Search Results - "ОПИОИДНЫЕ РЕЦЕПТОРЫ"

1

Academic Journal

INFARCT-REDUCING EFFECT OF DELTORPHIN II IN REPERFUSION OF THE HEART. THE ROLE OF NO-SYNTHASE, GUANYLYLCYCLASE, cGMP, MPT PORE ; ИНФАРКТ-ЛИМИТИРУЮЩИЙ ЭФФЕКТ ДЕЛЬТОРФИНА II ПРИ РЕПЕРФУЗИИ СЕРДЦА. РОЛЬ NO-СИНТАЗЫ, ГУАНИЛИЛЦИКЛАЗЫ, цГМФ, МРТ-ПОРЫ

Authors: Sergey V. Popov, Alexandr V. Mukhomedzyanov, Boris K. Kurbatov, Viacheslav N. Azev, Galina Z. Sufianova, Maria S. Khlestkina, Akpay Sh. Sarybaev, Leonid N. Maslov, Сергей Валентинович Попов, Александр Валерьевич Мухомедзянов, Борис Константинович Курбатов, Вячеслав Николаевич Азев, Галина Зиновьевна Суфианова, Мария Сергеевна Хлёсткина, Акпай Шогаибович Сарыбаев, Леонид Николаевич Маслов

Contributors: В работе использовано оборудование центра коллективного пользования «Медицинская геномика» Томского НИМЦ. Работа выполнена при поддержке РНФ (грант № 23-65-10017). Исследования с L-NAME проведены в рамках государственного задания 122020300042-4.

Source: Complex Issues of Cardiovascular Diseases; Том 13, № 4S (2024); 88-96 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 13, № 4S (2024); 88-96 ; 2587-9537 ; 2306-1278

Subject Terms: КАТФ-каналы, Ischemia/reperfusion, Opioid receptors, MPT pore, KATP channels, Ишемия-реперфузия, Опиоидные рецепторы, МРТ-пора

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Relation: https://www.nii-kpssz.com/jour/article/view/1129/976; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1129/1012; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1129/1013; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1129/1014; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1129/1015; Megaly M., Pershad A., Glogoza M., Elbadawi A., Omer M., Saad M., Mentias A., Elgendy I., Burke M.N., Capodanno D., Brilakis E.S. Use of intravascular imaging in patients with ST-segment elevation acute myocardial infarction. Cardiovasc Revasc Med. 2021; 30: 59-64. doi:10.1016/j.carrev.2020.09.032.; Ya'qoub L., Gad M., Saad A.M., Elgendy I.Y., Mahmoud A.N. National trends of utilization and readmission rates with intravascular ultrasound use for ST-elevation myocardial infarction. Catheter Cardiovasc Interv. 2021; 98(1): 1-9. doi:10.1002/ccd.29524.; Basir M.B., Lemor A., Gorgis S., Taylor A.M., Tehrani B., Truesdell A.G., Bharadwaj A., Kolski B., Patel K., Gelormini J., Todd J., Lasorda D., Smith C., Riley R., Marso S., Federici R., Kapur N.K., O'Neill W.W. National Cardiogenic Shock Initiative Investigators. Vasopressors independently associated with mortality in acute myocardial infarction and cardiogenic shock. Catheter Cardiovasc Interv. 2022; 99(3): 650-657. doi:10.1002/ccd.29895.; Sambola A., Elola F.J., Buera I., Fernández C., Bernal J.L., Ariza A., Brindis R., Bueno H., Rodríguez-Padial L., Marín F., Barrabés J.A., Hsia R., Anguita M. Sex bias in admission to tertiary-care centres for acute myocardial infarction and cardiogenic shock. Eur J Clin Invest. 2021; 51(7): e13526. doi:10.1111/eci.13526.; Liakopoulos O.J., Schlachtenberger G., Wendt D., Choi Y.H., Slottosch I., Welp H., Schiller W., Martens S., Welz A., Neuhäuser M., Jakob H., Wahlers T., Thielmann M. Early clinical outcomes of surgical myocardial revascularization for acute coronary syndromes complicated by cardiogenic shock: A Report From the North-Rhine-Westphalia Surgical Myocardial Infarction Registry. J Am Heart Assoc. 2019; 8(10): e012049. doi:10.1161/JAHA.119.012049.; Braile-Sternieri M.C.V.B., Mustafa E.M., Ferreira V.R.R., Braile Sabino S., Braile Sternieri G., Buffulin de Faria L.A., Sbardellini B.C., Vianna Queiroz C.O., Braile D.M., Zotarelli Filho I.J. Main considerations of cardiogenic shock and its predictors: systematic review. Cardiol Res. 2018; 9(2): 75-82. doi:10.14740/cr715w.; Григорьев Е.В., Баутин А.Е., Киров М.Ю., Шукевич Д.Л., Корнелюк Р.А. Кардиогенный шок при остром коронарном синдроме: современное состояние проблемы диагностики и интенсивной терапии. Вестник интенсивной терапии им. А.И. Салтанова. 2020; 2: 73–85. doi:10.21320/1818-474X-2020-2-73-85.; Maslov L.N., Mukhomedzyanov A.V., Tsibulnikov S.Y., Suleiman M.S., Khaliulin I., Oeltgen P.R. Activation of peripheral δ2-opioid receptor prevents reperfusion heart injury. Eur J Pharmacol. 2021; 907: 174302. doi:10.1016/j.ejphar.2021.174302.; Popov S.V., Mukhomedzyanov A.V., Tsibulnikov S.Y., Khaliuli I., Oeltgen P.R., Prasad N.R., Maslov L.N. Activation of peripheral opioid kappa1 receptor prevents cardiac reperfusion injury. Physiol Res. 2021; 70(4): 523-531. doi:10.33549/physiolres.934646.; Mukhomedzyanov A.V., Zhuk V.V., Maslov L.N., Shipunov A.I., Andrienko O.S., Gadirov R.M. Cardioprotective effect of opioids, derivatives of amide N-methyl-2-(pirrolidin-1-yl)cyclohexyl-1-amine, under conditions of ischemia/reperfusion of the heart. Bull Exp Biol Med. 2021; 170(6): 710-713. doi:10.1007/s10517-021-05138-y.; Маслов Л.Н., Лишманов Ю.Б. Проницаемость гематоэнцефалического барьера для опиоидных пептидов. Экспериментальная и клиническая фармакология. 2017; 80(6): 39-44. doi:10.30906/0869-2092-2017-80-6-39-44.; Heusch G. Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res. 2015; 116(4): 674-699. doi:10.1161/CIRCRESAHA.116.3 05348.; Yellon D.M., Downey J.M. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev. 2003; 83(4): 1113-1151. doi:10.1152/physrev.00009.2003.; Schultz J.E.J., Hsu A.K., Gross G.J.J. Ischemic preconditioning and morphine-induced cardioprotection involve the delta (δ)-opioid receptor in the intact rat heart. Mol Cell Cardiol. 1997; 29 (8): 2187–2195 doi:10.1006/jmcc.1997.0454.; Fryer R.M., Hsu A.K., Nagase H., Gross G.J. Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. J Pharmacol Exp Ther. 2000; 294: 451–457.; Schindler U., Strobel H., Schönafinger K., Linz W., Löhn M., Martorana P.A., Rütten H., Schindler P.W., Busch A.E., Sohn M., Töpfer A., Pistorius A., Jannek C., Mülsch A. Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase. Mol Pharmacol 2006; 69: 1260–1268. doi:10.1124/mol.105.018747.; Dorsch M., Behmenburg F., Raible M., Blase D., Grievink H., Hollmann M.W., Heinen A., Huhn R. Morphine-induced preconditioning: involvement of protein kinase A and mitochondrial permeability transition pore. PLoS One. 2016; 11: e0151025. doi:10.1371/ journal.pone.0151025.; Maslov L.N., Lishmanov Y.B. The anti-arrhythmic effect of D-Ala2,Leu5,Arg6-enkephalin and its possible mechanism. Int J Cardiol. 1993; 40(2): 89-94. doi:10.1016/0167-5273(93)90269-m.; Mukhomedzyanov A.V., Popov S.V., Maslov L.N. δ2-Opioid receptors as a target in designing new cardioprotective drugs: the role of protein kinase C, AMPK, and sarcolemmal KATP channels. Bull Exp Biol Med. 2022; 173(1): 33-36. doi:10.1007/s10517-022-05487-2.; Gross G.J., Hsu A., Nithipatikom K., Pfeiffer A.W., Bobrova I., Bissessar E. Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channels. Pharmacology. 2012; 90(1-2): 110-116. doi:10.1159/000340058.; Fan J., Li L., Qu P., Diao Y., Sun Y. κ-Opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO 1 pathway. Mol Med Rep. 2021; 23(4): 293. doi:10.3892/mmr.2021.11933.; Hu Q., Wang Q., Han C., Yang Y. Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression. Mol Med Rep. 2020; 22(5): 4298-4306. doi:10.3892/mmr.2020.11526.; Masini E., Vannacci A., Marzocca C., Pierpaoli S., Giannini L., Fantappié O., Mazzanti R., Mannaioni P. F. Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart. Exp Biol Med. 2003; 228(5): 546-549. doi:10.1177/15353702-0322805-25.; Han J., Kim N., Joo H., Kim E., Earm Y.E. ATP-sensitive K+ channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes. Am J Physiol Heart Circ Physiol. 2002; 283(4): H1545-H1554. doi:10.1152/ajpheart.01052.2001.

