РОЛЬ СТВОЛОВЫХ КЛЕТОК В РЕГЕНЕРАЦИИ ТКАНЕЙ И ОРГАНОВ

Subject Terms: стволовые клетки, регенерация, регенеративная медицина, эмбриональные стволовые клетки, индуцированные плюрипотентные клетки, органоиды, 3D-биопринтинг, трансплантация, клеточные технологии

РОЛЬ СТВОЛОВЫХ КЛЕТОК В РЕГЕНЕРАЦИИ ТКАНЕЙ И ОРГАНОВ

Subject Terms: стволовые клетки, регенерация, регенеративная медицина, эмбриональные стволовые клетки, индуцированные плюрипотентные клетки, органоиды, 3D-биопринтинг, трансплантация, клеточные технологии

ПОЛУЧЕНИЕ ИНСУЛИН-ПРОДУЦИРУЮЩИХ КЛЕТОК ИЗ ЭМБРИОНАЛЬНЫХ И ИНДУЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ СТВОЛОВЫХ КЛЕТОК

Authors: L. A. Mozheiko

Source: Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, Vol 19, Iss 4, Pp 376-381 (2021)

Subject Terms: инсулин-продуцирующие клетки, эмбриональные стволовые клетки, индуцированные плюрипотентные стволовые клетки, сахарный диабет, Medicine

File Description: electronic resource

Relation: http://journal-grsmu.by/index.php/ojs/article/view/2677; https://doaj.org/toc/2221-8785; https://doaj.org/toc/2413-0109

Access URL: https://doaj.org/article/0642adc42b9a4ba1a41f6043b524bf4b

The non-protein fraction of embryonic stem cell secretome exerts antibacterial effects against antibiotic-resistant bacterial strains ; Небелковая фракция секретома эмбриональных стволовых клеток обладает антибактериальным эффектом, в том числе против антибиотикорезистентных штаммов бактерий

Authors: Kaigorodov D.G., Kaigorodova A.D.

Contributors: 1

Source: Russian Journal of Infection and Immunity; Vol 12, No 6 (2022); 1061-1068 ; Инфекция и иммунитет; Vol 12, No 6 (2022); 1061-1068 ; 2313-7398 ; 2220-7619

Subject Terms: secretome, embryonic stem cells, antibacterial activity, antimicrobial properties, bactericidal effect, секретом, эмбриональные стволовые клетки, антибактериальная активность, противомикробные свойства, бактерицидный эффект

File Description: application/pdf

Relation: https://iimmun.ru/iimm/article/view/1940/1565; https://iimmun.ru/iimm/article/view/1940/1624; https://iimmun.ru/iimm/article/downloadSuppFile/1940/7986; https://iimmun.ru/iimm/article/downloadSuppFile/1940/7987; https://iimmun.ru/iimm/article/downloadSuppFile/1940/8854; https://iimmun.ru/iimm/article/downloadSuppFile/1940/9405; https://iimmun.ru/iimm/article/downloadSuppFile/1940/9406; https://iimmun.ru/iimm/article/view/1940

Availability: https://iimmun.ru/iimm/article/view/1940
https://doi.org/10.15789/2220-7619-NPF-1940

Common technological processes used in manufacture of biomedical cell culture products

Authors: M. V. Supotnitskiy, A. A. Elapov, V. A. Merkulov, I. V. Borisevich, V. I. Klimov, A. N. Mironov

Source: Биопрепараты: Профилактика, диагностика, лечение, Vol 0, Iss 2, Pp 36-45 (2018)

Subject Terms: biomedical cellular product, biomedical cell technologies, stem cells, cell lines, embryonic stem cells, pluripotent stem cells, human mesenchymal stromal/stem cell, adipocytes, osteoblasts, aneuploidy, malignant transformation, биомедицинский клеточный продукт, биомедицинские клеточные технологии, стволовые клетки, плюрипотентные стволовые клетки, клеточные линии, эмбриональные стволовые клетки, адипоциты, остеобласты, анеуплоидия, злокачественная трансформация, Biotechnology, TP248.13-248.65, Medicine

File Description: electronic resource

Relation: https://www.biopreparations.ru/jour/article/view/12; https://doaj.org/toc/2221-996X; https://doaj.org/toc/2619-1156

Access URL: https://doaj.org/article/390d7427bda348e98e2588f62f3bb1a4

Promising methodological approaches to preclinical studies of biomedical cell-based products and their possible quality characteristics

Authors: M. V. Supotnitskiy, A. A. Elapov, I. V. Borisevich, V. I. Klimov, E. V. Lebedinskaya, Mironov, V. A. Merkulov

Source: Биопрепараты: Профилактика, диагностика, лечение, Vol 0, Iss 1, Pp 36-44 (2018)

