The traffic jam hypothesis: Unravelling cellular dysfunctions in Parkinsonism diseases.

Authors: Manne M; Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar, College of Pharmacy, New Kamptee, Nagpur, Maharashtra 441 002, India., Taksande B; Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar, College of Pharmacy, New Kamptee, Nagpur, Maharashtra 441 002, India., Umekar M; Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar, College of Pharmacy, New Kamptee, Nagpur, Maharashtra 441 002, India., Vinchurney M; Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar, College of Pharmacy, New Kamptee, Nagpur, Maharashtra 441 002, India. Electronic address: madhura.p.dixit@gmail.com.

Source: Brain research [Brain Res] 2025 Dec 01; Vol. 1868, pp. 150002. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

MeSH Terms: Parkinsonian Disorders*/metabolism , Parkinsonian Disorders*/pathology , Parkinsonian Disorders*/physiopathology , Axonal Transport*/physiology , Parkinson Disease*/metabolism, Humans ; alpha-Synuclein/metabolism ; Animals ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology

Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model.

Authors: Salzinger A; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Özkan E; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Ramesh V; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Nanda J; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Burr K; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Story D; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Pham NT; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Chandran S; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Selvaraj BT; UK Dementia Research Institute at University of Edinburgh , Edinburgh, UK. bthangar@exseed.ed.ac.uk.; Centre for Clinical Brain Sciences and Euan McDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK. bthangar@exseed.ed.ac.uk.

Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2025 Nov 05; Vol. 31 (1), pp. 328. Date of Electronic Publication: 2025 Nov 05.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE

MeSH Terms: Neuromuscular Junction*/metabolism , Axonal Transport* , Mitochondria*/metabolism , Nerve Tissue Proteins*/genetics , Nerve Tissue Proteins*/metabolism , Stem Cells*/metabolism , Stem Cells*/cytology, Humans ; Motor Neurons/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/cytology ; Axons/metabolism ; Spinal Cord/metabolism ; Spinal Cord/cytology ; Organoids/metabolism

14-3-3θ phosphorylation at S232 reduces its interactome and regulates axonal trafficking.

Authors: Pair FS; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Pattanayak R; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Mobley JA; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Kojima K; Institutional Research Core Program, University of Alabama at Birmingham, Birmingham, AL 35294 , USA., Gannon M; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Ekkatine R; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Stone WJ; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Scholz K; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Yacoubian TA; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Source: Disease models & mechanisms [Dis Model Mech] 2025 Dec 01; Vol. 18 (12). Date of Electronic Publication: 2025 Dec 05.

Publication Type: Journal Article

Journal Info: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE

MeSH Terms: 14-3-3 Proteins*/metabolism , 14-3-3 Proteins*/chemistry , Axonal Transport* , Axons*/metabolism , Phosphoserine*/metabolism , Serine*/metabolism, Phosphorylation ; Animals ; Protein Binding ; Humans ; Mice ; Neurons/metabolism ; Dyneins/metabolism

Intraneuronal Nanotracers in Axonal Transport.

Authors: Yi Z; Department of Biomaterials and Stem Cells, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.; Jiangsu Key Laboratory for Advanced Theranostics and Medical Instrumentation, Suzhou 215163, China., All AH; Department of Chemistry, Hong Kong Baptist University, Ho Sin Hang Campus, 224 Waterloo Road, Kowloon, Hong Kong SAR 999077, China., Liu Y; Department of Chemistry, National University of Singapore, 117543 Singapore.; The N.1 Institute for Health, National University of Singapore, 117456 Singapore., Liu X; Department of Chemistry, National University of Singapore, 117543 Singapore.; The N.1 Institute for Health, National University of Singapore, 117456 Singapore.; Department of Materials Science and Engineering, National University of Singapore, 117575 Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore.

