Chrysoeriol-Mediated Neuroprotection in Parkinson’s Disease in Mice: Targeting Apoptosis, α-Synuclein Accumulation, and Functional Recovery

Συγγραφείς: Ali, Mehak, Mehreen, Mehwish, Batool, Saima, Khan, Shahrukh, Noor, Aneeqa, Mumtaz, Sara, Zafar, Saima

Πηγή: Yale J Biol Med
Yale journal of biology and medicine 99(1), 111-126 (2026). doi:10.59249/CTWM1697

Θεματικοί όροι: Male, Recovery of Function: drug effects, alpha-Synuclein: metabolism, Apoptosis: drug effects, chrysoeriol, Neuroprotection: drug effects, Neuroprotective Agents: pharmacology, Mice, Dopaminergic Neurons: metabolism, Animals, Bcl-2, Dopaminergic Neurons: drug effects, α-Synuclein, Parkinson Disease: metabolism, Neuroprotective Agents: therapeutic use, Original Contribution, Flavones, Mice, Inbred C57BL, Disease Models, Animal, Neuroprotective Agents, Parkinson Disease: drug therapy, BAX, Parkinson's disease, alpha-Synuclein, Flavones: pharmacology, Neuroprotective

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41918512/
https://doi.org/10.59249/CTWM1697
https://pmc.ncbi.nlm.nih.gov/articles/PMC13023422/
https://pub.dzne.de/record/285814

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling

Συγγραφείς: Javier Moral-Sanz, Isabel Fernández-Carrasco, Valentina Ramponi, Amanda Garrido, Izhar Karbat, Pablo Cabezas-Sainz, Esperanza Rivera-de-Torre, Osama Elsallabi, Roberto Martín-Hernández, José L. López-Aceituno, Nathan L. Price, Laura Sanchez, Gonzalo Colmenarejo, Álvaro Martínez-del-Pozo, Irina Vetter, Angel Cogolludo, Francisco Perez-Vizcaino, Jorge Del-Pozo, Eitan Reuveny, Manuel A. Fernández-Rojo, Paul D. Robbins, Rafael de Cabo, Manuel Serrano, Maria P. Ikonomopoulou

Πηγή: Nat Aging
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernández-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling', Nature Aging, vol. 6, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernandez-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodelling', Nature Aging, vol. 6, no. 2, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-Del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernández-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling', Nature Aging, vol. 6, no. 2, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w

Θεματικοί όροι: Calcium/metabolism, Transport, 32 Biomedical and Clinical Sciences, Cellular Senescence/drug effects, Lipid Metabolism/drug effects, Article, Exposure, Mice, Software News, Cell Line, Tumor, 3211 Oncology and carcinogenesis, Animals, Humans, name=SDG 3 - Good Health and Well-being, Cellular Senescence, Immunotoxin, Volume, Apoptosis/drug effects, Monoclonal-Antibody, Channel, Neoplasms/drug therapy, 3204 Immunology, Senotherapeutics/pharmacology, Sticholysin I, Lipidomics, Mechanism, Antineoplastic Agents/pharmacology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41526742
https://espace.library.uq.edu.au/view/UQ:cda843f
https://api.library.uq.edu.au/view/UQ:cda843f

Hesperetin Protects from Palmitic-Acid-Induced Lipotoxicity through the Inhibition of Glutaminolysis, mTORC1 Signaling, and Limited Apoptosis

Συγγραφείς: Wan Li, Zhengnan Cai, Florian Schindler, Martin Brenner, Christian Winter, Bianca Stiller, Petra Heffeter, Wolfram Weckwerth

Πηγή: J Agric Food Chem

Θεματικοί όροι: Hesperidin/pharmacology, Hesperidin, Glutamine, Apoptosis/drug effects, Palmitic Acid, Apoptosis, Mechanistic Target of Rapamycin Complex 1, Protective Agents, Article, Glutamine/metabolism, Palmitic Acid/toxicity, Non-alcoholic Fatty Liver Disease/metabolism, Protective Agents/pharmacology, Non-alcoholic Fatty Liver Disease, Signal Transduction/drug effects, Autophagy/drug effects, Autophagy, 303009 Ernährungswissenschaften, Humans, Mechanistic Target of Rapamycin Complex 1/metabolism, 303009 Nutritional sciences, Signal Transduction