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https://doi.org/10.17802/2306-1278-2024-13-4S-88-96

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2

Academic Journal

Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology, and Target Identification of Thiowurtzine, a Potent Inhibitor of the Opioid Receptors and the Ion Channels

Authors: Stephanie Aguero, Simon Megy, Valeria V. Eremina, Alexander I. Kalashnikov, Svetlana G. Krylova, Daria A. Kulagina, Ksenia A. Lopatina, Mailys Fournier, Tatyana N. Povetyeva, Alexander B. Vorozhtsov, Sergey V. Sysolyatin, Vadim V. Zhdanov, Raphael Terreux

Source: ACS Omega
ACS Omega, Vol 6, Iss 23, Pp 15400-15411 (2021)
ACS Omega. 2021. Vol. 6, № 23. P. 15400-15411

Subject Terms: 0301 basic medicine, Chemistry, 0303 health sciences, 03 medical and health sciences, тиовюрцин, опиоидные рецепторы, ненаркотические анальгетики, ионные каналы, QD1-999, 3. Good health

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Access URL: https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c01786
https://pubmed.ncbi.nlm.nih.gov/34151118
https://doaj.org/article/c876b4289ee84f78b2603a4fbc062daa
https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c01786
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210403
https://pubmed.ncbi.nlm.nih.gov/34151118/
https://europepmc.org/article/MED/34151118
https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000925499

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3

Academic Journal

Stress-Induced Myocardial Damage and Antiarrhythmic Effect of Opioid Peptides

Source: Кардиология в Беларуси. :888-901

Subject Terms: 0301 basic medicine, opioid peptides, аритмия, опиоидные рецепторы, опиоидные пептиды, myocardial ischemic injury, arrhythmia, opioid receptors, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, повреждение миокарда, myocardial damage, катехоламины, ишемическое повреждение сердца, catecholamines

4

Academic Journal

Stress-induced analgesia: The role of the HPA axis hormones

Authors: N. I. Yarushkina

Source: Интегративная физиология, Vol 1, Iss 1 (2020)

Subject Terms: глюкокортикоидные рецепторы, гипоталамо-гипофизарно-адренокортикальная система, Physiology, стресс-вызванная анальгезия, опиоидные рецепторы, QP1-981, рецепторы кортикотропин-рилизинг фактора 1 и 2 типа, 3. Good health

Access URL: https://intphysiology.ru/index.php/main/article/download/9/5
https://doaj.org/article/b5aff0ea0efd4ad2b31f6a085589ef9b
https://cyberleninka.ru/article/n/stress-vyzvannaya-analgeziya-rol-gormonov-gipotalamo-gipofizarno-adrenokortikalnoy-sistemy/pdf
https://intphysiology.ru/index.php/main/article/view/9
https://cyberleninka.ru/article/n/stress-vyzvannaya-analgeziya-rol-gormonov-gipotalamo-gipofizarno-adrenokortikalnoy-sistemy
https://intphysiology.ru/index.php/main/article/download/9/5

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5

Academic Journal

δ-Opioid receptor as a target for the creation of peptide drugs that increase cardiac resistance to reperfusion ; δ-Опиоидный рецептор – мишень для создания пептидных препаратов, повышающих резистентность сердца к реперфузии

