Discovery of flavonoids as potent inhibitors of CYP1A to alleviate cellular inflammation and oxidative stress induced by benzo[a]pyrene-induced high CYP1A expression.

Συγγραφείς: Li XD; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.; Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, PR China., Ma NS; Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, PR China., He CY; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, PR China., Zou LW; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China., Zhang J; Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, PR China., Ni ZH; Experimental Medicine Centre, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China., Ling Y; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.

Πηγή: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2579675. Date of Electronic Publication: 2025 Nov 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/pharmacology , Benzo(a)pyrene*/antagonists & inhibitors , Oxidative Stress*/drug effects , Cytochrome P-450 CYP1A1*/antagonists & inhibitors , Cytochrome P-450 CYP1A1*/metabolism , Cytochrome P-450 CYP1A1*/genetics , Flavonoids*/pharmacology , Flavonoids*/chemistry , Flavonoids*/chemical synthesis , Inflammation*/drug therapy , Inflammation*/metabolism , Drug Discovery*, Structure-Activity Relationship ; Humans ; Molecular Structure ; Dose-Response Relationship, Drug ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/antagonists & inhibitors

Transcriptomic profiling of Debaryomyces hansenii reveals detoxification and stress responses to benzo(a)pyrene exposure.

Συγγραφείς: Padilla-Garfias F; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico., Poot-Hernández AC; Unidad de Bioinformática y Manejo de la Información, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico., Araiza-Villanueva M; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico., Calahorra M; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico., Sánchez NS; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico., Peña A; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico.

Πηγή: Applied and environmental microbiology [Appl Environ Microbiol] 2025 Oct 22; Vol. 91 (10), pp. e0155725. Date of Electronic Publication: 2025 Sep 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7605801 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5336 (Electronic) Linking ISSN: 00992240 NLM ISO Abbreviation: Appl Environ Microbiol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/metabolism , Benzo(a)pyrene*/toxicity , Transcriptome* , Debaryomyces*/genetics , Debaryomyces*/metabolism , Debaryomyces*/drug effects , Saccharomycetales*/genetics , Saccharomycetales*/metabolism , Saccharomycetales*/drug effects, Gene Expression Profiling ; Inactivation, Metabolic ; Stress, Physiological ; Biodegradation, Environmental ; Gene Expression Regulation, Fungal/drug effects ; Fungal Proteins/genetics ; Fungal Proteins/metabolism

The competitive adsorption of phenanthrene and benzo[a]pyrene by fractionated soil particles in individual and coexistence pollution.

Συγγραφείς: Qi M; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China., Ning G; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China., Wang X; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China; Ministry of Education of China-Hebei Province Joint Innovation Center for Efficient Green Vegetable Industry, Baoding, Hebei 071001, PR China., Zhang M; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China., Liu M; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China., Li J; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China., Gao J; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China., Zhang G; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China., Hao R; Ordos Wulan Coal (Group) Co., LTD, Ordos, Neimeng 017000, PR China., Zhao X; Ordos Wulan Coal (Group) Co., LTD, Ordos, Neimeng 017000, PR China., Yang Z; State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, Hebei 071001, PR China; College of Resource and Environmental Sciences, Agricultural University of Hebei, Key Laboratory for Farmland Eco-Environment, Baoding, Hebei 071000, PR China; Ministry of Education of China-Hebei Province Joint Innovation Center for Efficient Green Vegetable Industry, Baoding, Hebei 071001, PR China. Electronic address: yangzhixin@126.com.

Πηγή: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Oct 01; Vol. 304, pp. 119073. Date of Electronic Publication: 2025 Oct 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Phenanthrenes*/chemistry , Phenanthrenes*/analysis , Benzo(a)pyrene*/chemistry , Benzo(a)pyrene*/analysis , Soil Pollutants*/chemistry , Soil Pollutants*/analysis , Soil*/chemistry, Adsorption

Mechanisms and targeted intervention of mitochondria-dependent ferroptosis and abnormal ductular reaction caused by benzo(a)pyrene.

