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    Academic Journal

    Contributors: The study was carried out with financial support within the framework of the search topic N 123052200003-6, Исследование выполнено при финансовой поддержке в рамках темы НИР № госрегистрации 123052200003-6.

    Source: Medical Genetics; Том 24, № 1 (2025); 23-33 ; Медицинская генетика; Том 24, № 1 (2025); 23-33 ; 2073-7998

    File Description: application/pdf

    Relation: https://www.medgen-journal.ru/jour/article/view/2601/1844; Резник А.М., Костюк Г.П., Морозова А.Ю., Захарова Н.В. Проблемы предпосылок шизофрении по данным молекулярно-генетических исследований. Heal Food Biotechnol. 2019;1(1):27–45.; Ermakov E.A., Dmitrieva E.M., Parshukova D.A., et al. Oxidative stress-related mechanisms in schizophrenia pathogenesis and new treatment perspectives. Oxid Med Cell Longev. 2021;2021:8881770.; Jorgensen A., Broedbaek K., Fink-Jensen A., et al. Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. Psychiatry Res. 2013;209(3):417-423.; Ma J., Yan L., Guo T., et al. A pilot study of biomarkers of oxidative stress in serum and schizophrenia. Psychiatry Res. 2020;284:112757.; Flatow J., Buckley P., Miller B. Meta-analysis of oxidative stress in schizophrenia. Biol Psychiatry. 2013;74(6):400–409.; Ershova E.S., Shmarina G.V., Martynov A.V., et al. NADPHoxidase 4 gene over-expression in peripheral blood lymphocytes of the schizophrenia patients. PLoS One. 2022;17(6):e0269130.; Ershova E.S., Savinova E.A., Kameneva L.V., et al. Satellite III (1q12) copy number variation in cultured human skin fibroblasts from schizophrenic patients and healthy controls. Front Biosci (Landmark Ed). 2023;28(8):191.; Steullet P., Janel N., Berthold C., et al. Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A ‘central hub’ in schizophrenia pathophysiology? Schizophr Res. 2016;176(1):41–51.; Veiko N.N., Egolina N.A., Radzivil G.G., et al. Quantitation of repetitive sequences in human genomic DNA and detection of an elevated ribosomal repeat copy number in schizophrenia: The results of molecular and cytogenetic analyses. Molecular Biology. 2003;37:349–357; Chestkov I.V., Jestkova E.M., Ershova E.S., et al. ROS-induced DNA damage associates with abundance of mitochondrial DNA in white blood cells of the untreated schizophrenic patients. Oxid Med Cell Longev. 2018;2018:8587475.; Ershova E.S., Malinovskaya E.M., Golimbet V.E., et al. Copy number variations of satellite III (1q12) and ribosomal repeats in health and schizophrenia. Schizophr Res. 2020 Sep;223:199-212.; Li S., Otsuka I., Tanifuji T., et al. Ribosomal DNA gene copies are increased in blood and brain of Japanese schizophrenia patients. PLoS One. 2023;18(1):e0280694.; Dor H., Hertzberg L. Schizophrenia biomarkers: Blood transcriptome suggests two molecular subtypes. Neuromolecular Med. 2024;26(1):50.; Beckmann H., Franzek E., Stober G. Genetic heterogeneity in catatonic schizophrenia: A family study. Am J Med Genet – Semin Med Genet. 1996;67(3):289–300.; Rogers J.P., Pollak T.A., Begum N., et al. Catatonia: demographic, clinical and laboratory associations. Psychol Med. 2023 Apr;53(6):2492-2502.; Bush G., Fink M., Petrides G., et al. Catatonia. I. Rating scale and standardized examination. Acta Psychiatr Scand. 1996;93(2):129–136.; Захарова Н.В., Зозуля С.А., Сарманова З.В., и др. Особенности иммунного профиля больных шизофренией с кататоническим синдромом. Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски. 2020;120(6‑2):46‑53.; Hall A.N., Turner T.N., Queitsch C. Thousands of high-quality sequencing samples fail to show meaningful correlation between 5S and 45S ribosomal DNA arrays in humans. Scientific Reports.2021;11:449.; Hori Y., Shimamoto A., Kobayashi T. The human ribosomal DNA array is composed of highly homogenized tandem clusters. Genome Research. 2021;31:1971–1982.; Malinovskaya E.M., Ershova E.S., Golimbet V.E., et al. Copy number of human ribosomal genes with aging: Unchanged mean, but narrowed range and decreased variance in elderly group. Front Genet. 2018;9:306.

