Εμφανίζονται 1 - 20 Αποτελέσματα από 110 για την αναζήτηση '"деполимеризация"', χρόνος αναζήτησης: 1,11δλ Περιορισμός αποτελεσμάτων
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    Academic Journal
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    Academic Journal

    Συνεισφορές: The study was carried out with the support of the Russian Science Foundation (RSF) (grant No. 20-15-00001) and was performed as a part of Russia Strategic Academic Leadership Program (“Priority-2030”) of Kazan (Volga Region) Federal University, Исследование выполнено при поддержке Российского научного фонда (грант № 20-15-00001) и проведено в рамках Программы стратегического академического лидерства ФГАОУ ВО «Казанский (Приволжский) федеральный университет» («Приоритет-2030»)

    Πηγή: Advances in Molecular Oncology; Vol 11, No 2 (2024); 130-146 ; Успехи молекулярной онкологии; Vol 11, No 2 (2024); 130-146 ; 2413-3787 ; 2313-805X

    Περιγραφή αρχείου: application/pdf

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    Conference

    Συνεισφορές: Сметанина, Евгения Ильинична

    Περιγραφή αρχείου: application/pdf

    Relation: Химия и химическая технология в XXI веке : материалы XXIV Международной научно-практической конференции студентов и молодых ученых имени выдающихся химиков Л. П. Кулёва и Н. М. Кижнера, посвященной 85-летию со дня рождения профессора А. В. Кравцова, Томск, 15-19 мая 2023 г. Т. 1; http://earchive.tpu.ru/handle/11683/76605

    Διαθεσιμότητα: http://earchive.tpu.ru/handle/11683/76605

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    Academic Journal

    Συνεισφορές: The study was carried out with the support of the Russian Science Foundation (grant No. 21-75-00014) and was performed as a part of Russia Strategic Academic Leadership Program (PRIORITY-2030) of Kazan Federal University of Ministry of Health., Исследование выполнено при поддержке Российского научного фонда (грант № 21-75-00014) и в рамках Программы стратегического академического лидерства Казанского (Приволжского) федерального университета (ПРИОРИТЕТ-2030).

    Πηγή: Advances in Molecular Oncology; Том 10, № 3 (2023); 59-71 ; Успехи молекулярной онкологии; Том 10, № 3 (2023); 59-71 ; 2413-3787 ; 2313-805X ; 10.17650/2313-805X-2023-10-3

