Neoplasms, Cancer Genes and Networks, Galactosyltransferases, 3. Good health, Signal Transduction

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37040171