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    Academic Journal

    Source: International Journal of Scientific Pediatrics; Vol. 4 No. 5 (2025): September-October; 1104-1109 ; Международный журнал научной педиатрии; Том 4 № 5 (2025): Сентябрь-Октябрь; 1104-1109 ; Xalqaro ilmiy pediatriya jurnali; Nashr soni. 4 No. 5 (2025): Sentabr-Oktabr; 1104-1109 ; 2181-2926

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    Academic Journal

    Contributors: The research was performed as part of the state assignment of the V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology of the Russian Ministry of Health (XSOZ 2024 0012), Исследование выполнено в рамках государственного задания Национального медицинского исследовательского центра психиатрии и неврологии им. В.М. Бехтерева Министерства здравоохранения Российской Федерации (XSOZ 2024 0012)

    Source: Safety and Risk of Pharmacotherapy; Том 13, № 1 (2025); 70-85 ; Безопасность и риск фармакотерапии; Том 13, № 1 (2025); 70-85 ; 2619-1164 ; 2312-7821 ; 10.30895/2312-7821-2025-13-1

    File Description: application/pdf

    Relation: https://www.risksafety.ru/jour/article/view/418/1357; https://www.risksafety.ru/jour/article/downloadSuppFile/418/449; https://www.risksafety.ru/jour/article/downloadSuppFile/418/515; https://www.risksafety.ru/jour/article/downloadSuppFile/418/516; https://www.risksafety.ru/jour/article/downloadSuppFile/418/527; Левин ОС, ред. Экстрапирамидные расстройства — вчера, сегодня, завтра. М.: МЕДпресс-информ; 2015.; Шнайдер НА, Вайман ЕЭ, Незнанов НГ, Насырова РФ. Фармакогенетика антипсихотик-индуцированных экстрапирамидных расстройств. СПб: Издательство ДЕАН; 2022.; Вайман ЕЭ, Шнайдер НА, Незнанов НГ, Насырова РФ. Лекарственно-индуцированный паркинсонизм. Социальная и клиническая психиатрия. 2021;31(1):96–103. EDN: MWEAHI; Mentzel CL, Bakker PR, van Os J, Drukker M, Matroos GE, Tijssen MAJ, vanHarten PN. Blink rate is associated with drug-induced parkinsonism in patients with severe mental illness but does not meet requirements to serve as a clinical test: The Curacao extrapyramidal syndromes study XIII. J Negat Results Biomed. 2017;16(1):15. https://doi.org/10.1186/s12952-017-0079-y; Левин ОС. Диагностика и лечение экстрапирамидных гиперкинезов. Лечащий врач. 2005;(6):20–6.; Иванова СА, Алифирова ВМ, Жукова ИА, Бойко АС, Федоренко ОЮ, Бохан Н.А. Ассоциация DRD3 гена с болезнью Паркинсона. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(5):71–4. https://doi.org/10.17116/jnevro20161165171-74; Koning JP, Vehof J, Burger H, Wilffert B, Al Hadithy A, Ali­zadeh B, et al. Genetic Risk and Outcome in Psychosis (GROUP) investigators. Association of two DRD2 gene polymorphisms with acute and tardive antipsychotic-induced movement disorders in young Caucasian patients. Psychopharmacology (Berl). 2012;219(3):727–36. https://doi.org/10.1007/s00213-011-2394-1; Knol W, van Marum RJ, Jansen PA, Strengman E, Al Hadithy AF, Wilffert B, et al. Genetic variation and the risk of haloperidol-related parkinsonism in elderly patients: a candidate gene approach. J Clin Psychopharmacol. 2013;33(3):405–10. https://doi.org/10.1097/JCP.0b013e3182902708; Vaiman EE, Shnayder NA, Novitsky MA, Dobrode­eva VS, Goncharova PS, Bochanova EN, et al. Candidate genes encoding dopamine receptors as predictors of the risk of antipsychotic-induced parkinsonism and tardive dyskinesia in schizophrenic patients. Biomedicines. 2021;9:879. https://doi.org/10.3390/biomedicines9080879; Shnayder NA, Abdyrakhmanova AK, Nasyrova RF. Oxidation of anti­psychotics. Encyclopedia. 2022;2:974–89. https://doi.org/10.3390/encyclopedia2020064; Preskorn SH. Drug-drug interactions (DDIs) in psychiatric practice, Part 9: Interactions mediated by drug-metabolizing cytochrome P450 enzymes. J Psychiatr Pract. 2020;26(2):126–34. https://doi.org/10.1097/PRA.0000000000000458; Шнайдер НА, Хасанова АК, Насырова РФ. Первая фаза метаболизма антипсихотиков в печени: роль окисления. Фармакогенетика и фармакогеномика. 