Εμφανίζονται 1 - 20 Αποτελέσματα από 50 για την αναζήτηση '"ЭКСТРАКОРПОРАЛЬНОЕ ОПЛОДОТВОРЕНИЕ (ЭКО)"', χρόνος αναζήτησης: 0,68δλ Περιορισμός αποτελεσμάτων
  1. 1
    Academic Journal

    Συγγραφείς: Kudratova , Rano

    Πηγή: Eurasian Journal of Medical and Natural Sciences; Vol. 5 No. 10 (2025): Eurasian Journal of Medical and Natural Sciences; 305-313 ; Евразийский журнал медицинских и естественных наук; Том 5 № 10 (2025): Евразийский журнал медицинских и естественных наук; 305-313 ; Yevrosiyo tibbiyot va tabiiy fanlar jurnali; Jild 5 Nomeri 10 (2025): Евразийский журнал медицинских и естественных наук; 305-313 ; 2181-287X

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    Academic Journal

    Συγγραφείς: P. O. Sotskiy, П. О. Соцкий

    Πηγή: Medical Genetics; Том 20, № 1 (2021); 3-11 ; Медицинская генетика; Том 20, № 1 (2021); 3-11 ; 2073-7998

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    Relation: https://www.medgen-journal.ru/jour/article/view/1837/1466; Siegal S. Benign paroxysmal peritonitis. Ann Intern Med. 1945;23(1):1; Ben-Chetrit E., Touitou I. Familial mediterranean Fever in the world. Arthritis Rheum. 2009;61(10):1447-1453.; Ben-Chetrit E., Levy M. Familial Mediterranean fever. Lancet 1998; 351:659-664. doi:10.1016/S0140-6736(97)09408-7; Sohar E., Gafni J., Pras M., Heller H. Familial Mediterranean fever: a survey of 470 cases and review of the literature. Am J Med 1967; 43:227-253. doi:10.1016/0002-9343(67)90167-2; Goldfinger S.E. Colchicine for familial Mediterranean fever. N Eng J Med. 1972;287:1302. doi:10.1056/NEJM197212212872514; Taylor E. W. The mechanism of colchicine inhibition of mitosis. Kinetics of Inhibition and the Binding of H3-Colchicine. J Cell Biol.1965;25(1):145-160. doi:10.1083/jcb.25.1.145; Ehrenfeld E.N., Polishuk W.Z. Gynecological aspects of recurrent polyserositis. Isr J Med Sci. 1970; 6:9-13.; Mamou H. Periodic Disease and Endocrine Disorders. Semin Hop Paris.1970;46:2027-2029.; Ismajovich B., Zemer D., Revach M. et al. The causes of infertility in females with familial editerranean fever. Fertil Steril.1973;24:844-847. doi:10.1016/s0015-0282(16)40030-0; Ben-Chetrit E., Ben-Chetrit A., Berkun Y., Ben-Chetrit E. Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified? Arthritis Care Res.2010; 62(2):143-148. doi:10.1002/acr.20061; Yanmaz M.N., Özcan A.J., Savan K. The impact of familial Mediterranean fever on reproductive system. Clin Rheumatol. 2014;33(10):1385-1388. doi:10.1007/s10067-014-2709-9; Sarı İ., Birlik M., Kasifoğlu T. Familial Mediterranean fever: An updated review. Eur J Rheumatol. 2014;1(1):21-33. doi:10.5152/eurjrheum.2014.006; Dotters-Katz S., Kuller J., Price T. The impact of familial Mediterranean fever on women’s health. Obstet Gynecol Surv. 2012;67(6):357-364. doi:10.1097/OGX.0b013e318259ed3a; Indraratna P., Virk S., Gurram D., Day R. Use of colchicine in pregnancy: A systematic review and meta-analysis. Rheumatology (Oxford) 2018; 57(2):382-387. doi:10.1093/rheumatology/kex353.; Granat M., Tur-Kaspa I., Zylber-Katz E., Schenker J.G. Reduction of peritoneal adhesion formation by colchicine: a comparative study in the rat. Fertil Steril 1983; 40:369-372. doi:10.1016/s0015-0282(16)47302-4.; Ben-Chetrit E., Levy M. Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 2003; 62:916-919. doi:10.1136/ard.62.10.916.; Ben-Chetrit E. Clinical manifestations and diagnosis of familial Mediterranean fever. Available at: https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-familial-mediterranean-fever/print; French FMFC. A candidate gene for Familial Mediterranean Fever. Nat Genet 1997;17:25-31. doi:10.1038/ng0997-25.; The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997; 90:797-807. doi:10.1016/s0092-8674(00)80539-5.; de Menthière С.S., Terrière S., Pugnère D., Ruiz M., Demaille J., Touitou I. INFEVERS: the Registry for FMF and hereditary inflammatory disorders mutations/ Nucleic Acids Research 2003; 31(1): 282-285. https://doi.org/10.1093/nar/gkg031; Ozdogan H., Ugurlu S. Familial Mediterranean Fever. Presse Med. 2019;48(1):61-76. doi:10.1016/j.lpm.2018.08.014.; Touitou I. The spectrum of Familial Mediterranean Fever (FMF) mutations. Eur J Hum Gen 2001;9(7):473-483. doi:10.1038/sj.ejhg.5200658.; Shinar Y., Obici L., Aksentijevich I., Sarkisian T. Guidelines for the genetic diagnosis of hereditary recurrent fevers. Ann Rheum Dis. 2012;71(10):1599-1605. doi:10.1136/annrheumdis-2011-201271; Gershoni-Baruch R., Вrik R., Shinawi M., Livneh A. The differential contribution of MEFV mutant alleles to the clinical profile of Familial Mediterranean Fever. Eur J Hum Genet 2002;10(2):145-149. doi:10.1038/sj.ejhg.5200776.; Mijatovic V., Hompes P.G., Wouters M.G. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gynecol Reprod Biol 2003.10;108(2):171-176. doi:10.1016/s0301-2115(02)00417-7.; Cerquaglia C., Verrecchia E., Fonnesu C. et al. Female reproductive dysfunction in familial Mediterranean fever patients with and without colchicine treatment. Clin Exp Rheumatol 2010;28:S101.; Ofir D., Levy A., Wiznitzer A. et al. Familial Mediterranean fever during pregnancy: an independent risk factor for preterm delivery. Eur J Obstet Gynecol Reprod Biol 2008; 141:115-118. doi:10.1016/j.ejogrb.2008.07.025.; Golden R.L., Weigers E.W., Meagher J.G. Periodic fever and menses. Am J Obstet Gynecol 1973; 117:855-856.; Ben-Chetrit E& Ben-Chetrit A. Familial Mediterranean fever and menstruation. BJOG: an international journal of obstetrics and gynaecology. 2001;108:403-407. doi:10.1111/j.1471-0528.2001.00083.x.; Koh K.K., Bui M.N., Mincemoyer R., Cannon R.O. 3rd. Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women. Am J Cardiol 1997;80:1505-1507.; Chaudoreille M.M., Peyrot V., Braquer D. et al. Qualitative study of the interaction mechanism of estrogenic drugs with tubulin.… Biochem Pharmacol 1991March 1;41(5):685-693.; Levy M., Yaffe C. Testicular function in patients with familial Mediterranean fever on long-term colchicine treatment. Fertil Steril 1978; 29:667-668.doi:10.1016/s0015-0282(16)43342-x.; Cronstein B.N., Molad Y., Reibman J. et al. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest 1995; 96:994-1002. doi:10.1172/JCI118147.; Ben-Chetrit E., Levy M. Colchicine update 1998. Semin Arthritis Rheum 1998;28:48-59. doi:10.1016/s0049-0172(98)80028-0.; Ehrenfeld M., Brzezinski A., Levy M., Eliakim M. Fertility and obstetric history in patients with familial Mediterranean fever on long term colchicines therapy. Br J Obstet Gynaecol 1987; 94:1186-1191. doi:10.1111/j.1471-0528. 