Search Results - "молекулярная патология"

1

Academic Journal

ФИБРОЛАМЕЛЛЯРНАЯ ГЕПАТОЦЕЛЛЮЛЯРНАЯ КАРЦИНОМА: FIBROLAMELLAR HEPATOCELLULAR CARCINOMA

Authors: Orucov, М.Т., Şamdancı, E.T., Həsənov, Ə.B.

Source: Azerbaijan Medical Journal. :172-178

Subject Terms: molekulyar patologiya, fibrolamelyar hepatosellulyar karsinoma, фиброламеллярная гепатоцеллюлярная карцинома, molecular pathology, immunohistochemistry, гистопатология, histopathology, fibrolamellar hepatocellular carcinoma, молекулярная патология, иммуногистохимия, immunhistokimya, 3. Good health, histopatologiya

2

Academic Journal

Cholangiocellular Cholangiocellular carcinoma today. Literature review ; Холангиоцеллюлярная карцинома сегодня. Литературный аналитический обзор

Authors: D. L. ROTIN, Д. Л. РОТИН

Source: Malignant tumours; № 3 (2015); 3-17 ; Злокачественные опухоли; № 3 (2015); 3-17 ; 2587-6813 ; 2224-5057

Subject Terms: лечение опухолей, oncology, molecular pathology, treatment of tumors, онкология, молекулярная патология