2022;(1):15–30. https://doi.org/10.37489/2588-0527-2022-1-15-30; Nasyrova RF, Shnayder NA, Osipova SM, Khasanova AK, Efremov IS, Al-Zamil M, et al. Genetic predictors of antipsychotic efflux impairment via blood-brain barrier: Role of transport proteins. Genes. 2023;14:1085. https://doi.org/10.3390/genes14051085; Ravyn D, Ravyn V, Lowney R, Nasrallah HA. CYP450 pharmacogenetic treatment strategies for antipsychotics: A review of the evidence. Schizophr Res. 2013;149(1–3):1–14. https://doi.org/10.1016/j.schres.2013.06.035; Насырова РФ, Добродеева ВС, Скопин СД, Шнайдер НА, Незнанов НГ. Проблемы и перспективы внедрения фармакогенетического тестирования в реальной клинической практике в Российской Федерации. Вестник неврологии, психиатрии и ­нейрохирургии. 2020;(3):6–12. https://doi.org/10.33920/med-01-2003-01; Костюк ГП, Захарова НВ, Резник АМ, Суркова ЕИ, Ильинский ВВ. Перспективы применения фармакогенетических тестов в психиатрии и неврологии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(9):131–5. https://doi.org/10.17116/jnevro2019119091131; Вайман ЕЭ, Шнайдер НА, Незнанов НГ, Насырова РФ. Методы диагностики лекарственно-индуцированного паркинсонизма: обзор отечественной и зарубежной литературы. Сибирский вестник психиатрии и наркологии. 2020;4(109):64–72. https://doi.org/10.26617/1810-3111-2020-4(109)-64-72; Temmingh HS, van den Brink W, Howells F, Sibeko G, Stein DJ. Methamphetamine use and anti­psychotic-related extrapyramidal side-effects in patients with psychotic disorders. J Dual Diagn. 2020;16(2):208–17. https://doi.org/10.1080/15504263.2020.1714099; Chouinard G, Cosci F, Chouinard VA, Alphs L. The Extrapyra­midal Symptom Rating Scale and its abbreviated version: A cri­tical review of clinimetric properties. Psychother Psychosom. 2023;92(6):359–66. https://doi.org/10.1159/000535113; Martínez-Martín P, Rodríguez-Blázquez C, Mario Alvarez, Arakaki T, Arillo VC, Chaná P, et al. Parkinson’s disease severity levels and MDS-Unified Parkinson’s Disease Rating Scale. Parkinsonism Relat Disord. 2015;21(1):50–4. https://doi.org/10.1016/j.parkreldis.2014.10.026; Opara J, Małecki A, Małecka E, Socha T. Motor assessment in Parkinson’s disease. Ann Agric Environ Med. 2017;24(3):411–5. https://doi.org/10.5604/12321966.1232774; Kapoor S, Saluja A, Margekar SL, Agarwal M, Mondal S, Dhamija RK. Neurogenic supine hypertension and cardio­vascular autonomic dysfunction in patients with Parkinson’s disease. Ann Indian Acad Neurol. 2023;26(1):33–8. https://doi.org/10.4103/aian.aian_476_22; Bersani G, Grispini A, Marini S, Pasini A, Valducci M, Ciani N. 5-HT2 antagonist ritanserin in neuroleptic-induced parkinsonism: A double-blind comparison with orphenadrine and placebo. Clin Neuropharmacol. 1990;13(6):500–6. https://doi.org/10.1097/00002826-199012000-00003; Rajput AH, Offord KP, Beard CM, Kurland LT. Epidemiology of parkinsonism: Incidence, classification, and mortality. Ann Neurol. 1984;16(3):278–82. https://doi.org/10.1002/ana.410160303; Kennedy PF, Hershon HI, McGuire RJ. Extrapyramidal disorders after prolonged phenothiazine therapy. Br J Psychiatry. 1971;118(546):509–18.; Левин ОС, Шиндряева НН, Аникина МА. Лекарственный паркинсонизм. Журнал неврологии и психиатрии. 2012;8:69–74. EDN: PDXMSD; Вайман ЕЭ, Шнайдер НА, Незнанов НГ, Насырова РФ. Гены-кандидаты развития антипсихотик-индуцированного паркинсонизма у пациентов с шизофренией. Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. 2021;57(4):15–35. https://doi.org/10.31363/2313-7053-2021-57-4-15-35; Micheli FE, Cersosimo MG. Drug-induced parkinsonism. Handb Clin Neurol. 2007;84:399–416. https://doi.org/10.1016/S0072-9752(07)84051-6; Caligiuri MR, Jeste DV, Lacro JP. Antipsychotic-induced movement disorders in the elderly: Epidemiology and treatment recommendations. Drugs Aging. 2000;17(5):363–84. https://doi.org/10.2165/00002512-200017050-00004; Thanvi B, Treadwell S. Drug induced parkinsonism: A common cause of parkinsonism in older people. Postgrad Med J. 2009;85(1004):322–6. https://doi.org/10.1136/pgmj.2008.073312; López-Sendón JL, Mena MA, de Yébenes JG. Drug-induced parkinsonism in the elderly: Incidence, management and prevention. Drugs Aging. 