Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Συγγραφείς: Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano

Συνεισφορές: Institut Català de la Salut, [López-Polo V, Stephan-Otto Attolini C] Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. [Maus M] Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Zacharioudakis E, Marques FDM] Department of Biochemistry, Department of Medicine, Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Institute for Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, USA. [Lafarga M] Department of Anatomy and Cell Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University of CantabriaIDIVAL, Santander, Spain, Vall d'Hebron Barcelona Hospital Campus, Universidad de Cantabria

Πηγή: Nat Commun
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Nature Communications, 2024, 15, 7378
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Θεματικοί όροι: ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación, 0301 basic medicine, Other subheadings::Other subheadings::Other subheadings::/genetics, Interferon-Induced Helicase, IFIH1, RNA, Mitochondrial, Science, Mitocondris, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate, Article, Mitochondrial Proteins, ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria, ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::citosol, Mice, 03 medical and health sciences, Cytosol, Otros calificadores::Otros calificadores::Otros calificadores::/genética, FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular, Humans, Animals, Receptors, Immunologic, ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytosol, Cellular Senescence, RNA, Double-Stranded, Adaptor Proteins, Signal Transducing, Inflammation, 0303 health sciences, RNA-Binding Proteins, Citoplasma, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata, Mitochondria, 3. Good health, Fenotip, PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence, Immunitat, Exoribonucleases, DEAD Box Protein 58, Inflamació - Aspectes genètics, Senescence-Associated Secretory Phenotype, ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias, DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, Signal Transduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39191740
https://hdl.handle.net/11351/12613
https://hdl.handle.net/10902/33656
https://doaj.org/article/cc28ced0dc1b40c9bf6f25abf11bb830