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Relation: https://www.malignanttumors.org/jour/article/view/147/157; Welzel TM, McGlynn KA, Hsing AW et al. Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States. J Natl Cancer Inst. 2006; Vol. 98: p. 873–875.; Blechacz B, Komuta M, Roskams T, Gores GJ. Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol. 2011; Vol. 8: p. 512–522.; Deoliveira ML, Schulick RD, Nimura Y, et al New staging system and a registry for perihilar cholangiocarcinoma. Hepatology. 2011; Vol. 53: p.1363–1371.; DeOliveira ML, Cunningham SC, Cameron JL, et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg. 2007; Vol. 245: p.755–762.; Blechacz BG, GJ. Feldman: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 9. Vol. 1. Saunders; 2010. Tumors of the Bile Ducts, Gallbladder, and Ampulla; pp. 1171–1176.; Khan SA, Davidson BR, Goldin RD, et al. Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut. 2012; Vol.61: p.1657–69.; Everhart JE, Ruhl CE. Burden of digestive diseases in the United States Part III: Liver, biliary tract, and pancreas. Gastroenterology. 2009; Vol.136: p.1134– 1144.; Tyson GL, El-Serag HB. Risk factors forcholangiocarcinoma. Hepatology. 2011; Vol. 54: p.173–184.; Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin Liver Dis. 2004; Vol. 24: p.115–125.; Sripa B, Pairojkul C. Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol. 2008; Vol. 24: p.349–356.; Khan SA, Taylor-Robinson SD, Toledano MB, et al. Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol. 2002; Vol. 37: p.806–813.; Khan SA, Toledano MB, Taylor-Robinson SD. Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford) 2008; Vol. 10: p.77–82.; McGlynn KA, Tarone RE, El-Serag HB. A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev. 2006; Vol. 15: p. 1198–1203.; Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology. 2001; Vol. 33: p.1353–1357.; Patel T. Worldwide trends in mortality from biliary tract malignancies. BMC Cancer. 2002; Vol. 2: p.10.; Khan SA, Emadossadaty S, Ladep NG, et al. Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us? Journal of Hepatology. 2012; Vol. 56: p.848–854.; Razumilava N, Gores GJ. Classification, diagnosis, and management of cholangiocarcinoma. Clin Gastroenterol Hepatol. 2013; Vol. 11: p.13–21.; Shin HR, Oh JK, Lim MK, et al. Descriptive epidemiology of cholangiocarcinoma and clonorchiasis in Korea. J Korean Med Sci. 2010; Vol. 25: p. 1011–1016.; Huang MH, Chen CH, Yen CM, et al. Relation of hepatolithiasis to helminthic infestation. J Gastroenterol Hepatol. 2005; Vol.20: p.141–146.; Edil BH, Cameron JL, Reddy S, et al. Choledochal cyst disease in children and adults: a 30-year singleinstitution experience. J Am Coll Surg. 2008; Vol. 206: p1000–1005. discussion 1005–8.; Mabrut JY, Bozio G, Hubert C, Gigot JF. Management of congenital bile duct cysts. Dig Surg. 2010; Vol. 27: p 12–18.; Kato I, Kido C. Increased risk of death in thorotrastexposed patients during the late follow-up period. Jpn J Cancer Res. 1987; vol. 78: p.1187–1192.; Lee TY, Lee SS, Jung SW, et al. Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study. Am J Gastroenterol. 2008; vol. 103: p.1716–720.; Shaib YH, El-Serag HB, Nooka AK, et al. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control study. Am J Gastroenterol. 2007; Vol. 102: p.1016–1021.; Sorensen HT, Friis S, Olsen JH, et al. Risk of liver and other types of cancer in patients with cirrhosis: a nationwide cohort study in Denmark. Hepatology. 1998; Vol. 28: p.921–925.; Palmer WC, Patel T. Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma. J Hepatol. 2012; Vol. 57: p. 69–76.; Shaib YH, El-Serag HB, Davila JA, et al. Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study. Gastroenterology. 2005; Vol.128: p. 620–626.; Welzel TM, Graubard BI, El-Serag HB, et al. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study. Clin Gastroenterol Hepatol. 2007; Vol. 5: p. 1221–1228.; Welzel TM, Mellemkjaer L, Gloria G, et al. Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case-control study. Int J Cancer. 2007; Vol.120: p.638–641.; Nakanuma Y, Sato Y, Harada K, et al. Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol. 2010; Vol.2: p.419–427.; Komuta M, Spee B, Vander Borght S, et al. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology. 