2012;29(2):105–18. https://doi.org/10.2165/11598540-000000000-00000; Van Gerpen JA. Drug-induced parkinsonism. Neurologist. 2002;8(6):363–70 https://doi.org/10.1097/00127893-200211000-00006; Stefani A, Pierantozzi M, Olivola E, Galati S, Cerroni R, D’Angelo V, et al. Homovanillic acid in CSF of mild stage Parkinson’s disease patients correlates with motor impairment. Neurochem Int. 2017;105:58–63. https://doi.org/10.1016/j.neuint.2017.01.007; Chia LG, Cheng FC, Kuo JS. Monoamines and their metabolites in plasma and lumbar cerebrospinal fluid of Chinese patients with Parkinson’s disease. J Neurol Sci. 1993;116(2):125–34. https://doi.org/10.1016/0022-510x(93)90316-q; Khasanova AK. Pharmacogenetic factors of cloza­pine-induced metabolic syndrome. Personalized Psychiatry and Neurology. 2023;3(2):38–47. https://doi.org/10.52667/2712-9179-2023-3-2-38-47; Neznanov NG. A paradigm shift to treat psychoneurological disorders. Personalized Psychiatry and Neurology. 2021;1(1):1–2.; Lara DV, Melo DO, Silva RAM, Santos PCJL. Pharmacogenetic testing in psychiatry and neurology: An overview of reviews. Pharmacogenomics. 2021;22(8):505–13. https://doi.org/10.2217/pgs-2020-0187; Redenšek S, Dolžan V. The role of pharmacogenomics in the personalization of Parkinson’s disease treatment. Pharmacogenomics. 2020;21(14):1033–43. https://doi.org/10.2217/pgs-2020-0031; Dahl ML. Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: Useful aid to prescribing? Clin Pharmacokinet. 2002;41(7):453–70. https://doi.org/10.2165/00003088-200241070-00001; Bousman CA, Bengesser SA, Aitchison KJ, Amare AT, Aschauer H, Baune BT, et al. Review and consensus on pharmacogenomic testing in psychiatry. Pharmacopsychiatry. 2021;54(1):5–17. https://doi.org/10.1055/a-1288-1061; Eum S, Lee AM, Bishop JR. Pharmacogenetic tests for antipsycho­tic medications: Clinical implications and considerations. Dialogues Clin Neurosci. 2016;18(3):323–37. https://doi.org/10.31887/DCNS.2016.18.3/jbishop; Urban AE, Cubała WJ. Therapeutic drug monitoring of atypical antipsychotics. Psychiatr Pol. 2017;51(6):1059–77. https://doi.org/10.12740/PP/65307; Mauri MC, Paletta S, Di Pace C, Reggiori A, Cirnigliaro G, Valli I, et al. Clinical pharmacokinetics of atypical antipsychotics: An update. Clin Pharmacokinet. 2018;57(12):1493–528. https://doi.org/10.1007/s40262-018-0664-3; Потанин СС, Морозова МА, Бениашвили АГ, Бурминский ДС, Мирошниченко ИИ. Рекомендации по применению терапевтического лекарственного мониторинга антипсихотиков для индивидуализации подбора терапии при обострении шизофрении. Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. 2023;57(4):111–9. https://doi.org/10.31363/2313-7053-2023-778; Milosavljevic F, Bukvic N, Pavlovic Z, Miljevic C, Pešic V, Molden E, et al. Association of CYP2C19 and CYP2D6 poor and intermediate metabolizer status with antidepressant and antipsychotic exposure: A systematic review and meta-analysis. JAMA Psychiatry. 2021;78(3):270–80. https://doi.org/10.1001/jamapsychiatry.2020.3643; Luvsantseren S, Whirl-Carrillo M, Sangkuhl K, Shin N, Wen A, Empey P, et al. Variant interpretation in current pharmacogenetic testing. J Pers Med. 2020;10(4):204. https://doi.org/10.3390/jpm10040204; Aronson JK. Francis Galton and the invention of terms for quantiles. J Clin Epidemiol. 2001;54(12):1191–4. https://doi.org/10.1016/s0895-4356(01)00420-6; Ward KM, Citrome L. Antipsychotic-related movement disorders: Drug-induced parkinsonism vs. tardive dyskinesia — key differences in pathophysiology and clinical management. Neurol Ther. 2018;7(2):233–48. https://doi.org/10.1007/s40120-018-0105-0; Сычев ДА, Кутузова ЛС, Васькова ЛБ. Современный подход к персонализации дозирования варфарина: где и как можно сделать фармакогенетическое тестирование в России? Фармакогенетика и фармакогеномика. 2016;(1):24–8. EDN: WCLOWD; https://www.risksafety.ru/jour/article/view/418

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    Academic Journal

    Subject Geographic: USPU

    Relation: Филологический класс. 2019. № 4 (58)

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