    Περιγραφή αρχείου: application/pdf

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Pironetin binds covalently to αCys316 and perturbs a major loop and helix of α-tubulin to inhibit microtubule formation. J Mol Biol 2016;428(15):2981–8. DOI:10.1016/j.jmb.2016.06.023; Steinmetz M.O., Prota A.E. Microtubule-targeting agents: strategies to hijack the cytoskeleton. Trends Cell Biol 2018;28(10):776–92. DOI:10.1016/j.tcb.2018.05.001; Fanale D., Bronte G., Passiglia F. et al. Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option? Anal Cell Pathol 2015;2015:690916. DOI:10.1155/2015/690916; Mooberry S.L., Tien G., Hernandez A.H. et al. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents. Cancer Res 1999;59(3):653–60.; West L.M., Northcote P.T., Battershill C.N., Peloruside A. A potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp. J Org Chem 2000;65(2):445–9. DOI:10.1021/jo991296y; Prota A.E., Bargsten K., Northcote P.T. et al. Structural basis of microtubule stabilization by laulimalide and peloruside A. Angew Chem Int Ed Engl 2014;53(6):1621–5. DOI:10.1002/anie.201307749; Munshi N., Jeay S., Li Y. et al. ARQ 197, a novel and selective inhibitor of the human c-met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther 2010;9(6):1544–53. DOI:10.1158/1535-7163.MCT-09-1173; Katayama R., Aoyama A., Yamori T. et al. Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition. Cancer Res 2013;73(10):3087–96. DOI:10.1158/0008-5472.CAN-12-3256; Aoyama A., Katayama R., Oh-Hara T. et al. Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance. Mol Cancer Ther 2014;13(12):2978–90. DOI:10.1158/1535-7163.MCT-14-0462; Gumireddy K., Reddy M.V.R., Cosenza S.C. et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell 2005;7:275–86. 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Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer 2010;10(3):194–204. DOI:10.1038/nrc2803; Зыкова С.С., Бойчук С.В., Галембикова А.Р. и др. 3-гидрокси-1,5-диарил-4-пивалоил-2,5-дигидро-2-пирролоны нарушают процессы митоза и индуцируют гибель опухолевых клеток in vitro. Цитология 2014;56:439–42.; Boichuk S., Galembikova A., Zykova S. et al. Ethyl-2-aminopyrrole-3-carboxylates are novel potent anticancer agents that affect tubulin polymerization, induce G2/M cell-cycle arrest, and effectively inhibit soft tissue cancer cell growth in vitro. Anti-Cancer Drugs 2016;27(7):620–34. DOI:10.1097/CAD.0000000000000372; Boichuk S., Galembikova A., Dunaev P. et al. Ethyl-2-aminopyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo. Anti-Cancer Drugs 2019;30(5):475–84. DOI:10.1097/CAD.0000000000000753; Carta D., Bortolozzi R., Sturlese M. et al. Synthesis, structureactivity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents. Eur J Med Chem 2017;127:643–60. DOI:10.1016/j.ejmech.2016.10.026; Brindisi M., Ulivieri C., Alfano G. et al. Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. Eur J Med Chem 2019;162:290–320. DOI:10.1016/j.ejmech.2018.11.004; Boichuk S., Galembikova A., Syuzov K. et al. The design, synthesis, and biological activities of pyrrole-based carboxamides: the novel tubulin inhibitors targeting the colchicine-binding site. Molecules 2021;26(19):5780. DOI:10.3390/molecules26195780; Boichuk S., Galembikova A., Sitenkov A. et al. Establishment and characterization of a triple negative basal-like breast cancer cell line with multi-drug resistance. Oncol Lett 2017;14(4):5039–45. DOI:10.3892/ol.2017.6795; Zykova S., Kizimova I., Syutkina A. et al. Synthesis and cytostatic activity of (E)-ethyl-2-amino-5-(3,3-dimethyl-4-oxobutyliden-4oxo-1-(2-phenylaminobenzamido)-4,5-dihydro-1Hpyrrol-3carboxylate. Pharm Chem J 2020;53:895–8. DOI:10.1007/s11094020-02096-z; Boichuk S., Bikinieva F., Valeeva E. et al. Establishment and characterization of multi-drug resistant p53-negative osteosarcoma SaOS-2 subline. Diagnostics 2023;13:2646. DOI:10.3390/diagnostics13162646; Boichuk S., Dunaev P., Mustafin I. et al. Infigratinib (BGJ 398), a pan-FGFR inhibitor, targets P-glycoprotein and increases chemotherapeutic-induced mortality of multidrug-resistant tumor cells. Biomedicines 2022;10(3):601. DOI:10.3390/biomedicines10030601; Distefano M., Scambia G., Ferlini C. et al. Antitumor activity of paclitaxel (taxol) analogues on MDR-positive human cancer cells. Anticancer Drug Des 1998;13(5):489–99.; Pirol Ş.C., Çalışkan B., Durmaz I. et al. Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3carboxylic acid amides with potent anti-proliferative activity on human cancer cell lines. Eur J Med Chem 2014;87:140–9. DOI:10.1016/j.ejmech.2014.09.056; Ke J., Lu Q., Wang X. et al. Discovery of 4,5-dihydro-1Hthieno[2’,3’:2,3]thiepino [4,5-c]pyrazole-3-carboxamide derivatives as the potential epidermal growth factor receptors for tyrosine kinase inhibitors. Molecules 2018;23:1980. DOI:10.3390/molecules23081980; Lin T., Li J., Liu L. et al. Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors. Eur J Med Chem 2021;215:113281. DOI:10.1016/j.ejmech.2021.113281; Yasuda Y., Arakawa T., Nawata Y. et al. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Bioorg Med Chem 2015;23(8):1776–87. DOI:10.1016/j.bmc.2015.02.038; Gul H.I., Mete E., Eren S.E. et al. Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydropyrazol-1-yl]benzenesulfonamides. J Enzyme Inhib Med Chem 2017;32(1):169–75. DOI:10.1080/14756366.2016.1243536; Gul H.I., Yamali C., Bulbuller M. et al. Anticancer effects of new dibenzenesulfonamides by inducing apoptosis and autophagy pathways and their carbonic anhydrase inhibitory effects on hCA I, hCA II, hCA IX, hCA XII isoenzymes. Bioorg Chem 2018;78: 290–7. DOI:10.1016/j.bioorg.2018.03.027; Gul H.I., Yamali C., Sakagami H. et al. New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors. Bioorg Chem 2018;77:411–9. DOI:10.1016/j.bioorg.2018.01.021; Yamali C., Sakagami H., Uesawa Y. et al. Comprehensive study on potent and selective carbonic anhydrase inhibitors: synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1Hpyrazole-1-yl) benzenesulfonamides. Eur J Med Chem 2021;217:113351. DOI:10.1016/j.ejmech.2021.113351; Mooberry S.L., Weiderhold K.N., Dakshanamurthy S. et al. Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole. Mol Pharmacol 2007;72(1):132–40. DOI:10.1124/mol.107.034876; Da C., Telang N., Barelli P. et al. Pyrrole-based antitubulin agents: two distinct binding modalities are predicted for C-2 analogues in the colchicine site. ACS Med Chem Lett 2012;3(1):53–7. DOI:10.1021/ml200217u; Romagnoli R., Oliva P., Salvador M.K. et al. A facile synthesis of diary l pyrroles led to the discovery of potent colchicine site antimitotic agents. Eur J Med Chem 2021;214:113229. DOI:10.1016/j.ejmech.2021.113229; https://umo.abvpress.ru/jour/article/view/571

