First-in-class anti-human CD45RC antibody targets CD45RChigh T and B cells to mitigate pathogenic immune responses

Συγγραφείς: Bergua, Cécile, Ahmil-Boiteau, Ghenima, Ouisse, Laure-Hélène, Vimond, Nadège, Sérazin, Céline, Dugast, Lisa, Humeau, Romain, Salama, Apolline, Tesson, Laurent, Swinnen, Katleen, van Brempt, Ronald, Collette, Alexis, Anegon, Ignacio, Guillonneau, Carole

Συνεισφορές: KERANDEL-DION, Céline

Πηγή: Mol Ther

Θεματικοί όροι: GvHD, humanized mouse model, B-Lymphocytes, monoclonal antibody therapy, T-Lymphocytes, apoptosis, Antibodies, Monoclonal, Graft vs Host Disease, T and B lymphocytes, ADCP, autoimmune disease, Apoptosis, immunomodulation, [SDV] Life Sciences [q-bio], Mice, Disease Models, Animal, antibody-dependent cellular phagocytosis, graft-versus-host disease, Humans, Animals, Leukocyte Common Antigens, Original Article, immune cell depletion, CD45RC

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41174880
https://pubmed.ncbi.nlm.nih.gov/41174880/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12882382/
https://doi.org/10.1016/j.ymthe.2025.10.057

Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement

Συγγραφείς: Poling, Holly M.^{Aff1, Aff2, Aff3}, Noël, Théo^Aff4, Singh, Akaljot^{Aff1, Aff3}, Fisher, Garrett W.^Aff1, Thorner, Konrad^Aff5, Chaturvedi, Praneet^Aff5, Nattamai, Kalpana^Aff3, Srivastava, Kalpana^Aff3, Batie, Matthew R.^Aff6, Hausfeld, Taylor^Aff1, Pitstick, Amy L.^Aff3, Brown, Nicole E.^{Aff1, Aff3}, Ménoret, Séverine^{Aff7, Aff8}, Anegon, Ignacio^Aff7, Barrile, Riccardo^{Aff2, Aff3}, Mayhew, Christopher N.^{Aff3, Aff5}, Takebe, Takanori^{Aff3, Aff5, Aff9}, Wells, James M.^{Aff3, Aff5}, Helmrath, Michael A.^{Aff1, Aff3, IDs41551026016886_cor1}, Mahe, Maxime M.^{Aff1, Aff3, Aff4, IDs41551026016886_cor2}

Πηγή: Nature Biomedical Engineering. :1-17

Generation of a compound heterozygous ABCA4 rat model with pathological features of STGD1

Συγγραφείς: Morival, Clément, Croyal, Mikaël, Remy, Séverine, Mortier, Elodie, Libeau, Lyse, Veziers, Joëlle, Provost, Nathalie, Demilly, Joanna, Mendes-Madeira, Alexandra, Isiegas, Carolina, Tesson, Laurent, Anegon, Ignacio, Adjali, Oumeya, Cronin, Therese

Συνεισφορές: JAULIN, Nicolas

Πηγή: Hum Mol Genet

Θεματικοί όροι: Heterozygote, Retina, Rats, [SDV] Life Sciences [q-bio], G1961E variant, Stargardt disease, Disease Models, Animal, Macular Degeneration, Phenotype, genetically modified rat, Mutation, Animals, Stargardt Disease, Humans, ATPase Binding Cassette Transporter 4, Original Article, ATP-Binding Cassette Transporters

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40273359
https://nantes-universite.hal.science/hal-05612886v1
https://doi.org/10.1093/hmg/ddaf057

Stabilization of Human CD8 + Treg in Inflammatory Environments Through FOXP3 Expression

Συγγραφείς: Bézie, Séverine, Greig, Jenny, Salle, Sonia, Lasselin, Juliette, Dugast, Lisa, Tesson, Laurent, Sérazin, Céline, Vimond, Nadège, Anegon, Ignacio, Guillonneau, Carole

Συνεισφορές: KERANDEL-DION, Céline

Πηγή: European Journal of Immunology. 56

Θεματικοί όροι: [SDV] Life Sciences [q-bio], Inflammation, FOXP3, inflammation, Humans, Cytokines, Forkhead Transcription Factors, stability, CD8-Positive T-Lymphocytes, gene regulation, T-Lymphocytes, Regulatory, Cells, Cultured, CD8+ Tregs