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40838694
https://pubmed.ncbi.nlm.nih.gov/40838694/
https://doi.org/10.1021/acs.jafc.5c05570
https://pmc.ncbi.nlm.nih.gov/articles/PMC12412169/
https://ucrisportal.univie.ac.at/de/publications/7355a6b3-e10c-4607-9c50-46652b28bac2
https://doi.org/10.1021/acs.jafc.5c05570

Carrier-Free Cisplatin–Dactolisib Nanoparticles for Enhanced Synergistic Antitumor Efficacy

Συγγραφείς: Mei Zhang, Qiuxia Tan, Sevil Gonca, Minhuan Lan, Bin-Zhi Qian, Xianfeng Chen, Norbert Radacsi

Πηγή: ACS Biomater Sci Eng
Zhang, M, Tan, Q, Gonca, S, Lan, M, Qian, B-Z, Chen, X & Radacsi, N 2025, 'Carrier-Free Cisplatin-Dactolisib Nanoparticles for Enhanced Synergistic Antitumor Efficacy', ACS Biomaterials Science & Engineering, vol. 11, no. 3, pp. 1456-1471. https://doi.org/10.1021/acsbiomaterials.4c00672

Θεματικοί όροι: Cisplatin/pharmacology, Mice, Nude, pure drug nanoparticles, Antineoplastic Agents, Apoptosis, TOR Serine-Threonine Kinases/metabolism, antitumor agents, combination therapy, Mice, Cell Line, Tumor, Neoplasms, Imidazoles/chemistry, Humans, Animals, Quinolines/pharmacology, Mice, Inbred BALB C, Drug Carriers, TOR Serine-Threonine Kinases, Apoptosis/drug effects, Imidazoles, Drug Synergism, self-assembly, drug delivery, Quinolines, Nanoparticles, Nanoparticles/chemistry, Phosphatidylinositol 3-Kinases/metabolism, Cisplatin, Antineoplastic Agents/pharmacology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39992316
https://www.research.ed.ac.uk/en/publications/f39ce4ee-1006-48e1-ba6a-43d381cc9189
https://hdl.handle.net/20.500.11820/f39ce4ee-1006-48e1-ba6a-43d381cc9189
https://www.pure.ed.ac.uk/ws/files/496062186/zhang-et-al-2025-carrier-free-cisplatin-dactolisib-nanoparticles-for-enhanced-synergistic-antitumor-efficacy.pdf
https://www.scopus.com/pages/publications/85218868924
https://doi.org/10.1021/acsbiomaterials.4c00672

Dual ligand functionalized pH-sensitive liposomes for metastatic breast cancer treatment: in vitro and in vivo assessment: in vitro and in vivo assessment

Συγγραφείς: Prashant Pandey, Dilip Kumar Arya, Anit Kumar, Ajeet Kaushik, Yogendra Kumar Mishra, P. S. Rajinikanth

Πηγή: Pandey, P, Arya, D K, Kumar, A, Kaushik, A, Mishra, Y K & Rajinikanth, P S 2025, 'Dual ligand functionalized pH-sensitive liposomes for metastatic breast cancer treatment : in vitro and in vivo assessment', Journal of Materials Chemistry B, vol. 13, no. 8, pp. 2682-2694. https://doi.org/10.1039/d4tb02570a

Θεματικοί όροι: Folic Acid/chemistry, Breast Neoplasms, Antineoplastic Agents, Apoptosis, Drug Screening Assays, Ligands, Cell Proliferation/drug effects, Rats, Sprague-Dawley, Folic Acid, Breast Neoplasms/drug therapy, Cell Movement, Antineoplastic Agents/chemistry, Humans, Animals, Particle Size, Cell Proliferation, Apoptosis/drug effects, Antitumor, Hydrogen-Ion Concentration, Rats, Drug Liberation, Liposomes, Fluorouracil/pharmacology, MCF-7 Cells, Female, Sprague-Dawley, Fluorouracil, Drug Screening Assays, Antitumor, Liposomes/chemistry, Oligopeptides, Cell Survival/drug effects

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39841132
https://portal.findresearcher.sdu.dk/da/publications/10377c9f-8091-462f-9771-97b9a1cf3a66
https://doi.org/10.1039/d4tb02570a

Two photon-responsive gold nanocapsules enable targeted photothermal hyperthermia of chemoresistant melanoma: injection-route-dependent efficacy and renal evidence of fragment clearance

