Genome-wide association studies reveal genomic regions for kernel-related traits in durum wheat.

Authors: Achilli AL; Crop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, SK, Canada. ana.achilli@usask.ca.; Centro de Recursos Naturales Renovables de la Zona Semiárida, Consejo Nacional de Investigaciones Científicas y Técnicas (CERZOS-CONICET), Bahía Blanca, Buenos Aires, Argentina. ana.achilli@usask.ca.; Departamento de Agronomía, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina. ana.achilli@usask.ca., Roncallo PF; Centro de Recursos Naturales Renovables de la Zona Semiárida, Consejo Nacional de Investigaciones Científicas y Técnicas (CERZOS-CONICET), Bahía Blanca, Buenos Aires, Argentina.; Departamento de Agronomía, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina., Rodrigo JM; Centro de Recursos Naturales Renovables de la Zona Semiárida, Consejo Nacional de Investigaciones Científicas y Técnicas (CERZOS-CONICET), Bahía Blanca, Buenos Aires, Argentina.; Departamento de Agronomía, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina., Pozniak CJ; Crop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, SK, Canada., Echenique VC; Centro de Recursos Naturales Renovables de la Zona Semiárida, Consejo Nacional de Investigaciones Científicas y Técnicas (CERZOS-CONICET), Bahía Blanca, Buenos Aires, Argentina. echeniq@cerzos-conicet.gob.ar.

Source: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik [Theor Appl Genet] 2026 Oct 01; Vol. 139 (10). Date of Electronic Publication: 2026 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 0145600 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-2242 (Electronic) Linking ISSN: 00405752 NLM ISO Abbreviation: Theor Appl Genet Subsets: MEDLINE

MeSH Terms: Triticum*/genetics , Seeds*/genetics , Genome-Wide Association Study* , Genome, Plant*, Chromosomes, Plant/genetics ; Polymorphism, Single Nucleotide ; Phenotype ; Chromosome Mapping ; Genotype ; Genetic Markers ; Quantitative Trait Loci ; Genetic Association Studies ; Linkage Disequilibrium

Conventional and Shared Genetic Association Analysis Between Diabetes Mellitus and Sensorineural Hearing Loss.

Authors: Wang X; Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn., Zhang Z; Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn., Qiu K; Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn., Luo Y; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK, bristol.ac.uk., Yi X; Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn., Pang W; Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn., Jiang D; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn., Ren J; Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn., Zhao Y; Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China, scu.edu.cn.

Source: Human mutation [Hum Mutat] 2026 Sep 15; Vol. 2026, pp. 5099141. Date of Electronic Publication: 2026 Sep 15 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9215429 Publication Model: eCollection Cited Medium: Internet ISSN: 1098-1004 (Electronic) Linking ISSN: 10597794 NLM ISO Abbreviation: Hum Mutat Subsets: MEDLINE

MeSH Terms: Hearing Loss, Sensorineural*/genetics , Hearing Loss, Sensorineural*/epidemiology , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/epidemiology , Diabetes Mellitus, Type 2*/complications , Genetic Predisposition to Disease* , Genetic Association Studies*, Humans ; Female ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Genome-Wide Association Study ; Linkage Disequilibrium ; Aged

Association mapping integrated with image-based phenomics identifies SNPs and candidate genes underpinning fruit morphology and development in chile pepper (Capsicum annum L.).

Authors: Khokhar ES; Department of Plant and Environmental Sciences, New Mexico State University, Las Cruces, NM 88003, United States., Lozada DN; Department of Plant and Environmental Sciences, New Mexico State University, Las Cruces, NM 88003, United States.; Chile Pepper Institute, New Mexico State University, Las Cruces, NM 88003, United States.

Source: G3 (Bethesda, Md.) [G3 (Bethesda)] 2026 Jul 06; Vol. 16 (7).

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE

MeSH Terms: Fruit*/genetics , Fruit*/anatomy & histology , Fruit*/growth & development , Capsicum*/genetics , Capsicum*/growth & development , Capsicum*/anatomy & histology , Phenomics*/methods , Polymorphism, Single Nucleotide* , Chromosome Mapping* , Genetic Association Studies* , Genes, Plant*, Genome-Wide Association Study ; Phenotype ; Quantitative Trait Loci ; Genotype ; Chile

Unraveling genotype-phenotype relationships in hereditary hemochromatosis through integrated biobank data analysis.

