Discrimination tasks increase the value of plasma p‐tau217 to predict presymptomatic Alzheimer's disease

Authors: Huyghe, Lara, Quenon, Lisa, Bayart, Jean-Louis, Colmant, Lise, Boyer, Emilien, Gérard, Thomas, Salman, Yasmine, Besson, Gabriel, Dricot, Laurence, Lhommel, Renaud, Ivanoiu, Adrian, Bastin, Christine, Delhaye, Emma, Hanseeuw, Bernard J

Source: Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 21 Suppl 8 (Suppl 8), e109967 (2025-12); Alzheimer's Association International Conference, 2025

Subject Terms: tau Proteins, Biomarkers, Amyloid beta-Peptides, Humans, Positron-Emission Tomography, Male, Female, Aged, Biomarkers/blood, Amyloid beta-Peptides/blood, Neuropsychological Tests, Aged, 80 and over, Middle Aged, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/blood, Alzheimer Disease/diagnosis, tau Proteins/blood, Brain/diagnostic imaging, Brain/metabolism, Alzheimer Disease, Brain, Epidemiology, Health Policy, Developmental Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Cellular and Molecular Neuroscience, Psychiatry and Mental Health, Social & behavioral sciences, psychology, Neurosciences & behavior, Sciences sociales & comportementales, psychologie, Neurosciences & comportement

Relation: https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz70862_109967; urn:issn:1552-5260; urn:issn:1552-5279

Access URL: https://orbi.uliege.be/handle/2268/339247

The Role of Sequential Organ Failure Assessment Scores and Perfusion Markers in Predicting Postoperative Complications After Cardiac Surgery

Authors: Vujović, Bojana, Giraud, Raphaël, Miličić, Biljana, Kalezić, Nevena, Bendjelid, Karim

Source: Journal of Cardiothoracic and Vascular Anesthesia. 40:1187-1194

Subject Terms: Male, Postoperative Complications / diagnosis, Organ Dysfunction Scores, Alactic base excess, Cardiac surgery, Middle Aged, Postoperative complications, Postoperative Complications / epidemiology, Predictive Value of Tests, Postoperative Complications / blood, Lactate, Humans, Biomarkers / blood, Female, Cardiac Surgical Procedures / trends, SOFA score, Perfusion markers, Cardiac Surgical Procedures / adverse effects, ScvO₂, Retrospective Studies, Aged

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/41558919
https://archive-ouverte.unige.ch/unige:192749
https://doi.org/10.1053/j.jvca.2025.12.022

Transient early blood eosinophil increases do not affect dupilumab’s long-term efficacy in patients with moderate-to-severe asthma

Authors: Pavord, Ian D, Lugogo, Njira L, Castro, Mario, Papi, Alberto, Bourdin, Arnaud, Wechsler, Michael E, Côté, Andréanne, Chapman, Kenneth R, Xia, Changming, Soliman, Mena, Pandit-Abid, Nami, Jacob-Nara, Juby A, Sacks, Harry

Source: Journal of Allergy and Clinical Immunology. 157:363-373

Subject Terms: Asthma, FENO, biomarkers, blood eosinophil count, dupilumab, efficacy, exacerbations, lung function, safety, type 2, Asthma, biomarkers, blood eosinophil count, dupilumab, efficacy, exacerbations, FENO, lung function, safety, type 2

Access URL: https://pubmed.ncbi.nlm.nih.gov/41242639

Elevated serum glutathione reflects endoscopic disease activity in inflammatory bowel disease

Authors: Sem Geertsema, Hannah J. Holstein, Marian L.C. Bulthuis, Sofie de Jong, Marjan Reinders-Luinge, Karin Koerts-Steijn, Anneke C. Muller Kobold, Klaas Nico Faber, Harry van Goor, Gerard Dijkstra, Arno R. Bourgonje