2008; Vol.47: p.1544–1556.; Tsuchiya A, Kamimura H, Tamura Y, et al. Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM. Cancer Lett. 2011; Vol.309: p.95–103.; Cardinale V, Carpino G, Reid L, et al. Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity. World J Gastrointest Oncol. 2012; Vol.4: p. 94–102.; Komuta M, Govaere O, Vandecaveye V, et al. Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes. Hepatology. 2012; Vol. 55: p.1876–1888.; Fan B, Malato Y, Calvisi DF, et al. Cholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest. 2012; Vol.122: p.2911–2915.; Sekiya S, Suzuki A. Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest. 2012; Vol.122: p.3914– 3918.; Holczbauer A, Factor VM, Andersen JB, et al. Modeling pathogenesis of primary liver cancer in lineagespecific mouse celltypes. Gastroenterology. 2013; Vol. 145: p. 221–231.; Jaiswal M, LaRusso NF, Burgart LJ, Gores GJ. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res. 2000; Vol. 60: p.184–190.; Park J, Tadlock L, Gores GJ, Patel T. Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line. Hepatology. 1999; Vol.30: p.1128–1133.; Kobayashi S, Werneburg NW, Bronk SF, et al. Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. Gastroenterology. 2005; Vol.128: p.2054–2065.; Taniai M, Grambihler A, Higuchi H, et al. Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. Cancer Res. 2004; Vol. 64: p. 3517–3524.; Isomoto H, Kobayashi S, Werneburg NW, et al. Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology. 2005; Vol.42: p.1329–38.; Meng F, Yamagiwa Y, Ueno Y, Patel T. Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes. J Hepatol. 2006; Vol. 44: p.1055–1065.; Sia D, Tovar V, Moeini A, Llovet JM. Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies. Oncogene. 2013.; Sia D, Hoshida Y, Villanueva A, et al. Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Gastroenterology. 2013; Vol.144: p.829–840.; Isomoto H, Mott JL, Kobayashi S, et al. Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing. Gastroenterology. 2007; Vol. 132: p .384–396.; Yoon JH, Gwak GY, Lee HS, et al. Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells. J Hepatol. 2004; Vol. 41: p. 808–814.; Kiguchi K, Carbajal S, Chan Ket al. Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma. Cancer Res. 2001; Vol.61: p.6971–6976.; Matsumoto K, Nakamura T. Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions. Int J Cancer. 2006; Vol. 119: p. 477–483.; Nishimura K, Kitamura M, Miura H, et al. Prostate stromal cell-derived hepatocyte growth factor induces invasion of prostate cancer cell line DU145 through tumor-stromal interaction. Prostate. 1999; Vol. 41: p. 145–153.; Nakamura T, Matsumoto K, Kiritoshi A, et al. Induction of hepatocyte growth factor in fibroblasts by tumorderived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res. 1997; Vol.57: p.3305–3313.; Comoglio PM, Giordano S, Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov. 2008; Vol. 7: p. 504–516.; Lai GH, Radaeva S, Nakamura T, Sirica AE. Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated “intestinal-type” biliary cancer chemically induced in rat liver. Hepatology. 2000; Vol.31: p.1257–1265.; Miyamoto M, Ojima H, Iwasaki M, et al. Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. Br J Cancer. 2011; Vol.105: p.131–138.; Radaeva S, Ferreira-Gonzalez A, Sirica AE. Overexpression of C-NEU and C–MET during rat liver cholangiocarcinogenesis: A link between biliary intestinal metaplasia and mucin-producingcholangiocarcinoma. Hepatology. 1999; Vol. 29: p.1453–1462.; Yoon JH, Higuchi H, Werneburg NW, et al. Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. Gastroenterology. 2002; Vol.122: p.985–993.; Yoon JH, Canbay AE, Werneburg NW, et al. Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. Hepatology. 2004; Vol.39: p. 732–738.; Kuver R. Mechanisms of oxysterol-induced disease: insights from the biliary system. Clin Lipidol. 2012; Vol. 7: p. 537–548.; Nachtergaele S, Mydock LK, Krishnan K, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012; Vol. 8: p. 211– 220.; Fingas CD, Bronk SF, Werneburg NW, et al. Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells. Hepatology. 2011; Vol. 54: p. 2076–2088.; Andersen JB, Thorgeirsson SS. Genetic profiling of intrahepatic cholangiocarcinoma. Curr Opin Gastroenterol. 