Authors: Nurm M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. miriam.nurm@ut.ee., Annilo T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., May-Wilson S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Reigo A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Võsa U; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Tõnisson N; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Genetics and Personalized Medicine Clinic, Tartu University Hospital, Tartu, Estonia., Haller T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. toomas.haller@ut.ee.

Corporate Authors: Estonian Biobank Research Team

Source: BMC genomics [BMC Genomics] 2026 Mar 16; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 16.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

MeSH Terms: Hemochromatosis*/genetics , Biological Specimen Banks* , Genetic Association Studies*, Hemochromatosis Protein/genetics ; Humans ; Phenotype ; Female ; Genome-Wide Association Study ; Genotype ; Male ; Middle Aged ; Estonia ; UK Biobank ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide

Causal modelling of gene effects from regulators to programs to traits.

Authors: Ota M; Department of Genetics, Stanford University, Stanford, CA, USA. mineto-ota@g.ecc.u-tokyo.ac.jp.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. mineto-ota@g.ecc.u-tokyo.ac.jp.; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. mineto-ota@g.ecc.u-tokyo.ac.jp., Spence JP; Department of Genetics, Stanford University, Stanford, CA, USA.; Institute for Human Genetics (IHG), University of California San Francisco, San Francisco, CA, USA.; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA., Zeng T; Department of Genetics, Stanford University, Stanford, CA, USA., Dann E; Department of Genetics, Stanford University, Stanford, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Milind N; Department of Genetics, Stanford University, Stanford, CA, USA., Marson A; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. alex.marson@gladstone.ucsf.edu.; Institute for Human Genetics (IHG), University of California San Francisco, San Francisco, CA, USA. alex.marson@gladstone.ucsf.edu.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA. alex.marson@gladstone.ucsf.edu.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. alex.marson@gladstone.ucsf.edu.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. alex.marson@gladstone.ucsf.edu.; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. alex.marson@gladstone.ucsf.edu.; Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, USA. alex.marson@gladstone.ucsf.edu., Pritchard JK; Department of Genetics, Stanford University, Stanford, CA, USA. pritch@stanford.edu.; Department of Biology, Stanford University, Stanford, CA, USA. pritch@stanford.edu.

Source: Nature [Nature] 2026 Feb; Vol. 650 (8101), pp. 399-408. Date of Electronic Publication: 2025 Dec 10.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH Terms: Causality* , Gene Expression Regulation* , Genetic Association Studies* , Models, Genetic*, Humans ; Gene Regulatory Networks ; Genome-Wide Association Study ; Loss of Function Mutation ; Phenotype ; Quantitative Trait Loci ; Quantitative Trait, Heritable ; Animals

Genome-wide association study (GWAS) identifies genetic loci controlling Distinctness, Uniformity, and Stability (DUS) traits in wheat.

Authors: Zanella CM; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK., Horsnell R; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK., Love B; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK., Wright TIC; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK., Taferner-Kriegl J; Austrian Agency for Health and Food Safety (AGES), Spargelfeldstraße 191, 1220, Vienna, Austria., Flamm C; Austrian Agency for Health and Food Safety (AGES), Spargelfeldstraße 191, 1220, Vienna, Austria., Andreani L; Council for Agricultural Research and Economics - Research Centre for Plant Protection and Certification, Tavazzano, LO, Italy., Delogu C; Council for Agricultural Research and Economics - Research Centre for Plant Protection and Certification, Tavazzano, LO, Italy., McMillan V; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK., Wallace M; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK., Scott E; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK., Cockram J; Niab, Park Farm, Villa Road, Histon, Cambridge, CB24 9NZ, UK. james.cockram@niab.com.

Source: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik [Theor Appl Genet] 2026 Jan 28; Vol. 139 (2), pp. 49. Date of Electronic Publication: 2026 Jan 28.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 0145600 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-2242 (Electronic) Linking ISSN: 00405752 NLM ISO Abbreviation: Theor Appl Genet Subsets: MEDLINE

MeSH Terms: Triticum*/genetics , Genome-Wide Association Study* , Quantitative Trait Loci*, Phenotype ; Genetic Markers ; Genotype ; Chromosome Mapping ; Polymorphism, Single Nucleotide ; Genome, Plant ; Plant Breeding ; Genetic Association Studies

Variant Classification Using Proteomics-Informed Large Language Models Increases Power of Rare Variant Association Studies and Enhances Target Discovery.