Source: ACS nano [ACS Nano] 2025 Oct 14; Vol. 19 (40), pp. 35306-35321. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

MeSH Terms: Axonal Transport* , Axons*/metabolism , Nanostructures*/chemistry, Humans ; Animals ; Microtubules/metabolism

Action potential as a contributing factor in axonal transport: a numerical study.

Authors: Saboorian A; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran., Vahidi B; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran. bahman.vahidi@ut.ac.ir.

Source: Physical and engineering sciences in medicine [Phys Eng Sci Med] 2025 Sep; Vol. 48 (3), pp. 1375-1388. Date of Electronic Publication: 2025 Jul 21.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 101760671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-4737 (Electronic) Linking ISSN: 26624729 NLM ISO Abbreviation: Phys Eng Sci Med Subsets: MEDLINE

MeSH Terms: Axonal Transport*/physiology , Action Potentials*/physiology , Models, Neurological*, Animals ; Axons/physiology ; Decapodiformes ; Computer Simulation ; Hydrodynamics

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age.

Authors: Villarroel-Campos D; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute, University College London, London, UK., Rhymes ER; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Tosolini AP; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, St Lucia, Australia; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Australia., Malik B; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Vagnoni A; Department of Basic and Clinical Neurosciences, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; MIA-Portugal, Multidisciplinary Institute of Ageing, University of Coimbra, Coimbra, Portugal., Schiavo G; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute, University College London, London, UK., Sleigh JN; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute, University College London, London, UK. Electronic address: j.sleigh@ucl.ac.uk.

Source: Neurobiology of aging [Neurobiol Aging] 2025 Sep; Vol. 153, pp. 1-9. Date of Electronic Publication: 2025 May 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE

MeSH Terms: Axonal Transport*/physiology , Axonal Transport*/genetics , Brain-Derived Neurotrophic Factor*/physiology , Brain-Derived Neurotrophic Factor*/pharmacology , Brain-Derived Neurotrophic Factor*/metabolism , Aging*/pathology , Aging*/physiology , Aging*/metabolism , Endosomes*/metabolism , Endosomes*/physiology , Signal Transduction*/physiology, Animals ; Mice, Inbred C57BL ; Sciatic Nerve/metabolism ; Male ; Mice ; Mitochondria/metabolism ; Motor Neurons/metabolism

Direct Reversible Conjugation of an Adenosine Receptor Antagonist to an Axonal Transport Protein Carrier.

Authors: Hakobyan K; School of Chemical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia.; Australian Centre for NanoMedicine, UNSW Sydney, Sydney, NSW 2052, Australia., Yong J; School of Chemical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia.; Australian Centre for NanoMedicine, UNSW Sydney, Sydney, NSW 2052, Australia., Violi JP; School of Chemistry, UNSW Sydney, Sydney, NSW 2052, Australia., Xu J; School of Chemical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia., Mao G; School of Chemical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia.; Institute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh EH9 3FB, United Kingdom.

Source: ACS nano [ACS Nano] 2025 Jul 15; Vol. 19 (27), pp. 24784-24796. Date of Electronic Publication: 2025 Jul 03.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

MeSH Terms: Axonal Transport*/drug effects , Purinergic P1 Receptor Antagonists*/chemistry , Purinergic P1 Receptor Antagonists*/pharmacology , Wheat Germ Agglutinins*/chemistry , Wheat Germ Agglutinins*/metabolism , Drug Carriers*/chemistry , Xanthines*/chemistry , Xanthines*/pharmacology , Nanoconjugates*/chemistry, Animals ; Mice ; Cell Line ; Blood-Brain Barrier/metabolism

Maintenance of neuronal TDP-43 expression requires axonal lysosome transport.

