Photoporation enables non-viral delivery of prime editing RNP complexes into human iPSC-derived cardiomyocytes for cardiac genome correction

Συγγραφείς: Yao, Bing, Yang, Geng, Wang,Qian, Daniels, Mark A., Dokter, Inge, Shang,Peng, van Mil, Alain, Doevendans, Pieter A., Gonçalves,Manuel A.F.V., Stillitano, Francesca, Sluijter, Joost P.G., Schiffelers, Raymond, Lei, Zhiyong, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 1, Experimental Cardiology Laboratory, Orthopaedie Onderzoek, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Team Medisch, Experimentele Afd. Cardiologie 2, Centraal Diagnostisch Laboratorium, Cancer, CDL Nanomedicine

Θεματικοί όροι: Pharmacology, Cardiomyopathy, Journal Article, Prime editor ribonucleoprotein, IPSC-CMs, Non-viral delivery, Photoporation, Genome editing

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/483624

LAH5-mediated delivery of prime editor ribonucleoprotein complexes for genome editing

Συγγραφείς: Yao, Bing, Öktem,Mert, Yang, Geng, Wang,Qian, Daniels, Mark A, Dokter, Inge, Lefferts, Juliet W, Gonçalves,Manuel A F V, Doevendans, Pieter A, van Mil, Alain, Sluijter, Joost P G, Schiffelers, Raymond, Mastrobattista,Enrico, Lei, Zhiyong, Experimentele Afd. Cardiologie 2, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 1, Orthopaedie Onderzoek, Cellular disease models 1, Team Medisch, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Centraal Diagnostisch Laboratorium, Cancer, CDL Nanomedicine

Θεματικοί όροι: Cardiomyopathy, Journal Article, Pharmaceutical Science, PLN R14del mutation, Cell-penetrating peptides, Endosomalescape, Primeediting, LAH5

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/469358

Magnetic Lipid Nanoparticles for Targeted mRNA Delivery and Enhanced Organ-Specific Expression

Συγγραφείς: Jin, Xin, Yang,Qiangbin, Yang,Liqiang, Yang,Geng, Fang, Juntao, Seinen,Cornelis, Daniëls, Mark, Blok,Christian Snijders, Barendrecht, Arjan, Koekman, Arnold, van Steenbergen,Mies J, Mastrobattista,Enrico, Sluijter, Joost P G, Schiffelers, Raymond M, Wang,Jiong-Wei, Lei, Zhiyong, CDL Nanomedicine, Experimentele Afd. Cardiologie 1, CDL Research analisten, CDL Staf Research, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Cancer

Θεματικοί όροι: magnetically responsive nanoparticles, Taverne, Journal Article, targeted mRNA delivery, endosomal escape, magnetic lipid nanoparticles, gene therapy, nanomedicine

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/469451

Toward In Vivo CAR T Cell Therapy:Perfecting CAR and Lipid Nanoparticle Design

Συγγραφείς: Sciuto, Ludovica, Kooijmans, Sander A A, Schiffelers, Raymond M, CDL Nanomedicine, Metabole ziekten onderzoek 2, Circulatory Health, Centraal Diagnostisch Laboratorium, Cancer

Θεματικοί όροι: Taverne, Journal Article, Review

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/469450

Converging laser-induced forward transfer and melt electrowriting for biofabrication of reinforced cartilage constructs

Συγγραφείς: Vasilopoulou, Antonia G, Ginés Rodriguez, Núria, Mansouri, Ardalan, Spauwen, Lennard, Loste-Berdot,Mathieu, Iazzolino,Antonio, Nicodeme,Marc, Ilsievic,Luka, Korpershoek, Jasmijn V, Levato, Riccardo, de Ruijter, Mylène, Malda, Jos, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, CDL Nanomedicine, MS Orthopaedie Algemeen

Θεματικοί όροι: Polyesters/chemistry, Cell Survival, Lasers, Cartilage/cytology, Cell Differentiation, Spheroids, Cellular/cytology, Tissue Scaffolds/chemistry, Bioprinting/methods, Printing, Three-Dimensional, Stem Cells/cytology, Journal Article, Animals, Tissue Engineering/methods, Cartilage, Articular/cytology, Chondrogenesis