Authors: Gillies CE; Regeneron Genetics Center, Tarrytown, New York, USA., Mbatchou J; Regeneron Genetics Center, Tarrytown, New York, USA., Habegger L; Regeneron Genetics Center, Tarrytown, New York, USA., Kessler MD; Regeneron Genetics Center, Tarrytown, New York, USA., Bao S; Regeneron Genetics Center, Tarrytown, New York, USA., Balasubramanian S; Regeneron Genetics Center, Tarrytown, New York, USA., Delaneau O; Regeneron Genetics Center, Tarrytown, New York, USA., Kosmicki JA; Regeneron Genetics Center, Tarrytown, New York, USA., Willer CJ; Regeneron Genetics Center, Tarrytown, New York, USA., Kang HM; Regeneron Genetics Center, Tarrytown, New York, USA., Baras A; Regeneron Genetics Center, Tarrytown, New York, USA., Reid JG; Regeneron Genetics Center, Tarrytown, New York, USA., Marchini J; Regeneron Genetics Center, Tarrytown, New York, USA., Abecasis GR; Regeneron Genetics Center, Tarrytown, New York, USA., Ghoussaini M; Regeneron Genetics Center, Tarrytown, New York, USA.

Source: Genetic epidemiology [Genet Epidemiol] 2025 Dec; Vol. 49 (8), pp. e70023.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8411723 Publication Model: Print Cited Medium: Internet ISSN: 1098-2272 (Electronic) Linking ISSN: 07410395 NLM ISO Abbreviation: Genet Epidemiol Subsets: MEDLINE

MeSH Terms: Proteomics*/methods , Genetic Association Studies*/methods , Genetic Variation*, Humans ; Machine Learning ; Models, Genetic ; Phenotype ; Genome-Wide Association Study ; Deep Learning ; Language ; Mutation, Missense ; Large Language Models

Causal Variants in CHRNA1 and CHRNB1 Genes for Anti-acetylcholine Receptor Antibody Positive Myasthenia Gravis: Evidence from Bayesian Fine-Mapping and Genetic Association Study.

Authors: Garai N; University of Belgrade-Faculty of Biology, Center for Human Molecular Genetics, Studentski Trg 16, 11158, Belgrade, Serbia., Petrovic K; Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, 11000, Belgrade, Serbia., Peric S; University Clinical Center of Serbia, Neurology Clinic, Dr Subotica Starijeg 6, 11000, Belgrade, Serbia.; University of Belgrade-Faculty of Medicine, Dr Subotica Starijeg 8, 11000, Belgrade, Serbia., Djordjevic I; University Clinical Center of Serbia, Neurology Clinic, Dr Subotica Starijeg 6, 11000, Belgrade, Serbia., Pesovic J; University of Belgrade-Faculty of Biology, Center for Human Molecular Genetics, Studentski Trg 16, 11158, Belgrade, Serbia., Brkusanin M; University of Belgrade-Faculty of Biology, Center for Human Molecular Genetics, Studentski Trg 16, 11158, Belgrade, Serbia., Brajuskovic G; University of Belgrade-Faculty of Biology, Center for Human Molecular Genetics, Studentski Trg 16, 11158, Belgrade, Serbia., Lavrnic D; University Clinical Center of Serbia, Neurology Clinic, Dr Subotica Starijeg 6, 11000, Belgrade, Serbia.; University of Belgrade-Faculty of Medicine, Dr Subotica Starijeg 8, 11000, Belgrade, Serbia., Apostolski S; Outpatient Neurological Clinic 'Apostolski', Vojislava Ilica 100, 11010, Belgrade, Serbia., Basta I; University Clinical Center of Serbia, Neurology Clinic, Dr Subotica Starijeg 6, 11000, Belgrade, Serbia.; University of Belgrade-Faculty of Medicine, Dr Subotica Starijeg 8, 11000, Belgrade, Serbia., Jovanovic VM; Department for Biology, Chemistry and Pharmacy-Human Biology and Primate Evolution, Freie Universität Berlin, Arnimallee 22, 14195, Berlin, Germany., Savic-Pavicevic D; University of Belgrade-Faculty of Biology, Center for Human Molecular Genetics, Studentski Trg 16, 11158, Belgrade, Serbia. duska@bio.bg.ac.rs.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Sep; Vol. 62 (9), pp. 11286-11296. Date of Electronic Publication: 2025 Apr 25.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Receptors, Nicotinic*/genetics , Myasthenia Gravis*/genetics , Myasthenia Gravis*/immunology , Polymorphism, Single Nucleotide*/genetics , Autoantibodies*/immunology , Genetic Predisposition to Disease* , Genetic Association Studies* , Chromosome Mapping*, Linkage Disequilibrium/genetics ; Humans ; Bayes Theorem ; Female ; Male ; Genome-Wide Association Study ; Middle Aged ; Adult