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41630158
https://inserm.hal.science/inserm-05577894v1
https://doi.org/10.1002/eji.70140

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Συγγραφείς: Leuillier, Matthieu, Chelgham, Mustapha, Messaoudi, Hind, Tu, Ly, Ménoret, Severine, Thuillet, Raphaël, Groussard, Déborah, Lillich, Felix, Ottaviani, Mina, Nicol, Lionel, Mulder, Paul, Humbert, Marc, Richard, Vincent, Anegon, Ignacio, Morisseau, Christophe, Proschak, Ewgenij, Guignabert, Christophe, Bellien, Jérémy

Συνεισφορές: KERANDEL-DION, Céline

Πηγή: Compr Physiol

Θεματικοί όροι: Epoxide Hydrolases, Male, phosphatase activity, Hypertension, Pulmonary, Myocytes, Smooth Muscle, soluble epoxide hydrolase, Pulmonary Artery, Rats, SIRT3, [SDV] Life Sciences [q-bio], Rats, Sprague-Dawley, Sirtuin 3, pulmonary hypertension, Animals, Humans, Sirtuins, Cells, Cultured, Research Article

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41652841
https://pmc.ncbi.nlm.nih.gov/articles/PMC12881838/
https://pubmed.ncbi.nlm.nih.gov/41652841/
https://doi.org/10.1002/cph4.70108
https://inserm.hal.science/inserm-05577851v1
https://inserm.hal.science/inserm-05577851v1/document
https://doi.org/10.1002/cph4.70108

The phosphatase activity of soluble epoxide hydrolase regulates vascular calcification through the metabolism of pyrophosphate anions

Συγγραφείς: Messaoudi, Hind, Varennes, Olivier, Berg, Elodie, Perzo, Nicolas, Renet, Sylvanie, Chegrani, Ghiles, Duflot, Thomas, Feugray, Guillaume, Lillich, Felix, Kauffenstein, Gilles, Brunel, Valéry, Six, Isabelle, Mentaverri, Romuald, Richard, Vincent, Anegon, Ignacio, Morisseau, Christophe, Kamel, Saïd, Proschak, Ewgenij, Bellien, Jérémy

Συνεισφορές: Nothias, Denis

Πηγή: Cell Death Dis

Θεματικοί όροι: Diphosphates, Epoxide Hydrolases, Male, Myocytes, Smooth Muscle, Animals, Humans, Renal Insufficiency, Chronic, Vascular Calcification, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Article, Aorta, Rats

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41455787
https://pmc.ncbi.nlm.nih.gov/articles/PMC12847717/
https://doi.org/10.1038/s41419-025-08390-6
https://pubmed.ncbi.nlm.nih.gov/41455787/
https://u-picardie.hal.science/hal-05442030v1/document
https://doi.org/10.1038/s41419-025-08390-6
https://u-picardie.hal.science/hal-05442030v1

Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson’s disease

Συγγραφείς: Kinet, Rémi^Aff1, Sikora, Joanna^{Aff1, Aff2}, Arotcarena, Marie-Laure^Aff1, Decourt, Melina^Aff2, Balado, Eric^Aff2, Doudnikoff, Evelyne^Aff1, Bohic, Sylvain^Aff3, Vesnaver, Marta^Aff4, Lovisotto, Anna^Aff1, Thiolat, Marie-Laure^Aff1, Dutheil, Nathalie^Aff1, Mazzocco, Claire^Aff1, Harhouri, Karim^Aff5, Steinschneider, Rémy^Aff5, Menoret, Severine^Aff6, Tesson, Laurent^Aff7, Anegon, Ignacio^Aff8, Morari, Michele^Aff9, Vila, Miquel^{Aff10, Aff11, Aff12, Aff13}, Georges, François^Aff1, Bezard, Erwan^Aff1, Fernagut, Pierre-Olivier^{Aff2, IDs41531025011710_cor1}, Dehay, Benjamin^{Aff1, IDs41531025011710_cor2}