Authors: Ryan VH; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.; Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, United States., Lawton S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Reyes JF; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Hawrot J; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Frankenfield AM; Department of Chemistry, George Washington University, Washington, DC, United States., Seddighi S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Ramos DM; Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, United States., Epstein J; Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, United States., Faghri F; Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, United States.; DataTecnica, Washington, DC, United States., Johnson NL; Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, United States.; DataTecnica, Washington, DC, United States., Zou J; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States., Kampmann M; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States., Replogle J; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Qi YA; Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, United States., Yuan H; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Johnson K; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Maric D; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States., Hao L; Department of Chemistry and Biochemistry, University of Maryland, College Park, United States., Nalls MA; Center for Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, United States.; DataTecnica, Washington, DC, United States., Ward ME; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.

Source: ELife [Elife] 2025 Sep 19; Vol. 14. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH Terms: Lysosomes*/metabolism , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Neurons*/metabolism , Axons*/metabolism , Axonal Transport*, Humans ; Induced Pluripotent Stem Cells/metabolism

Delivery of AAV vectors to the superior olivary complex enables efficient adult cochlear transduction via axonal transport.

Authors: Naidoo J; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA. Electronic address: jerusha.naidoo@osumc.edu., Ren Y; Department of Otolaryngology- Head and Neck Surgery, The Ohio State University, 915 Olentangy River Road, Columbus, OH 43212, USA., Rocco M; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA., Bielefeld E; Department of Speech and Hearing Science, The Ohio State University, 1070 Carmack Road, Columbus, OH 43210, USA., O'Brien A; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA., Kuo HC; Department of Otolaryngology- Head and Neck Surgery, The Ohio State University, 915 Olentangy River Road, Columbus, OH 43212, USA., McFarland N; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA., Avenarius M; Department of Pathology, The Ohio State University, 410 W 10th Avenue, Columbus, OH 43210, USA., Takhar M; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA., Frank G; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA., Van Laar V; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA., Bankiewicz K; Department of Neurological Surgery, Gene Therapy Institute, The Ohio State University, 2255 Kenny Road, Columbus, OH 43210, USA.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Sep 03; Vol. 33 (9), pp. 4290-4302. Date of Electronic Publication: 2025 May 28.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Dependovirus*/genetics , Genetic Vectors*/genetics , Genetic Vectors*/administration & dosage , Axonal Transport* , Transduction, Genetic* , Cochlea*/metabolism, Animals ; Rats ; Gene Transfer Techniques ; Spiral Ganglion/metabolism ; Genetic Therapy ; Male ; Hair Cells, Auditory/metabolism ; Humans

TDP-43 mutants with different aggregation properties exhibit distinct toxicity, axonal transport, and secretion for disease progression in a mouse ALS/FTLD model.

Authors: Mori H; Department of Neurology, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan., Sato T; Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan., Tsuboguchi S; Department of Neurology, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan., Takahashi M; Division of Virology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8585, Japan., Nakamura Y; Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan., Hoshina K; Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan., Kato T; Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan., Fujii M; Division of Virology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8585, Japan., Onodera O; Department of Neurology, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan; Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan. Electronic address: onodera@bri.niigata-u.ac.jp., Ueno M; Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Niigata 951-8585, Japan. Electronic address: ms-ueno@bri.niigata-u.ac.jp.

Source: Neurobiology of disease [Neurobiol Dis] 2025 Aug; Vol. 212, pp. 106988. Date of Electronic Publication: 2025 Jun 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/toxicity , Axonal Transport*/physiology , Frontotemporal Lobar Degeneration*/pathology , Frontotemporal Lobar Degeneration*/metabolism , Frontotemporal Lobar Degeneration*/genetics, Animals ; Disease Progression ; Mice ; Disease Models, Animal ; Mutation/genetics ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Cells, Cultured ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/genetics ; Protein Aggregation, Pathological/pathology ; Humans ; Mice, Inbred C57BL

Role of LRRK2 in axonal transport and Parkinson's disease.

Authors: Twellsieck B; Department of Neurology, University Medical Center Goettingen, 37077 Goettingen, Germany., Boecker CA; Department of Neurology, University Medical Center Goettingen, 37077 Goettingen, Germany.