BiTUGA: scalable prevalence-based unitig association testing for binary traits.

Authors: Mittelbach J; Center for Bioinformatics, MIN-Faculty, University of Hamburg, 22761 Hamburg, Hamburg, Germany., Kersten B; Genome Research, Thünen Institute of Forest Genetics, 22927 Großhansdorf, Schleswig-Holstein, Germany., Kurtz S; Center for Bioinformatics, MIN-Faculty, University of Hamburg, 22761 Hamburg, Hamburg, Germany.

Source: G3 (Bethesda, Md.) [G3 (Bethesda)] 2026 Aug 05; Vol. 16 (8).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE

MeSH Terms: Software* , Genetic Association Studies* , Quantitative Trait, Heritable* , Genome-Wide Association Study*, Populus/genetics ; Ginkgo biloba/genetics ; Genomics/methods ; Genome, Plant ; Phenotype ; Sex Determination Processes

A multi-ancestry genome-wide association study of dry eye disease and systemic comorbidities.

Authors: Gorman BR; Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, 02130, USA., Huang JJ; Surgical and Research Services, Miami Veterans Administration Medical Center, Miami, FL, 33125, USA; Bascom Palmer Eye Institute, University of Miami, Miami, FL, 33136, USA., Barr PB; Research Service, VA New York Harbor Healthcare System, Brooklyn, NY, 11209, USA; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA; Epidemiology & Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA., Halladay CW; Center of Innovation in Long Term Services and Supports, Providence VA Medical Center, Providence, RI, 02908, USA., Nealon CL; Eye Clinic, VA Northeast Ohio Healthcare System, Cleveland, OH, 44106, USA; Ophthalmology & Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA., Chatzinakos C; Research Service, VA New York Harbor Healthcare System, Brooklyn, NY, 11209, USA; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA., Francis M; Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, 02130, USA., Jiang C; Division of Research, Kaiser Permanente Northern California (KPNC), Pleasanton, CA, 94588, USA., Greenberg PB; Ophthalmology Section, Providence VA Medical Center, Providence, RI, 02909, USA; Division of Ophthalmology, Alpert Medical School, Brown University, Providence, RI, 02903, USA., Wu WC; Cardiology Section, Medical Service, Providence VA Medical Center, Providence, RI, 02908, USA., Pyarajan S; Center for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA, 02130, USA., Choquet H; Division of Research, Kaiser Permanente Northern California (KPNC), Pleasanton, CA, 94588, USA; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, 91101, USA., Bigdeli TB; Research Service, VA New York Harbor Healthcare System, Brooklyn, NY, 11209, USA; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA; Epidemiology & Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA., Iyengar SK; Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA; Research Service, VA Northeast Ohio Healthcare System, Cleveland, OH, 44106, USA., Peachey NS; Research Service, VA Northeast Ohio Healthcare System, Cleveland, OH, 44106, USA; Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA., Galor A; Surgical and Research Services, Miami Veterans Administration Medical Center, Miami, FL, 33125, USA; Bascom Palmer Eye Institute, University of Miami, Miami, FL, 33136, USA. Electronic address: AGalor@med.miami.edu.