Subject Terms: биомедицинский клеточный продукт, биомедицинские клеточные технологии, стволовые клетки, клеточные линии, мультипотентные мезенхимальные стромальные клетки, эмбриональные стволовые клетки, адипоциты, остеобласты, миоциты, бмкп, Biotechnology, TP248.13-248.65, Medicine

File Description: electronic resource

Relation: https://www.biopreparations.ru/jour/article/view/5; https://doaj.org/toc/2221-996X; https://doaj.org/toc/2619-1156

Access URL: https://doaj.org/article/29f40a1edaf94b14b35b81bce5589a59

Некоторые правовые аспекты использования стволовых клеток в медицинской практике

Subject Terms: биомедицина, cell technology, эмбрион, legal regulation, biomedicine, embryo, cell products, embryonic stem cells, 16. Peace & justice, 3. Good health, эмбриональные стволовые клетки, клеточные технология, клеточные продукты, правовое регулирование

Значение и механизмы регуляции диапаузы

Subject Terms: эмбриональные стволовые клетки, diapause, реактивация, reactivation, blastocyst, бластоциста, embryonic stem cells, диапауза, signal transduction, сигнальная трансдукция

Common technological processes used in manufacture of biomedical cell culture products ; Основные технологические процессы, используемые при производстве биомедицинских клеточных продуктов

Authors: M. V. Supotnitskiy, A. A. Elapov, V. A. Merkulov, I. V. Borisevich, V. I. Klimov, A. N. Mironov, М. В. Супотницкий, А. А. Елапов, В. А. Меркулов, И. В. Борисевич, В. И. Климов, А. Н. Миронов

Source: Biological Products. Prevention, Diagnosis, Treatment; № 2 (2015); 36-45 ; БИОпрепараты. Профилактика, диагностика, лечение; № 2 (2015); 36-45 ; 2619-1156 ; 2221-996X ; undefined

Subject Terms: анеуплоидия, злокачественная трансформация, biomedical cell technologies, stem cells, cell lines, embryonic stem cells, pluripotent stem cells, human mesenchymal stromal/stem cell, adipocytes, osteoblasts, aneuploidy, malignant transformation, биомедицинский клеточный продукт, биомедицинские клеточные технологии, стволовые клетки, плюрипотентные стволовые клетки, клеточные линии, эмбриональные стволовые клетки, адипоциты, остеобласты

File Description: application/pdf

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Mesenchymal stem cells as a therapeutic tool to treat sepsis. World J Stem Cells 2015; 7(2): 368-79.; Adipogenic differentiation and analysis of MSC. PromoCell GmbH. [cited 2015 March 5]. Available from: www.promocell.com.; Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F., Krause D. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-7.; Phinney D.G., Sensebé L. Mesenchymal stromal cells: misconceptions and evolving concepts. Cytotherapy 2013; 15: 140-5.; Pieternella S., Noort W.A., Scherjon S.A., Kleuburg-van der Keur G., Krusselbrink A.B., van Bezoouen R.L. et al. Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential. J Hematol. 2003; 88: 845-52.; Бурунова В.И. Проблемы стандартизации при получении клеточных культур мезенхимального происхождения: экспериментальный и теоретический анализ: автореф. дис. канд. биол. наук. М.; 2011.; Goodwin H.S., Bicknese A.R., Chien S.N., Bogucki B.D., Quinn C.O., Wall D.A. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant. 2001; 7(11): 581-8.; Gronthos S., Franklin D.M., Leddy H.A., Robey P.G., Storms R.W., Gimble J.M. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol. 2001; 189(1): 54-63.; Viswanathan S., Keating A., Deans R., Hematti P., Prockop D., Stroncek D.F. et al. Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation. Stem Cells Develop. 2014; 23(11): 1157-67.; Vater C., Kasten P., Stiehler M. Culture media for the differentiation of mesenchymal stromal cells. 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Availability: https://www.biopreparations.ru/jour/article/view/12

Manipulations with early mouse embryos for generation of genetically modified animals ; Манипуляции с ранними эмбрионами мыши для создания генетически модифицированных животных

Authors: A. N. Korablev, I. A. Serova, B. V. Skryabin, А. Н. Кораблев, И. А. Серова, Б. В. Скрябин

Source: Vavilov Journal of Genetics and Breeding; Том 21, № 7 (2017); 758-763 ; Вавиловский журнал генетики и селекции; Том 21, № 7 (2017); 758-763 ; 2500-3259

Subject Terms: трансплантация эмбрионов, zygote injection, embryonic stem cells (ESKs), injection of ESKs into blastocyst, embryotransfer, инъекция в зиготу, эмбриональные стволовые клетки (ЭСК), инъекция ЭСК в бластоцисту

File Description: application/pdf

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Availability: https://vavilov.elpub.ru/jour/article/view/1221
https://doi.org/10.18699/VJ17.291

Genome editing using CRISPR/ Cas9 system: a practical guide ; Практическое руководство по редактированию геномов системой CRISPR/Cas9