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    Conference

    Συνεισφορές: Волгина, Татьяна Николаевна

    Περιγραφή αρχείου: application/pdf

    Relation: Химия и химическая технология в XXI веке : материалы XXII Международной научно-практической конференции студентов и молодых ученых имени выдающихся химиков Л. П. Кулёва и Н. М. Кижнера, посвященной 125-летию со дня основания Томского политехнического университета, Томск, 17-20 мая 2021 г. Т. 2. — Томск, 2021; http://earchive.tpu.ru/handle/11683/67621

    Διαθεσιμότητα: http://earchive.tpu.ru/handle/11683/67621

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    Conference

    Συνεισφορές: Волгина, Татьяна Николаевна

    Περιγραφή αρχείου: application/pdf

    Σύνδεσμος πρόσβασης: http://earchive.tpu.ru/handle/11683/67621

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    Conference

    Συνεισφορές: Новиков, Виктор Тимофеевич

    Περιγραφή αρχείου: application/pdf

    Relation: Химия и химическая технология в XXI веке : материалы XXI Международной научно-практической конференции студентов и молодых ученых имени выдающихся химиков Л. П. Кулёва и Н. М. Кижнера, посвященной 110-летию со дня рождения профессора А. Г. Стромберга, 21–24 сентября 2020 г., г. Томск; http://earchive.tpu.ru/handle/11683/63540

    Διαθεσιμότητα: http://earchive.tpu.ru/handle/11683/63540

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    Conference

    Συνεισφορές: Волгина, Татьяна Николаевна

    Περιγραφή αρχείου: application/pdf

    Relation: Химия и химическая технология в XXI веке : материалы XXI Международной научно-практической конференции студентов и молодых ученых имени выдающихся химиков Л. П. Кулёва и Н. М. Кижнера, посвященной 110-летию со дня рождения профессора А. Г. Стромберга, 21–24 сентября 2020 г., г. Томск; http://earchive.tpu.ru/handle/11683/63531

    Διαθεσιμότητα: http://earchive.tpu.ru/handle/11683/63531

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    Conference

    Συνεισφορές: Новиков, Виктор Тимофеевич

    Περιγραφή αρχείου: application/pdf

    Σύνδεσμος πρόσβασης: http://earchive.tpu.ru/handle/11683/63540

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