Source: The Biochemical journal [Biochem J] 2025 Jun 25; Vol. 482 (13). Date of Electronic Publication: 2025 Jun 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

MeSH Terms: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics , Parkinson Disease*/genetics , Parkinson Disease*/metabolism , Parkinson Disease*/pathology , Axonal Transport*, Humans ; Animals ; Mutation ; Mitochondria/metabolism ; Mitochondria/genetics ; Synaptic Vesicles/metabolism

Fat traffic control: S-acylation in axonal transport.

Authors: Doerksen AH; Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Ontario, Canada., Herath NN; Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Ontario, Canada., Sanders SS; Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Ontario, Canada. Electronic address: ssande03@uoguelph.ca.

Source: Molecular pharmacology [Mol Pharmacol] 2025 Jun; Vol. 107 (6), pp. 100039. Date of Electronic Publication: 2025 Apr 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

MeSH Terms: Axonal Transport*/physiology , Axons*/metabolism, Animals ; Humans ; Acylation/physiology ; Protein Transport/physiology ; Protein Processing, Post-Translational/physiology

Direct observation of importin α family member KPNA1 in axonal transport with or without a schizophrenia-related mutation.

Authors: Mizuno K; Department of Cell Biology and Biochemistry, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui Prefecture, Japan; Life Science Innovation Center, University of Fukui, Fukui City, Fukui Prefecture, Japan., Sugahara M; Department of Cell Biology and Biochemistry, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui Prefecture, Japan; Department of Frontier Fiber Technology and Science, Graduate School of Engineering, University of Fukui, Fukui City, Fukui Prefecture, Japan., Kutomi O; Department of Cell Biology and Biochemistry, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui Prefecture, Japan; Life Science Innovation Center, University of Fukui, Fukui City, Fukui Prefecture, Japan., Kato R; Department of Cell Biology and Biochemistry, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui Prefecture, Japan; Department of Frontier Fiber Technology and Science, Graduate School of Engineering, University of Fukui, Fukui City, Fukui Prefecture, Japan., Itoh T; Department of Bioscience and Biotechnology, Fukui Prefectural University, Yoshida-gun, Fukui Prefecture, Japan., Fujita S; Life Science Innovation Center, University of Fukui, Fukui City, Fukui Prefecture, Japan; Department of Frontier Fiber Technology and Science, Graduate School of Engineering, University of Fukui, Fukui City, Fukui Prefecture, Japan., Yamada M; Department of Cell Biology and Biochemistry, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui Prefecture, Japan; Life Science Innovation Center, University of Fukui, Fukui City, Fukui Prefecture, Japan. Electronic address: yamadama@u-fukui.ac.jp.

Source: The Journal of biological chemistry [J Biol Chem] 2025 Apr; Vol. 301 (4), pp. 108343. Date of Electronic Publication: 2025 Feb 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH Terms: alpha Karyopherins*/genetics , alpha Karyopherins*/metabolism , Axonal Transport* , Mutation* , Schizophrenia*/genetics , Schizophrenia*/metabolism, Animals ; Mice ; Humans ; beta Karyopherins/metabolism ; beta Karyopherins/genetics ; Axons/metabolism ; Active Transport, Cell Nucleus ; Cell Nucleus/metabolism ; Cell Nucleus/genetics ; Neurons/metabolism

Reprogramming miR-146b-snphb Signaling Activates Axonal Mitochondrial Transport in the Zebrafish M-cell and Facilitates Axon Regeneration After Injury.

Authors: Wang XL; Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China., Wang ZY; Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China., Chen XH; Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China., Cai Y; First Affiliated Hospital of USTC, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. cy0901@ustc.edu.cn., Hu B; Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. bhu@ustc.edu.cn.; Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China. bhu@ustc.edu.cn.