Source: Free Radical Biology and Medicine. 243:522-533

Subject Terms: Male, Adult, Glutathione/blood, Serum Albumin, Human, Crohn Disease/blood, Middle Aged, Colitis, Glutathione, Thioredoxins/blood, Oxidative Stress, Thioredoxins, Ulcerative/blood, Crohn Disease, Humans, Female, Colitis, Ulcerative, Sulfhydryl Compounds/blood, Prospective Studies, Sulfhydryl Compounds, Biomarkers/blood, Serum Albumin, Biomarkers, Human

Access URL: https://pubmed.ncbi.nlm.nih.gov/41317929
https://research.rug.nl/en/publications/462a0e6f-d7db-42f5-863d-7c7d15aca8ce
https://hdl.handle.net/11370/462a0e6f-d7db-42f5-863d-7c7d15aca8ce
https://doi.org/10.1016/j.freeradbiomed.2025.11.057

Utility of placental growth factor for preeclampsia prediction in pregnancies complicated by sickle cell disease

Authors: Evangelia Vlachodimitropoulou, Tharshini Balasubramaniam, Nadine Shehata, Richard Ward, Kevin H. M. Kuo, John C. Kingdom, A. Kinga Malinowski

Source: Blood Adv
Vlachodimitropoulou, E, Balasubramaniam, T, Shehata, N, Ward, R, Kuo, K H M, Kingdom, J C & Malinowski, A K 2026, 'Utility of placental growth factor for preeclampsia prediction in pregnancies complicated by sickle cell disease', Blood Advances, vol. 10, no. 2, pp. 402-412. https://doi.org/10.1182/bloodadvances.2025016821

Subject Terms: Adult, Pre-Eclampsia/diagnosis, Anemia, Sickle Cell, Placenta Growth Factor/blood, Red Cells, Iron, and Erythropoiesis, Pre-Eclampsia, Pregnancy, Anemia, Sickle Cell/complications, Humans, Female, Biomarkers/blood, Biomarkers, Placenta Growth Factor, Retrospective Studies

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/41117637
https://pubmed.ncbi.nlm.nih.gov/41117637/
https://doi.org/10.1182/bloodadvances.2025016821
https://pmc.ncbi.nlm.nih.gov/articles/PMC12828821/
https://kclpure.kcl.ac.uk/ws/files/368510067/blooda_adv-2025-016821-main.pdf
https://doi.org/10.1182/bloodadvances.2025016821
https://www.scopus.com/pages/publications/105027414891
https://kclpure.kcl.ac.uk/portal/en/publications/80330aa5-fc7b-4417-8ac6-acb6eaabcc15

A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology

Authors: Hanna Huber, Laia Montoliu-Gaya, Wagner S. Brum, Jakub Vávra, Yara Yakoub, Haley Weninger, Luisa Sophie Braun-Wohlfahrt, Joel Simrén, Mercé Boada, Agustín Ruiz, Amanda Cano, Adelina Orellana, Sergi Valero, Laia Cañada, Natalia Tantinya, Ana Belen Nogales, Pilar Sanz-Cartagena, Anna Dittrich, Ingmar Skoog, Millie Sander-Long, Clive Ballard, Megan Richards, Mary O’Leary, Frederikke Kragh Clemmensen, Hannah H. D. Wandall, Daniele Altomare, Valentina Cantoni, Erik Stomrud, Sebastian Palmqvist, Alberto Lleo, Daniel Alcolea, Maria Carmona Iragui, Aida Sanjuan Hernandez, Bessy Benejam, Laura Videla Toro, Alpana Singh, Marisa N. Denkinger, Anja Hviid Simonsen, Silke Kern, Anne Corbett, Juan Fortea, Lee Honigberg, Barbara Borroni, Oskar Hansson, Xavier Morató, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton

Source: Nat Med
Nature medicine 32(2), 599-608 (2026). doi:10.1038/s41591-025-04080-0