Authors: A. G. Menzorov, V. A. Lukyanchikova, A. N. Korablev, I. A. Serova, V. S. Fishman, А. Г. Мензоров, В. А. Лукьянчикова, А. Н. Кораблев, И. А. Серова, В. С. Фишман

Source: Vavilov Journal of Genetics and Breeding; Том 20, № 6 (2016); 930-944 ; Вавиловский журнал генетики и селекции; Том 20, № 6 (2016); 930-944 ; 2500-3259

Subject Terms: эмбриональные стволовые клетки, CRISPR/Cas9, embryonic stem cells

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Relation: https://vavilov.elpub.ru/jour/article/view/874/870; Bindra R.S., Goglia A.G., Jasin M., Powell S.N. Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucl. Acids Res. 2013;41(11):e115-e115. DOI 10.1093/nar/gkt255.; Brinster R.L., Chen H.Y., Trumbauer M.E., Yagle M.K., Palmiter R.D. Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc. Natl. Acad. Sci. USA. 1985;82(13): 4438-4442.; Bryja V., Bonilla S., Arenas E. Derivation of mouse embryonic stem cells. Nat. Protoc. 2006;1(4):2082-2087. DOI 10.1038/nprot.2006.355.; Chari R., Mali P., Moosburner M., Church G.M. Unraveling CRISPRCas9 genome engineering parameters via a library-on-library approach. Nature Methods. 2015;12(9):823-826. DOI 10.1038/nmeth.3473.; Datta S., Roychoudhury S., Ghosh A., Dasgupta D., Ghosh A., Chakraborty B., Roy S., Gupta S., Santra A.K., Datta S., Das K. Distinct distribution pattern of hepatitis B virus genotype C and D in liver tissue and serum of dual genotype infected liver cirrhosis and hepatocellular carcinoma patients. PloS One. 2014;9(7):e102573. DOI 10.1371/journal.pone.0102573.; Fu Y., Foden J.A., Khayter C., Maeder M.L., Reyon D., Joung J.K., Sander J.D. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 2013;31(9): 822-826. DOI 10.1038/nbt.2623.; Golding S.E., Rosenberg E., Khalil A., McEwen A., Holmes M., Neill S., Povirk L.F., Valerie K. Double strand break repair by homologous recombination is regulated by cell cycle- independent signaling via ATM in human glioma cells. J. Biol. Chemistry. 2004; 279(15):15402-15410. DOI 10.1074/jbc.M314191200.; Hogan B., Beddington R., Costantini F., Lacy E. Manipulating the Mouse Embryo. A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press, 1994.; Jinek M., Chylinski K., Fonfara I., Hauer M., Doudna J.A., Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012;337(6096):816-821. DOI 10.1126/science.1225829.; Kistler K., Vosshall L., Matthews B. Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti. Cell Report. 2015; 11(1):51-60. DOI 10.1016/j.celrep.2015.03.009.; Kouranova E., Forbes K., Zhao G., Warren J., Bartels A., Wu Y. CRISPRs for optimal targeting: Delivery of CRISPR components as DNA, RNA, and protein into cultured cells and single-cell embryos. Hum. Gene Ther. 2016;27(6):464-475. DOI 10.1089/hum. 2016.009.; Kulkarni A.S., Fortunato E.A. Stimulation of homology-directed repair at I-SceI-induced DNA breaks during the permissive life cycle of human cytomegalovirus. J. Virology. 2011;85(12):6049-6054. DOI 10.1128/JVI.02514-10.; Li K., Wang G., Andersen T., Zhou P., Pu W.T. Optimization of genome engineering approaches with the CRISPR/Cas9 system. PLoS One. 2014;9(8):e105779. DOI 10.1371/journal.pone.0105779.; Liu Y.G., Chen Y. High-efficiency thermal asymmetric interlaced PCR for amplification of unknown flanking sequences. Biotechniques. 2007;43(5):649-650,652,654.; Pierce A.J., Hu P., Han M., Ellis N., Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes & Development. 2001;15(24):3237-3242. DOI 10.1101/gad.946401.; Pierce A.J., Johnson R.D., Thompson L.H., Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes & Development. 1999;13(20):2633-2638.; Sakurai T., Kamiyoshi A., Kawate H., Mori C., Watanabe S., Tanaka M. A non-inheritable maternal Cas9-based multiple-gene editing system in mice. Sci. Reports. 2016;6:20011. DOI 101038/srep20011.; Sambrook J.F., Russell D.W. Molecular Cloning: A Laboratory Manual, 3rd ed. Cold Spring Harbor Laboratory Press, 2001.; Shchelkunov S.N. Geneticheskaya inzheneriya [Genetic Engineering]. Novosibirsk, 2004. (in Russian); Smirnov A.V., Yunusova A.M., Lukyanchikova V.A., Battulin N.R. CRISPR/Cas9: a universal tool for genomic engineering. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2016;20(4):493-510. DOI 10.18699/VJ16.175. (in Russian); Smith A.M., Takeuchi R., Pellenz S., Davis L., Maizels N., Monnat R.J., Stoddard B.L. Generation of a nicking enzyme that stimulates sitespecific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc. Natl. Acad. Sci. 2009;106(13):5099-5104. DOI 10.1073/pnas.0810588106.; Windbichler N., Papathanos P.A., Catteruccia F., Ranson H., Burt A., Crisanti A. Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos. Nucl. Acids Res. 2007;35(17): 5922-5933. DOI 10.1093/nar/gkm632.; Yang H., Wang H., Jaenisch R. Generating genetically modified mice using CRISPR/Cas- mediated genome engineering. Nat. Protocols. 2014;9:1956-1968.; https://vavilov.elpub.ru/jour/article/view/874