Συγγραφείς: Du X; Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215002, Jiangsu Province, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Song S; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Wang J; Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215002, Jiangsu Province, China., Zhang H; Department of Hepatopancreatobiliary Surgery, Huzhou Key Laboratory of Translational Medicine, The First Affiliated Hospital of Huzhou University, Huzhou, 313000, Zhejiang Province, China; Zhejiang Key Laboratory of Digital Technology in Medical Diagnostics, The First Affiliated Hospital of Huzhou University, Huzhou, 313000, Zhejiang Province, China., Ma Y; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Wang Z; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Mo Q; Department of Hepatopancreatobiliary Surgery, Huzhou Key Laboratory of Translational Medicine, The First Affiliated Hospital of Huzhou University, Huzhou, 313000, Zhejiang Province, China; Zhejiang Key Laboratory of Digital Technology in Medical Diagnostics, The First Affiliated Hospital of Huzhou University, Huzhou, 313000, Zhejiang Province, China., Ji M; Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215002, Jiangsu Province, China., Liu S; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Wang Z; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Wang M; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Zhou C; Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215002, Jiangsu Province, China. Electronic address: zhouchunxiao@njmu.edu.cn., Li Y; Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215002, Jiangsu Province, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China; School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education in Stitutions in Jiangsu Province, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China. Electronic address: liyuan@njmu.edu.cn., Tang C; Department of Hepatopancreatobiliary Surgery, Huzhou Key Laboratory of Translational Medicine, The First Affiliated Hospital of Huzhou University, Huzhou, 313000, Zhejiang Province, China; Zhejiang Key Laboratory of Digital Technology in Medical Diagnostics, The First Affiliated Hospital of Huzhou University, Huzhou, 313000, Zhejiang Province, China. Electronic address: dr_tcw@zjhu.edu.cn.

Πηγή: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 543-555. Date of Electronic Publication: 2025 Oct 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Ferroptosis*/drug effects , Mitochondria*/metabolism , Mitochondria*/drug effects , Mitochondria*/pathology , Bile Ducts*/drug effects , Bile Ducts*/pathology , Bile Ducts*/metabolism, Humans ; Animals ; Reactive Oxygen Species/metabolism ; 14-3-3 Proteins/metabolism ; 14-3-3 Proteins/genetics ; Voltage-Dependent Anion Channel 1/metabolism ; Voltage-Dependent Anion Channel 1/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Mice ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/pathology ; Calcium/metabolism

Dual antioxidant delivery based on liposome sustained release system: Molecular mechanisms for inhibiting lipid oxidation and benzo[a]pyrene formation in Chinese sausage.

Συγγραφείς: Lu J; Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Hefei University of Technology, Hefei 230009, China., Wu L; Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Hefei University of Technology, Hefei 230009, China., Wang R; Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Hefei University of Technology, Hefei 230009, China., Chen X; Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Hefei University of Technology, Hefei 230009, China., Cai K; Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Hefei University of Technology, Hefei 230009, China. Electronic address: kzcai@hfut.edu.cn., Xu B; Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Hefei University of Technology, Hefei 230009, China.

Πηγή: Food chemistry [Food Chem] 2025 Dec 01; Vol. 494, pp. 146060. Date of Electronic Publication: 2025 Aug 26.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Liposomes*/chemistry , Antioxidants*/chemistry , Meat Products*/analysis , Benzo(a)pyrene*/chemistry , Benzo(a)pyrene*/analysis, Oxidation-Reduction ; Animals ; Delayed-Action Preparations/chemistry ; Swine ; Resveratrol/chemistry ; Gallic Acid/chemistry ; Kinetics ; Food Preservation/methods

Comprehensive macroscopic, histopathological and molecular assessment of B[a]P and NNK-induced lung tumours in A/J mice reveals no chemopreventive efficacy of Thearubigins.