2012; Vol. 28: p.266–272.; McKay SC, Unger K, Pericleous S, et al. Array comparative genomic hybridization identifies novel potential therapeutic targets in cholangiocarcinoma. HPB (Oxford) 2011; Vol.13: p.309–319.; Koo SH, Ihm CH, Kwon KC, et al. Genetic alterations in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Cancer Genet Cytogenet. 2001; Vol.130: p.22–28.; Uhm KO, Park YN, Lee JY, et al. Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization. Cancer Genet Cytogenet. 2005; Vol.157: p.37–41.; Lee JY, Park YN, Uhm KO, et al. Genetic alterations in intrahepatic cholangiocarcinoma as revealed by degenerate oligonucleotide primed PCR-comparative genomic hybridization. J Korean Med Sci. 2004; Vol.19: p.682–687.; Wong N, Li L, Tsang K, Lai PB, et al. Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma. J Hepatol. 2002; Vol.37: p. 633–639.; Homayounfar K, Gunawan B, Cameron S, et al. Pattern of chromosomal aberrations in primary liver cancers identified by comparative genomic hybridization. Hum Pathol. 2009; Vol.40: p. 834–842.; Ong CK, Subimerb C, Pairojkul C, et al. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet. 2012; Vol. 44: p.690–693.; Xu RF, Sun JP, Zhang SR, et al. KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients. Biomed Pharmacother. 2011; Vol.65: p.22–26.; Ohashi K, Nakajima Y, Kanehiro H, et al. Ki-ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: relation to gross tumor morphology. Gastroenterology. 1995; Vol.109: p.1612–1617.; Andersen JB, Spee B, Blechacz BR, et al. Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology. 2012; Vol.142: p.1021–1031.; Tada M, Omata M, Ohto M. High incidence of ras gene mutation in intrahepatic cholangiocarcinoma. Cancer. 1992; Vol.69: p.1115–1118.; Khan SA, Thomas HC, Toledano MB, et al. p53 Mutations in human cholangiocarcinoma: a review. Liver Int. 2005; Vol.25: p.704–716.; Kipp BR, Voss JS, Kerr SE, et al. Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma. Hum Pathol. 2012; Vol.43: p.1552–1558.; Borger DR, Tanabe KK, Fan KC, et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist. 2012; Vol.17: p.72–79.; Wang P, Dong Q, Zhang C, et al. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene. 2012.; Reitman ZJ, Parsons DW, Yan H. IDH1 and IDH2: not your typical oncogenes. Cancer Cell. 2010; Vol. 17: p. 215–216.; Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013; Vol.340: p.626–630.; Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013; Vol.340: p.622–626.; Oishi N, Kumar MR, Roessler S, et al. Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepaticcholangiocarcinoma. Hepatology. 2012; Vol.56: p.1792–1803.; Chen L, Yan HX, Yang W, et al. The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma. J Hepatol. 2009; Vol. 50: p. 358–369.; Wu YM, Su F, Kalyana-Sundaram S, et al. Identification of targetable FGFR gene fusions in diverse cancers. Cancer discovery. 2013; Vol.3: p.636–647.; Yamanaka S, Olaru AV, An F, et al. MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer. Dig Liver Dis. 2012; Vol.44: p.589–596.; Meng F, Henson R, Lang M, et al. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology. 2006; Vol.130: p.2113–2129.; Hofmann JJ, Zovein AC, Koh H, et al. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development. 2010; Vol.137: p.4061–4072.; Zender S, Nickeleit I, Wuestefeld T, et al. A critical role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell. 2013; Vol.23: p.784–795.; Jinawath A, Akiyama Y, Sripa B, Yuasa Y. Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J Cancer Res Clin Oncol. 2007; Vol.133: p.271–278.; El Khatib M, Kalnytska A, Palagani V, et al. Inhibition of hedgehog signaling attenuates carcinogenesis in vitro and increases necrosis of cholangiocellular carcinoma. Hepatology. 2013; Vol.57: p.1035–1045.; Sirica AE, Nathanson MH, Gores GJ, Larusso NF. Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M and Lillian Stratton Basic Research Single-TopicConference. Hepatology. 2008; Vol.48: p. 2040–2046.; Tanaka S, Sugimachi K, Kameyama T, et al. WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma. Hepatology. 2003; Vol.37: p.1122–1129.; Junttila MR, de Sauvage FJ. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature. 2013; Vol.501: p.346–354.; Sirica AE. The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma. Nat Rev Gastroenterol Hepatol. 