High prevalence of FAP+ cancer-associated fibroblasts predicts poor outcome in patients with high-grade serous ovarian cancer with high CD8 T-cell density

Authors: Corvigno, Sara, Fernebro, Josefin, Severin-Karisson, Josefin, Mezheieusky, Artur, Martin-Bernabe, Alfonso, Fuente, Laura Martin De La, Westbom-Fremer, Sofia, Carlson, Joseph W., Klein, Christian, Kannisto, Paivi, Hedenfalk, Ingrid, Malander, Susanne, Ostma, Arne, Dahlstrand, Hanna

Contributors: Institut Català de la Salut, [Corvigno S, Martín-Bernabé A] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. [Fernebro J] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Gynecologic Oncology, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden. [Severin Karlsson J] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden. [Mezheieusky A] IGP, Uppsala University, Sweden. Molecular Oncology Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Martin De La Fuente L] Department of Clinical Sciences, Division of Oncology and Pathology, Lund University and Skåne University Hospital, Lund, Sweden, Vall d'Hebron Barcelona Hospital Campus

Source: Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname

Subject Terms: Adult, DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Cystadenocarcinoma::Cystadenocarcinoma, Serous, ANATOMÍA::células::células del tejido conectivo::fibroblastos::fibroblastos asociados al cáncer, CD8-Positive T-Lymphocytes, Adenocarcinoma - Prognosi, ANATOMY::Cells::Connective Tissue Cells::Fibroblasts::Cancer-Associated Fibroblasts, Cohort Studies, ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales::carcinoma::adenocarcinoma::cistoadenocarcinoma::cistoadenocarcinoma seroso, Lymphocytes, Tumor-Infiltrating, Cancer-Associated Fibroblasts, Endopeptidases, Tumor Microenvironment, Humans, FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico, Aged, Ovarian Neoplasms, Aged, 80 and over, Cancer och onkologi, ANATOMÍA::sistemas sanguíneo e inmunológico::sangre::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T::sistemas sanguíneo e inmunológico::linfocitos T CD8-positivos, Serine Endopeptidases, FAP, T cell, Membrane Proteins, CD8, Fibroblasts, Middle Aged, ANATOMY::Hemic and Immune Systems::Blood::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::Hemic and Immune Systems::CD8-Positive T-Lymphocytes, Prognosis, Progression-Free Survival, Cystadenocarcinoma, Serous, Tumor microenvironment, Cèl·lules T, Gelatinases, Cancer and Oncology, PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas, Ovaris - Càncer - Prognosi, Fibroblast, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis, Female, DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms, Neoplasm Grading, High-grade serous ovarian cancer

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39914230
http://hdl.handle.net/11351/12857
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-551880

Fusobacterium nucleatum interacts with cancer-associated fibroblasts to promote colorectal cancer

Authors: Karta, Jessica, Meyers, Marianne, Rodriguez, Fabien, Koncina, Eric, Gilson, Cédric, Klein, Eliane, Alonso Landeira, Lidia, Aguilera Pujabet, Mònica, Nuciforo, Paolo

Contributors: Institut Català de la Salut, Karta J, Meyers M, Rodriguez F, Koncina E, Gilson C, Klein E Department of Life Sciences and Medicine (DLSM), Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. Aguilera Pujabet M, Alonso L, Nuciforo PG Molecular Oncology Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

Source: Scientia

Subject Terms: Recte - Càncer, Intestins - Microbiologia, Fibroblasts, Malalties bacterianes gramnegatives, PHENOMENA AND PROCESSES::Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome, DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Fusobacteriaceae Infections::Fusobacterium Infections, DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms, ANATOMY::Cells::Connective Tissue Cells::Fibroblasts::Cancer-Associated Fibroblasts, FENÓMENOS Y PROCESOS::fenómenos microbiológicos::microbiota::microbiota intestinal, ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::infecciones por Fusobacteriaceae::infecciones por Fusobacterium, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales, ANATOMÍA::células::células del tejido conectivo::fibroblastos::fibroblastos asociados al cáncer

File Description: application/pdf

Relation: The EMBO Journal;44(19); https://doi.org/10.1038/s44318-025-00542-w; info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00889; https://hdl.handle.net/11351/13983; 001555491700001

Availability: https://hdl.handle.net/11351/13983
https://doi.org/10.1038/s44318-025-00542-w