Συγγραφείς: Paula Zamora-Pérez, Qiutian She, Harrisson D. Santos, Jose J. Conesa, M. Carmen Iglesias de la Cruz, Nuria Fernández, Daniel Jaque, Pilar Rivera-Gil

Συνεισφορές: Departamento de Fisiología, Facultad de Medicina, Departamento de Física de Materiales, Facultad de Ciencias, Fluorescence Imaging Group, Agencia Estatal de Investigación, Gobierno de España

Πηγή: Repositorio Digital de la UPF
Universitat Pompeu Fabra

Θεματικοί όροι: Kidney / metabolism, Photons, Medicina, Photothermal Therapy, Nanocapsules / chemistry, Melanoma, Experimental, Física, Antineoplastic Agents, Apoptosis, Hyperthermia, Induced, Apoptosis / drug effects, Kidney, Gold / chemistry, Gold / pharmacology, Mice, Inbred C57BL, Mice, Nanocapsules, Drug Resistance, Neoplasm, Cell Line, Tumor, Animals, Humans, Gold, Particle Size, Melanoma

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40673396

Amelioration of cisplatin-induced myocardial injury by nanocurcumin through antioxidant, anti-inflammatory, and calcium regulatory mechanisms

Συγγραφείς: Alqahtani, Qamraa H, ALMatrafi, Tahani A, Mohammed, Raeesa, Mahmoud, Ayman M, Hasan, Iman H

Πηγή: Journal of Molecular Histology. 57

Θεματικοί όροι: Male, Cisplatin - adverse effects, Curcumin, Apoptosis - drug effects, Anti-Inflammatory Agents, Apoptosis, Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism, Cardioprotection, Antioxidants, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Calcium homeostasis, Curcumin - pharmacology - therapeutic use, Animals, Cardiotoxicity - drug therapy, Rats, Wistar, Inflammation, Antioxidants - pharmacology, Myocardium, S100 Proteins, Calcium - metabolism, Myocardium - pathology - metabolism, Anti-Inflammatory Agents - pharmacology - therapeutic use, Cardiotoxicity, Rats, Nanoparticles - chemistry, Oxidative Stress, Oxidative Stress - drug effects, Oxidative stress, Nanoparticles, Calcium, Cisplatin

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41254419
https://e-space.mmu.ac.uk/643149/

Novel Active Homo-Aza (Lactam) Steroidal Antimetabolites for the Treatment of Human Pancreatic and Colorectal Cancer

Συγγραφείς: Konstantinos E. Alifieris, Panagiotis Dalezis, Sofia Sagredou, Ioanna A. Anastasiou, Maria Deligiorgi, Christos Siokatas, Nikolaos Spanakis, Konstantinos Almpanakis, Maria Voura, Kyriakos Orfanakos, Mihalis Panayiotidis, Vasiliki Sarli, Dimitrios T. Trafalis

Πηγή: Pharmaceuticals ; Volume 19 ; Issue 2 ; Pages: 331

Θεματικοί όροι: colorectal neoplasms/drug therapy, pancreatic neoplasms/drug therapy, antimetabolites, antineoplastic/pharmacology, steroids/pharmacology, thymidylate synthase inhibitors/pharmacology, dihydrofolate reductase inhibitors/pharmacology, molecular docking simulation, structure–activity relationship, apoptosis/drug effects, homo-aza lactam steroidal conjugates

Περιγραφή αρχείου: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/ph19020331

Διαθεσιμότητα: https://doi.org/10.3390/ph19020331

Broad-spectrum antibiotics disrupt homeostatic efferocytosis

Συγγραφείς: Pedro H. V. Saavedra, Alissa J. Trzeciak, Allie Lipshutz, Andrew W. Daman, Anya J. O’Neal, Zong-Lin Liu, Zhaoquan Wang, Jesús E. Romero-Pichardo, Waleska Saitz Rojas, Giulia Zago, Marcel R. M. van den Brink, Steven Z. Josefowicz, Christopher D. Lucas, Christopher J. Anderson, Alexander Y. Rudensky, Justin S. A. Perry

Πηγή: Nat Metab
Saavedra, P H, Trzeciak, A J, Lipshutz, A, Daman, A W, O'Neal, A J, Liu, Z-L, Wang, Z, Romero-Pichardo, J E, Saitz Rojas, W, Zago, G, Brink, M R M V D, Josefowicz, S Z, Lucas, C D, Anderson, CJ, Rudensky, A Y & Perry, J S A 2024, 'Broad-spectrum antibiotics disrupt homeostatic efferocytosis', Nature Metabolism, vol. 6, no. 9, pp. 1682-1694. https://doi.org/10.1038/s42255-024-01107-7