Subject Terms: Male, Aged, 80 and over, Dried Blood Spot Testing: methods, tau Proteins: blood, Alzheimer Disease: diagnosis, tau Proteins, MAPT protein, human, Middle Aged, Alzheimer Disease: blood, Article, Neurofilament Proteins: blood, Alzheimer Disease: pathology, Biomarkers: blood, Neurofilament Proteins, Glial Fibrillary Acidic Protein, Humans, Biomarkers: cerebrospinal fluid, Female, Glial Fibrillary Acidic Protein: blood, Phosphorylation, neurofilament protein L, Biomarkers, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/41491101
https://pubmed.ncbi.nlm.nih.gov/41491101/
https://doi.org/10.1038/s41591-025-04080-0
https://pmc.ncbi.nlm.nih.gov/articles/PMC12920126/
https://pub.dzne.de/record/285353

Lipoprotein(a) and Vascular Redox State in Patients With Advanced Coronary Atherosclerosis

Authors: Murray D. Polkinghorne, Ileana Badi, Andrea Baragetti, Jagat Chauhan, Cheng Xie, Elizabeth Wahome, Ioannis Akoumianakis, Daniel Foran, Parijat Patel, Edmarcia de Araujo, Christos P. Kotanidis, George Krasopoulos, Rana Sayeed, Vivek Srivastava, Antonios Kourliouros, Nicholas Walcot, Priya Sastry, Tomasz Guzik, Keith M. Channon, Giuseppe D. Norata, Charalambos Antoniades

Source: Arterioscler Thromb Vasc Biol
Polkinghorne, M D, Badi, I, Baragetti, A, Chauhan, J, Xie, C, Wahome, E, Akoumianakis, I, Foran, D, Patel, P, de Araujo, E, Kotanidis, C P, Krasopoulos, G, Sayeed, R, Srivastava, V, Kourliouros, A, Walcot, N, Sastry, P, Guzik, T, Channon, K M, Norata, G D & Antoniades, C 2026, 'Lipoprotein(a) and Vascular Redox State in Patients With Advanced Coronary Atherosclerosis', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 46, no. 1, pp. 232-247. https://doi.org/10.1161/ATVBAHA.125.322924

Subject Terms: Male, Nitric Oxide Synthase Type III, Nitric Oxide Synthase Type III/metabolism, NADPH Oxidases, Lipoprotein(a)/blood, Coronary Artery Disease, Middle Aged, Coronary Artery Disease/blood, Oxidative Stress, NADPH Oxidases/metabolism, Translational Sciences, Superoxides, Humans, Female, Superoxides/metabolism, Oxidation-Reduction, Biomarkers/blood, Biomarkers, Lipoprotein(a), Aged

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/41164877
https://pmc.ncbi.nlm.nih.gov/articles/PMC12721630/
https://pubmed.ncbi.nlm.nih.gov/41164877/
https://doi.org/10.1161/ATVBAHA.125.322924
https://www.ahajournals.org/doi/10.1161/ATVBAHA.125.322924
https://ruj.uj.edu.pl/handle/item/570691

Limited evidence for heart rate variability as a predictor of cognitive and pathophysiological brain markers

Authors: Sofia Marcolini, Jaime D. Mondragón, Arie M. van Roon, Balewgizie Sileshi Tegegne, Harriëtte Riese, Rozemarijn Vliegenthart, Rudi A.J.O. Dierckx, Ronald H. Borra, Peter Paul De Deyn

Source: Journal of Alzheimer's disease

Subject Terms: Male, Alzheimer Disease/physiopathology, Middle Aged, Neuropsychological Tests, Brain/diagnostic imaging, Cognitive Dysfunction/physiopathology, Humans, Female, Human medicine, Coronary Artery Disease/physiopathology, Heart Rate/physiology, Biomarkers/blood, Cognition/physiology, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/41468026
https://hdl.handle.net/11370/cbbf7d5f-fb83-44cb-9583-e99160fc95be
https://research.rug.nl/en/publications/cbbf7d5f-fb83-44cb-9583-e99160fc95be
https://doi.org/10.1177/13872877251409343
https://repository.uantwerpen.be/docstore/d:irua:32953
https://hdl.handle.net/10067/2197520151162165141