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/469342

Impaired placental vascular remodeling and persistent uNK cells in the RUPP model:A time-dependent perspective

Συγγραφείς: van Kammen, C. M., Al Darwish,F. M., Strijkers,G. J., Coolen,B. F., Alles,L. K., Faas,M. M., Schiffelers, R., Lely, A. T., Terstappen, F., MS Verloskunde, CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, Child Health, Arts-assistenten Kinderen

Θεματικοί όροι: Placental vascular development, Trophoblast invasion, Reproductive Medicine, Obstetrics and Gynaecology, Journal Article, uNK cells, Placental insufficiency, RUPP model, Spiral artery remodeling, Developmental Biology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/468585

Validation of plasmin-cleaved VWF as a biomarker for microthrombosis in Japanese patients with acute immune-mediated TTP

Συγγραφείς: El Otmani, Hinde, Tersteeg,Claudia, Vanhoorelbeke,Karen, Matsumoto,Masanori, Sakai,Kazuya, CDL Nanomedicine

Θεματικοί όροι: Oncology, Surgery, Hematology, Cardiology and Cardiovascular Medicine

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/468942

Enhancing cardiomyocyte reprogramming efficiency by targeting cellular senescence is mediated via Rb1 gene

Συγγραφείς: Fang, Juntao, Yang, Qiangbing, Maas, Renée G.C., Vader, Pieter, Mokry, Michal, van den Dungen, Noortje A.M., Qian,Li, Xiao,Junjie, Schiffelers, Raymond, Lei, Zhiyong, Sluijter, Joost P.G., Cardiologie, Experimentele Afd. Cardiologie 1, CDL Staf Research, CDL Nanomedicine, Experimentele Afd. Cardiologie 2, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, CDL Poli WKZ, CDL Onderzoek Pasterkamp, Child Health, CDL Research analisten, Cancer, Centraal Diagnostisch Laboratorium, Regenerative Medicine and Stem Cells, Onderzoek Cardiovasculair Reg. Med.

Θεματικοί όροι: Direct cardiac reprogramming, Medicine (miscellaneous), Molecular Medicine, Cell Biology, RB1, Senescence, Biochemistry, Genetics and Molecular Biology (miscellaneous)

Περιγραφή αρχείου: text/plain

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/469057

Π-Π stacking stabilized polymeric micelles for hydrophobic drug delivery in the treatment of leishmaniasis

Συγγραφείς: Gomes-Alves,Ana G., Varela-Moreira, Aida, Cruz,Tânia, Duarte,Margarida, Castro,Helena, Moreira,Rui, Ressureição,Ana S., Storm,Gert, Hennink,Wim E., Tomás,Ana M., CDL Nanomedicine

Θεματικοί όροι: Leishmania, Quinoline-(1H)-imines, Polymeric micelles, Pharmaceutical Science, Antiparasitic agents

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/468239

Incorporation of cellular membrane protein extracts into lipid nanoparticles enhances their cellular uptake and mRNA delivery efficiency

Συγγραφείς: Rodríguez, Diego A, Lefebvre, Gaspard P R, Yang, Qiangbing, Barendrecht, Arjan D, Seinen, Cor W, Schiffelers, Raymond M, Vader, Pieter, CDL Nanomedicine, CDL extracellular vesicles, CDL Research analisten, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, CDL Cluster Onderzoek en Onderwijs

Συνεισφορές: CDL Nanomedicine, CDL extracellular vesicles, CDL Research analisten, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, CDL Cluster Onderzoek en Onderwijs

Θεματικοί όροι: mRNA delivery, Drug delivery system, Lipid nanoparticles, Journal Article, Hybrids, Membrane protein extracts

Περιγραφή αρχείου: text/plain; application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/461058

Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice

Συγγραφείς: Escudé Martinez de Castilla, Pol, Estapé Senti, Mariona, Erkens,Sigrun, van Weerden,Wytske M., Kooijmans, Sander A.A., Fens, Marcel H., Vader, Pieter, Schiffelers, Raymond M., CDL Staf Research, CDL Nanomedicine, Cancer, Metabole ziekten onderzoek 2, Circulatory Health, Onderzoek Vrouw Hart & Vaatziekten, CDL Cluster Onderzoek en Onderwijs, Centraal Diagnostisch Laboratorium

Συνεισφορές: CDL Staf Research, CDL Nanomedicine, Cancer, Metabole ziekten onderzoek 2, Circulatory Health, Onderzoek Vrouw Hart & Vaatziekten, CDL Cluster Onderzoek en Onderwijs, Centraal Diagnostisch Laboratorium

Θεματικοί όροι: Tissue distribution, Liposomes, siRNA-lipid nanoparticles, Pharmaceutical Science, Pharmacokinetics, Dextran sulfate, Reticuloendothelial system (RES)

Περιγραφή αρχείου: application/pdf; text/plain

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/460812

Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression

Συγγραφείς: Fang,Qinliang, Luo,Changhong, Lu, Yuyan, Chen,Xijun, Zhan,Ping, Yao,Qin, Wu,Huita, Wang,Fuqiang, Yin,Zhenyu, Xie,Chengrong, CDL Nanomedicine

Θεματικοί όροι: Journal Article

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/468604

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

Συγγραφείς: Elsharkasy, Omnia M, Hegeman,Charlotte V, Driedonks, Tom A P, Liang,Xiuming, Lansweers,Ivana, Cotugno,Olaf L, de Groot,Ingmar Y, de Wit,Zoë E M N J, Garcia-Guerra,Antonio, Moorman,Niels J A, Boonstra,Sjoerd H, Bosman,Esmeralda D C, Lefferts, Juliet W, de Voogt, Willemijn S, François,Jerney J, van Wesel,Annet C W, El Andaloussi,Samir, Schiffelers, Raymond M, Kooijmans, Sander A A, Mastrobattista,Enrico, Vader, Pieter, de Jong, Olivier G, CDL Nanomedicine, CDL extracellular vesicles, Cellular disease models 1, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, Metabole ziekten onderzoek 2, CDL Cluster Onderzoek en Onderwijs

Θεματικοί όροι: Gene Editing/methods, HEK293 Cells, CRISPR-Associated Protein 9/metabolism, Ultraviolet Rays, Aptamers, Nucleotide/metabolism, Journal Article, CRISPR-Cas Systems/genetics, Humans, Extracellular Vesicles/metabolism, RNA, Guide, CRISPR-Cas Systems/genetics

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/468422

In vitro and in vivo disease models of cardiac amyloidosis:progress, pitfalls and potential

Συγγραφείς: Qin, Jiabin, Qiu,Zeping, Fan,Yingze, Xiong,Qipeng, Lei, Zhiyong, Wei,Jin, van der Harst, Pim, Minnema, Monique C, Sluijter, Joost P G, van Mil, Alain, Oerlemans, Marish I F J, Experimentele Afd. Cardiologie 2, Regenerative Medicine and Stem Cells, CDL Nanomedicine, Circulatory Health, DHL-Bedrijfsvoering, MS Hematologie, Cancer, Infection & Immunity, Onderzoek Cardiovasculair Reg. Med., Team Medisch

Θεματικοί όροι: Light chain, iPSC, Transgenic mouse, Proteolysis, C. elegans, Journal Article, ER stress, Transthyretin, Amyloid fibrils, Zebrafish

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/467498

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

Συγγραφείς: Wilbie,Danny, Eising,Selma, Amo-Addae,Vicky, Walther,Johanna, Bosman,Esmeralda, Lei, Zhiyong, de Jong, Olivier G., Molenaar,Jan J., Mastrobattista,Enrico, CDL Nanomedicine, Circulatory Health