Θεματικοί όροι: Efferocytosis, Phagocytosis/drug effects, Macrophages, Apoptosis/drug effects, Membrane Proteins, Apoptosis, Article, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents, Gastrointestinal Microbiome, Mice, Inbred C57BL, Mice, Butyrates, Phagocytosis, Macrophages/metabolism, Macrophages, Peritoneal/metabolism, Butyrates/pharmacology, Macrophages, Peritoneal, Animals, Homeostasis, Humans, Membrane Proteins/metabolism, Gastrointestinal Microbiome/drug effects

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39122784
https://hdl.handle.net/20.500.11820/db356304-3f20-41ae-b9df-2ead4757495d
https://www.research.ed.ac.uk/en/publications/db356304-3f20-41ae-b9df-2ead4757495d
https://www.pure.ed.ac.uk/ws/files/464931465/s42255-024-01107-7.pdf
https://www.pure.ed.ac.uk/ws/files/460147648/Saavedra_20204_Accepted_CJ_Anderson.pdf
https://doi.org/10.1038/s42255-024-01107-7

Ruthenium Drug BOLD-100 Regulates BRAF MT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation

Συγγραφείς: Daryl Griffin, Robbie Carson, Debbie Moss, Tamas Sessler, Deborah Lavin, Vijay K. Tiwari, Shivaali Karelia, Richard Kennedy, Kienan I. Savage, Simon McDade, Adam Carie, Jim Pankovich, Mark Bazett, Sandra Van Schaeybroeck

Πηγή: Mol Cancer Res
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium drug BOLD-100 regulates BRAFmt colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V K, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151

Θεματικοί όροι: Proto-Oncogene Proteins B-raf, Basic Helix-Loop-Helix Proteins, Ataxia Telangiectasia Mutated Proteins/metabolism, name=Oncology, name=Cancer Research, colorectal cancer, Apoptosis, Ataxia Telangiectasia Mutated Proteins, Cancer Genes and Networks, Receptors, Aryl Hydrocarbon/metabolism, Cell Line, ruthenium drug, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects, Cell Line, Tumor, Proto-Oncogene Proteins B-raf/genetics, Receptors, Basic Helix-Loop-Helix Transcription Factors, Humans, name=SDG 3 - Good Health and Well-being, Tumor, cell apoptosis, Apoptosis/drug effects, Colorectal Neoplasms/drug therapy, 3. Good health, Receptors, Aryl Hydrocarbon, Aryl Hydrocarbon/metabolism, BOLD-100, BRAFMT, Colorectal Neoplasms, Reactive Oxygen Species, Signal Transduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39083088
https://pure.qub.ac.uk/en/publications/357b4c8d-d077-4033-8c9a-433d6c961788
https://doi.org/10.1158/1541-7786.MCR-24-0151
https://pureadmin.qub.ac.uk/ws/files/611793665/Ruthenium_drug.pdf
https://findresearcher.sdu.dk/ws/files/279240332/mcr-24-0151.pdf
https://doi.org/10.1158/1541-7786.MCR-24-0151
https://portal.findresearcher.sdu.dk/da/publications/3d27516f-a3d5-4134-9523-74594c733a9f

The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

Συγγραφείς: Joan Kyula-Currie, Victoria Roulstone, James Wright, Francesca Butera, Arnaud Legrand, Richard Elliott, Martin McLaughlin, Galabina Bozhanova, Dragomir Krastev, Stephen Pettitt, Tencho Tenev, Magnus Dillon, Shane Foo, Emmanuel C. Patin, Victoria Jennings, Charleen Chan Wah Hak, Elizabeth Appleton, Amarin Wongariyapak, Malin Pedersen, Antonio Rullan, Jyoti Choudhary, Chris Bakal, Pascal Meier, Christopher J. Lord, Alan Melcher, Kevin J. Harrington