Πηγή: npj Parkinson's Disease. 11(1)

Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction

Συγγραφείς: Willer, Anaïs Saint-Martin, Ruffenach, Grégoire, Masson, Bastien, El Jekmek, Kristelle, Boët, Angèle, Adão, Rui, Gourmelon, Mathieu, Beauvais, Antoine, Sabourin, Jessica, Dutheil, Mary, Ghigna, Maria-Rosa, Tesson, Laurent, Ménoret, Séverine, Anegon, Ignacio, Bauer, Fabrice, de Montpréville, Vincent, Hebbar, Sudarshan, Brás-Silva, Carmen, Stauderman, Kenneth, Humbert, Marc, Mercier, Olaf, Montani, David, Capuano, Véronique, Antigny, Fabrice

Συνεισφορές: KERANDEL-DION, Céline

Πηγή: JCI Insight

Θεματικοί όροι: Male, Pulmonary Arterial Hypertension, Monocrotaline, Indoles, Pulmonology, ORAI1 Protein, Phenylpropionates, Hypertension, Pulmonary, Myocytes, Smooth Muscle, Calcium signaling, Pulmonary Artery, Cardiovascular disease, Vascular biology, Sildenafil Citrate, Rats, [SDV] Life Sciences [q-bio], Pyridazines, Rats, Sprague-Dawley, Disease Models, Animal, Animals, Humans, Female, Drug Therapy, Combination, Pyrroles, Research Article

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41212057
https://pmc.ncbi.nlm.nih.gov/articles/PMC12643499/
https://pubmed.ncbi.nlm.nih.gov/41212057/
https://doi.org/10.1172/jci.insight.191780
https://inserm.hal.science/inserm-05444511v1/document
https://doi.org/10.1172/jci.insight.191780
https://inserm.hal.science/inserm-05444511v1

Efficient generation of human immune system rats using human CD34+ cells

Συγγραφείς: Ménoret, Séverine, Renart-Depontieu, Florence, Martin, Gaelle, Thiam, Kader, Anegon, Ignacio

Συνεισφορές: Nantes Université, Bibliothèque universitaire, Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Team 2 : Cell and gene engineering in tolerance, fertility and regenerative medicine (Team 2 - U1064 Inserm - CR2TI), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), genOway Lyon, Région Pays de la Loire through the research network Biogenouest, Fondation pour la Re-cherche Me´dicale (FRM REP202110014143)

Πηγή: Stem Cell Reports

Θεματικοί όροι: MESH: Hematopoietic Stem Cells / cytology, MESH: T-Lymphocytes / immunology, MESH: Rats, [SDV]Life Sciences [q-bio], T-Lymphocytes, regenerative medicine, Antigens, CD34, MESH: Hematopoietic Stem Cells / immunology, Mice, Report, MESH: Receptors, Immunologic / metabolism, Animals, Humans, MESH: Animals, MESH: B-Lymphocytes / cytology, Immunologic / genetics, immunodeficient rodents, Receptors, Immunologic, MESH: Immune System / metabolism, cancer models, MESH: Mice, human immune system mice, B-Lymphocytes, MESH: Humans, MESH: Hematopoietic Stem Cells / metabolism, MESH: Cytokines / metabolism, Hematopoietic Stem Cell Transplantation, CD34/metabolism, Hematopoietic Stem Cells, Antigens, Differentiation, MESH: B-Lymphocytes / immunology, Rats, [SDV] Life Sciences [q-bio], MESH: B-Lymphocytes / metabolism, MESH: Hematopoietic Stem Cell Transplantation / methods, Differentiation, Immune System, Cytokines, MESH: Antigens, Immunologic / immunology, immunotherapy, MESH: T-Lymphocytes / metabolism, transplantation

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39151431
https://inserm.hal.science/inserm-04711780v1/document
https://doi.org/10.1016/j.stemcr.2024.07.005
https://inserm.hal.science/inserm-04711780v1

Two subsets of regulatory CD8+ T cells with differential transcriptome revealed by single cell analysis