Corporate Authors: VA Million Veteran Program

Source: EBioMedicine [EBioMedicine] 2026 Oct; Vol. 132, pp. 106490. Date of Electronic Publication: 2026 Sep 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE

MeSH Terms: Dry Eye Syndromes*/genetics , Dry Eye Syndromes*/epidemiology , Genome-Wide Association Study* , Genetic Predisposition to Disease*, Humans ; Comorbidity ; Female ; Case-Control Studies ; Polymorphism, Single Nucleotide ; Aged ; Male ; Phenotype ; Middle Aged

Large impact of genetic data processing steps on stability and reproducibility of set-based analyses in genome-wide association studies.

Authors: Kui N; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.; Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States., Yu Y; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States., Choi J; Department of Mathematical and Statistical Sciences, Marquette University, Milwaukee, WI 53233, United States., McCaw ZR; The Voleon Group, Berkeley, CA 94704, United States., Li X; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States., Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States., Huff C; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States., Sun R; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.

Source: Genetics [Genetics] 2026 Sep 02; Vol. 234 (1).

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE

MeSH Terms: Genome-Wide Association Study*/methods , Genome-Wide Association Study*/standards, Humans ; Reproducibility of Results ; Models, Genetic ; Genetic Risk Score ; Models, Statistical ; Polymorphism, Single Nucleotide

A Guide for Exploring Pleiotropic Associations in Genome-Wide Association Studies Using Summary Statistics.

Authors: Feng CY; School of Mathematical and Physical Sciences, Macquarie University, Sydney, New South Wales, Australia., Sugier PE; Laboratoire de Mathématiques et de leurs Applications, UMR CNRS 5142, Université de Pau et des Pays de l'Adour, E2S-UPPA, Pau, France.; Université Paris Cité, CNRS, MAP5, Paris, France., Zou N; School of Mathematical and Physical Sciences, Macquarie University, Sydney, New South Wales, Australia., Liquet B; School of Mathematical and Physical Sciences, Macquarie University, Sydney, New South Wales, Australia.; Laboratoire de Mathématiques et de leurs Applications, UMR CNRS 5142, Université de Pau et des Pays de l'Adour, E2S-UPPA, Pau, France.

Source: Statistics in medicine [Stat Med] 2026 Sep; Vol. 45 (20-22), pp. e70717.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Genome-Wide Association Study*/methods , Genome-Wide Association Study*/statistics & numerical data , Genetic Pleiotropy*, Breast Neoplasms/genetics ; Thyroid Neoplasms/genetics ; Humans ; Polymorphism, Single Nucleotide ; Meta-Analysis as Topic ; Phenotype ; Female ; Models, Statistical ; Data Interpretation, Statistical

From Germline Variants to Tumor Outcome: GWAS-Based Functional Genomics Prioritizes Colorectal Cancer Susceptibility Genes and Links SMAD9 to Prognosis.

Authors: Hu C; Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China, fimmu.com.; Department of Gastroenterology, Guangzhou Medical University Affiliated Women and Children's Medical Center, Guangzhou, China., Yang G; Department of General Surgery, Guangzhou Twelfth People's Hospital, Guangzhou Medical University, Guangzhou, China, gzhmc.edu.cn., Xiong H; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.; Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Xie Y; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Yuan Z; The second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China, glmc.edu.cn., Liu J; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.; Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Wang P; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Li M; Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Xu J; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.; Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Li Q; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.; Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Li C; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Han W; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Peng X; Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Zhang L; Department of Nursing, Jiuquan Hospital of Shanghai General Hospital (Jiuquan People's Hospital), Jiuquan, China., Cai S; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, Lancashire, UK, lancs.ac.uk., Zhong F; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.; Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com., Dai L; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China, fimmu.com., Liu S; Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China, fimmu.com.; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com.

Source: Human mutation [Hum Mutat] 2026 Aug 20; Vol. 2026, pp. 5617762. Date of Electronic Publication: 2026 Aug 20 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9215429 Publication Model: eCollection Cited Medium: Internet ISSN: 1098-1004 (Electronic) Linking ISSN: 10597794 NLM ISO Abbreviation: Hum Mutat Subsets: MEDLINE

MeSH Terms: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Genomics*/methods , Genome-Wide Association Study* , Genetic Predisposition to Disease* , Germ-Line Mutation*, Humans ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Prognosis ; Gene Expression Regulation, Neoplastic ; Delta-5 Fatty Acid Desaturase

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits.