Availability: https://vavilov.elpub.ru/jour/article/view/874
https://doi.org/10.18699/VJ16.214

Computer analysis of co-localization of transcription factor binding sites in genome by ChIP-seq data ; Компьютерный анализ совместной локализации сайтов связывания транскрипционных факторов в геноме по данным ChIP-seq

Authors: A. I. Dergilev, A. M. Spitsina, I. V. Chadaeva, A. V. Svichkarev, F. M. Naumenko, E. V. Kulakova, E. R. Galieva, E. E. Vityaev, M. Chen, Y. L. Orlov, А. И. Дергилев, А. М. Спицина, И. В. Чадаева, А. В. Свичкарев, Ф. М. Науменко, Е. В. Кулакова, Э. Р. Галиева, Е. Е. Витяев, М. Чен, Ю. Л. Орлов

Source: Vavilov Journal of Genetics and Breeding; Том 20, № 6 (2016); 770-778 ; Вавиловский журнал генетики и селекции; Том 20, № 6 (2016); 770-778 ; 2500-3259

Subject Terms: энхансеры, embryonic stem cells, data mining, regularity discovery, ChIP-seq, enhancers, нуклеотидные мотивы, эмбриональные стволовые клетки, поиск закономерностей

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Relation: https://vavilov.elpub.ru/jour/article/view/850/849; Babenko V.N., Kosarev P.S., Vishnevsky O.V., Levitsky V.G., Basin V.V., Frolov A.S. Investigating extended regulatory regions of genomic DNA sequences. Bioinformatics. 1999;15(7-8):644-653. DOI 10.1093/bioinformatics/15.7.644.; Babenko V.N., Matvienko V.F., Safronova N.S. 19 Implication of transposons distribution on chromatin state and genome architecture in human. J. Biomol. Struct. Dyn. 2015;33(1):10- 11. DOI 10.1080/07391102.2015.1032559.; Bieda M., Xu X., Singer M.A., Green R., Farnham P. Unbiased location analysis of E2F1- binding sites suggests a widespread role for E2F1 in the human genome. Genome Res. 2006;16(5):595-605. DOI 10.1101/gr.4887606.; Boeva V. Analysis of genomic sequence motifs for deciphering transcription factor binding and transcriptional regulation in eukaryotic cells. Front. Genet. 2016;7:24. DOI 10.3389/fgene.2016.00024.; Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., Gifford D.K., Melton D.A., Jaenisch R., Young R.A. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005; 122(6):947-956. DOI 10.1016/j.cell.2005.08.020.; Chen X., Xu H., Yuan P., Fang F., Huss M., Vega V.B., Wong E., Orlov Y.L., Zhang W., Jiang J., Loh Y.H., Yeo H.C., Yeo Z.X., Narang V., Govindarajan K.R., Leong B., Shahab A., Ruan Y., Bourque G., Sung W.K., Clarke N.D., Wei C.L., Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008;133(6):1106-1117. DOI 10.1016/j.cell.2008.04.043.; Goh W.S., Orlov Y., Li J., Clarke N.D. Blurring of high-resolution data shows that the effect of intrinsic nucleosome occupancy on transcription factor binding is mostly regional, not local. PLoS Comput. Biol. 2010;6(1):e1000649. DOI 10.1371/journal.pcbi.1000649.; Golosova O., Henderson R., Vas’kin Yu., Gabrielian A., Grekhov G., Nagarajan V., Oler A.J., Quiñones M., Hurt D., Fursov M., Huyen Y. Unipro UGENE NGS pipelines and components for variant calling, RNA-seq and ChIP-seq data analyses. Peer J. 2014;2:e644. DOI 10.7717/peerj.644.; Guo Y., Mahony S., Gifford D.K. High resolution genome wide binding event finding and motif discovery reveals transcription factor spatial binding constraints. PLoS Comput. Biol. 2012;8(8):e1002638. DOI 10.1371/journal.pcbi.1002638.; Han J., Yuan P., Yang H., Zhang J., Soh B.S., Li P., Lim S.L., Cao S., Tay J., Orlov Y.L., Lufkin T., Ng H.H., Tam W.L., Lim B. Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature. 2010;463(7284):1096-1100.; He X., Cicek A.E., Wang Y., Schulz M.H., Le H.-S., Ziv B.-J. De novo ChIP-seq analysis. Genome Biol. 2015;16(1):205. DOI 10.1186/s13059-015-0756-4.; Heinemeyer T., Wingender E., Reuter I., Hermjakob H., Kel A.E., Kel O.V., Ignatieva E.V., Ananko E.A., Podkolodnaya O.A., Kolpakov F.A., Podkolodny N.L., Kolchanov N.A. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 1998;26(1):362-367. DOI 10.1093/nar/26.1.362.; Heng J.C., Feng B., Han J., Jiang J., Kraus P., Ng J.H., Orlov Y.L., Huss M., Yang L., Lufkin T., Lim B., Ng H.H. The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell. 2010;6(2):167-174. DOI 10.1016/j.stem.2009.12.009.; Hutter B., Bieg M., Helms V., Paulsen M. Imprinted genes show unique patterns of sequence conservation. BMC Genomics. 2010;11:649. DOI 10.1186/1471-2164-11-649.; Ignatieva E.V., Podkolodnaya O.A., Orlov Yu.L., Vasiliev G.V., Kolchanov N.A. Regulatory genomics: Combined experimental and computational approaches. Rus. J. Genet. 2015;51(4):334-352. DOI 10.1134/S1022795415040067.; Ivanova N., Dobrin R., Lu R., Kotenko I., Levorse J., DeCoste C., Schafer X., Lun Yi., Lemischka I.R. Dissecting self-renewal in stem cells with RNA interference. Nature. 2006;442(7102):533-538. DOI 10.1038/nature04915.; Kuznetsov V.A., Orlov Yu.L., Wei C.L., Ruan Y. Computational analysis and modeling of genome-scale avidity distribution of transcription factor binding sites in chip-pet experiments. Genome Inform. 2007;19:83-94.; Kulakova E.V., Spitsina A.M., Orlova N.G., Dergilev A.I., Svichkarev A.V., Safronova N.S., Chernykh I.G., Orlov Yu.L. Programs for the analysis of genomic sequence data obtained by ChIP-seq, ChIA-PET, and Hi-C technologies. Programmnye Sistemy: Teoriya i Prilozheniya = Program Systems: Theory and Applications. 2015;6(2(25)):129-148. (in Russian); Kuznetsov V.A., Singh O., Jenjaroenpun P. Statistics of protein-DNA binding and the total number of binding sites for a transcription factor in the mammalian genome. BMC Genomics. 2010;11(1):S12. DOI 10.1186/1471-2164-11-S1-S12.; Kuzniewska B., Nader K., Dabrowski M., Kaczmarek L., Kalita K. Adult deletion of SRF increases epileptogenesis and decreases activity-induced gene expression. Mol. Neurobiol. 2015;1-16. DOI 10.1007/s12035-014-9089-7.; Lee K.L., Lim S.K., Orlov Y.L., Yit le Y., Yang H., Ang L.T., Poellinger L., Lim B. Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet. 2011;7(6):e1002130. DOI 10.1371/journal.pgen.1002130.; Li G., Cai L., Chang H., Hong P., Zhou Q., Kulakova E.V., Kolchanov N.A., Ruan Y. Chromatin interaction analysis with Paired-End Tag (ChIA-PET) sequencing technology and application. BMC Genomics. 2014;15(12):S11. DOI 10.1186/1471-2164-15-S12-S11.; Loh Y.H., Wu Q., Chew J.L., Vega V.B., Zhang W., Chen X., Bourque G., George J., Leong B., Liu J., Wong K.Y., Sung K.W., Lee C.W., Zhao X.D., Chiu K.P., Lipovich L., Kuznetsov V.A., Robson P., Stanton L.W., Wei C.L., Ruan Y., Lim B., Ng H.H. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 2006;38(4):431- 440. DOI 10.1038/ng1760.; Orlov Yu.L. Computer-assisted study of the regulation of eukaryotic gene transcription on the base of data on chromatin sequencing and precipitation. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2014;18(1):193-206. (in Russian); Orlov Yu.L., Bragin A.O., Medvedeva I.V., Gunbin K.V., Demenkov P.S., Vishnevsky O.V., Levitsky V.G., Oshchepkov D.Y., Podkolodnyy N.L., Afonnikov D.A., Grosse I., Kolchanov N.A. ICGenomics: Software for analysis of symbol genomics sequences. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2012;16(4/1):732-741. (in Russian); Orlov Yu.L., Huss M.E., Joseph R., Xu H., Vega V.B., Lee Y.K., Goh W.S., Thomsen J.S., Cheung E.C., Clarke N.D., Ng H.H. Genome-wide statistical analysis of multiple transcription factor binding sites obtained by ChIP-seq technologies. Proc. 1st ACM Workshop on Breaking Frontiers of Computational Biology (Comp- Bio ‘09). ACM, New York. N.Y., 2009;11-18.; Orlov Yu.L., Levitskii V.G., Smirnova O.G., Podkolodnaya O.A., Khlebodarova T.M., Kolchanov N.A. Statistical analysis of nucleosome formation sites. Biofizika = Biophysics. 