Συγγραφείς: Sérazin, Céline ¹, Dugast, Lisa ¹, Flippe, Léa ¹, Streitz, Mathias ², Wendering, Désirée-Jacqueline ^{2, 3}, Schlickeiser, Stephan ^{2, 3}, Heinrich, Frederik ⁴, Durek, Pawel ⁴, Guerra, Gabriela Maria ⁴, Lehmann, Katrin ⁴, Mashreghi, Mir-Farzin ⁴, Wajant, Harald ⁵, Volk, Hans Dieter ², Anegon, Ignacio ¹, David, Laurent ¹, Bézie, Séverine ¹, Guillonneau, Carole ^{1, 6, ∗}

Πηγή: In iScience 17 October 2025 28(10)

CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury

Συγγραφείς: Leuillier, Matthieu, Duflot, Thomas, Ménoret, Séverine, Messaoudi, Hind, Djerada, Zoubir, Groussard, Déborah, Denis, Raphaël GP, Chevalier, Laurence, Karoui, Ahmed, Panthu, Baptiste, Thiébaut, Pierre-Alain, Schmitz-Afonso, Isabelle, Nobis, Séverine, Campart, Cynthia, Henry, Tiphaine, Sautreuil, Camille, Luquet, Serge H, Beseme, Olivia, Féliu, Catherine, Peyret, Hélène, Nicol, Lionel, Henry, Jean-Paul, Renet, Sylvanie, Mulder, Paul, Wan, Debin, Tesson, Laurent, Heslan, Jean-Marie, Duché, Angéline, Jacques, Sébastien, Ziegler, Frédéric, Brunel, Valéry, Rautureau, Gilles JP, Monteil, Christelle, do Rego, Jean-Luc, do Rego, Jean-Claude, Afonso, Carlos, Hammock, Bruce, Madec, Anne-Marie, Pinet, Florence, Richard, Vincent, Anegon, Ignacio, Guignabert, Christophe, Morisseau, Christophe, Bellien, Jérémy

Πηγή: Journal of Advanced Research. 43

Θεματικοί όροι: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Nutrition (rcdc), Cardiovascular (rcdc), Genetics (rcdc), Obesity (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), Cardiovascular (hrcs-hc), Metabolic and endocrine (hrcs-hc), Animals (mesh), Female (mesh), Male (mesh), Rats (mesh), CRISPR-Cas Systems (mesh), Epoxide Hydrolases (mesh), Heart Diseases (mesh), Heart Injuries (mesh), Insulin Resistance (mesh), Lysophospholipids (mesh), Obesity (mesh), Phosphoric Monoester Hydrolases (mesh), Reperfusion Injury (mesh), Soluble epoxide hydrolase, Lipid phosphatase, CRISPR-Cas9, Thermogenesis, Obesity, Cardiac ischemic injury, Animals (mesh), Rats (mesh), Heart Diseases (mesh), Reperfusion Injury (mesh), Insulin Resistance (mesh), Obesity (mesh), Heart Injuries (mesh), Epoxide Hydrolases (mesh), Phosphoric Monoester Hydrolases (mesh), Lysophospholipids (mesh), Female (mesh), Male (mesh), CRISPR-Cas Systems (mesh), CRISPR-Cas9, Cardiac ischemic injury, Lipid phosphatase, Obesity, Soluble epoxide hydrolase, Thermogenesis, Animals (mesh), Female (mesh), Male (mesh), Rats (mesh), CRISPR-Cas Systems (mesh), Epoxide Hydrolases (mesh), Heart Diseases (mesh), Heart Injuries (mesh), Insulin Resistance (mesh), Lysophospholipids (mesh), Obesity (mesh), Phosphoric Monoester Hydrolases (mesh), Reperfusion Injury (mesh)

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/1qj4r9ns
https://escholarship.org/content/qt1qj4r9ns/qt1qj4r9ns.pdf

Rat model of X-linked myotubular myopathy with pathological signs in skeletal muscles and liver

Συγγραφείς: Navas-Navarro, Paloma, Renaud-Gabardos, Edith, Salman, Badih, Mangin, Louise, Benyamine, Hélène, Corre, Guillaume, Goddard, Melissa, Tanniou, Guillaume, Guerchet, Nicolas, Krakau, Paul, Martin, Samia, Lawlor, Michael D., Concordet, Jean-Paul, Anegon, Ignacio, Buj-Bello, Ana