1987. Tb 02320.x.; Dor J., Homburg R., Rabau E. An evaluation of etiologic factors and therapies in 665 infertile couples. Fertil Steril 1977;28:718-722.; Uzunaslan D., Saygin C., Hatemi G. et al. No appreciable decrease in fertility in Behçet’s syndrome. Rheumatology (Oxford) 2014;53(5):828-833. doi:10.1093/rheumatology/ket436.; Zadeh N., Getzug T., Grody W.W. Diagnosis and management of familial Mediterranean fever: Integrating medical genetics in a dedicated interdisciplinary clinic. Genet Med 2011;13(3):263-269. doi:10.1097/GIM.0b013e31820e27b1.; Haimov-Kochman R., Prus D., Ben-Chetrit E. Azoospermia due to testicular amyloidosis in a patient with familial Mediterranean fever. Hum Reprod 2001;16:1218-1220. doi:10.1093/humrep/16.6.1218.; Shepard T.H. Catalog of teratogenic agents, 6th ed. Baltimore, MD: Johns Hopkins University Press; 1989:164-166.; Merlin H.E. Azoospermia caused by colchicine - a case report. Fertil Steril 1972; 23:180-181. doi:10.1016/s0015-0282(16)38823-9.; Yu T.F., Gutman A.B. Efficacy of colchicine prophylaxis in gout. Ann Int Med 1961;55:179-192. doi:10.7326/0003-4819-55-2-179.; Bremner W.J., Plausen C.A. Colchicine and testicular function in man. N Eng J Med 1976; 294:1384-1385. doi:10.1056/NEJM197606172942508.; Sarica K., Suzer O., Gurler A. et al. Urological evaluation of Behcet patients and the effect of colchicine on fertility. Eur J Urol 1995; 22:39-42. doi:10.1159/000475121.; Ben-Chetrit E., Backenroth R., Haimov-Kochman R., Pizov G. Azoospermia in familial Mediterranean fever patients: the role of colchicines and amyloidosis. Ann Rheum Dis 1998; 57:259-260. doi:10.1136/ard.57.4.259; Ben-Chetrit A., Ben-Chetrit E., Nitzan R., Ron M. Colchicine inhibits human spermatozoal motility in-vitro. Inter J Fertil 1993;88:301-304.; Zemer D., Pras M., Shemer Y. Daily prophylactic colchicine in familial Mediterranean fever. In: Amyloid and Amyloidosis. Proceedings of the 3rd International Symposium on Amyloidosis. ExerptaMedica. Amsterdam-Oxford-Prinston. 1980:580-583.; Ben-Chetrit E., Berkun Y., Ben-Chetrit E., Ben-Chetrit A. The outcome of pregnancy in the wives of men with familial mediterranean fever treated with colchicine. Semin Arthritis Rheum 2004 Oct;34(2):549-552. doi:10.1016/j.semarthrit.2004.07.004.; Ugurlu S., Seyahi E., Hatemi G. et al. Canakinumab Therapy in Patients with Familial Mediterranean Fever. Arthritis Rheumatol 2015;67:362-363; Youngstein T., Hoffman P., Gul A. et al. International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology 2017;456:2102-2108. doi:10.1093/rheumatology/ kex305.; Yilmaz N.K., Kara M., Kaba M. et al. Effect of Familial Mediterranean Fever on IVF outcome: A Retrospective Case Series. Acta Clin Croat 2016;55:254-258. doi:10.20471/acc.2016.55.02.11.; Ozgur K., Bulut H., Berkkanoglu M. et al. Colchicine treatment for FMF does not affect IVF outcome. Fertility and Sterility 2013;100(3):S507. doi:https://doi.org/10.1016/j.fertnstert. 2013.07.205; Diav-Citrin O., Shechtman S., Schwartz V. et al. Pregnancy outcome after in utero exposure to colchicine. Am J Obstet Gynecol. 2010; 203:144. doi:10.1016/j.ajog.2010.02.063.; Oner G., Muderris I.I. Assessment of ovarian reserve based on hormonal parameters, ovarian volume, and antral follicle count in women with familial Mediterranean fever. Eur J Obstet Gynecol Reprod Biol 2013. Oct;170(2):449-451. doi:10.1016/j.ejogrb.2013.07.023.; Ozen S., Demirkaya E., Erer B. et al. EULAR recommendations for the management of familial Mediterranean fever. Annals of the Rheumatic Diseases 2016;75:644-651. doi:10.1136/ annrheumdis-2015-208690.