Prevalence of Alzheimer’s disease pathology in the community

Authors: Dag Aarsland, Anita Lenora Sunde, Diego A. Tovar-Rios, Antoine Leuzy, Tormod Fladby, Henrik Zetterberg, Kaj Blennow, Kübra Tan, Giovanni De Santis, Yara Yakoub, Burak Arslan, Hanna Huber, Ilaria Pola, Lana Grötschel, Guglielmo Di Molfetta, Håvard K. Skjellegrind, Geir Selbaek, Nicholas J. Ashton

Source: Nature
Nature 650(8100), 182-186 (2026). doi:10.1038/s41586-025-09841-y

Subject Terms: Male, Alzheimer Disease: diagnosis, General Science & Technology, BIOMARKERS, tau Proteins, Alzheimer Disease: blood, Article, Cohort Studies, Alzheimer Disease: pathology, Alzheimer Disease, Biomarkers: blood, Cognitive Dysfunction: pathology, Prevalence, Humans, Cognitive Dysfunction, Alzheimer Disease: epidemiology, Phosphorylation, Aged, RISK, Aged, 80 and over, Science & Technology, tau Proteins: blood, Norway, DEMENTIA, tau Proteins: chemistry, Age Factors, Middle Aged, Cognitive Dysfunction: epidemiology, Multidisciplinary Sciences, Cognitive Dysfunction: blood, Science & Technology - Other Topics, Female, Norway: epidemiology, Biomarkers

Access URL: https://pubmed.ncbi.nlm.nih.gov/41407852
https://pubmed.ncbi.nlm.nih.gov/41407852/
https://doi.org/10.1038/s41586-025-09841-y
https://pmc.ncbi.nlm.nih.gov/articles/PMC12872468/
https://pub.dzne.de/record/285022

Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder

Authors: Yan, S, Sahoo, A, Zerenner, T, Marek, K, Sommerauer, M, Oertel, W, Hu, MT, Tofaris, GK

Source: Ann Neurol
Annals of neurology 99(4), 912-921 (2026). doi:10.1002/ana.78109

Subject Terms: Male, Parkinson Disease: diagnosis, Polysomnography, tau Proteins, MAPT protein, human, REM Sleep Behavior Disorder: diagnosis, REM Sleep Behavior Disorder: blood, Neurofilament Proteins: blood, Cohort Studies, Biomarkers: blood, Neurofilament Proteins, Humans, Cognitive Dysfunction: etiology, Lewy Body Disease: diagnosis, Phosphorylation, neurofilament protein L, Aged, Aged, 80 and over, tau Proteins: blood, Parkinson Disease: blood, Lewy Body Disease: blood, Cognitive Dysfunction: diagnosis, Multiple System Atrophy: blood, Middle Aged, Prognosis, Multiple System Atrophy: diagnosis, Cognitive Dysfunction: blood, Female, REM Sleep Behavior Disorder: psychology, REM Sleep Behavior Disorder: complications, Biomarkers, Research Article

Access URL: https://pubmed.ncbi.nlm.nih.gov/41312760
https://pub.dzne.de/record/282539

GDF-15 plasma levels are elevated in mobility-limited older adults with frailty and sarcopenia—results from the BIOFRAIL study

Authors: Pernille Hansen, Hanne Nygaard, Louis Praeger-Jahnsen, Martin Schultz, Flemming Dela, Per Aagaard, Jesper Ryg, Charlotte Suetta

Source: GeroScience
Hansen, P, Nygaard, H, Praeger-Jahnsen, L, Schultz, M, Dela, F, Aagaard, P, Ryg, J & Suetta, C 2026, ' GDF-15 plasma levels are elevated in mobility-limited older adults with frailty and sarcopenia — results from the BIOFRAIL study ', GeroScience, vol. 48, no. 2, pp. 1955-1966 . https://doi.org/10.1007/s11357-025-01946-6
Hansen, P, Nygaard, H, Praeger-Jahnsen, L, Schultz, M, Dela, F, Aagaard, P, Ryg, J & Suetta, C 2026, 'GDF-15 plasma levels are elevated in mobility-limited older adults with frailty and sarcopenia-results from the BIOFRAIL study', GeroScience, vol. 48, no. 2, pp. 1955-1966. https://doi.org/10.1007/s11357-025-01946-6