Συνεισφορές: Navas Navarro, Paloma

Θεματικοί όροι: [SDV.BA] Life Sciences [q-bio]/Animal biology, [SDV.GEN] Life Sciences [q-bio]/Genetics

Σύνδεσμος πρόσβασης: https://hal.science/hal-05312314v1

Evaluation of an AAV9-mini-dystrophin gene therapy candidate in a rat model of Duchenne muscular dystrophy

Συγγραφείς: Le Guiner, Caroline, Xiao, Xiao, Larcher, Thibaut, Lafoux, Aude, Huchet, Corinne, Toumaniantz, Gilles, Adjali, Oumeya, Anegon, Ignacio, Remy, Séverine, Grieger, Josh, Li, Juan, Farrokhi, Vahid, Neubert, Hendrik, Owens, Jane, Mcintyre, Maritza, Moullier, Philippe, Samulski, R. Jude

Συνεισφορές: KERANDEL-DION, Céline, Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques / Translational Research in Gene Therapy - UMR_S 1089 (TARGET), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Shanghai Jiao Tong University Shanghai, Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Therassay Platform, CAPACITES, Université de Nantes (UN), Nantes Université (Nantes Univ), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Plate-forme Therassay Onco-Hématologie, Capacités UN Nantes, Institut du Thorax Nantes, Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Team 2 : Cell and gene engineering in tolerance, fertility and regenerative medicine (Team 2 - U1064 Inserm - CR2TI), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Institut de Transplantation et de Recherche en Transplantation CHU Nantes (ITERT), Bamboo Therapeutics Chapel Hill, NC, USA (BT - Pfizer), University of North Carolina at Chapel Hill NC, USA (UNC), Pfizer Inc. Andover, MA, USA, Pfizer Inc. Cambridge, MA, USA, University of North Carolina Chapel Hill (UNC), University of North Carolina System (UNC)

Πηγή: Mol Ther Methods Clin Dev
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss, Pp 30-47 (2023)

Θεματικοί όροι: Duchenne muscular dystrophy, QH573-671, [SDV]Life Sciences [q-bio], recombinant adeno-associated virus, QH426-470, gene therapy, DMDmdx rat, 3. Good health, [SDV] Life Sciences [q-bio], mini-dystrophin, age, dose study, Genetics, Original Article, Cytology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37746247
https://doaj.org/article/7a89e1515ecf4452944c4318d3851f25
https://inserm.hal.science/inserm-04240276v1/document
https://doi.org/10.1016/j.omtm.2023.05.017
https://inserm.hal.science/inserm-04240276v1

Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells

Συγγραφείς: Gantier, Malika^{Aff1, Aff2, IDs13287024036739_cor1}, Rispal, Raphaël^Aff2, Fourrier, Angélique^Aff1, Ménoret, Séverine^Aff3, Delbos, Frédéric^Aff1, Anegon, Ignacio^Aff2, Nguyen, Tuan Huy^Aff1

Πηγή: Stem Cell Research & Therapy. 15(1)

Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling

Συγγραφείς: Berrebeh, Nihel, Mbouamboua, Yvon, Thuillet, Raphaël, Ottaviani, Mina, Robert, Fabien, Kamel Chelgham, Mustapha, Magnone, Virginie, Desroches-Castan, Agnès, Ricard, Nicolas, Anegon, Ignacio, Remy, Séverine, Schermuly, Ralph Theo, Lebrigand, Kevin, Kojonazarov, Baktybek, Savale, Laurent, Humbert, Marc, Bailly, Sabine, Barbry, Pascal, Tu, Ly, Guignabert, Christophe

Συνεισφορές: Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), BioSanté (UMR BioSanté), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Department of Internal Medicine, Member of the German Center of Lung Research (DZL), Justus-Liebig-University of Giessen (JLU), Giessen, Germany, Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France, ANR-23-IAHU-0007,RespirERA,Santé Respiratoire, Environnement et Vieillissement(2023)

Πηγή: ISSN: 0027-8424.