Contributors: Тhe article was prepared with the financial support of the Russian Science Foundation, grant MMP (23-65-10017). The introduction to the article was prepared with the support of the state assignment 122020300042-4, Статья подготовлена при финансовой поддержке Российского Научного Фонда (грант 23-65-10017). Введение к статье подготовлено при поддержке государственного задания 122020300042-4

Source: Siberian Journal of Clinical and Experimental Medicine; Том 39, № 1 (2024); 11-17 ; Сибирский журнал клинической и экспериментальной медицины; Том 39, № 1 (2024); 11-17 ; 2713-265X ; 2713-2927

Subject Terms: MPT-пора, reperfusion, myocardial infarction, opioid receptors, kinases, K ATP channels, MPT pore, реперфузия, инфаркт миокарда, опиоидные рецепторы, киназы, К АТФ -каналы

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Relation: https://www.sibjcem.ru/jour/article/view/1853/927; Megaly M., Pershad A., Glogoza M., Elbadawi A., Omer M., Saad M. et al. Use of intravascular imaging in patients with ST-segment elevation acute myocardial infarction. Cardiovasc. Revasc. Med. 2021;30:59–64. DOI:10.1016/j.carrev.2020.09.032.; Ya’qoub L., Gad M., Saad A.M., Elgendy I.Y., Mahmoud A.N. National trends of utilization and readmission rates with intravascular ultrasound use for ST-elevation myocardial infarction. Catheter. Cardiovasc. Interv. 2021;98(1):1–9. DOI:10.1002/ccd.29524.; Garcia S., Schmidt C.W., Garberich R., Henry T.D., Bradley S.M., Brilakis E.S. et al. Temporal changes in patient characteristics and outcomes in ST-segment elevation myocardial infarction 2003–2018. Catheter. Cardiovasc. Interv. 2021;97(6):1109–1117. DOI:10.1002/ccd.28901.; Maslov L.N., Popov S.V., Mukhomedzyanov A.V., Naryzhnaya N.V., Voronkov N.S., Ryabov V.V. et al. Reperfusion cardiac injury: Receptors and the signaling mechanisms. 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Med. 1997;124(3):873–875. DOI:10.1007/BF02446988.; Patel H.H., Hsu A., Moore J., Gross G.J. BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. J. Mol. Cell. Cardiol. 2001;33(8):1455–1465. DOI:10.1006/jmcc.2001.1408.; Maslov L.N., Khaliulin I., Oeltgen P.R., Naryzhnaya N.V., Pei J.-M., Brown S.A. et al. Prospects of creation of cardioprotective and antiarrhythmic drugs based on opioid receptor agonists. Med. Res. Rev. 2016;36(5):871–923. DOI:10.1002/med.21395.; Maslov L.N., Lishmanov Yu.B., Oeltgen P.R., Barzakh E.I., Krylatov A.V., Govindaswami M. Activation of peripheral δ2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury: Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system. Life Sci. 2009;84(19–20):657–663. DOI:10.1016/j.lfs.2009.02.016.; Peart J.N., Patel H.H., Gross G.J. 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Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts. Korean J. Anesthesiol. 2011;60(5):351–356. DOI:10.4097/kjae.2011.60.5.351.; Wu X., Zhang B., Fan R., Zhao L., Wang Y., Zhang S. et al. U50,488H inhibits neutrophil accumulation and TNF-α induction induced by ischemia-reperfusion in rat heart. Cytokine. 2011;56(2):503–507. DOI:10.1016/j.cyto.2011.07.015.; Gross G.J., Hsu A., Nithipatikom K., Pfeiffer A.W., Bobrova I., Bissessar E. Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channels. Pharmacology. 2012;90(1–2):110–116. DOI:10.1111/j.1745-7254.2005.00100.x.; Zhang Y., Chen Z.W., Girwin M., Wong T.M. Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats. Acta Pharmacol. Sin. 2005;26(5):546–550. DOI:10.1111/j.1745-7254.2005.00100.x.; Popov S.V., Mukhomedzyanov A.V., Maslov L.N., Naryzhnaya N.V., Kurbatov B.K., Prasad N.R. et al. The infarct-reducing effect of the δ2 opioid receptor agonist deltorphin II: The molecular mechanism. Membranes (Basel). 2023;13(1):63. DOI:10.3390/membranes13010063.; Maslov L.N., Lishmanov Y.B. The anti-arrhythmic effect of D-Ala2, Leu5, Arg6-enkephalin and its possible mechanism. Int. J. Cardiol. 1993;40(2):89–94. DOI:10.1016/0167-5273(93)90269-m.; Li D.Y., Gao S.J., Sun J., Zhang L.Q., Wu J.Y., Song F.H. et al. Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain. Neural. Regen Res. 2023; 18(5):996–1003. DOI:10.4103/1673-5374.355748.; Krylatov A.V., Tsibulnikov S.Y., Mukhomedzyanov A.V., Boshchenko A.A., Goldberg V.E., Jaggi A.S. et al. The role of natriuretic peptides in the regulation of cardiac tolerance to ischemia/reperfusion and postinfarction heart remodeling. J. Cardiovasc. Pharmacol. Ther. 2021;26(2):131–148. DOI:10.1177/1074248420952243.; Wu G., Sharina I., Martin E. Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo. Front. Mol. Biosci. 2022;9:1007768. DOI:10.3389/fmolb.2022.1007768.; Xu J., Zhu K., Wang Y., Chen J. The dual role and mutual dependence of heme/HO-1/Bach1 axis in the carcinogenic and anti-carcinogenic intersection. J. Cancer Res. Clin. Oncol. 2023;149(1):483–501. DOI:10.1007/s00432-022-04447-7.; Castany S., Carcolé M., Leánez S., Pol O. The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1. Neurosci. Lett. 2016;614:49–54. DOI:10.1016/j.neulet.2015.12.059.; Stagni E., Bucolo C., Motterlini R., Drago F. Morphine-induced ocular hypotension is modulated by nitric oxide and carbon monoxide: role of mu3 receptors. J. Ocul. Pharmacol. Ther. 2010;26(1):31–35. DOI:10.1089/jop.2009.0081.; Krylatov A.V., Maslov L.N., Voronkov N.S., Boshchenko A.A., Popov S.V., Gomez L. et al. Reactive oxygen species as intracellular signaling molecules in the cardiovascular system. Curr. Cardiol. Rev. 2018;14(4):290–300. DOI:10.2174/1573403X14666180702152436.; Tsutsumi Y.M., Yokoyama T., Horikawa Y., Roth D.M., Patel H.H. Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization. Life Sci. 2007;81(15):1223– 1227. DOI:10.1016/j.lfs.2007.08.031.; Rong F., Peng Z., Ye M.X., Zhang Q.Y., Zhao Y., Zhang S.M., et al. Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by κ-opioid receptor agonist. Arch. Med. Res. 2009;40(4):227–234. DOI:10.1016/j.arcmed.2009.04.009.; Peart J.N., Gross E.R., Reichelt M.E., Hsu A., Headrick J.P., Gross G.J. Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts. Basic Res. Cardiol. 2008;103(5):454– 463. DOI:10.1007/s00395-008-0726-z.; Jang Y., Xi J., Wang H., Mueller R.A., Norfleet E.A., Xu Z. Postconditioning prevents reperfusion injury by activating δ-opioid receptors. Anesthesiology. 2008;108(2):243–250. DOI:10.1097/01.anes.0000299437.93898.4a.; Kim J.H., Chun K.J., Park Y.H., Kim J., Kim J.S., Jang Y.H. et al. Morphine-induced postconditioning modulates mitochondrial permeability transition pore opening via delta-1 opioid receptors activation in isolated rat hearts. Korean J. Anesthesiol. 2011;61(1):69–74. DOI:10.4097/kjae.2011.61.1.69.; https://www.sibjcem.ru/jour/article/view/1853