Subject Terms: Male, Aged, 80 and over, Mobility-Limited Patients, Sarcopenia, Frailty, Frail Elderly, Frailty/blood, Old Age, Biomarker, GDF-15, ROC Curve, Geriatric Assessment/methods, Growth Differentiation Factor 15/blood, 80 and over, Humans, Sarcopenia/blood, Female, Original Article, Mobility Limitation, Biomarkers/blood, Aged

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/41286529
https://pubmed.ncbi.nlm.nih.gov/41286529/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12972285/
https://doi.org/10.1007/s11357-025-01946-6
https://researchprofiles.ku.dk/da/publications/4abfb53a-2f89-4dfc-9bbe-0829663823a4
https://curis.ku.dk/ws/files/539045618/s11357-025-01946-6.pdf
https://doi.org/10.1007/s11357-025-01946-6
https://portal.findresearcher.sdu.dk/da/publications/da8df270-8b25-4d44-899f-20da5280cce7
https://doi.org/10.1007/s11357-025-01946-6
https://findresearcher.sdu.dk/ws/files/305658899/s11357-025-01946-6.pdf
https://portal.findresearcher.sdu.dk/da/publications/da8df270-8b25-4d44-899f-20da5280cce7
https://doi.org/10.1007/s11357-025-01946-6

Prospective associations of blood-based biomarkers of neurodegenerative diseases with cognitive performance in a cohort of patients with chronic coronary syndrome

Authors: Valerie Lohner, Laura Perna, Ben Schöttker, Robert Perneczky, Matthias Kliegel, Hermann Brenner, Ute Mons

Source: Journal of Alzheimer's disease 108(4), 1507-1513 (2025). doi:10.1177/13872877251389147
Journal of Alzheimer's Disease

Subject Terms: cognition, Male, tau Proteins, Neuropsychological Tests, Neurodegenerative Diseases: complications, amyloid-beta ratio, Neurofilament Proteins: blood, Cohort Studies, mild cognitive impairment, Cognition, Biomarkers: blood, Neurofilament Proteins, Glial Fibrillary Acidic Protein, Humans, Glial Fibrillary Acidic Protein: blood, Cognitive Dysfunction, Prospective Studies, neurofilament protein L, Aged, chronic coronary syndrome, tau Proteins: blood, Amyloid beta-Peptides, biomarkers of neurodegenerative diseases, Neurodegenerative Diseases, Alzheimer's disease, Middle Aged, Peptide Fragments: blood, Peptide Fragments, Cognitive Dysfunction: blood, Cognitive Dysfunction: psychology, neurofilament light chain, Neurodegenerative Diseases: blood, Amyloid beta-Peptides: blood, epidemiology, Female, Biomarkers, Cognition: physiology

Access URL: https://pubmed.ncbi.nlm.nih.gov/41252287
https://pub.dzne.de/record/282603
https://hdl.handle.net/21.11116/0000-0012-2DC7-A

Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation: clinical correlates and risk of incident atrial fibrillation

Authors: Navin Suthahar, Sing-Chien Yap, Antoine A. F. de Vries, Kevin Damman, Larissa Fabritz, Stephan J. L. Bakker, Ron T. Gansevoort, Paulus Kirchhof, Michiel Rienstra, Rudolf A. de Boer

Source: Am J Physiol Heart Circ Physiol

Subject Terms: Male, Adult, general population, Risk Assessment, Article, SDG 3 - Good Health and Well-being, Natriuretic Peptide, Risk Factors, Atrial Fibrillation, Natriuretic Peptide, Brain, Humans, atrial fibrillation, Aged, biology, Incidence, cohort, Middle Aged, Peptide Fragments, BMP10, Atrial Fibrillation/epidemiology, Bone Morphogenetic Proteins, Female, Brain/blood, Peptide Fragments/blood, Biomarkers/blood, Biomarkers