Πηγή: Nat Commun

Θεματικοί όροι: Poly (ADP-Ribose) Polymerase-1/metabolism, Poly (ADP-Ribose) Polymerase-1, Apoptosis, Poly(ADP-ribose) Polymerase Inhibitors, Reoviridae, Article, Cell Line, Mice, DEAD Box Protein 58/metabolism, Cell Line, Tumor, Neoplasms, Neoplasms/therapy, Animals, Humans, Oncolytic Virotherapy, Tumor, Animal, Apoptosis/drug effects, NF-kappa B, Drug Synergism, Poly(ADP-ribose) Polymerase Inhibitors/pharmacology, Disease Models, Animal, Oncolytic Viruses, Oncolytic Virotherapy/methods, Disease Models, NF-kappa B/metabolism, Phthalazines, DEAD Box Protein 58, Female, Phthalazines/pharmacology

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40628717
https://eprints.whiterose.ac.uk/id/eprint/230921/

Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors

Συγγραφείς: Pellattiero, Anna, Quirin, Charlotte, Magrin, Federico, Sturlese, Mattia, Fracasso, Alberto, Biris, Nikolaos, Herkenne, Stéphanie, Cendron, Laura, Gavathiotis, Evripidis, Moro, Stefano, Mattarei, Andrea, Scorrano, Luca

Πηγή: Sci Adv

Θεματικοί όροι: Pyrazoles/pharmacology, Small Molecule Libraries/chemistry, Pyrazoles/chemistry, Apoptosis, Antineoplastic Agents, OPA1 protein, human, GTP Phosphohydrolases/antagonists & inhibitors, Drug Resistance, Neoplasm/drug effects, Biochimie, biophysique & biologie moléculaire, GTP Phosphohydrolases, Cytochromes c/metabolism, Enzyme Inhibitors/chemistry, Small Molecule Libraries, Structure-Activity Relationship, Cell Line, Tumor, Mitochondria/metabolism, Antineoplastic Agents/chemistry, Small Molecule Libraries/pharmacology, Humans, Enzyme Inhibitors, Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors, Enzyme Inhibitors/pharmacology, Apoptosis/drug effects, Cytochromes c, GTP Phosphohydrolases/chemistry, Life sciences, Mitochondria/drug effects, Mitochondria, Proto-Oncogene Proteins c-bcl-2, Drug Resistance, Neoplasm, Sciences du vivant, Pyrazoles, Proto-Oncogene Proteins c-bcl-2/metabolism, Biomedicine and Life Sciences, GTP Phosphohydrolases/metabolism, Antineoplastic Agents/pharmacology, Biochemistry, biophysics & molecular biology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40614185

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia

Συγγραφείς: Lawson, H, Holt-Martyn, JP, Dembitz, V, Kabayama, Y, Wang, LM, Bellani, A, Atwal, S, Saffoon, N, Durko, J, van de Lagemaat, LN, De Pace, AL, Tumber, A, Corner, T, Salah, E, Arndt, C, Brewitz, L, Bowen, M, Dubusse, L, George, D, Allen, L, Guitart, AV, Fung, TK, So, CWE, Schwaller, J, Gallipoli, P, O'Carroll, D, Schofield, CJ, Kranc, KR

Συνεισφορές: University of Zagreb. University of Zagreb, School of Medicine. Department of Physiology and Immunology, Bellani, Aarushi, Kranc, Kamil

Πηγή: Nat Cancer
Lawson, H, Holt-Martyn, J P, Dembitz, V, Kabayama, Y, Wang, L M, Bellani, A, Atwal, S, Saffoon, N, Durko, J, van de Lagemaat, L N, De Pace, A L, Tumber, A, Corner, T, Salah, E, Arndt, C, Brewitz, L, Bowen, M, Dubusse, L, George, D, Allen, L, Guitart, A V, Fung, T K, So, C W E, Schwaller, J, Gallipoli, P, O'Carroll, D, Schofield, C J & Kranc, K R 2024, 'The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia', nature cancer, vol. 5, no. 6, pp. 916-937. https://doi.org/10.1038/s43018-024-00761-w