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https://doi.org/10.29001/2073-8552-2022-585

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6

Academic Journal

SIGNIFICANCE OF OPIOID, CANNABINOID, BRADYKININ RECEPTORS AND КАТP-CHANNELS IN THE CARDIOPROTECTIVE EFFECT OF ADAPTATION TO COLD ; ЗНАЧЕНИЕ ОПИОИДНЫХ, КАННАБИНОИДНЫХ, БРАДИКИНИНОВЫХ РЕЦЕПТОРОВ И КАТФ-КАНАЛОВ В КАРДИОПРОТЕКТОРНОМ ЭФФЕКТЕ АДАПТАЦИИ К ХОЛОДУ

Authors: Nikita S. Voronkov, Leonid N. Maslov, Yuri V. Bushov, Никита Сергеевич Воронков, Леонид Николаевич Маслов, Юрий Валентинович Бушов

Contributors: Работа выполнена при поддержке РФФИ (грант № 20-315-90054). Эксперименты с налтрексоном проведены в рамках государственного задания 122020300042-4. В работе использовано оборудование Центра коллективного пользования «Медицинская геномика» Томского НИМЦ.

Source: Complex Issues of Cardiovascular Diseases; Том 12, № 3 (2023); 50-56 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 12, № 3 (2023); 50-56 ; 2587-9537 ; 2306-1278

Subject Terms: КАТФ-каналы, Ischemia/reperfusion, Cold adaptation, Opioid receptors, Cannabinoid receptors, Bradykinin receptors, КАТP-channels, Ишемия/реперфузия, Адаптация к холоду, Опиоидные рецепторы, Каннабиноидные рецепторы, Брадикининовые рецепторы

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Relation: https://www.nii-kpssz.com/jour/article/view/1148/810; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1148/1084; Oganov R.G. Maslennikova GYa. Noncommunicable diseases in Russia, the role of risk factors. In: Glazunov IS, Stachenko S, editors. Health promotion and prevention of noncommunicable disease in Russia and Canada. Experience and recommendations. Public Health Agency of Canada; 2006. p.3–18.; Ya'qoub L., Gad M., Saad A.M., Elgendy I.Y., Mahmoud A.N. National trends of utilization and readmission rates with intravascular ultrasound use for ST-elevation myocardial infarction. Catheter Cardiovasc Interv. 2021; 98(1): 1-9. doi:10.1002/ccd.29524.; Megaly M., Pershad A., Glogoza M., Elbadawi A., Omer M., Saad M., Mentias A., Elgendy I., Burke M.N., Capodanno D., Brilakis E.S. Use of intravascular imaging in patients with ST-segment elevation acute myocardial infarction. Cardiovasc Revasc Med. 2021; 30: 59-64. doi:10.1016/j.carrev.2020.09.032.; Sambola A., Elola F.J., Buera I., Fernandez C., Bernal J.L., Ariza A., Brindis R., Bueno H., Rodriguez-Padial L., Marin F., Barrabis J.A., Hsia R., Anguita M. Sex bias in admission to tertiary-care centres for acute myocardial infarction and cardiogenic shock. Eur J Clin Invest. 2021; 51(7): e13526. doi:10.1111/eci.13526.; Liakopoulos O.J., Schlachtenberger G., Wendt D., Choi Y.H., Slottosch I., Welp H., Schiller W., Martens S., Welz A., Neuhauser M., Jakob H., Wahlers T., Thielmann M. Early clinical outcomes of surgical myocardial revascularization for acute coronary syndromes complicated by cardiogenic shock: A Report From the North-Rhine-Westphalia Surgical Myocardial Infarction Registry. J Am Heart Assoc. 2019; 8(10): e012049. doi:10.1161/JAHA.119.012049.; Маслов Л.Н., Барбараш О.Л. Фармакологические подходы к ограничению размера инфаркта миокарда у пациентов с острым инфарктом миокарда. Экспериментальная и клиническая фармакология. 2018; 81(3): 75-82.; Цибульников С.Ю., Маслов Л.Н., Иванов В.В., Нарыжная Н.В., Цибульникова М.Р. Инфаркт-лимитирующий эффект адаптации к непрерывному холодовому воздействию. Рос физиол ж им И.М. Сеченова. 2016; 102(11): 1363-1368.; de Miranda D.C., de Oliveira Faria G., Hermidorff M.M., Dos Santos Silva F.C., de Assis L.V.M., Isoldi M.C. Pre- and post-conditioning of the heart: an overview of cardioprotective signaling pathways. Curr Vasc Pharmacol. 2021; 19(5): 499-524. doi:10.2174/1570161119666201120160619.; Maslov L.N., Naryzhnaia N.V., Tsibulnikov S.Y., Kolar F., Zhang Y., Wang H., Gusakova A.M., Lishmanov Y.B. Role of endogenous opioid peptides in the infarct size-limiting effect of adaptation to chronic continuous hypoxia. Life Sci. 2013; 93(9-11): 373-379. doi:10.1016/j.lfs.2013.07.018.; Maslov L.N., Khaliulin I., Oeltgen P.R., Naryzhnaya N.V., Pei J.M., Brown S.A., Lishmanov Y.B., Downey J.M. Prospects for creation of cardioprotective and antiarrhythmic drugs based on opioid receptor agonists. Med Res Rev. - 2016a; 36(5): 871-923. doi:10.1002/med.21395.; Maslov L.N., Khaliulin I., Zhang Y., Krylatov A.V., Naryzhnaya N.V, Mechoulam R., De Petrocellis L., Downey J.M. Prospects for creation of cardioprotective drugs based on cannabinoid receptor agonists. J Cardiovasc Pharmacol Ther. 2016; 21(3): 262-272. doi:10.1177/1074248415612593.; Atgie C., D'Allaire F., Bukowiecki L.J. Role of beta1- and beta3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes. Am J Physiol. 1997; 273(41): 1136-1142. doi:10.1152/ajpcell.1997.273.4.C1136.; Asimakis G.K., Inners-McBride K., Conti V.R., Yang C.J. Transient beta adrenergic stimulation can precondition the rat heart against postischaemic contractile dysfunction. Cardiovasc Res 1994; 28(11): 1726-1734. doi:10.1093/cvr/28.11.1726.; Cohen M.V., Downey J.M. Signalling pathways and mechanisms of protection in pre- and postconditioning: historical perspective and lessons for the future. Br J Pharmacol. 2015; 172(8): 1913-1932. doi:10.1111/bph.12903.; Heusch G. Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res. 2015; 116(4): 674–699. doi:10.1161/CIRCRESAHA.116.305348.

