Melatonin Enhances the Mitochondrial Functionality of Brown Adipose Tissue in Obese-Diabetic Rats

Συγγραφείς: Agil, Ahmad, Navarro-Alarcon, Miguel, Ali, Fatma Abo Zakaib, Albrakati, Ashraf, Salagre, Diego, Campoy, Cristina, Elmahallawy, Ehab K.

Συνεισφορές: Agil,A, Salagre,D Department of Pharmacology and Neurosciences Institute, School of Medicine, University of Granada, Granada, Spain. Agil,A, Salagre,D, Campoy,C Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospital of Granada, Granada, Spain. Navarro-Alarcon,M Department of Nutrition and Bromatology, School of Pharmacy, University of Granada, Granada, Spain. Ali,FAZ Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt. Albrakati,A Department of Human Anatomy, College of Medicine, Taif University,Taif, Saudi Arabia. Campoy,C Department of Pediatric, School of Medicine, University of Granada, Granada, Spain. Elmahallawy,EK Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt., This work was supported by grant SAF2016-79794-R from the Ministerio de Ciencia e Innovación (Spain) and European Regional Development Fund (ERDF).

Θεματικοί όροι: Melatonin, Brown adipose tissue, Mitochondrial function, Zücker diabetic fatty rat, Melatonina, Tejido adiposo pardo, Roedores, Diabetes Mellitus Tipo 2, Medical Subject Headings::Organisms::Eukaryota::Animals, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats, Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, Brown, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2, Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria, Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose, Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis, Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purine Nucleotides::Adenine Nucleotides::Adenosine Diphosphate, 2-Ring::Purines::Purine Nucleotides::Adenine Nucleotides::Adenosine Triphosphate

Περιγραφή αρχείου: application/pdf

Relation: https://www.mdpi.com/2076-3921/10/9/1482/htm; Agil A, Navarro-Alarcon M, Ali FAZ, Albrakati A, Salagre D, Campoy C, et al. Melatonin Enhances the Mitochondrial Functionality of Brown Adipose Tissue in Obese-Diabetic Rats. Antioxidants. 2021 Sep 17;10(9):1482; http://hdl.handle.net/10668/3727; PMC8466890

Διαθεσιμότητα: http://hdl.handle.net/10668/3727
https://doi.org/10.3390/antiox10091482

Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

Συγγραφείς: Gonzalez-Cano, Rafael, Montilla-García, Ángeles, Perazzoli, Gloria, Torres, Jesús M., Cañizares, Francisco J., Fernández-Segura, Eduardo, Costigan, Michael, Baeyens, José M., Cobos, Enrique J.

Συνεισφορές: Gonzalez-Cano,R, Montilla-García,A, Baeyens,JM, Cobos,EJ Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain. Gonzalez-Cano,R, Torres,JM, Cañizares,FJ, Fernández-Segura,E, Cobos,EJ Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain. Gonzalez-Cano,R, Cobos,EJ Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. Perazzoli,G Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. Torres,JM Department of Biochemistry, Molecular Biology and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Cañizares,FJ, Fernández-Segura,E Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain. Costigan,M Departments of Anesthesia and Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Cobos,EJ Teófilo Hernando Institute for Drug Discovery, Madrid, Spain., This study was partially supported by the Spanish State Research Agency (10.13039/501100011033) under the auspices of MINECO (grant number PID2019-108691RB-I00), and by the Junta de Andalucía (grant CTS-109).

Θεματικοί όροι: Mustard oil, Visceral pain, Resiniferatoxin, TRPA1, TRPV1, P2X, Dolor visceral, Hyperalgesia, Hiperalgesia, Nociceptors, Nociceptores, Abdominal wall, Pared abdominal, Spinal cord, Médula espinal, Medical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Sensation Disorders::Somatosensory Disorders::Hyperalgesia, Medical Subject Headings::Anatomy::Cells::Neurons::Neurons, Afferent::Sensory Receptor Cells::Nociceptors, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Irritants, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Nociceptive Pain::Visceral Pain, Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Perception::Pain Perception::Nociception, Medical Subject Headings::Anatomy::Body Regions::Torso::Abdomen::Abdominal Wall, Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purine Nucleotides::Adenine Nucleotides::Adenosine Triphosphate, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Spinal Cord, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Ligand-Gated Ion Channels::Receptors, Purinergic P2X

Περιγραφή αρχείου: application/pdf

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.613068/full; Gonzalez-Cano R, Montilla-García Á, Perazzoli G, Torres JM, Cañizares FJ, Fernández-Segura E, et al. Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors. Front Pharmacol. 2021 Jan 21;11:613068; http://hdl.handle.net/10668/4002; PMC7859884

Διαθεσιμότητα: http://hdl.handle.net/10668/4002
https://doi.org/10.3389/fphar.2020.613068