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/41071685
https://pmc.ncbi.nlm.nih.gov/articles/PMC7618395/
https://doi.org/10.1152/ajpheart.00659.2025
https://pubmed.ncbi.nlm.nih.gov/41071685/
https://pure.eur.nl/en/publications/45865ecf-d407-41a9-8f76-d744dfa7fd4d
https://doi.org/10.1152/ajpheart.00659.2025
https://research.rug.nl/en/publications/c4dea888-5120-463e-97fc-d44361f14e1b
https://hdl.handle.net/11370/c4dea888-5120-463e-97fc-d44361f14e1b
https://doi.org/10.1152/ajpheart.00659.2025
https://hdl.handle.net/1887/4300664

Phosphatidylethanol and self-reported alcohol intake to subclassify individuals at risk of steatotic liver disease: an analysis of data from a prospective cohort study: an analysis of data from a prospective cohort study

Authors: Torp, Nikolaj, Bech, Katrine Tholstrup, Schnefeld, Helle Lindholm, Johansen, Stine, Hansen, Camilla Dalby, Semmler, Georg, Benjumea, Javier Vega, Lindvig, Katrine Prier, Thorhauge, Katrine Holtz, Jensen, Ellen Lyngbeck, Petersen, Ellen Elise, Hansen, Johanne Kragh, Villesen, Ida Falk, Andersen, Peter, Bergmann, Marianne Lerbæk, Krag, Aleksander, Israelsen, Mads, Thiele, Maja

Source: Torp, N, Bech, K T, Schnefeld, H L, Johansen, S, Hansen, C D, Semmler, G, Benjumea, J V, Lindvig, K P, Thorhauge, K H, Jensen, E L, Petersen, E E, Hansen, J K, Villesen, I F, Andersen, P, Bergmann, M L, Krag, A, Israelsen, M & Thiele, M 2025, 'Phosphatidylethanol and self-reported alcohol intake to subclassify individuals at risk of steatotic liver disease : an analysis of data from a prospective cohort study', The Lancet Gastroenterology & Hepatology, vol. 10, no. 11, pp. 975-985. https://doi.org/10.1016/S2468-1253(25)00187-6

Subject Terms: Male, Adult, Alcohol Drinking, Glycerophospholipids/blood, Denmark, Glycerophospholipids, Middle Aged, Denmark/epidemiology, Alcohol Drinking/epidemiology, Fatty Liver, Humans, Female, Self Report, Prospective Studies, Biomarkers/blood, Biomarkers, Fatty Liver/diagnosis, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/40945520

Associations of Soluble Inflammatory and Endothelial Activation Biomarkers with Cognitive Function Over Three Years After Ischemic Stroke—PROSCIS-B

Authors: Giesers, Naomi K, Schaeff, Viktoria, Gertz, Karen, Endres, Matthias, Liman, Thomas G

Source: Translational stroke research 16(6), 2249-2257 (2025). doi:10.1007/s12975-025-01388-4

Subject Terms: Male, Vascular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1: blood, Cognition, Biomarkers: blood, Post stroke cognitive impairment, Humans, Cognitive Dysfunction: etiology, Cognitive Dysfunction, Interleukin-6: blood, Endothelial dysfunction, Prospective Studies, Aged, Ischemic Stroke, Inflammation, Ischemic stroke, Interleukin-6, Tumor Necrosis Factor-alpha, Ischemic Stroke: complications, Ischemic Stroke: psychology, Tumor Necrosis Factor-alpha: blood, Ischemic Stroke: blood, Middle Aged, Cognitive Dysfunction: blood, Female, Inflammation: blood, Biomarkers, Cognition: physiology, Follow-Up Studies