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https://doi.org/10.17802/2306-1278-2023-12-3-50-56

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7

Academic Journal

The role of reactive oxygen species and redoxsensitive protein kinases in the infarction-limiting effect of opioid peptide deltorphin II in cardiac reperfusion in rats ; Роль активных форм кислорода и редокс-чувствительных протеинкиназ в инфаркт-лимитирующем эффекте опиоидного пептида дельторфина II при реперфузии сердца у крыс

Authors: S. V. Popov, A. V. Mukhomedzyanov, M. Sirotina, B. K. Kurbatov, V. N. Azev, G. Z. Sufianova, M. S. Khlestkina, L. N. Maslov, С. В. Попов, А. В. Мухомедзянов, М. Сиротина, Б. К. Курбатов, В. Н. Азев, Г. З. Суфианова, М. С. Хлёсткина, Л. Н. Маслов

Contributors: В работе было использовано оборудование Центра коллективного пользования «Медицинская геномика» ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук». Работа выполнена при поддержке РНФ (грант № 22-15-00048). Исследования с темполом выполнялись в рамках государственного задания 122020300042-4

Source: Acta Biomedica Scientifica; Том 8, № 2 (2023); 254-262 ; 2587-9596 ; 2541-9420

Subject Terms: киназы, ischemia, reperfusion, opioid receptors, reactive oxygen species, kinases, ишемия, реперфузия, опиоидные рецепторы, активные формы кислорода