Source: Neuroscience bulletin [Neurosci Bull] 2025 Apr; Vol. 41 (4), pp. 633-648. Date of Electronic Publication: 2024 Dec 08.

Publication Type: Journal Article

Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE

MeSH Terms: MicroRNAs*/metabolism , MicroRNAs*/genetics , Nerve Regeneration*/physiology , Mitochondria*/metabolism , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics , Axons*/metabolism , Axonal Transport*/physiology , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/genetics, Animals ; Zebrafish ; Signal Transduction/physiology

Stretch-induced recruitment of myosin into transversal actin rings stabilises axonal large cargo transport.

Authors: Rahman N; School of Mathematics and Physics, The University of Queensland, QLD, 4072, Australia; Department of Mathematics, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: nizhum@umich.edu., Oelz DB; School of Mathematics and Physics, The University of Queensland, QLD, 4072, Australia.

Source: Mathematical biosciences [Math Biosci] 2025 Mar; Vol. 381, pp. 109400. Date of Electronic Publication: 2025 Feb 13.

Publication Type: Journal Article

Journal Info: Publisher: American Elsevier Country of Publication: United States NLM ID: 0103146 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3134 (Electronic) Linking ISSN: 00255564 NLM ISO Abbreviation: Math Biosci Subsets: MEDLINE

MeSH Terms: Axonal Transport*/physiology , Myosins*/metabolism , Myosins*/physiology , Actins*/metabolism , Actins*/physiology , Axons*/physiology , Models, Biological* , Models, Neurological*, Animals ; Computer Simulation ; Actomyosin

KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons.

Authors: Guerra San Juan I; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam and VU Medical Center, Amsterdam, the Netherlands; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Department of Human Genetics, Amsterdam University Medical Center, Amsterdam, the Netherlands. Electronic address: i.guerrasanjuan@vu.nl., Brunner JW; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam and VU Medical Center, Amsterdam, the Netherlands; Department of Human Genetics, Amsterdam University Medical Center, Amsterdam, the Netherlands., Eggan K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Toonen RF; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam and VU Medical Center, Amsterdam, the Netherlands; Department of Human Genetics, Amsterdam University Medical Center, Amsterdam, the Netherlands., Verhage M; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam and VU Medical Center, Amsterdam, the Netherlands; Department of Human Genetics, Amsterdam University Medical Center, Amsterdam, the Netherlands. Electronic address: m.verhage@cncr.vu.nl.

Source: Neurobiology of disease [Neurobiol Dis] 2025 Jan; Vol. 204, pp. 106759. Date of Electronic Publication: 2024 Dec 05.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

MeSH Terms: Kinesins*/metabolism , Kinesins*/genetics , Axonal Transport*/physiology , Mitochondria*/metabolism , Motor Neurons*/metabolism , Axons*/metabolism, Humans ; PTB-Associated Splicing Factor/metabolism ; Nerve Regeneration/physiology ; Cells, Cultured ; Neuronal Outgrowth/physiology

Protocol for live imaging of axonal transport in iPSC-derived iNeurons.

Authors: Dou D; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Holzbaur ELF; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Boecker CA; Department of Neurology, University Medical Center Goettingen, 37077 Goettingen, Germany. Electronic address: alexander.boecker@med.uni-goettingen.de.

Source: STAR protocols [STAR Protoc] 2025 Mar 21; Vol. 6 (1), pp. 103556. Date of Electronic Publication: 2025 Jan 12.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

MeSH Terms: Induced Pluripotent Stem Cells*/cytology , Induced Pluripotent Stem Cells*/metabolism , Axonal Transport*/physiology , Neurons*/cytology , Neurons*/metabolism, Humans ; Cell Differentiation ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/genetics ; Time-Lapse Imaging/methods ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism

Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2b ^intron5 .