Συγγραφείς: Shaikh ZM; Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, Maharashtra, 400094, India., Banerji S; Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India., Sunil S; Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India., Zachariah A; Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India., Aradhye P; Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India., Anbarasu A; Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India., Gawde J; Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India., Kaushal RK; Department of Pathology, Tata Memorial Hospital (TMH) & ACTREC, Mumbai, India., Yadav S; Department of Pathology, Tata Memorial Hospital (TMH) & ACTREC, Mumbai, India., Thorat R; Laboratory Animal Facility, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai, India., Mahimkar MB; Mahimkar Lab, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, Maharashtra, 400094, India. Electronic address: mmahimkar@actrec.gov.in.

Πηγή: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 28; Vol. 791, pp. 152951. Date of Electronic Publication: 2025 Nov 08.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Nitrosamines*/toxicity , Lung Neoplasms*/pathology , Lung Neoplasms*/chemically induced , Lung Neoplasms*/prevention & control , Benzo(a)pyrene*/toxicity , Anticarcinogenic Agents*, Animals ; Mice ; Carcinogens/toxicity ; Mice, Inbred A ; Male ; Butanones

Integrated transcriptomics and proteomics reveal ferroptosis induced by B[a]P and BPDE in mouse hippocampal neurons.

Συγγραφείς: He H; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Ding S; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Zhou C; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Ma Z; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Guo X; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Ji T; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Li X; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Chen J; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Lyu Y; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Tian F; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China., Zheng J; Department of Health Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China. zheng_jp@sxmu.edu.cn.; Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Center of Healthy Aging, School of Public Health, Changzhi Medical College, Changzhi, 046000, China. zheng_jp@sxmu.edu.cn.

Πηγή: Scientific reports [Sci Rep] 2025 Nov 25; Vol. 15 (1), pp. 41739. Date of Electronic Publication: 2025 Nov 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ferroptosis*/drug effects , Ferroptosis*/genetics , Hippocampus*/drug effects , Hippocampus*/metabolism , Hippocampus*/pathology , Hippocampus*/cytology , Neurons*/drug effects , Neurons*/metabolism , Neurons*/pathology , Benzo(a)pyrene*/toxicity , Transcriptome*/drug effects, Animals ; Mice ; Proteomics/methods ; Male ; Gene Expression Profiling ; Mice, Inbred C57BL

Benzo[a]pyrene exacerbates allergen-induced airway inflammation through NLRP3-dependent dendritic cell activation and pathogenic T helper cell polarization.

Συγγραφείς: Zou H; Department of Otolaryngology of Longgang Central Hospital & Clinical Collage of Guangzhou University of Chinese Medicine, Shenzhen, China.; Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, and Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China., Duan J; Department of Otolaryngology of Longgang Central Hospital & Clinical Collage of Guangzhou University of Chinese Medicine, Shenzhen, China.; Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, and Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China., Xie Y; Department of Otolaryngology of Longgang Central Hospital & Clinical Collage of Guangzhou University of Chinese Medicine, Shenzhen, China.; Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, and Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China., Chen R; Department of Otolaryngology of Longgang Central Hospital & Clinical Collage of Guangzhou University of Chinese Medicine, Shenzhen, China.; Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, and Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China., Ye Y; Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, and Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China., Zhang A; Department of Critical Care Medicine, Second Hospital of Shanxi Medical University, Taiyuan, China., Yang P; Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, and Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China., Yang G; Department of Otolaryngology of Longgang Central Hospital & Clinical Collage of Guangzhou University of Chinese Medicine, Shenzhen, China., Liu X; Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, and Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.

Πηγή: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1699886. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/immunology , Dendritic Cells*/immunology , Dendritic Cells*/metabolism , Dendritic Cells*/drug effects , Benzo(a)pyrene*/toxicity , Allergens*/immunology , T-Lymphocytes, Helper-Inducer*/immunology , T-Lymphocytes, Helper-Inducer*/metabolism, Animals ; Mice ; Mice, Knockout ; Pyroglyphidae/immunology ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Cytokines/metabolism ; Mice, Inbred C57BL ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Disease Models, Animal

Novel molecular mechanisms of eosinophil-mediated chronic obstructive pulmonary disease induced by bezo[a]pyrene.