2006;51(4):608-614. (in Russian); Orlov Yu.L., Potapov V.N. Complexity: an internet resource for analysis of DNA sequence complexity. Nucleic Acids Res. 2004;32:W628-W633. DOI 10.1093/nar/gkh466.; Orlov Yu.L., Te Boekhorst R., Abnizova I.I. Statistical measures of the structure of genomic sequences: entropy, complexity, and position information. J. Bioinform. Comput. Biol. 2006;4:523-536. DOI 10.1142/S0219720006001801.; Orlov Yu., Xu H., Afonnikov D., Lim B., Heng J.C., Yuan P., Chen M., Yan J., Clarke N., Orlova N., Huss M., Gunbin K., Podkolodnyy N., Ng H.H. Computer and statistical analysis of transcription factor binding and chromatin modifications by ChIP-seq data in embryonic stem cell. J. Integr. Bioinform. 2012;9(2):211. DOI 10.2390/biecolljib-2012-211.; Panne D., Maniatis T., Harrison S.C. An atomic model of the interferonbeta enhanceosome. Cell. 2007;129(6):1111-1123. DOI 10.1016/j.cell.2007.05.019.; Polunin D.A., Shtaiger I.A., Efimov V.M. JACOBI 4 software for multivariate analysis of microarray data. Vestnik NGU. Ser. Informatsionnye tekhnologii = Novosibirsk State University Journal of Information Technologies. 2014;12(2):90-98. (in Russian); Putta P., Orlov Yu.L., Podkolodnyy N.L., Mitra C.K. Relatively conserved common short sequences in transcription factor binding sites and miRNA. Vavilov Journal Genetics and Breeding. 2011;15(4): 750-756.; Safronova N.S., Babenko V.N., Orlov Yu.L. 117 Analysis of SNP containing sites in human genome using text complexity estimates. J. Biomol. Struct. Dyn. 2015;33(1):73-74. DOI 10.1080/07391102.2015.1032750.; Sirito M., Lin Q., Deng J.M., Behringer R.R., Sawadogo M. Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice. Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice. Proc. Natl. Acad. Sci. USA. 1998;95(7):3758- 3763.; Spitsina A.M., Orlov Yu.L., Podkolodnaya N.N., Svichkarev A.V., Dergilev A.I., Chen M., Kuchin N.V., Chernych I.G., Glinskiy B.M. Supercomputer analysis of genomics and transcriptomics data revealed by high-throughput DNA sequencing. Programmnye Sistemy: Teoriya i Prilozheniya = Program Systems: Theory and Applications. 2015;6(1(23)):157-174. (in Russian); Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-676. DOI 10.1016/j.cell.2006.07.024.; Vas’kin Yu., Khomicheva I.V., Ignatieva E.V., Vityaev E.E. Expert discovery and UGENE integrated system for intelligent analysis of regulatory regions of genes. In Silico Biol. 2011- 2012;11(3-4):97-108. DOI 10.3233/ISB-2012-0448.; Vas’kin Yu.Yu., Khomicheva I.V., Ignatieva E.V., Vityaev E.E. Sequence analysis of regulatory regions of genes with the Expert Discovery relational system built in package UGENE. Vestnik NGU. Ser. Informatsionnye tekhnologii = Novosibirsk State University Journal of Information Technologies. 2012;10(1):73-86. (in Russian); Vityaev E.E. Izvlechenie znaniy iz dannykh. Kompyuternoe poznanie. Modeli kognitivnykh protsessov [Data mining: Computerized cognition. Models of cognitive processes]. Novosibirsk: Novosibirsk State University Publ., 2006. (in Russian); Vityaev E.E., Orlov Yu.L., Vishnevsky O.V., Belenok A.S., Kolchanov N.A. Computer system “Gene Discovery” to search for patterns in eukaryotic regulatory nucleotide sequences. Molekulyarnaya biologiya = Molecular Biology (Moscow). 2001;35(6):952-960. (in Russian); Xu D., Wei G., Lu P., Luo J., Chen X., Skogerb G., Chen R. Analysis of the p53/CEP-1 regulated non-coding transcriptome in C. elegans by an NSR-seq strategy. Protein Cell. 2014;5(10):770-782. DOI 10.1007/s13238-014-0071-y.; Yanan Z., Quan X., Ya G., Qiang W. Characterization of a cluster of CTCF-binding sites in a protocadherin regulatory region. Yi Chuan. 2016;38(4):323-336. DOI 10.16288/j.yczz.16-037.; Zhang Y., Wang P. A fast cluster motif finding algorithm for ChIPSeq data sets. Biomed. Res. Int. 2015;2015;218068. DOI 10.1155/2015/218068.; https://vavilov.elpub.ru/jour/article/view/850