Θεματικοί όροι: Myeloid, 0301 basic medicine, Sulfonamides / therapeutic use, Proto-Oncogene Proteins / metabolism, Hypoxia-Inducible Factor 1, alpha Subunit / metabolism, Apoptosis, Mice, Temeljne medicinske znanosti, Hypoxia-Inducible Factor-Proline Dioxygenases / antagonists & inhibitors, Sulfonamides, 0303 health sciences, Leukemia, Tumor, Protein Stability, Heterocyclic, Protein Stability / drug effects, Prolyl-Hydroxylase Inhibitors / pharmacology, Membrane Proteins / metabolism, 3. Good health, Leukemia, Myeloid, Acute, Proto-Oncogene Proteins c-bcl-2, Biomedicina i zdravstvo, Leukemia, Myeloid, Acute / metabolism, Disease Progression, Hypoxia-Inducible Factor 1, Proto-Oncogene Proteins c-bcl-2 / metabolism, Acute, alpha Subunit, Apoptosis / drug effects, Article, Cell Line, Hypoxia-Inducible Factor-Proline Dioxygenases, Hypoxia-Inducible Factor-Proline Dioxygenases / metabolism, Bridged Bicyclo Compounds, 03 medical and health sciences, Proto-Oncogene Proteins, Cell Line, Tumor, Humans, Animals, Biomedicine and Health Sciences, Sulfonamides / pharmacology, Membrane Proteins / genetics, Prolyl-Hydroxylase Inhibitors / therapeutic use, Membrane Proteins, Basic Medical Sciences, Prolyl-Hydroxylase Inhibitors, Hypoxia-Inducible Factor 1, alpha Subunit, Bridged Bicyclo Compounds, Heterocyclic, Human Physiology, fiziologija čovjeka, Leukemia, Myeloid, Acute / drug therapy

Περιγραφή αρχείου: application/pdf; Print-Electronic

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38637657
https://www.research.ed.ac.uk/en/publications/493491ab-d111-46df-b299-a28599f819ec
https://hdl.handle.net/20.500.11820/493491ab-d111-46df-b299-a28599f819ec
https://doi.org/10.1038/s43018-024-00761-w
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE232644
https://www.pure.ed.ac.uk/ws/files/508611763/s43018-024-00761-w.pdf

Dexamethasone: a double-edged sword in the treatment of osteoarthritis

Συγγραφείς: Tarasova, Karyna, Arteaga, Maria Belen, Kidtiwong, Angkana, Gueltekin, Sinan, Bileck, Andrea, Gerner, Christopher, Gerner, Iris, Jenner, Florien

Πηγή: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Θεματικοί όροι: Triamcinolone Acetonide Pharmacology, Chondrocytes Metabolism, Science, Anti-Inflammatory Agents, Apoptosis, Chondrocytes Drug Effects, Triamcinolone, Senescence, Triamcinolone Acetonide, Article, Dexamethasone, Cellular Senescence Drug Effects, Chondrocytes, Osteoarthritis Pathology, Osteoarthritis, Humans, Inflammation Drug Therapy, Glucocorticoids, Cells, Cultured, Cellular Senescence, Osteoarthritis Drug Therapy, Cell Proliferation, Inflammation, Glucocorticoids Pharmacology, Gene Expression Profiling, Anti-Inflammatory Agents Pharmacology, Osteoarthritis Metabolism, Cell Proliferation Drug Effects, Gene Expression Regulation Drug Effects, Chondrocytes Pathology, Dexamethasone Therapeutic Use, Dexamethasone Pharmacology, Gene Expression Regulation, Medicine, Apoptosis Drug Effects

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40195473
https://doaj.org/article/194006edd23b4f7aaa0a959c0531241b
https://phaidra.vetmeduni.ac.at/o:4102
https://doi.org/10.1038/s41598-025-96050-2

Sustainable Nanoparticles from Stephania glabra and Analysis of Their Anticancer Potential on 2D and 3D Models of Prostate Cancer

Συγγραφείς: Prachi Vaid, Adesh K. Saini, Raju Kumar Gupta, Eshu Singhal Sinha, Deepak Sharma, Walaa F. Alsanie, Vijay Kumar Thakur, Reena V. Saini

Πηγή: Applied Biochemistry and Biotechnology. 196:3511-3533

Θεματικοί όροι: Male, 3D tumor model, Silver, Silver/chemistry, Metal Nanoparticles, Antineoplastic Agents, Apoptosis, Cell Line, SDG 3 - Good Health and Well-being, Reactive Oxygen Species/metabolism, Cell Line, Tumor, Humans, Bimetallic nanoparticles, Prostate cancer, Tumor, Plant Extracts, Apoptosis/drug effects, Plant Extracts/pharmacology, Metal Nanoparticles/chemistry, Prostatic Neoplasms, 3. Good health, Stephania glabra, Copper oxide nanoparticles, PC-3 Cells, Copper/chemistry, Prostatic Neoplasms/drug therapy, Silver nanoparticles, Reactive Oxygen Species, Antineoplastic Agents/pharmacology, Copper