Συγγραφείς: Wang X; The First Hospital of Harbin Medical University, Harbin, China., Liu L; The First Hospital of Harbin Medical University, Harbin, China., Zhang C; The First Hospital of Harbin Medical University, Harbin, China., Liu H; The First Hospital of Harbin Medical University, Harbin, China., Jiao C; The First Hospital of Harbin Medical University, Harbin, China., Yu S; The First Hospital of Harbin Medical University, Harbin, China. yushihuan2000@126.com., Xiao J; The First Hospital of Harbin Medical University, Harbin, China. 602067@hrbmu.edu.cn.

Πηγή: Clinical and experimental medicine [Clin Exp Med] 2025 Nov 06; Vol. 25 (1), pp. 358. Date of Electronic Publication: 2025 Nov 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Pulmonary Disease, Chronic Obstructive*/chemically induced , Pulmonary Disease, Chronic Obstructive*/pathology , Eosinophils*/drug effects , Eosinophils*/immunology , Benzo(a)pyrene*/toxicity, Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Interaction Maps

Multigenerational and persistent toxicity of environmentally relevant concentrations of Benzo[a]pyrene in Marine Medaka (Oryzias melastigma).

Συγγραφείς: Sun D; College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China; Zhanjiang Key Laboratory of Pollutant Control and Ecological Restoration for Coastal Marine Aquaculture, Guangdong Ocean University, Zhanjiang 524088, China; Research Center for Coastal Environmental Protection and Ecological Resilience, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address: jnu_sundong@163.com., Zhang X; College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China., Chen S; College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China., Liu Q; College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China., Huang Y; College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China., Zhao H; College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China; Zhanjiang Key Laboratory of Pollutant Control and Ecological Restoration for Coastal Marine Aquaculture, Guangdong Ocean University, Zhanjiang 524088, China; Research Center for Coastal Environmental Protection and Ecological Resilience, Guangdong Ocean University, Zhanjiang 524088, China., Duan M; College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China; Zhanjiang Key Laboratory of Pollutant Control and Ecological Restoration for Coastal Marine Aquaculture, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address: duanmeinahuanjing@163.com.

Πηγή: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 01; Vol. 306, pp. 119385. Date of Electronic Publication: 2025 Nov 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Oryzias*/physiology , Oryzias*/growth & development , Benzo(a)pyrene*/toxicity , Water Pollutants, Chemical*/toxicity, Animals ; Male ; Reproduction/drug effects ; Female

Enhanced MOA-based probabilistic dose-response assessment: Integrating alternative fitting functions and validating early-stage data extrapolation.

Συγγραφείς: Ji Y; Engineering Research Center of Natural Medicine, Ministry of Education, Beijing Normal University at Zhuhai, Zhuhai 519087, China; Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China; Faculty of Art and Science, Beijing Normal University at Zhuhai, Zhuhai 519087, China., Woo J; Engineering Research Center of Natural Medicine, Ministry of Education, Beijing Normal University at Zhuhai, Zhuhai 519087, China; Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China; Faculty of Art and Science, Beijing Normal University at Zhuhai, Zhuhai 519087, China., Xiang M; The Key Laboratory of Environmental Pollution Health Risk Assessment, Ministry of Ecology and Environment of the People's Republic of China, South China Institute of Environmental sciences, Guangzhou 510655, China., Cao H; Engineering Research Center of Natural Medicine, Ministry of Education, Beijing Normal University at Zhuhai, Zhuhai 519087, China; Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China., Zhang W; Engineering Research Center of Natural Medicine, Ministry of Education, Beijing Normal University at Zhuhai, Zhuhai 519087, China; Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China; Faculty of Art and Science, Beijing Normal University at Zhuhai, Zhuhai 519087, China. Electronic address: zws@bnu.edu.cn.