Θεματικοί όροι: Pulmonary Vascular Remodeling, Pulmonary Microvasculature, Pulmonary Hypertension, VEGF, ALK1, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/40549904; PUBMED: 40549904; PUBMEDCENTRAL: PMC12232436

Διαθεσιμότητα: https://hal.science/hal-05190343
https://hal.science/hal-05190343v1/document
https://hal.science/hal-05190343v1/file/BMP-9%20controls%20pulmonary%20vascular%20growth%20and%20remodeling.pdf
https://doi.org/10.1073/pnas.2410229122

Human pluripotent stem cell-derived hepatic progenitors exhibit a partially hypoimmunogenic phenotype and actively inhibit immune responses

Συγγραφείς: Gantier, Malika, Ménoret, Séverine, Fourrier, Angélique, Delbos, Frédéric, Nguyen, Tuan Huy, Anegon, Ignacio

Συνεισφορές: LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ), Immunology and New Concepts in ImmunoTherapy (INCIT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Team 2 : Cell and gene engineering in tolerance, fertility and regenerative medicine (Team 2 - U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Plateforme "Production de protéines recombinantes" (P2R - INSERM UMS016/CNRS UMS3556/UN FED4203), Structure fédérative de recherche François Bonamy (SFR François Bonamy), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), GoLiver Therapeutics UNIV Nantes (Institut de Recherche en Santé), Institut de Recherche en Santé de l'Université de Nantes (IRS-UN), The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by a fellowship CIFRE-ANRT (2019/0174) and the French Government’s “France Relance” program « Soutien à l’investissement et la modernisation de l’industrie » and Bpifrance (GOMILLENIUM project).

Πηγή: ISSN: 1664-3224.

Θεματικοί όροι: hepatic progenitors, liver, pluripotent stem cells, tolerance, transplantation, MESH: Cell Differentiation / immunology, MESH: Cells, Cultured, MESH: Pluripotent Stem Cells / metabolism, MESH: T-Lymphocytes / immunology, MESH: Hepatocytes / immunology, MESH: Hepatocytes / metabolism, MESH: Humans, MESH: Killer Cells, Natural / immunology, Natural / metabolism, MESH: Liver / immunology, MESH: Phenotype, MESH: Pluripotent Stem Cells / immunology, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/40070824; PUBMED: 40070824; PUBMEDCENTRAL: PMC11893836

Διαθεσιμότητα: https://inserm.hal.science/inserm-05039836
https://inserm.hal.science/inserm-05039836v1/document
https://inserm.hal.science/inserm-05039836v1/file/fimmu-1-1507317.pdf
https://doi.org/10.3389/fimmu.2025.1507317

Can Humanized Immune System Mouse and Rat Models Accelerate the Development of Cytomegalovirus-Based Vaccines Against Infectious Diseases and Cancers?

Συγγραφείς: Craft, Kaci, Amanor, Athina, Barnett, Ian, Donaldson, Clarke, Anegon, Ignacio, Madduri, Srinivas, Tang, Qiyi, Bility, Moses

Συνεισφορές: Howard University College of Medicine Washington, DC, USA, Team 2 : Cell and gene engineering in tolerance, fertility and regenerative medicine (Team 2 - U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Université de Genève = University of Geneva (UNIGE), R01 AI152655/AI/NIAID NIH HHS/United StatesR01 AI162615/AI/NIAID NIH HHS/United StatesSC1 AI112785/AI/NIAID NIH HHS/United StatesR01AI15265/GF/NIH HHS/United States

Πηγή: ISSN: 1661-6596.

Θεματικοί όροι: HCMV-based vaccines, HIV vaccines, HIV/AIDS-animal models, human cancer xenograft models, humanized immune system and rats, MESH: Animals, MESH: Cytomegalovirus Infections / immunology, MESH: Rats, MESH: Cytomegalovirus Infections / prevention & control, MESH: Cytomegalovirus Vaccines / immunology, MESH: Cytomegalovirus / immunology, MESH: Disease Models, Animal, MESH: Humans, MESH: Mice, MESH: Neoplasms / immunology, MESH: Neoplasms / prevention & control, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/40243710; PUBMED: 40243710; PUBMEDCENTRAL: PMC11988357

Διαθεσιμότητα: https://inserm.hal.science/inserm-05117161
https://inserm.hal.science/inserm-05117161v1/document
https://inserm.hal.science/inserm-05117161v1/file/ijms-26-03082.pdf
https://doi.org/10.3390/ijms26073082