Availability: https://vavilov.elpub.ru/jour/article/view/850
https://doi.org/10.18699/VJ16.194

Тестикулярна інтраепітеліальна неоплазія (ТІН) в патогенезі герміногенних пухлин яєчка (огляд та результати власних досліджень)

Authors: Sakalo, A.V.

Source: Урологія; Том 21, № 2 (2017)
Урология; Том 21, № 2 (2017)
Urology; Том 21, № 2 (2017)

Subject Terms: 03 medical and health sciences, 0302 clinical medicine, герміногенні пухлини яєчка, ТІН, ембріональні стовбурові клітини, фетальні гоноцити, синдром дисгенезії яєчок, біопсія яєчка, діагностика ТІН, germ cell testicular tumors, IGCN, embryonic stem cells, testicular dysgenesis, testicular biopsy, diagnosis of IGCN, герминогенные опухоли яичка, ТИН, эмбриональные стволовые клетки, фетальные гоноциты, синдром дисгенезии яичек, биопсия яичка, диагностика ТИН, 3. Good health

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Access URL: http://journals.uran.ua/urology/article/view/149996

About some problems of formation of international legal regulation on embryonic stem cells transplant

Authors: T R Guseynov

Source: RUDN Journal of Law, Vol 0, Iss 3, Pp 118-124 (2009)

Subject Terms: эмбрион, эмбриональные стволовые клетки, правовой статус, право на жизнь, Law

File Description: electronic resource

Relation: http://journals.rudn.ru/law/article/view/5703; https://doaj.org/toc/2313-2337; https://doaj.org/toc/2408-9001

Access URL: https://doaj.org/article/e2dd2c2e89284f5ebdf6f0615e380e6a

Human pluripotent stem cells in contemporary medicine ; Применение плюрипотентных стволовых клеток в медицине

Authors: S. A. Rodin, С. А. Родин

Source: Research and Practical Medicine Journal; Том 2, № 2 (2015); 44-52 ; Research'n Practical Medicine Journal; Том 2, № 2 (2015); 44-52 ; 2410-1893 ; 10.17709/2409-2231-2015-2-2

Subject Terms: человеческие плюрипотентные стволовые клетки (чПСК), человеческие эмбриональные стволовые клетки, человеческие индуцированные плюрипотентные стволовые клетки, клинические испытания с применением чПСК

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Relation: https://www.rpmj.ru/rpmj/article/view/62/74; Geens M., Mateizel I., Sermon K., De Rycke M., Spits C., Cauffman G., et al. Human embryonic stem cell lines derived from single blastomeres of two 4-cell stage embryos. Hum Reprod. 2009;24(11):2709-17.; Silva J., Smith A. Capturing pluripotency. Cell. 2008;132(4):532-6.; Wu J., Okamura D., Li M., Suzuki K., Luo C., Ma L., et al. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015.; Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145-7.; Hovatta O., Rodin S., Antonsson L., Tryggvason K. Concise review: animal substance-free human embryonic stem cells aiming at clinical applications. Stem Cells Transl Med. 2014;3(11):1269-74.; Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30;131(5):861-72.; Revazova E.S., Turovets N.A., Kochetkova O.D., Kindarova L.B., Kuzmichev L.N., Janus J.D., et al. Patient-specific stem cell lines derived from human parthenogenetic blastocysts. Cloning Stem Cells. 2007;9(3):432-49.; Tachibana M., Amato P., Sparman M., Gutierrez N.M., Tippner-Hedges R., Ma H., et al. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell. 2013;153(6):1228-38.; Klimanskaya I., Chung Y., Becker S., Lu S.J., Lanza R. Human embryonic stem cell lines derived from single blastomeres. Nature. 2006;444(7118):481-5.; Gurdon J.B., Elsdale T.R., Fischberg M. Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature. 1958;182(4627):64-5.; Wabl M.R., Brun R.B., Du Pasquier L. Lymphocytes of the toad Xenopus laevis have the gene set for promoting tadpole development. 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Cell Stem Cell. 2012;10(5):620-34.; Ruiz S., Diep D., Gore A., Panopoulos A.D., Montserrat N., Plongthongkum N., et al. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012;109(40):16196-201.; Lister R., Pelizzola M., Kida Y.S., Hawkins R.D., Nery J.R., Hon G., et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. 2011;471(7336):68-73.; Foldes G., Matsa E., Kriston-Vizi J., Leja T., Amisten S., Kolker L., et al. Aberrant ?-Adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells. Stem Cell Reports. 2014;3(5):905-14.; Takahashi K., Yamanaka S. Induced pluripotent stem cells in medicine and biology. Development. 2013;140(12):2457-61.; Revazova E.S., Turovets N.A., Kochetkova O.D., Agapova L.S., Sebastian J.L., Pryzhkova M.V., et al. HLA homozygous stem cell lines derived from human parthenogenetic blastocysts. 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https://doi.org/10.17709/2409-2231-2015-2-2-44-52