  7. 7
    Academic Journal

    Πηγή: Medical Genetics; Том 20, № 2 (2021); 27-38 ; Медицинская генетика; Том 20, № 2 (2021); 27-38 ; 2073-7998

    Περιγραφή αρχείου: application/pdf

    Relation: https://www.medgen-journal.ru/jour/article/view/1876/1473; Ben-Chetrit E., Levy M. Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 2003; 62:916-919. doi:10.1136/ard.62.10.916.; French FMFC. A candidate gene for Familial Mediterranean Fever. Nat Genet 1997;17:25-31. doi:10.1038/ng0997-25.; Milhavet F., Cuisset L., Hoffman H.M. The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997; 90:797-807. doi:10.1016/S0092-8674(00)80539-5.; The Infevers Autoinflammatory Mutation Online Registry: Update With New Genes and Functions. Hum Mutat. 2008;29(6):803-808. doi:10.1002/humu.20720.; Ozdogan H., Ugurlu S. Familial Mediterranean Fever. Presse Med. 2019;48(1):61-76. doi:10.1016/j.lpm.2018.08.014.; van Jaarsveld C.H., Sanderman R., Ranchor A.V. et al. Gender-specific changes in quality of life following cardiovascular disease: a prospective study. J Clin Epidemiol. 2002;55(11):1105-1112. doi:10.1016/s0895-4356(02)00506-1.; Taylor E. W. The mechanism of colchicine inhibition of mitosis. Kinetics of Inhibition and the Binding of H3-Colchicine. J Cell Biol. 1965;25(1):145-160. doi:10.1083/jcb.25.1.145; Ehrenfeld M., Brzezinski A., Levy M., Eliakim M. Fertility and obstetric history in patients with familial Mediterranean fever on long-term colchicine therapy. Br J Obstet Gynaecol 1987; 94(12): 1186-1191. doi:10.1111/j.1471-0528.1987.tb02320.x.; Ismajovich B., Zemer D., Revach M. et al. The causes of infertility in females with familial editerranean fever. Fertil Steril 1973; 24:844-847.; Mamou H. Periodic Disease and Endocrine Disorders. Semin Hop Paris.1970;46:2027-2029.; Mijatovic V., Hompes P.G., Wouters M.G. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gynecol Reprod Biol 2003.10;108(2):171-176. doi:10.1016/s0301-2115(02)00417-7.; Zemer D., Pras M., Shemer Y. et al. Daily prophylactic colchicine in familial Mediterranean fever. In: Amyloid and amyloidosis. Proc 3rd International Symposium on Amyloidosis. Amsterdam-Oxford-Prinston: Exerpta Medica 1980:580-583.; Kasifoglu T. et al. Amyloidosis and its related factors in Turkish patients with familial Mediterranean fever: a multicentre study. Rheumatology (Oxford) 2014; 53:741-745. doi:10.1093/rheumatology/ket400.; Ben-Chetrit E., Ben-Chetrit A., Berkun Y., Ben-Chetrit E. Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified? Arthritis Care Res. 2010; 62(2):143-148. doi:10.1002/acr.20061.; Dotters-Katz S., Kuller J., Price T. The impact of familial Mediterranean fever on women’s health. Obstet Gynecol Surv 2012;67(6):357-364. doi:10.1097/OGX.0b013e318259ed3a.; Yanmaz M.N., Özcan A.J., Savan K. The impact of familial Mediterranean fever on reproductive system. Clin Rheumatol. 2014;33(10):1385-1388. doi:10.1007/s10067-014-2709-9.; Sarı İ., Birlik M., Kasifoğlu T. Familial Mediterranean fever: An updated review. Eur J Rheumatol. 2014;1(1):21-33. doi:10.5152/eurjrheum.2014.006; Livneh A., Langevitz P., Zemer D., et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997;40(10):1879-1885. doi:10.1002/art.1780401023.; Mor A., Shinar Y., Zaks N. et al. Evaluation of diseases verity in familial Mediterranean fever. Semin Arthritis Rheum. 2005;35(1):57-64. doi:10.1016/j.semarthrit.2005.02.002.; Ben-Chetrit E, Ben-Chetrit A. Familial Mediterranean fever and menstruation. BJOG: an international journal of obstetrics and gynaecology. 2001; 108:403-407.; Dewalle M., Domingo C., Rozenbaum M. et al. Phenotype-genotype correlation in Jewish patients suffering from familial Mediterranean fever (FMF). Eur J Hum Genet. 1998;6(1):95-97. doi:10.1038/sj.ejhg.5200170.; Tunca M., Akar S., Onen F. et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine 2005;84:1-11.doi:10.1097/01.md.0000152370.84628.0c; Ben-Chetrit E., Touitou I. Familial Mediterranean Fever in the World. Arthritis Care & Research. 2009;61(10):1447-1453. doi:10.1002/art.24458.; Aksentijevich I., Torosyan Y., Samuels J. et al. Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population. Am J Hum Genet. 1999;64(4):949-962. doi:10.1086/302327.; Buades J., Ben-Chetrit E., Levy M. Familial Mediterranean fever in the “Chuetas” of Mallorca-origin in inquisition? Isr J Med Sci.1995;31(8):497-499.; Domingo C., Touitou I., Bayou A. et al. Familial Mediterranean fever in the ‘Chuetas’ of Mallorca: a question of Jewish origin or genetic heterogeneity. Eur J Hum Genet. 2000;8(4):242-246. doi:10.1038/sj.ejhg.5200462; Cazeneuve C., Sarkisian T., Pêcheux C. MEFV-Gene analysis in armenian patients with Familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications. Am J Hum Genet. 1999; 65(1):88-97. doi:10.1016/S0002-9297(07)62944-9.; Atoyan S., Hayrapetyan H., Sarkisian T., Ben-Chetrit E. MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia. Clin Exp Rheumatol 2016;34(6 Suppl 102):72-76.; Grossman C., Kassel Y., Livneh A., Ben-Zvi I. Familial Mediterranean fever (FMF) phenotype in patients homozygous to the MEFV M694V mutation. Eur J Med Genet 2019; 62(6):103532. doi:10.1016/j.ejmg.2018.08.013.; Giancane G., TerHaar N.M., Wulffraat N. et al. Evidence-based recommendations forgenetic diagnosis of Familial Mediterranean Fever. Ann Rheum Dis 2015;74(4):635-641. doi:10.1136/annrheumdis-2014-206844.; Booty M.G., Chae J.J., Masters S.L. Familial Mediterranean fever with a single MEFV mutation: where is the second hit? Arthritis Rheum. 2009;60(6):1851-1861. doi:10.1002/art.24569.; Marek-Yagel D., Berkun Y., Padeh S. et al. Clinical disease among patients heterozygous for familial Mediterranean fever. Arthritis Rheum. 2009; 60(6):1862-1866. doi:10.1002/art.24570.; Procopio V., Manti S., Bianco G. et al. Genotype-phenotype correlation in FMF patients: A “non classic» recessive autosomal or “atypical» dominant autosomal inheritance? Gene 2018;641:279-286. doi:10.1016/j.gene.2017.10.068.; Federici S., Caorsi R., Gattorno M. The autoinflammatory diseases. Swiss Med Wkly. 2012Jun 19;142:w13602. doi:10.4414/smw.2012.13602.; Yilmaz E., Ozen S. Balci B. et al. Mutation frequency of Familial Mediterranean Fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet 2001;9(7):553-555. doi:10.1038/sj.ejhg. 5200674.; Kogan A., Shinar Y., Lidar M. et al. Common MEFV mutations among Jewish ethnic groups in Israel: high frequency of carrier and phenotype III states and absence of a perceptible biological advantage for the carrier state. Am J Med Genet 2001;102:272-276. doi:10.1002/ajmg.1438.; Fujikura K. Global epidemiology of Familial Mediterranean Fever mutations using population exome sequences. Mol Genet Genomic Med 2015;3:272-282. doi:10.1002/mgg3.140.; Айрапетян А.С., Саркисян Т.Ф., Атоян С.А. Сравнение фенотипических проявлений периодической болезни у гетерозиготных носителей мутаций гена MEFV и гомозигот по тем же мутациям. Медицинская генетика.2016;15(10):45-49.; Zadeh N., Getzug T., Grody W.W. Diagnosis and management of familial Mediterranean fever: Integrating medical genetics in a dedicated interdisciplinary clinic. Genet Med. 2011;13(3):263-269. doi:10.1097/GIM.0b013e31820e27b1.; Yasar O., Iskender C., Kaymak O. et al. Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever. J Matern Fetal Neonatal Med. 2014; 27(7):733-736. doi:10.3109/14767058.2013.837446; Schwabe A.D., Peters R.S. Familial Mediterranean fever in Armenians. Analysis of 100 cases. Medicine 1974;53(6):453-462. doi:10.1097/00005792-197411000-00005.; Ozen S. Changing concepts in familial Mediterranean fever: is it possible to have an autosomal-recessive disease with only one mutation? Arthritis Rheum. 2009;60:1575-1577. doi:10.1002/art.24565.; Touitou I. The spectrum of Familial Mediterranean Fever (FMF) mutations. Eur J Hum Gen 2001;9(7):473-483. doi:10.1038/sj.ejhg.5200658.; Lidar M., Tokov I., Chetrit A. et al. Diagnosis delay in familial Mediterranean fever (FMF): social and gender gaps disclosed. Clin Exp Rheumatol. 2005;23(3):357-363.; Waldron I. et al. Sex differences in human mortality: The role of genetic factors. Social Science & Medicine. 1983;(6):321-333. https://doi.org/10.1016/0277-9536(83)90234-4