Authors: Kirwan KR; Neurobiology and Behavior PhD Program, Columbia University, New York, NY, USA., Puerta-Alvarado V; Neurobiology and Behavior PhD Program, Columbia University, New York, NY, USA., Waites CL; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA cw2622@cumc.columbia.edu.; Department of Neuroscience, Columbia University, New York, NY, USA.

Source: Life science alliance [Life Sci Alliance] 2025 Feb 28; Vol. 8 (5). Date of Electronic Publication: 2025 Feb 28 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

MeSH Terms: Axonal Transport*/physiology , Endosomal Sorting Complexes Required for Transport*/metabolism , Endosomal Sorting Complexes Required for Transport*/genetics, Animals ; Kinesins/metabolism ; Humans ; Presynaptic Terminals/metabolism ; Mutation ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/genetics ; Axons/metabolism ; Protein Transport ; Neurons/metabolism ; Protein Binding ; Mice

Polyphenol Mediated Assembly: Tailored Nano-Dredger Unblocks Axonal Autophagosomes Retrograde Transport Traffic Jam for Accelerated Alzheimer's Waste Clearance.

Authors: Meng R; Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China., Li Y; Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China., Yang X; Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China., Cheng Y; Shanxi Academy of Traditional Chinese Medicine, Xi'an, 710003, P. R. China., Xu M; Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China., Zhou L; Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China., Wu C; Guangzhou CSR Biotech Co. Ltd, Guangzhou, 510700, P. R. China., Yu S; Guangzhou CSR Biotech Co. Ltd, Guangzhou, 510700, P. R. China., Huang W; Guangzhou CSR Biotech Co. Ltd, Guangzhou, 510700, P. R. China., Wang T; Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China., Zhang Q; Key Laboratory of Smart Drug Delivery, Ministry of Education, National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.

Source: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2025 Feb; Vol. 37 (5), pp. e2413614. Date of Electronic Publication: 2024 Dec 17.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/drug therapy , Alzheimer Disease*/pathology , Autophagy*/drug effects , Axonal Transport*/drug effects , Nanostructures*/chemistry , rho-Associated Kinases*/antagonists & inhibitors , RNA, Small Interfering*/pharmacology, Animals ; Female ; Humans ; Mice ; Cell Line ; Disease Models, Animal ; Drug Delivery Systems ; Drugs, Chinese Herbal/pharmacology ; Mice, Inbred ICR ; Mice, Transgenic ; Neurons/drug effects ; Neurons/pathology

Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma.

Authors: Kaipa BR; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, and.; Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA., Kasetti R; Department of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Texas, USA., Sundaresan Y; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, and.; Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA., Li L; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, and.; Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA., Yacoub S; Department of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Texas, USA., Millar JC; Department of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Texas, USA., Cho W; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, and.; Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA., Skowronska-Krawczyk D; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, and.; Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA., Maddineni P; Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, Missouri, USA., Palczewski K; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, and.; Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA.; Department of Chemistry and.; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA., Zode GS; Gavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, and.; Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA.

Source: JCI insight [JCI Insight] 2025 Jan 21; Vol. 10 (5). Date of Electronic Publication: 2025 Jan 21.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

MeSH Terms: Glycoproteins*/genetics , Glycoproteins*/metabolism , Eye Proteins*/genetics , Eye Proteins*/metabolism , Cytoskeletal Proteins*/genetics , Cytoskeletal Proteins*/metabolism , Axonal Transport*/physiology , Glaucoma, Open-Angle*/pathology , Glaucoma, Open-Angle*/genetics , Glaucoma, Open-Angle*/metabolism, Animals ; Disease Models, Animal ; Mice ; Retinal Ganglion Cells/pathology ; Retinal Ganglion Cells/metabolism ; Intraocular Pressure ; Trabecular Meshwork/metabolism ; Trabecular Meshwork/pathology ; Humans ; Mice, Transgenic ; Integrases/metabolism ; Integrases/genetics ; Male ; Glaucoma/pathology