New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma

Συγγραφείς: Joalland, Noémie, Quéméner, Agnès, Deshayes, Sophie, Humeau, Romain, Maillasson, Mike, Lebihan, Héloïse, Salama, Apolline, Fresquet, Judith, Remy, Séverine, Mortier, Erwan, Blanquart, Christophe, Guillonneau, Carole, Anegon, Ignacio

Συνεισφορές: Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ), Team 2 : Cell and gene engineering in tolerance, fertility and regenerative medicine (Team 2 - U1064 Inserm - CR2TI), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers (CRCI2NA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Manipulation of Lymphocytes for Immunotherapy (CRCI2NA / Eq 12), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Immunomodulation of the Tumor Microenvironment and Immunotherapy of Thoracic Cancers (CRCI2NA / Eq 1), BioCore Nantes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Nantes Université (Nantes Univ), ANR-11-LABX-0016,IGO,Immunothérapies Grand Ouest(2011)

Πηγή: ISSN: 2051-1426 ; Journal for Immunotherapy of Cancer ; https://inserm.hal.science/inserm-05036353 ; Journal for Immunotherapy of Cancer, 2025, 13 (3), pp.e010112. ⟨10.1136/jitc-2024-010112⟩.

Θεματικοί όροι: Cytokine, Immunotherapy, Macrophages, Mesothelioma, Tolerance, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/40101804; PUBMED: 40101804; PUBMEDCENTRAL: PMC11927444

Διαθεσιμότητα: https://inserm.hal.science/inserm-05036353
https://inserm.hal.science/inserm-05036353v1/document
https://inserm.hal.science/inserm-05036353v1/file/e010112.full%20copie.pdf
https://doi.org/10.1136/jitc-2024-010112

Excess of guide RNA reduces knockin efficiency and drastically increases on-target large deletions

Συγγραφείς: Chenouard, Vanessa ^{1, 2}, Leray, Isabelle ³, Tesson, Laurent ¹, Remy, Severine ¹, Allan, Alasdair ⁴, Archer, Daniel ⁴, Caulder, Adam ⁴, Fortun, Agnès ^{5, 6}, Bernardeau, Karine ⁵, Cherifi, Yacine ², Teboul, Lydia ⁴, David, Laurent ^{1, 3}, Anegon, Ignacio ^{1, 7, ∗}

Πηγή: In iScience 21 April 2023 26(4)

Federation of Clinical Immunology Societies goes South 2021: Advanced Course on Molecular and Cellular Translational Immunology

Συγγραφείς: Diethelm-Varela, Benjamin, Reyes, Antonia, Rosenstein, Yvonne, Kalil, Jorge, Hill, Marcelo, Docena, Guillermo, Anegon, Ignacio, González, Pablo, Kalergis, Alexis

Συνεισφορές: Nantes Université, Bibliothèque universitaire, Pontificia Universidad Católica de Chile (UC), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Universidade de São Paulo = University of São Paulo (USP), Institut Pasteur de Montevideo, Pasteur Network (Réseau International des Instituts Pasteur), University of the Republic of Uruguay, Universidad Nacional de la Plata Argentine (UNLP), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Aix-Marseille Université - Institut d'Urbanisme et d'Aménagement Régional (AMU IUAR), Aix Marseille Université (AMU), Facultad de ciencias biologicas Santiago

Πηγή: Immunotherapy. 14:839-842

Θεματικοί όροι: 0301 basic medicine, [SDV]Life Sciences [q-bio], Translational immunology, infectious diseases, Vaccine development, 03 medical and health sciences, 0302 clinical medicine, Allergy and Immunology, Neoplasms, 03 Salud y bienestar, cancer, Humans, Flow cytometry, Chile, Pandemics, Cancer, tolerance, flow cytometry, autoimmunity, COVID-19, 3. Good health, [SDV] Life Sciences [q-bio], translational immunologyvaccine development, 03 Good Health and Well-being, Immunotherapy, FOCIS Goes South 2021, Tolerance

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35757836
https://hal.science/hal-04697216v1
https://doi.org/10.2217/imt-2022-0075