Access URL: https://pubmed.ncbi.nlm.nih.gov/41057606
https://pub.dzne.de/record/281867

Anti-VGLUT2 autoantibodies in neurological diseases

Authors: Merle Corty, Friederike A. Arlt, Kathrin Borowski, Stephanie Wernick, Madeleine Scharf, Fabian A. Piecha, Claudia Steen, Philipp Oehler, Maria Buthut, Moritz Krill, Johann-Philipp Zöllner, Tammo Krafft, Robert Markewitz, Christiane Radzimski, Yvonne Denno, Christian Probst, Bianca Teegen, Christian Grefkes, Susanne Knake, Karsten Witt, Carsten Finke, Georg Hagemann, Jana Becker, Markus Kraemer, Torsten Witte, Lars Komorowski, Klaus-Peter Wandinger, Harald Prüss, Nico Melzer, Ramona Miske

Source: Brain, behavior and immunity 129, 470-484 (2025). doi:10.1016/j.bbi.2025.06.014

Subject Terms: Autoantibodies: immunology, Male, Adult, Adolescent, Autoimmune Diseases: immunology, VGLUT2, Autoimmune Diseases, Nervous System Diseases: blood, Young Adult, Autoantibody, Biomarkers: blood, Autoimmune dementia, Polyneuropathy, Vesicular Glutamate Transport Protein 2: immunology, Humans, Encephalitis: immunology, Autoimmune encephalitis, Child, Autoantibodies, Aged, Retrospective Studies, Aged, 80 and over, Immunoglobulin G: blood, Autoantibodies: blood, Infant, Middle Aged, Nervous System Diseases: immunology, HEK293 Cells, Excitatory Amino Acid Transporter 2, Child, Preschool, Immunoglobulin G, Vesicular Glutamate Transport Protein 2, Female, Immunotherapy, Nervous System Diseases, Biomarkers

Access URL: https://pubmed.ncbi.nlm.nih.gov/40494504
https://pub.dzne.de/record/279430

Point-of-Care Placental Growth Factor for Predicting Adverse Outcomes in Sierra Leone

Authors: Katy Kuhrt, Rossetta Cole, Moses M’Bayoh, Chileshe Mabula-Bwalya, Alice Hurrell, Alexandra Ridout, Cristina Fernandez-Turienzo, Paul T. Seed, Lucy C. Chappell, Kate Bramham, Andrew H. Shennan, Adetunji Adeniji, Matron Christiana Squire, Victoria Wisman, Zainab Bangura, Sister Edith Macauley, Eric Macarthy-N’dolenge, Sovula Haja, Emmanuel Chinonso, Suzanne Thomas, Thomasia Weekes, Davida Sesay, Mariama Koker, Rebecca M’Bayoh

Source: Hypertension
Kuhrt, K, Cole, R, M'Bayoh, M, Mabula-Bwalya, C, Hurrell, A, Ridout, A, Fernandez-Turienzo, C, Seed, P T, Chappell, L C, Bramham, K, Shennan, A H 2025, 'Point-of-Care Placental Growth Factor for Predicting Adverse Outcomes in Sierra Leone', Hypertension (Dallas, Tex. : 1979), vol. 82, no. 10, pp. 1719-1728. https://doi.org/10.1161/HYPERTENSIONAHA.125.24526

Subject Terms: Adult, Point-of-Care Systems, Pregnancy Outcome, Infant, Newborn, Original Articles, Placenta Growth Factor/blood, Sierra Leone, Pre-Eclampsia/blood, Pre-Eclampsia, Pregnancy, Predictive Value of Tests, Point-of-Care Testing, Humans, Female, Prospective Studies, Sierra Leone/epidemiology, Biomarkers/blood, Biomarkers, Placenta Growth Factor

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40762064

Performance of clinical decision rules in patients presenting with suspected recurrent venous thromboembolism: a multicenter prospective cohort study: a multicenter prospective cohort study