Πηγή: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 01; Vol. 306, pp. 119291. Date of Electronic Publication: 2025 Oct 30.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Naphthalenes*/toxicity , Toxicity Tests*/methods , Environmental Pollutants*/toxicity, Dose-Response Relationship, Drug ; No-Observed-Adverse-Effect Level ; Risk Assessment/methods ; Animals ; Humans ; Probability

Integrative insights into benzo[a]pyrene degradation mechanisms by Aspergillus fumigatus Z5: Spectroscopic, transcriptomic, and computational biological analyses.

Συγγραφείς: Zhang G; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, China., Yang Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, China., Dou M; Research Institute of Oilfield Chemistry, Xi'an Changqing Chemical Group Co., Ltd., Xi'an 710018, China., Pan J; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, China., Du J; Research Institute of Oilfield Chemistry, Xi'an Changqing Chemical Group Co., Ltd., Xi'an 710018, China., Zhang Z; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, China., Mao N; School of Agriculture and Bioengineering, Longdong University, Qingyang, Gansu 745000, China., Luo L; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, China., Wang S; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, China. Electronic address: wangsw@nwu.edu.cn., Sun Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an 710069, China. Electronic address: sunyanmei@nwu.edu.cn.

Πηγή: Journal of environmental sciences (China) [J Environ Sci (China)] 2025 Nov; Vol. 157, pp. 866-878. Date of Electronic Publication: 2025 Feb 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/metabolism , Aspergillus fumigatus*/metabolism, Biodegradation, Environmental ; Transcriptome ; Molecular Docking Simulation ; Cytochrome P-450 Enzyme System/metabolism

Utilization of the CometChip assay for detecting PAH-induced DNA bulky adducts in a 3D primary human bronchial epithelial cell model.

Συγγραφείς: Colvin VC; Department of Environmental and Molecular Toxicology, USA; OSU/PNNL Superfund Research Program, Oregon State University, Corvallis, OR, USA., Owiti NA; Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Engelward BP; Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Tilton SC; Department of Environmental and Molecular Toxicology, USA; OSU/PNNL Superfund Research Program, Oregon State University, Corvallis, OR, USA. Electronic address: susan.tilton@oregonstate.edu.

Πηγή: Toxicology [Toxicology] 2025 Nov; Vol. 517, pp. 154241. Date of Electronic Publication: 2025 Jul 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): DNA Adducts*/metabolism , DNA Adducts*/drug effects , Bronchi*/drug effects , Bronchi*/cytology , Bronchi*/metabolism , Bronchi*/pathology , Comet Assay*/methods , Epithelial Cells*/drug effects , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Benzo(a)pyrene*/toxicity , Polycyclic Aromatic Hydrocarbons*/toxicity, Humans ; DNA Damage/drug effects ; Hep G2 Cells ; Cells, Cultured ; Cytochrome P-450 CYP1A1/metabolism ; Dose-Response Relationship, Drug

Role of inflammatory response in benzo[a]pyrene-induced noradrenergic axon degeneration in mouse brain.

Συγγραφείς: Reda Y; Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt., Zong C; Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan., Ikoma A; Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan., Fergany A; Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan; Genetics and Genetic Engineering in Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria 21500, Egypt., Ahmed S; Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan., Abd El Naby WSH; Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan; Genetics and Genetic Engineering in Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria 21500, Egypt., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University, Shimotsuke 329-0498, Japan., Ichihara G; Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan. Electronic address: gak@rs.tus.ac.jp.

Πηγή: Toxicology letters [Toxicol Lett] 2025 Nov; Vol. 413, pp. 111737. Date of Electronic Publication: 2025 Sep 27.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Axons*/drug effects , Axons*/pathology , Axons*/metabolism , Brain*/drug effects , Brain*/pathology , Brain*/metabolism , Neurotoxicity Syndromes*/pathology , Neurotoxicity Syndromes*/etiology , Neurotoxicity Syndromes*/prevention & control , Nerve Degeneration*/chemically induced , Nerve Degeneration*/pathology, Animals ; Male ; Mice, Inbred C57BL ; Isothiocyanates/pharmacology ; Mice ; Sulfoxides ; Microglia/drug effects ; Anti-Inflammatory Agents/pharmacology ; Neuroprotective Agents/pharmacology

Discovery of Blood-Based Proteins That Mark Benzo[a]pyrene Modulation of Autoimmunity.