Authors: Wang D; Department of Mathematics & Statistics, University of Calgary, Calgary, Alberta, Canada., Kossinna P; Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada., Ardila K; Department of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada., Kumarapeli S; Department of Mathematics & Statistics, University of Calgary, Calgary, Alberta, Canada.; Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada., MacDonald ME; Department of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada., Wu J; Department of Mathematics & Statistics, University of Calgary, Calgary, Alberta, Canada., Zhang Q; Department of Mathematics & Statistics, University of Calgary, Calgary, Alberta, Canada.; Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Source: PLoS computational biology [PLoS Comput Biol] 2026 Aug 17; Vol. 22 (8), pp. e1014640. Date of Electronic Publication: 2026 Aug 17 (Print Publication: 2026).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

MeSH Terms: Genetic Association Studies*/methods , Genome-Wide Association Study*/methods , Multifactorial Inheritance*/genetics, Polymorphism, Single Nucleotide/genetics ; Computational Biology/methods ; Gene Regulatory Networks/genetics ; Quantitative Trait Loci/genetics ; Humans ; Phenotype ; Computer Simulation ; Models, Genetic ; Reproducibility of Results ; Epistasis, Genetic

Genetic association meta-analysis is susceptible to confounding by between-study cryptic relatedness.

Authors: Tu T; Program of Computational Biology and Bioinformatics, Duke University, Durham, NC, USA; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA; Duke Center for Statistical Genetics and Genomics, Duke University, Durham, NC, USA., Ochoa A; Program of Computational Biology and Bioinformatics, Duke University, Durham, NC, USA; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA; Duke Center for Statistical Genetics and Genomics, Duke University, Durham, NC, USA. Electronic address: alejandro.ochoa@duke.edu.

Source: HGG advances [HGG Adv] 2026 Oct 08; Vol. 7 (4), pp. 100657. Date of Electronic Publication: 2026 Jul 27.

Publication Type: Journal Article; Meta-Analysis

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: MEDLINE

MeSH Terms: Genome-Wide Association Study*/methods, Humans ; Meta-Analysis as Topic ; Models, Genetic ; Computer Simulation ; Female ; Male ; Polymorphism, Single Nucleotide

A pseudotime-dependent TWAS framework identifies disease genes along cell developmental paths.

Authors: Cao R; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: cao00128@umn.edu., Li C; Department of Statistics, College and Graduate School of Arts and Sciences, University of Virginia, Charlottesville, VA 22904, USA; Department of Statistics, College of Liberal Arts and Sciences, Iowa State University, Ames, IA 50011, USA., Cui E; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA., Spector L; Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA., Raduski A; Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA., Anderson N; Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA., Guan W; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA., Gordon P; Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA., Im C; Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA., Yang T; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: yang3704@umn.edu.

Source: HGG advances [HGG Adv] 2026 Oct 08; Vol. 7 (4), pp. 100634. Date of Electronic Publication: 2026 Jun 23.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: MEDLINE

MeSH Terms: Genome-Wide Association Study*/methods , Transcriptome*/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Genetic Predisposition to Disease*, Gene Expression Profiling/methods ; Humans ; Single-Cell Gene Expression Analysis ; Single-Cell Analysis

Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.

Authors: Ipata AE; Department of Neuroscience, Columbia University, New York, New York 10027 ai2019@columbia.edu vf226@columbia.edu.; Mahoney Center for Brain and Behavior Research, Columbia University, New York, New York 10027., Fascianelli V; Center for Theoretical Neuroscience, Columbia University, New York, New York 10027 ai2019@columbia.edu vf226@columbia.edu.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027., De Zeeuw CI; Department of Neuroscience, Erasmus MC, Rotterdam 3015, The Netherlands.; Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts and Science (KNAW), Amsterdam 1105, The Netherlands., Sendhilnathan N; Department of Neuroscience, Columbia University, New York, New York 10027.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027., Fusi S; Department of Neuroscience, Columbia University, New York, New York 10027.; Center for Theoretical Neuroscience, Columbia University, New York, New York 10027.; Kavli Institute for Brain Science, Columbia University, New York, New York 10027.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027., Goldberg ME; Department of Neuroscience, Columbia University, New York, New York 10027.; Mahoney Center for Brain and Behavior Research, Columbia University, New York, New York 10027.; Kavli Institute for Brain Science, Columbia University, New York, New York 10027.; Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, New York 10027.; Department of Neurology, Psychiatry, and Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York 10027.

Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2026 Oct 07; Vol. 46 (40). Date of Electronic Publication: 2026 Oct 07.

Publication Type: Journal Article

Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

MeSH Terms: Purkinje Cells*/physiology , Psychomotor Performance*/physiology , Choice Behavior*/physiology , Association Learning*/physiology , Reinforcement, Psychology*, Action Potentials/physiology ; Animals ; Male ; Photic Stimulation ; Macaca mulatta

A novel support vector regression approach for detecting gene-environment interactions and predicting trait values.

Authors: Li X; Department of Statistics, Heilongjiang University, Harbin 150080, China., Xie W; Department of Statistics, Heilongjiang University, Harbin 150080, China.; School of Mathematical Sciences, Peking University, Beijing 100871, China., Tong L; Department of Statistics, Heilongjiang University, Harbin 150080, China., Zhou Y; Department of Statistics, Heilongjiang University, Harbin 150080, China., Fang X; Department of Statistics, Heilongjiang University, Harbin 150080, China.; School of Mathematical Sciences, Peking University, Beijing 100871, China.

Source: Genetics [Genetics] 2026 Oct 07; Vol. 234 (2).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE

MeSH Terms: Genome-Wide Association Study*/methods , Gene-Environment Interaction* , Models, Genetic* , Support Vector Machine*, Glycine max/genetics ; Phenotype

Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine.

Authors: Zhou S; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Tan J; West China School of Nursing, Sichuan University, Chengdu, China., Li X; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Ran Z; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., He J; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Li Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Yuan X; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Hu Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Chen M; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Dai Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Wang X; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Liu X; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Li R; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Xu Y; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Cheng G; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China. gcheng@scu.edu.cn.; West China School of Nursing, Sichuan University, Chengdu, China. gcheng@scu.edu.cn.; Children's Medicine Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. gcheng@scu.edu.cn.; West China School of Public Health and West China Fourth Hospital, West China Second University Hospital, Sichuan University, 16 Renminnan Road 3rd Section, Chengdu, 610041, China. gcheng@scu.edu.cn., Xiong J; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; Health Promotion and Food Nutrition & Safety Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; Occupational Health and Occupational Medicine Key Laboratory of Sichuan Provincial Health Commission, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; Molecular Toxicology Key Laboratory of Sichuan Provincial Education Office, West ChinaSchool of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; West China School of Public Health and West China Fourth Hospital, West China Second University Hospital, Sichuan University, 16 Renminnan Road 3rd Section, Chengdu, 610041, China. jzx0004@tigermail.auburn.edu.

Source: Functional & integrative genomics [Funct Integr Genomics] 2026 Oct 06; Vol. 26 (1). Date of Electronic Publication: 2026 Oct 06.

Publication Type: Journal Article; Meta-Analysis

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 100939343 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-7948 (Electronic) Linking ISSN: 1438793X NLM ISO Abbreviation: Funct Integr Genomics Subsets: MEDLINE

MeSH Terms: Taurine*/blood , Taurine*/genetics , Genome-Wide Association Study*, Humans ; Polymorphism, Single Nucleotide ; Linkage Disequilibrium

Development, Normative Data, and Psychometric Properties of the Turkish Semantic Association Test (SEMAT) for Middle-Aged and Older Adults.

Authors: Tosun S; Department of Speech and Language Therapy, Biruni University, Istanbul, Turkey., Karalı FS; Department of Speech and Language Therapy, Biruni University, Istanbul, Turkey., Macoir J; École Des Sciences de La Réadaptation, Faculté de Médecine, Université Laval, Québec, Canada.; CERVO Brain Research Centre, Québec, Canada.

Source: Brain and behavior [Brain Behav] 2026 Oct; Vol. 16 (10), pp. e71833.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE

MeSH Terms: Psychometrics*/standards , Neuropsychological Tests*/standards , Semantics* , Association* , Aging*, Cognition/physiology ; Humans ; Aged ; Male ; Female ; Turkey ; Middle Aged ; Aged, 80 and over ; Reproducibility of Results ; Reference Values