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Relation: https://www.actabiomedica.ru/jour/article/view/4092/2541; https://www.actabiomedica.ru/jour/article/view/4092/2644; Menees DS, Peterson ED, Wang Y, Curtis JP, Messenger JC, Rumsfeld JS, et al. Door-to-balloon time and mortality among patients undergoing primary PCI. N Engl J Med. 2013; 369(10): 901-909. doi:10.1056/NEJMoa1208200; Fabris E, Kilic S, Schellings DAAM, Ten Berg JM, Kennedy MW, van Houwelingen KG, et al. Long-term mortality and prehospital tirofiban treatment in patients with ST elevation myocardial infarction. Heart. 2017; 103(19): 1515-1520. doi:10.1136/heartjnl-2017-311181; Olier I, Sirker A, Hildick-Smith DJR, Kinnaird T, Ludman P, de Belder MA, et al. British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research. Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention. Association of different antiplatelet therapies with mortality after primary percutaneous coronary intervention. Heart. 2018; 104(20): 1683-1690. doi:10.1136/heartjnl-2017-312366; Basi MB, Lemor A, Gorgis S, Taylor AM, Tehrani B, Truesdell AG, et al. National Cardiogenic Shock Initiative Investigators. Vasopressors independently associated with mortality in acute myocardial infarction and cardiogenic shock. Catheter Cardiovasc Interv. 2022; 99(3): 650-657. doi:10.1002/ccd.29895; Liakopoulos OJ, Schlachtenberger G, Wendt D, Choi YH, Slottosch I, Welp H, et al. Early clinical outcomes of surgical myocardial revascularization for acute coronary syndromes complicated by cardiogenic shock: A report from the North-Rhine-Westphalia Surgical Myocardial Infarction Registry. J Am Heart Assoc. 2019; 8(10): e012049. doi:10.1161/JAHA.119.012049; Braile-Sternieri MCVB, Mustafa EM, Ferreira VRR, Braile Sabino S, Braile Sternieri G, Buffulin de Faria LA, et al. Main considerations of cardiogenic shock and its predictors: Systematic review. Cardiol Res. 2018; 9(2): 75-82. doi:10.14740/cr715w; McCartney PJ, Berry C. Redefining successful primary PCI. Eur Heart J Cardiovasc Imaging. 2019; 20(2): 133-135. doi:10.1093/ehjci/jey159; Mukhomedzyanov AV, Zhuk VV, Maslov LN, Shipunov AI, Andrienko OS, Gadirov RM. Cardioprotective effect of opioids, derivatives of amide N-methyl-2-(pirrolidin-1-yl)cyclohexyl-1-amine, under conditions of ischemia/reperfusion of the heart. Bull Exp Biol Med. 2021; 170(6): 710-713. doi:10.1007/s10517-021-05138-y; Maslov LN, Mukhomedzyanov AV, Tsibulnikov SY, Suleiman MS, Khaliulin I, Oeltgen PR. Activation of peripheral δ2-opioid receptor prevents reperfusion heart injury. Eur J Pharmacol. 2021; 907: 174302. doi:10.1016/j.ejphar.2021.174302; Heusch G. Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res. 2015; 116(4): 674-699. doi:10.1161/CIRCRESAHA.116.305348; Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev. 2003; 83(4): 1113-1151. doi:10.1152/physrev.00009.20 03; Mukhomedzyanov AV, Popov SV, Maslov LN. δ2-opioid receptors as a target in designing new cardioprotective drugs: the role of protein kinase C, AMPK, and sarcolemmal KATP channels. Bull Exp Biol Med. 2022; 173(1): 33-36. doi:10.1007/s10517-022-05487-2; Меерсон Ф.З. Патогенез и предупреждение стрессорных и ишемических повреждений сердца. М.: Медицина; 1984.; Биленко М.В. Ишемические и реперфузионные повреждения органов. М.: Медицина; 1989.; Matsushima S, Tsutsui H, Sadoshima J. Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion. Trends Cardiovasc Med. 2014; 24(5): 202-205. doi:10.1016/j.tcm.2014.03.003; Frangogiannis NG. Pathophysiology of myocardial infarction. Compr Physiol. 2015; 5(4): 1841-1875. doi:10.1002/cphy.c150006; Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol. 2015; 6: 524-551. doi:10.1016/j.redox.2015.08.020; Garlick PB, Davies MJ, Hearse DJ, Slater TF. Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy. Circ Res. 1987; 61(5): 757-760. doi:10.1161/01.res.61.5.757; Zweier JL, Rayburn BK, Flaherty JT, Weisfeldt ML. Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium. J Clin Invest. 1987; 80(6): 1728-1734. doi:10.1172/JCI113264; Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB. Demonstration of free radical generation in “stunned” myocardium of intact dogs with the use of the spin tap alpha phenyl N-tert-butyl nitrone. J Clin Invest. 1988; 82(2): 476-485. doi:10.1172/JCI113621; Näslund U, Häggmark S, Johansson G, Marklund SL, Reiz S, Oberg A. Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion-reperfusion model. J Mol Cell Cardiol. 1986; 18(10): 1077-1084. doi:10.1016/s0022-2828(86)80294-2; Myers ML, Bolli R, Lekich RF, Hartley CJ, Roberts R. N2-mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia. J Am Coll Cardiol. 1986; 8(5): 1161-1168. doi:10.1016/s0735-1097(86)80396-5; Bolli R, Zhu WX, Hartley CJ, Michael LH, Repine JE, Hess ML, et al. Attenuation of dysfunction in the postischemic ‘stunned’ myocardium by dimethylthiourea. Circulation. 1987; 76(2): 458-468. doi:10.1161/01.cir.76.2.458; Tsutsumi YM, Yokoyama T, Horikawa Y, Roth DM, Patel HH. Reactive oxygen species trigger ischemic and pharmacological postconditioning: In vivo and in vitro characterization. Life Sci. 2007; 81(15): 1223-1227. doi:10.1016/j.lfs.2007.08.031; Bolli R, Jeroudi MO, Patel BS, Aruoma OI, Halliwell B, Lai EK, et al. Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial “stunning” is a manifestation of reperfusion injury. Circ Res. 1989; 65(3): 607-622. doi:10.1161/01.res.65.3.607; Tang XL, Takano H, Rizvi A, Turrens JF, Qiu Y, Wu WJ, et al. Oxidant species trigger late preconditioning against myocardial stunning in conscious rabbits. Am J Physiol Heart Circ Physiol. 2002; 282(1): H281-H291. doi:10.1152/ajpheart.2002.282.1.H281; Sekili S, McCay PB, Li XY, Zughaib M, Sun JZ, Tang L, et al. Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial “stunning” in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects. Circ Res. 1993; 73(4): 705-723. doi:10.1161/01.res.73.4.705; Семенцов А.С., Нарыжная Н.В., Сиротина М.А., Маслов Л.Н. Роль активных форм кислорода в инфаркт-лимитирующем эффекте гипоксического прекондиционирования. Регионарное кровообращение и микроциркуляция. 2021; 20(2): 87-91. doi:10.24884/1682-6655-2021-20-2-87-91; Krylatov AV, Maslov LN, Voronkov NS, Boshchenko AA, Popov SV, Gomez L, et al. Reactive oxygen species as intracellular signaling molecules in the cardiovascular system. Curr Cardiol Rev. 2018; 14(4): 290-300. doi:10.2174/1573403X14666180702152436; Schultz JEJ, Hsu AK, Gross GJJ. Ischemic preconditioning and morphine-induced cardioprotection involve the delta (δ)opioid receptor in the intact rat heart. Mol Cell Cardiol. 1997; 29(8): 2187-2195. doi:10.1006/jmcc.1997.0454; Pınar N, Kaplan M, Özgür T, Özcan O. Ameliorating effects of tempol on methotrexate-induced liver injury in rats. Biomed Pharmacother. 2018; 102: 758-764. doi:10.1016/j.biopha.2018.03.147; Zatta AJ, Kin H, Lee G, Wang N, Jiang R, Lust R, et al. Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signaling. Cardiovasc Res. 2006; 70: 315-334. doi:10.1016/j.cardiores.2005.11.030; Fettiplace MR, Kowal K, Ripper R, Young A, Lis K, Rubinstein I, et al. Insulin signaling in bupivacaine-induced cardiac toxicity: Sensitization during recovery and potentiation by lipid emulsion. Anesthesiology. 2016; 124: 428-442. doi:10.1097/aln.0000000000000974; Lasley RD, Keith BJ, Kristo G, Yoshimura Y, Mentzer RM Jr. Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent. Am J Physiol Heart Circ Physiol. 2005; 289: H785-H791. doi:10.1152/ajpheart.01008.2004; https://www.actabiomedica.ru/jour/article/view/4092

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https://doi.org/10.29413/ABS.2023-8.2.25

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8

Academic Journal

The infarct-limiting efficacy of deltorphin-II in old rats with diet-induced metabolic syndrome ; Инфаркт-лимитирующая эффективность дельторфина-II при индуцированном диетой метаболическом синдроме у старых крыс

Authors: N. V. Naryzhnaya, A. V. Mukhomedzyanov, B. K. Kurbatov, M. A. Sirotina, M. Kilin, V. N. Azev, L. N. Maslov, Н. В. Нарыжная, А. В. Мухомедзянов, В. К. Курбатов, М. А. Сиротина, М. Килин, В. Н. Азев, Л. Н. Маслов

Contributors: Работа выполнена при поддержке Российского научного фонда (грант № 22-15-00048). Исследование влияния возраста на инфаркт-лимитирующий эффект дельторфина-II проводили в рамках Гос. задания 122020300042-4. В работе было использовано оборудование Центра коллективного пользования «Медицинская геномика» Томского НИМЦ.