Authors: Mai, Vicky, Martens, Emily S L, Righini, Marc Philip, Schulman, Sam, Thiruganasambandamoorthy, Venkatesh, Kahn, Susan R, Pecarskie, Amanda, Kovacs, Michael J, Visser, Shaun, Shivakumar, Sudeep, Tan, Melanie, Kearon, Clive, Rodger, Marc, Scarvelis, Dimitrios, Delluc, Aurélien, Girard, Philippe, Huisman, Menno V, Wells, Philip S, Klok, Frederikus A, Le Gal, Grégoire, PREDICTORS study group

Source: Journal of Thrombosis and Haemostasis. 23:3239-3250

Subject Terms: Male, Adult, pulmonary embolism, Time Factors, clinical decision rules, venous thromboembolism, Clinical Decision-Making, Venous Thrombosis / epidemiology, Risk Assessment, Fibrin Fibrinogen Degradation Products, Venous Thromboembolism / epidemiology, Pulmonary Embolism / blood, Recurrence, Predictive Value of Tests, Risk Factors, Clinical Decision Rules, Biomarkers / blood, Humans, Prospective Studies, deep venous thrombosis, Aged, Venous Thrombosis, Venous Thromboembolism / blood, Pulmonary embolism, Pulmonary Embolism / epidemiology, Clinical decision rules, prediction, Venous Thromboembolism, Fibrin Fibrinogen Degradation Products / analysis, Middle Aged, Venous Thrombosis / diagnosis, Venous Thromboembolism / diagnosis, Pulmonary Embolism / diagnosis, Deep venous thrombosis, Female, Prediction, Venous Thrombosis / blood, Pulmonary Embolism, Biomarkers, Venous thromboembolism

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40578691
https://archive-ouverte.unige.ch/unige:191212
https://doi.org/10.1016/j.jtha.2025.06.019

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression

Authors: Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre

Source: Mov Disord
Movement disorders 40(12), 2700-2709 (2025). doi:10.1002/mds.70049

Subject Terms: Male, Aged, 80 and over, Adult, tauopathy, progressive supranuclear palsy, Middle Aged, Supranuclear Palsy, Progressive: blood, Supranuclear Palsy, Progressive: drug therapy, Progranulins, Treatment Outcome, Double-Blind Method, Biomarkers: blood, Supranuclear Palsy, Progressive: cerebrospinal fluid, lysosome, progranulin, Disease Progression, Biomarkers: cerebrospinal fluid, Humans, Female, Supranuclear Palsy, Progressive, Biomarkers, Research Article, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/41014124
https://pmc.ncbi.nlm.nih.gov/articles/PMC12710188/
https://doi.org/10.1002/mds.70049
https://pubmed.ncbi.nlm.nih.gov/41014124/
https://pub.dzne.de/record/282953

Serum NfL, but not GFAP, differentiates primary lateral sclerosis from adrenomyeloneuropathy and hereditary spastic paraplegia type 4

Authors: Kessler, Christoph, Wilke, Carlo, Hengel, Holger, Rattay, Tim W, Maleska Maceski, Aleksandra, Kuhle, Jens, Schöls, Ludger, Schüle, Rebecca

Source: Amyotrophic lateral sclerosis & frontotemporal degeneration 27(1-2), 110-117 (2026). doi:10.1080/21678421.2025.2557936

Subject Terms: Male, Adult, Spastic Paraplegia, Hereditary: blood, PLS, Neurofilament Proteins: blood, Diagnosis, Differential, Cohort Studies, Young Adult, Biomarkers: blood, Neurofilament Proteins, Glial Fibrillary Acidic Protein, Humans, HSP, Glial Fibrillary Acidic Protein: blood, neurofilament protein L, Aged, GFAP, GFAP protein, human, Spastic Paraplegia, Hereditary: diagnosis, Biomarker, Middle Aged, NfL, Adrenoleukodystrophy: blood, Adrenoleukodystrophy: diagnosis, Female, Biomarkers

Access URL: https://pubmed.ncbi.nlm.nih.gov/40961460
https://pub.dzne.de/record/285033