Συγγραφείς: Kennicott K; Departments of Physiology and Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA., Nie Y; Departments of Physiology and Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA., Liang Y; Departments of Physiology and Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.

Πηγή: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 21; Vol. 26 (20). Date of Electronic Publication: 2025 Oct 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Autoimmunity*/drug effects , Autoimmune Diseases*/blood , Autoimmune Diseases*/immunology , Autoimmune Diseases*/chemically induced , Blood Proteins*/metabolism, Animals ; Mice ; Male ; Cytokines/blood ; Biomarkers/blood ; Female ; Humans ; Mice, Inbred MRL lpr

Cerium dioxide nanoparticles coated with benzo[a]pyrene modify aryl hydrocarbon receptor activity, trophoblast differentiation and mitochondrial network phenotype in human placenta.

Συγγραφείς: Degrelle SA; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France.; Inovarion, Paris, F-75005, France., Deval G; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France., Tête A; Université Paris Cité, INSERM U1124, Health and Functional Exposomics - HealthFex, Paris, F-75006, France., Mikolajczak C; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France., Giton F; AP-HP, Pôle Biologie-Pathologie Henri Mondor, INSERM U955, IMRB, Créteil, F-94010, France., Vignaud ML; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France., Boland S; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, 75013, France., Guigon CJ; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France., Coumoul X; Université Paris Cité, INSERM U1124, Health and Functional Exposomics - HealthFex, Paris, F-75006, France., Zerrad-Saadi A; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France., Golinelli-Cohen MP; Université Paris-Saclay, Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Gif-Sur-Yvette, 91190, France., Fournier T; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France., Ferecatu I; Université Paris Cité, INSERM U1139, Fonctions Placentaires et Reproductives Microbiote pré et post-natal (FPRM), Faculté de Pharmacie, FHU Prem'IMPACT, Paris, F-75006, France. ioana.ferecatu@u-paris.fr.

Πηγή: Particle and fibre toxicology [Part Fibre Toxicol] 2025 Oct 14; Vol. 22 (1), pp. 25. Date of Electronic Publication: 2025 Oct 14.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 101236354 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-8977 (Electronic) Linking ISSN: 17438977 NLM ISO Abbreviation: Part Fibre Toxicol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Benzo(a)pyrene*/chemistry , Trophoblasts*/drug effects , Trophoblasts*/metabolism , Trophoblasts*/pathology , Mitochondria*/drug effects , Mitochondria*/metabolism , Mitochondria*/pathology , Cerium*/toxicity , Cerium*/chemistry , Receptors, Aryl Hydrocarbon*/metabolism , Cell Differentiation*/drug effects , Placenta*/drug effects , Placenta*/metabolism , Nanoparticles*/toxicity , Metal Nanoparticles*/toxicity , Metal Nanoparticles*/chemistry , Air Pollutants*/toxicity , Air Pollutants*/chemistry, Humans ; Female ; Pregnancy ; Phenotype ; Cells, Cultured

Immunosuppressive role of benzo[a]pyrene exposure in prostate cancer progression.

Συγγραφείς: Zhang Z; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Zhang W; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Wang H; Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China., Chen H; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Wang H; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Yu Y; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Shen D; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Pi M; Department of Pathology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China., Wu Y; School of Medicine, Tongji University, Shanghai 200092, China., Luo M; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., He Y; Department of Pathology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China., Mao S; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Geng J; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Li W; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Wang G; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China., Guo C; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China. Electronic address: greatwall063030@126.com., Yin D; Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China. Electronic address: yindq@tongji.edu.cn., Yao X; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai 200072, China. Electronic address: yaoxudong1967@163.com.