Source: Acta Biomedica Scientifica; Том 7, № 6 (2022); 281-289 ; 2587-9596 ; 2541-9420

Subject Terms: опиоидные рецепторы, reperfusion, metabolic syndrome, age, opioid receptors, реперфузия, метаболический синдром, возраст

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Relation: https://www.actabiomedica.ru/jour/article/view/3911/2490; Megaly M, Pershad A, Glogoza M, Elbadawi A, Omer M, Saad M, et al. Use of intravascular imaging in patients with ST-segment elevation acute myocardial infarction. Cardiovasc Revasc Med. 2021; 30: 59-64. doi:10.1016/j.carrev.2020.09.032; Мухомедзянов А.В., Маслов Л.Н., Овчинников М.В., Сидорова М.В., Пей Ж.М., Цибульников С.Ю., и др. Влияние дельторфина и его ретро-энантиоаналога на устойчивость сердца к действию ишемии и реперфузии. Бюллетень экспериментальной биологии и медицины. 2016; 162(9): 284-288. doi:10.1007/s10517-017-3601-9; Dommermuth R, Ewing K. Metabolic syndrome: Systems thinking in heart disease. Prim Care. 2018; 45(1): 109-129. doi:10.1016/j.pop.2017.10.003; Sperling LS, Mechanick JI, Neeland IJ, Herrick CJ, Després J-P, Ndumele CE, et al. The CardioMetabolic Health Alliance: Working toward a new care model for the metabolic syndrome. J Am Coll Cardiol. 2015; 66(9): 1050-1067. doi:10.1016/j.jacc.2015.06.1328; Lind L, Sundström J, Ärnlöv J, Risérus U, Lampa E. A longitudinal study over 40 years to study the metabolic syndrome as a risk factor for cardiovascular diseases. Sci Rep. 2021; 11(1): 2978. doi:10.1038/s41598-021-82398-8; Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin North Am. 2014; 43(1): 1-23. doi:10.1016/j.ecl.2013.09.009; Вильсон Н.И., Беленькая Л.В., Шолохов Л.Ф., Игумнов И.А., Наделяева Я.Г., Сутурина Л.В. Метаболический синдром: эпидемиология, критерии диагностики, расовые особенности. Acta biomedica scientifica. 2021; 6(4): 180-191. doi:10.29413/ABS.2021-6.4.16; Gutiérrez-Cuevas J, Sandoval-Rodriguez A, Meza-Rios A, Monroy-Ramírez HC, Galicia-Moreno M, García-Bañuelos J, et al. Molecular mechanisms of obesity-linked cardiac dysfunction: An up-date on current knowledge. Cells. 2021; 10(3): 629. doi:10.3390/cells10030629; Tofler GH, Muller JE, Stone PH, Willich SN, Davis VG, Poole WK, et al. Factors leading to shorter survival after acute myocardial infarction in patients ages 65 to 75 years compared with younger patients. Am J Cardiol. 1988; 62(13): 860-867. doi:10.1016/0002-9149(88)90882-x; Strait JB, Lakatta EG. Aging-associated cardiovascular changes and their relationship to heart failure. Heart Failure Clinics. 2012; 8(1): 143-164. doi:10.1016/j.hfc.2011.08.011; Logvinov SV, Naryzhnaya NV, Kurbatov BK, Gorbunov AS, Birulina YuG, Maslov LN, et al. High carbohydrate high fat diet causes arterial hypertension and histological changes in the aortic wall in aged rats: The involvement of connective tissue growth factors and fibronectin. Exp Gerontol. 2021; 154: 111543. doi:10.1016/j.exger.2021.111543; Лишманов Ю.Б., Маслов Л.Н. Опиоидные нейропептиды, стресс и адаптационная защита сердца. Томск: Изд-во Томского университета; 1994.; Maslov LN, Lishmanov YuB, Oeltgen PR, Barzakh EI, Krylatov AV, Govindaswami M, et al. Activation of peripheral δ2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury: Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system. Life Sci. 2009; 84(19-20): 657-663. doi:10.1016/j.lfs.2009.02.016; Alexandre-Santos B, Machado MV, Menezes AC, Velasco LL, Sepúlveda-Fragoso V, Vieira AB, et al. Exercise-induced cardiac opioid system activation attenuates apoptosis pathway in obese rats. Life Sci. 2019; 231: 116542. doi:10.1016/j.lfs.2019.06.017; Zemljic-Harpf AE, See Hoe LE, Schilling JM, Zuniga-Hertz JP, Nguyen A, Vaishnav YJ, et al. Morphine induces physiological, structural, and molecular benefits in the diabetic myocardium. FASEB J. 2021; 35(3): e21407. doi:10.1096/fj.201903233R; Zhang L, Guo H, Yuan F, Hong ZC, Tian YM, Zhang XJ, et al. Limb remote ischemia per-conditioning protects the heart against ischemia-reperfusion injury through the opioid system in rats. Can J Physiol Pharmacol. 2018; 96(1): 68-75. doi:10.1139/cjpp-2016-0585; Kunecki M, Oleksy T, Biernat J, Kukla P, Szwajkos K, Podolec P, et al. Ischemic conditioning of human heart muscle depends on opioid-receptor system. Folia Med Cracov. 2017; 57(2): 31-39.; Xin W, Yang X, Rich TC, Krieg T, Barrington R, Cohen MV, et al. All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte. J Cardiovasc Pharmacol Ther. 2012; 17(2): 190-198. doi:10.1177/1074248411416815; Verouhis D, Sörensson P, Gourine A, Henareh L, Persson J, Saleh N, et al. Long-term effect of remote ischemic conditioning on infarct size and clinical outcomes in patients with anterior ST-elevation myocardial infarction. Catheter Cardiovasc Interv. 2021; 97(3): 386-392. doi:10.1002/ccd.28760; Andreadou I, Schulz R, Badimon L, Adameová A, Kleinbongard P, Lecour S, et al. Hyperlipidaemia and cardioprotection: Animal models for translational studies. Br J Pharmacol. 2020; 177(23): 5287-5311. doi:10.1111/bph.14931; Penna C, Andreadou I, Aragno M, Beauloye C, Bertrand L, Lazou A, et al. Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols. Br J Pharmacol. 2020; 177(23): 5312-5335. doi:10.1111/bph.14993; Oosterlinck W, Dresselaers T, Geldhof V, Nevelsteen I, Janssens S, Himmelreich U, et al. Diabetes mellitus and the metabolic syndrome do not abolish, but might reduce, the cardioprotective effect of ischemic postconditioning. J Thorac Cardiovasc Surg. 2013; 145(6): 1595-1602. doi:10.1016/j.jtcvs.2013.02.016; Нарыжная Н.В., Логвинов С.В., Курбатов Б.К., Мухомедзянов А.В., Сиротина М.А., Чепелев С.Н., и др. Эффективность дистантного ишемического посткондиционирования миокарда у крыс с индуцированным метаболическим синдромом зависит от уровня лептина. Известия Национальной академии наук Беларуси. Серия медицинских наук. 2022; 19(1): 38-47. doi:10.29235/1814-6023-2022-19-1-38-47; Baranyai T, Nagy CT, Koncsos G, Onódi Z, Károlyi-Szabó M, Makkos A, et al. Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning. Cardiovasc Diabetol. 2015; 14: 151. doi:10.1186/s12933-015-0313-1; https://www.actabiomedica.ru/jour/article/view/3911