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    Academic Journal

    Πηγή: Proceedings of the National Academy of Sciences of Belarus. Agrarian Series; Том 57, № 2 (2019); 192-203 ; Известия Национальной академии наук Беларуси. Серия аграрных наук; Том 57, № 2 (2019); 192-203 ; 1817-7239 ; 1817-7204 ; 10.29235/1817-7204-2019-57-2

    Περιγραφή αρχείου: application/pdf

    Relation: https://vestiagr.belnauka.by/jour/article/view/343/336; Boni, R. Ovum pick-up in cattle: a 25 year retrospective analysis / R. Boni // Animal Reprod. Science. - 2012. - Vol. 9, N 3. - P. 362-369.; Эффективность получения ооцитов методом трансвагинальной аспирации у коров-доноров / В. К. Пестис [и др.] // Сельское хозяйство - проблемы и перспективы : сб. науч. тр. / Гродн. гос. аграр. ун-т. - Гродно, 2014. - Т. 26 : Зоотехния. - С. 218-225.; Использование биотехнологических методов в решении современных проблем репродукции сельскохозяй-ственных животных, как стратегия инновационного развития животноводства в Республике Беларусь / Л. В. Голубец [и др.] // Актуальные проблемы интенсивного развития животноводства : материалы XV Междунар. науч.-практ. конф. / Белорус. гос. с.-х. акад.; ред.: А. П. Курдеко [и др.]. - Горки, 2012. - С. 321-326.; Первый опыт получения эмбрионов крупного рогатого скота in vitro в системе трансвагинальной аспирации ооцитов (ТАО) / В. К. 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