Πηγή: Journal of environmental sciences (China) [J Environ Sci (China)] 2025 Oct; Vol. 156, pp. 185-199. Date of Electronic Publication: 2024 Dec 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Prostatic Neoplasms*/chemically induced , Prostatic Neoplasms*/immunology, Male ; Animals ; Mice ; Humans ; Disease Progression ; Cell Line, Tumor ; Apoptosis/drug effects ; Cell Proliferation/drug effects

Deciphering the carcinogenic role of benzo[a]pyrene in glioblastoma: Insights from network toxicology, single-cell transcriptomics, and Mendelian randomization.

Συγγραφείς: Yi L; The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: liye_yi@foxmail.com., Wang W; The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: wangwencai0912@163.com., Sun Z; Medical School of Nanjing University, Nanjing 210093, China. Electronic address: sunzhonghua20@163.com., Chen Y; The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: 3114129491@qq.com., Xiong Z; The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: 18315074479@163.com., Ma L; Juntendo University, Tokyo, Japan. Electronic address: maluyao19971219@163.com., Ye W; The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: yewei9999@aliyun.com., Li X; The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: lixianfeng2000@163.com.

Πηγή: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Oct 01; Vol. 304, pp. 119155. Date of Electronic Publication: 2025 Oct 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Glioblastoma*/chemically induced , Glioblastoma*/genetics , Brain Neoplasms*/chemically induced , Brain Neoplasms*/genetics , Carcinogens*/toxicity, Humans ; Mendelian Randomization Analysis ; Transcriptome/drug effects ; Single-Cell Analysis ; Gene Expression Profiling ; Molecular Docking Simulation

Predicting the developmental toxicity of 8-methyl-benzo[a]pyrene (BaP) by physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry and read-across from BaP.

Συγγραφείς: Wang D; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. danlei.wang@wur.nl., Fang J; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands., Shi M; NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing, 100021, China., Kamelia L; Shell Global Solutions International B.V., 2596HR, The Hague, The Netherlands.; Member of Concawe, Brussels, Belgium., Rietjens IMCM; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands., Boogaard PJ; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.

Πηγή: Archives of toxicology [Arch Toxicol] 2025 Oct; Vol. 99 (10), pp. 4035-4050. Date of Electronic Publication: 2025 Jul 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Models, Biological* , Benzo(a)pyrene*/toxicity , Benzo(a)pyrene*/pharmacokinetics , Benzopyrenes*/toxicity , Benzopyrenes*/pharmacokinetics, Animals ; Mice ; Dose-Response Relationship, Drug ; Rats ; Male ; Mouse Embryonic Stem Cells/drug effects ; Rats, Sprague-Dawley ; Female ; Toxicity Tests/methods

Benzo[a]pyrene and UV light co-exposure: differential effects on oxidative stress and genotoxicity in human keratinocytes and ex vivo skin.

Συγγραφείς: Kersch C; Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 9-11, 91054, Erlangen, Germany., Masutin V; Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 9-11, 91054, Erlangen, Germany., Alsaleh R; Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 9-11, 91054, Erlangen, Germany., Schmitz-Spanke S; Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 9-11, 91054, Erlangen, Germany. simone.schmitz-spanke@fau.de.

Πηγή: Archives of toxicology [Arch Toxicol] 2025 Oct; Vol. 99 (10), pp. 4215-4226. Date of Electronic Publication: 2025 Jul 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzo(a)pyrene*/toxicity , Ultraviolet Rays*/adverse effects , Oxidative Stress*/drug effects , Oxidative Stress*/radiation effects , Keratinocytes*/drug effects , Keratinocytes*/radiation effects , Keratinocytes*/metabolism , DNA Damage*/drug effects , DNA Damage*/radiation effects , Skin*/drug effects , Skin*/radiation effects , Skin*/metabolism , Skin*/pathology, Humans ; Dose-Response Relationship, Drug ; Comet Assay ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Histones/metabolism