Θεματικοί όροι: General

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/467842

Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH

Συγγραφείς: Yu,Xiaodong, Huang,Chenyuan, Evers, Martijn, Liu,Jingjing, Ting,Hui Jun, Zhang,Sitong, Chong,Suet Yen, Tan,Michelle Siying, Wang,Siyu, Sayed,Nilofer, Gao,Liang, Muthiah,Mark D., Soon,Gwyneth S.T., Wee,Aileen, Chow,Edward Kai Hua, Soh,Natalie Jun Hui, Pastorin,Giorgia, Yu,Victor C., Liu,Bin, Dan,Yock Young, Torta,Federico, Schiffelers, Raymond, Storm,Gert, Wang,Jiong Wei, CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health

Θεματικοί όροι: General

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/467854

Insights into pegRNA design from editing of the cardiomyopathy-associated phospholamban R14del mutation

Συγγραφείς: Yao, Bing, Yang, Qiangbing, Snijders Blok,Christian J B, Daniels, Mark A, Doevendans, Pieter A, Schiffelers, Raymond, Sluijter, Joost P G, Lei, Zhiyong, Experimentele Afd. Cardiologie 2, Regenerative Medicine and Stem Cells, CDL Nanomedicine, Experimentele Afd. Cardiologie 1, Team Medisch, Circulatory Health, Centraal Diagnostisch Laboratorium, Cancer, Onderzoek Cardiovasculair Reg. Med.

Θεματικοί όροι: prime editing, Structural Biology, Biophysics, Genetics, PLN R14del mutation, Cell Biology, gene therapy, Biochemistry, Molecular Biology, Phospholamban, pegRNA optimization

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/466672

Nanobody-Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Συγγραφείς: Escudé Martinez de Castilla, Pol, Verdi,Vincenzo, de Voogt, Willemijn, Estapé Sentí, Mariona, Koekman, Arnold C, Rietveld,Julian, van Kempen, Sven, Yang, Qiangbing, van Merris,Juliette, Jenster,Guido, van Royen,Martin E, Fens, Marcel H, Kooijmans, Sander A A, van Weerden,Wytske M, van Niel,Guillaume, Vader, Pieter, Schiffelers, Raymond M, CDL Nanomedicine, Cancer, CDL extracellular vesicles, CDL Staf Research, Pathologie Research, Metabole ziekten onderzoek 2, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, Centraal Diagnostisch Laboratorium

Θεματικοί όροι: Biomaterials, nanobody, mRNA-lipid nanoparticles, targeted delivery, Biomedical Engineering, Journal Article, Pharmaceutical Science, prostate cancer, prostate specific membrane antigen (PSMA)

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/466830

Comparative Analysis of Methods for Assessing On-Target Gene Editing Efficiencies

Συγγραφείς: Yao, Bing, Yang, Qiangbing, Gonçalves,Manuel A F V, Schiffelers, Raymond, Sluijter, Joost P G, Lei, Zhiyong, Experimentele Afd. Cardiologie 2, Regenerative Medicine and Stem Cells, CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, Onderzoek Cardiovasculair Reg. Med.

Συνεισφορές: Experimentele Afd. Cardiologie 2, Regenerative Medicine and Stem Cells, CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, Onderzoek Cardiovasculair Reg. Med.

Θεματικοί όροι: genome editing assays, Structural Biology, Journal Article, genome editing, on-target gene editing, editing efficiency, CRISPR/Cas9, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biotechnology

Περιγραφή αρχείου: application/pdf; text/plain

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/460993

Integrin beta 1 and fibronectin mediate extracellular vesicle uptake and functional RNA delivery

Συγγραφείς: Elsharkasy, Omnia M., de Voogt, Willemijn S., Tognoli, Maria Laura, van der Werff,Leanne, Gitz-Francois, Jerney J., Seinen, Cornelis W., Schiffelers, Raymond M., de Jong, Olivier G., Vader, Pieter, CDL Nanomedicine, CDL extracellular vesicles, Cancer, CDL Research analisten, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Onderzoek en Onderwijs

Συνεισφορές: CDL Nanomedicine, CDL extracellular vesicles, Cancer, CDL Research analisten, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Onderzoek en Onderwijs

Θεματικοί όροι: EV uptake, fibronectin, integrins, RNA delivery, Cell Biology, extracellular vesicles, Biochemistry, Molecular Biology

Περιγραφή αρχείου: application/pdf; text/plain

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/460929