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37682510

Organoid drug profiling identifies methotrexate as a therapy for SCCOHT, a rare pediatric cancer

Συγγραφείς: Seok-Young Kim, Tamar A. E. de Weert, Marijn Vermeulen, Femke Ringnalda, Lennart Kester, Jozsef Zsiros, Selma Eising, Jan J. Molenaar, Karin Sanders, Marc van de Wetering, Hans Clevers

Πηγή: Sci Adv

Θεματικοί όροι: Adolescent, Resistance, Apoptosis, Anticancer drugs, Gene, Cell Line, In-vitro, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Patient-derived organoids, Humans, Child, Tumor Suppressor Protein p53/metabolism, Inhibition, Tumor, Hypercalcemic type, Ovary, Apoptosis/drug effects, Smarca4 mutations, Organoids, Methotrexate, Methotrexate/pharmacology, Small-cell carcinoma, Female, Biomedicine and Life Sciences, Tumor Suppressor Protein p53, Organoids/drug effects

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40009666

CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer

Συγγραφείς: Ziegler, Dorian, Parashar, Kanishka, Leal-Esteban, Lucia, López-Alcalá, Jaime, Castro, Wilson, Zanou, Nadège, Martinez-Carreres, Laia, Huber, Katharina, Berney, Xavier Pascal, Malagón, María, Roger, Catherine, Berger, Marie-Agnès, Gouriou, Yves, Paone, Giulia, Gallart-Ayala, Hector, Sflomos, George, Ronchi, Carlos, Ivanisevic, Julijana, Brisken, Cathrin, Rieusset, J., Irving, Melita, Fajas, Lluis

Συνεισφορές: Gouriou, Yves

Πηγή: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-23 (2025)
Nature communications, vol. 16, no. 1, pp. 541

Θεματικοί όροι: Triple Negative Breast Neoplasms/metabolism, Triple Negative Breast Neoplasms/pathology, Triple Negative Breast Neoplasms/genetics, Humans, Apoptosis/drug effects, Mitochondria/metabolism, Female, Cyclin-Dependent Kinase 4/metabolism, Cyclin-Dependent Kinase 4/genetics, Cell Line, Tumor, Animals, Cell Proliferation/drug effects, Mitochondrial Dynamics/drug effects, Endoplasmic Reticulum/metabolism, Mice, Cyclic AMP-Dependent Protein Kinases/metabolism, Cyclic AMP-Dependent Protein Kinases/genetics, Calcium Signaling, Science, Cyclin-Dependent Kinase 4, Triple Negative Breast Neoplasms, Apoptosis, Endoplasmic Reticulum, Mitochondrial Dynamics, Cyclic AMP-Dependent Protein Kinases, Article, Mitochondria, [SDV] Life Sciences [q-bio], Cell Proliferation

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39788939
https://doaj.org/article/b375f83e71b8478aa0b895a1b114bfdc
https://serval.unil.ch/notice/serval:BIB_C59FE7AA0BFC
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_C59FE7AA0BFC3
https://serval.unil.ch/resource/serval:BIB_C59FE7AA0BFC.P001/REF.pdf
https://hdl.handle.net/10668/30890
https://univ-lyon1.hal.science/hal-05001542v1/document
https://univ-lyon1.hal.science/hal-05001542v1
https://doi.org/10.1038/s41467-024-55605-z

Exploring the antiproliferative effect of PI3K/Akt/mTOR pathway and CDK4/6 inhibitors in human papillomavirus‑positive and ‑negative head and neck squamous cell carcinoma cell lines

Συγγραφείς: Verhees, Femke, Demers, Imke, Legemaate, Dion, Jacobs, Robin, Hoeben, Ann, Kremer, Bernd, Speel, Ernst-Jan