Регламентация использования биотехнологий в зарубежном законодательстве

Authors: Трусов Александр Игоревич, Aleksandr I. Trusov, Ефимов Александр Александрович, Aleksandr A. Efimov, Губарева Татьяна Ивановна, Tatiana I. Gubareva

Source: Образование и наука в современных условиях; № 3(4); 350-353 ; ISSN: 2412-0537 ; 2412-0537

Subject Terms: биотехнологии, опасность, последствия, общественно опасные деяния, терапевтическое клонирование, эмбриональные стволовые клетки, правила и условия, медицинская генетика, геном человека, генная инженерия, генная терапия, биологическое оружие, биотерроризм, репродуктивное клонирование человека

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МОДЕЛЬНЫЕ СИСТЕМЫ БОЛЕЗНЕЙ ДВИГАТЕЛЬНЫХ НЕЙРОНОВ ПЛАТФОРМА ДЛЯ ИЗУЧЕНИЯ МЕХАНИЗМОВ ПАТОГЕНЕЗА И ПОИСКА ТЕРАПЕВТИЧЕСКИХ СРЕДСТВ

Authors: Валетдинова, К., Медведев, С., Закиян, С.

Subject Terms: БОКОВОЙ АМИОТРОФИЧЕСКИЙ СКЛЕРОЗ,ИНДУЦИРОВАННЫЕ ПЛЮРИПОТЕНТНЫЕ СТВОЛОВЫЕ КЛЕТКИ,МОТОРНЫЕ НЕЙРОНЫ,СПИНАЛЬНАЯ МЫШЕЧНАЯ АТРОФИЯ,ЭМБРИОНАЛЬНЫЕ СТВОЛОВЫЕ КЛЕТКИ

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Роль жорсткості підложки для підтримки плюрипотентності ембріональних стовбурових клітин у культурі in vitro ; Роль жесткости подложки для поддержания плюрипотентности эмбриональных стволовых клеток в культуре in vitro ; The role of substrate stiffness in maintaining pluripotency of embryonic stem cells in vitro culture

Authors: Білько, Денис, Чайковський, Юрій

Subject Terms: плюрипотентність, ембріональні стовбурові клітини, ембріоїдні тільця, проліферація, диференціювання, культура in vitro, стаття, плюрипотентность, эмбриональные стволовые клетки, эмбриоидные тельца, пролиферация, дифференциация, pluripotency, embryonic stem cells, embryoid body, differentiation, culture in vitro

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Relation: Фізіологічний журнал.; https://doi.org/10.15407/fz67.03.027; https://ekmair.ukma.edu.ua/handle/123456789/21552

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https://doi.org/10.15407/fz67.03.027

APPLICATION OF STEM CELLS AND PRECURSOR CELLS FOR STIMULATION OF ORGAN REVASCULARIZATION AND REGENERATION ; ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СТВОЛОВЫХ КЛЕТОК И КЛЕТОК-ПРЕДШЕСТВЕННИКОВ ДЛЯ СТИМУЛЯЦИИ РЕВАСКУЛЯРИЗАЦИИ И РЕГЕНЕРАЦИИ ОРГАНОВ

Authors: M. V. Eremeeva, М. В. Еремеева

Source: Russian Journal of Transplantology and Artificial Organs; Том 12, № 1 (2010); 86-93 ; Вестник трансплантологии и искусственных органов; Том 12, № 1 (2010); 86-93 ; 1995-1191 ; 10.15825/1995-1191-2010-1

Subject Terms: мезенхимальные стволовые клетки, myocardial regeneration, embryonic stem cells, hematopoetic stem cells, mesenhimal stem cell, регенерация миокарда, эмбриональные стволовые клетки, гематопоэтические стволовые клетки

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https://doi.org/10.15825/1995-1191-2010-1-86-93

ОРГАНЫ «ИЗ ПРОБИРКИ»

Authors: ЗАХАРОВА ИРИНА СЕРГЕЕВНА, ШЕВЧЕНКО АЛЕКСАНДР ИГОРЕВИЧ

Subject Terms: ЭМБРИОНАЛЬНЫЕ СТВОЛОВЫЕ КЛЕТКИ (ЭСК), ИНДУЦИРОВАННЫЕ ПЛЮРИПОТЕНТНЫЕ СТВОЛОВЫЕ КЛЕТКИ (ИПСК), ТРЕХМЕРНЫЕ ОРГАНОПОДОБНЫЕ СТРУКТУРЫ, EMBRYONIC STEM CELLS (ESC), INDUCED PLURIPOTENT STEM CELLS (IPSC)

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