2012; Vol. 9: p.44–54.; Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006; Vol.6: p.392–401.; Dranoff JA, Wells RG. Portal fibroblasts: Underappreciated mediators of biliary fibrosis. Hepatology. 2010; Vol.51: p.1438–1444.; Okabe H, Beppu T, Hayashi H, et al. Hepatic stellate cells may relate to progression of intrahepatic cholangiocarcinoma. Ann Surg Oncol. 2009; Vol.16: p.2555–2564.; Quante M, Tu SP, Tomita H, et al. Bone marrowderived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 2011; Vol.19: p.257–272.; Li T, Li D, Cheng L, et al. Epithelial-mesenchymal transition induced by hepatitis C virus core protein in cholangiocarcinoma. Ann Surg Oncol. 2010; Vol. 17: p.1937–1944.; Sato Y, Harada K, Itatsu K, et al. Epithelialmesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma. Am J Pathol. 2010; Vol.177: p.141–152.; Korita PV, Wakai T, Ajioka Y, et al. Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma. Anticancer Res. 2010; Vol.30: p.2279–2285.; Cadamuro M, Nardo G, Indraccolo S, et al. Plateletderived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma. Hepatology. 2013; Fingas CD, Mertens JC, Razumilava N, et al. Targeting PDGFR-beta in Cholangiocarcinoma. Liver Int. 2012; Vol.32: p. 400–409.; Utispan K, Thuwajit P, Abiko Y, et al. Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker. Mol Cancer. 2010; Vol.9: p.13.; Baril P, Gangeswaran R, Mahon PC, et al. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3kpathway. Oncogene. 2007; Vol.26: p.2082–2094.; Menakongka A, Suthiphongchai T. Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion. World J Gastroenterol. 2010; Vol.16: p.713–722.; Ohira S, Sasaki M, Harada K, et al. Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. Am J Pathol. 2006; Vol.168: p.1155–1168.; Leelawat K, Leelawat S, Narong S, Hongeng S. Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. World J Gastroenterol. 2007; Vol.13: p.1561–1568.; Terada T, Okada Y, Nakanuma Y. Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors. Hepatology. 1996; Vol. 23: p. 1341–1344.; Prakobwong S, Yongvanit P, Hiraku Y, et al. Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model. Int J Cancer. 2010; Vol.127: p.2576–2587.; Cohen SJ, Alpaugh RK, Palazzo I, et al. Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma. Pancreas. 2008; Vol.37: p.154–158.; Mertens JC, Fingas CD, Christensen JD, et al. Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma. Cancer Res. 2013; Vol. 73: p. 897–907.; Ko KS, Peng J, Yang H. Animal models of cholangiocarcinoma. Curr Opin Gastroenterol. 2013; Vol.29: p.312–318.; Fava G, Marucci L, Glaser S, et al. gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. Cancer Res. 2005; Vol.65: p.11437–11446.; Pawar P, Ma L, Byon CH, et al. Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin. Clin Cancer Res. 2009; Vol.15: p. 1288–1296.; Tang T, Zheng JW, Chen B, et al. Effects of targeting magnetic drug nanoparticles on human cholangiocarcinoma xenografts in nude mice. Hepatobiliary Pancreat Dis Int. 2007; Vol.6: p. 303–307.; Zhang J, Han C, Wu T. MicroRNA-26a promotes cholangiocarcinoma growth by activating betacatenin. Gastroenterology. 2012; Vol.143: p.246–526.; Olaru AV, Ghiaur G, Yamanaka S, et al. MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint. Hepatology. 2011; Vol. 54: p.2089–2098.; Zhang K, Chen D, Wang X, et al. RNA Interference Targeting Slug Increases Cholangiocarcinoma Cell Sensitivity to Cisplatin via Upregulating PUMA. Int J Mol Sci. 2011; Vol.12: p.385–400.; Obchoei S, Weakley SM, Wongkham S, et al. Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer. 2011; Vol.10: p.102.; Hou YJ, Dong LW, Tan YX, et al. Inhibition of active autophagy induces apoptosis and increases chemosensitivity in cholangiocarcinoma.Lab Invest.2011; Vol. 91: p.1146–1157.; Xu X, Kobayashi S, Qiao W, et al. Induction of intrahepatic cholangiocellular carcinoma by liverspecific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; Vol.116: p.1843–1152.; Farazi PA, Zeisberg M, Glickman J, et al. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res. 2006; Vol. 66: p. 6622–6627.; Song H, Mak KK, Topol L, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010; Vol.107: p.1431–1436.; Lee KP, Lee JH, Kim TS, et al. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A. 2010; Vol.107: p.8248–8253.; O’Dell MR, Huang JL, Whitney-Miller CL, et al. Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma. Cancer Res. 2012; Vol.72: p.1557–1567.; Sirica AE, Zhang Z, Lai GH, et al. A novel “patientlike” model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. Hepatology. 2008; Vol. 47: p.1178–1190.; Campbell DJ, Dumur CI, Lamour NF, et al. Novel organotypic culture model of cholangiocarcinoma progression. Hepatol Res. 2012; Vol.42: p.1119–1130.; Fava G, Alpini G, Rychlicki C, et al. Leptin enhances cholangiocarcinoma cell growth. Cancer Res. 2008; Vol.68: p.6752–6761.; Yang H, Li TW, Peng J, et al. A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression. Gastroenterology. 2011; Vol.141: p.378–388.; Plengsuriyakarn T, Eursitthichai V, Labbunruang N, et al. Ultrasonography as a tool for monitoring the development and progression of cholangiocarcinoma in Opisthorchis viverrini/dimethylnitrosamine-induced hamsters. Asian Pac J Cancer Prev. 2012; Vol.13: p.87–90.; Yamasaki S. Intrahepatic cholangiocarcinoma: macroscopic type and stage classification. J Hepatobiliary Pancreat Surg. 2003; Vol. 10: p.288–291.; Rimola J, Forner A, Reig M, et al. Cholangiocarcinoma in cirrhosis: absence of contrast washout in delayed phases by magnetic resonance imaging avoids misdiagnosis of hepatocellularcarcinoma. Hepatology. 2009; Vol.50: p.791–798.; Vilgrain V. Staging cholangiocarcinoma by imaging studies. HPB (Oxford) 2008; Vol. 10: p.106–109.; Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology. 2008; Vol.48: p.308–321.; Patel AH, Harnois DM, Klee GG, et al. The utility of CA 19–9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis. Am J Gastroenterol. 2000; Vol. 95: p. 204–207.; Sapisochin G, Fidelman N, Roberts JP, Yao FY. Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma. Liver Transpl. 2011; Vol.17: p.934–942.; Endo I, Gonen M, Yopp AC, et al. Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg. 2008; Vol.248: p.84–96.; Choi SB, Kim KS, Choi JY, et al. The prognosis and survival outcome of intrahepatic cholangiocarcinoma following surgical resection: association of lymph node metastasis and lymph node dissection with survival. Ann Surg Oncol. 2009; Vol. 16: p.3048–3056.; Li YY, Li H, Lv P, et al. Prognostic value of cirrhosis for intrahepatic cholangiocarcinoma after surgical treatment. J Gastrointest Surg. 2011; Vol.15: p.608–613.; Fabris L, Cadamuro M, Moserle L, et al. Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization. Hepatology. 2011; Vol.54: p.890–899.; Kuhlmann JB, Blum HE. Locoregional therapy for cholangiocarcinoma. Curr Opin Gastroenterol. 2013; Vol.29: p.324–328.; Valle J, Wasan H, Palmer DH, et al. Investigators ABCT. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010; Vol.362: p.1273–1281.; Yamashita Y, Takahashi M, Kanazawa S, et al. Hilar cholangiocarcinoma. An evaluation of subtypes with CT and angiography. Acta Radiol. 1992; Vol.33: p.351–355.; Heimbach JK, Sanchez W, Rosen CB, Gores GJ. Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination.HPB (Oxford) 2011; Vol.13: p.356–360.; Moreno Luna LE, Kipp B, Halling KC, et al. Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures.Gastroenterology.2006; Vol.131: p.1064–1072.; Barr Fritcher EG, Kipp BR, Voss JS, et al. Primary sclerosing cholangitis patients with serial polysomy fluorescence in situ hybridization results are at increased risk of cholangiocarcinoma.Am J Gastroenterol.2011; Vol.106:2023–2028.; Barr Fritcher EG, Voss JS, Jenkins SM, et al. Primary sclerosing cholangitis with equivocal cytology: Fluorescence in situ hybridization and serum CA 19–9 predict risk of malignancy.Cancer Cytopathol.2013.; Nagorney DM, Kendrick ML. Hepatic resection in the treatment of hilar cholangiocarcinoma.Adv Surg.2006; Vol.40: p.159–171.; Darwish Murad S, Kim WR, Harnois DM, et al. Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers.Gastroenterology.2012; Vol.143: p.88–98.; Hong JC, Jones CM, Duffy JP, et al. Comparative analysis of resection and liver transplantation for intrahepatic and hilar cholangiocarcinoma: a 24- year experience in a single center. Arch Surg. 2011; Vol.146: p.683–689.; Geynisman DM, Catenacci DV. Toward personalized treatment of advanced biliary tract cancers. Discov Med. 2012; Vol.14: p.41–57.; https://www.malignanttumors.org/jour/article/view/147

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