Πηγή: Int J Oncol

Θεματικοί όροι: Pyridines, Cell Survival, Aminopyridines, Apoptosis, Head and Neck Neoplasms/drug therapy virology metabolism, cell survival, Piperazines, Cell Line, Cell Proliferation/drug effects, Phosphatidylinositol 3-Kinases, Papillomavirus Infections/drug therapy virology, Signal Transduction/drug effects, Cell Line, Tumor, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Thiazoles/pharmacology, Proto-Oncogene Proteins c-akt/metabolism, Humans, Piperazines/pharmacology, human papillomavirus, Protein Kinase Inhibitors, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Pyridines/pharmacology, Tumor, Squamous Cell Carcinoma of Head and Neck, TOR Serine-Threonine Kinases, Apoptosis/drug effects, Papillomavirus Infections, apoptosis, Cyclin-Dependent Kinase 4, Human Papillomavirus Viruses, cell line, Articles, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase 6/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism antagonists & inhibitors, Aminopyridines/pharmacology, Protein Kinase Inhibitors/pharmacology therapeutic use, Head and Neck Neoplasms, Purines, Squamous Cell Carcinoma of Head and Neck/drug therapy virology metabolism pathology, cell cycle, head and neck cancer, Cyclin-Dependent Kinase 4/antagonists & inhibitors metabolism, Phosphatidylinositol 3-Kinases/metabolism, Proto-Oncogene Proteins c-akt, Purines/pharmacology, Cell Survival/drug effects, Signal Transduction

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39791215

Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

Συγγραφείς: Stevenson, Leanne, Cairns, Lauren, Li, Xiaodun, Jammula, Sriganesh, Taylor, Harriet, Douglas, Rosalie, McCabe, Niamh, Gavory, Gerald, Jacq, Xavier, Fitzgerald, Rebecca C., Kennedy, Richard D., Harrison, Timothy, Turkington, Richard C.

Συνεισφορές: Apollo - University of Cambridge Repository

Πηγή: Sci Rep
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Stevenson, L, Cairns, L, Li, X, Jammula, S, Taylor, H, Douglas, R, McCabe, N, Gavory, G, Jacq, X, Fitzgerald, R C, Kennedy, R D, Harrison, T & Turkington, R C 2024, 'Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma', Scientific Reports, vol. 14, 32121 . https://doi.org/10.1038/s41598-024-83912-4

Θεματικοί όροι: 0301 basic medicine, tumor, Esophageal Neoplasms, Cell Survival, Science, Apoptosis, Antineoplastic Agents, Adenocarcinoma, inhibitor of apoptosis proteins - metabolism - antagonists & inhibitors, Article, Inhibitor of Apoptosis Proteins, apoptosis - drug effects, proto-oncogene proteins c-akt - metabolism, 03 medical and health sciences, Cell Line, Tumor, cell survival - drug effects, Humans, cell proliferation - drug effects, humans, Cell Proliferation, drug synergism, 0303 health sciences, drug resistance, neoplasm - drug effects, drug resistance, neoplasm - drug effects, Drug Synergism, cell line, adenocarcinoma - drug therapy - metabolism - pathology, cell line, tumor, signal transduction - drug effects, Drug Resistance, Neoplasm, Medicine, Proto-Oncogene Proteins c-akt, antineoplastic Agents - pharmacology, esophageal neoplasms - drug therapy - metabolism - pathology, Signal Transduction

Περιγραφή αρχείου: application/pdf; application/zip; text/xml

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39739112
https://doaj.org/article/fef048df10404b758cee606c430aea71

Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome

Συγγραφείς: Catello Giordano, Jonatan Kendler, Maximilian Sexl, Sebastian Kollman, Maxim Varenicja, Boglárka Szabó, Gerald Timelthaler, Dominik Kirchhofer, Oldamur Hollóczki, Suzanne D. Turner, Richard Moriggl, Lukas Kenner, Mohamed Touaibia, Olaf Merkel

Πηγή: issn:2213-2317 ; Redox Biology.

Θεματικοί όροι: Humans, Caffeic Acids Pharmacology, Caffeic Acids Chemistry, Phenylethyl Alcohol Analogs & Derivatives, Phenylethyl Alcohol Pharmacology, Phenylethyl Alcohol Chemistry, Centrosome Drug Effects, Centrosome Metabolism, Antineoplastic Agents Pharmacology, Antineoplastic Agents Chemistry, Apoptosis Drug Effects, Cell Line, Tumor, Cell Proliferation Drug Effects

Περιγραφή αρχείου: application/pdf

Relation: isPartOf:https://phaidra.vetmeduni.ac.at/o:605[Open Access Publikationen]; https://phaidra.vetmeduni.ac.at/o:4027

Διαθεσιμότητα: https://doi.org/10.1016/j.redox.2025.103582
https://phaidra.vetmeduni.ac.at/o:4027