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https://doi.org/10.29413/ABS.2022-7.6.29

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9

Academic Journal

Modern realities of emotional burnout of IT-staff

Source: New Collegium; Vol. 4 No. 106 (2021): New Collegium; 40-44
Новый Коллегиум; Том 4 № 106 (2021): Новый Коллегиум; 40-44
Новий Колегіум; Том 4 № 106 (2021): Новий Колегіум; 40-44

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10

Academic Journal

Pharmacogenetic aspects of substance use disorders

Authors: A. O. Kibitov

Source: Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, Vol 0, Iss 1, Pp 17-28 (2018)

Subject Terms: наркология, генетика, наследственность, фармакогенетика, генетический риск, полиморфизм генов, опиоидные рецепторы, дофамин, drug and alcohol abuse, genetics, heredity, pharmacogenetics, genetic risk, gene polymorphism, opioid receptors, dopamine, Psychiatry, RC435-571

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Relation: https://www.bekhterevreview.com/jour/article/view/160; https://doaj.org/toc/2313-7053; https://doaj.org/toc/2713-055X

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11

Academic Journal

Association of opioid receptors gene OPRM1 polymorphism and phenotypic diversity of chronic pain syndrome of oncological genesis ; Ассоциация полиморфизма гена опиоидных рецепторов OPRM1 с фенотипическим разнообразием хронического болевого синдрома онкологического генеза

Authors: O. P. Bobrova, N. A. Shnayder, S. K. Zyryanov, A. A. Modestov, О. П. Боброва, Н. А. Шнайдер, С. К. Зырянов, А. А. Модестов

Source: Medical Genetics; Том 16, № 6 (2017); 3-8 ; Медицинская генетика; Том 16, № 6 (2017); 3-8 ; 2073-7998

Subject Terms: safety, онкология, однонуклеотидный полиморфизм (ОНП), опиоидные рецепторы, ген мю-опиоидного рецептора 1 типа (OPRM1), фармакогенетика, эффективность, безопасность, chronic pain syndrome, oncology, single nucleotide polymorphisms (SNPs), opioid receptors, mu-opioid receptor type 1 gene (OPRM1), pharmacogenetics, efficacy

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Relation: https://www.medgen-journal.ru/jour/article/view/301/217; Абузарова ГР. Диагностика и дифференцированная фармакотерапия хронического болевого синдрома у онкологическихбольных. ГЭОТАР-Медия, 2015.; Bаr KJ, Terhaar J, Boettger MK et al. Pseudohypoalgesia on the skin: a novel view on the paradox of pain perception in depression. J. Clin. Psychopharmacol. 2011; 31 (1): 103-107.doi:10.1097/JCP.0b013e3182046797.; Andersen SE. Drugdispensingerrorsin a wardstocksystem. Basic Clin. Pharmacol. Toxicol. 2010; 106 (2): 100-105. doi:10.1111/j.1742-7843.2009.00481.x.; McKeen MJ and Quraishi SA. Clinical review of intravenous opioids in acute care. Journal of Anesthesiology and Clinical Science.2013:1-11.doi : http://dx.doi.org/10.7243/2049-9752-2-1.; Арбак ДМ, Абузарова ГР, Алексеева ГС. Опиоидные анальгетики в клинической медицине xxІв.Российский журнал боли. 2014; 2:39 - 50.; Lennon FE, Moss J, Singleton PA. The m-opioid receptor in cancer progression: is there a direct effect? Anesthesiology. 2012;116: 940-945.doi:10.1097/ALN.0b013e31824b9512.; Bastami S. Practical and clinical use of opioids. Liu-Tryck, 2013.; Gretton SK and Droney J. Splice variation of the mu-opioid receptor and its effecton the action of opioids. British Journal of Pain. 2014; 8(4):133-138.doi:10.1177/2049463714547115.; Dietis N, Rowbotham DJ and Lambert DG. Opioid receptor subtypes: factor artifact? Br J Anaesth. 2011 Jul; 107(1):8 - 18.doi:10.1093/bja/aer115.; Pasternak GW. Molecular insights into mu opioid pharmacology: from the clinic to the bench. Clin J Pain.2010 Jan;26 (10): 10:3 - 9.doi:10.1097/AJP.0b013e3181c49d2e.; Neziri AY, Scaramozzino P, Andersen OK. et al. Reference values of mechanical and thermal pain tests in a pain free population. Eur. J. Pain. 2011; 15 (4): 376-383.doi:10.1016/j.ejpain.2010.08.011.; Ross JR, Riley J, Quigley C.et al. Clinical pharmacology and pharmacotherapy of opioid switching in cancer patients.The Oncologist.2006;11:765 - 773.doi:10.1634/theoncologist.11-7-765.; Williams JT, Ingram SL, Henderson G et al. Regulation of µ-opioid receptors: desensitization, phosphorylation, internalization and tolerance. Pharmacol Rev. 2013 Jan 15; 65 (1): 223 - 54.doi:10.1124/pr.112.005942.; Branford R, Droney J, Ross JR. Opioid genetics: the key to personalized pain control? Clin Genet. 2012; 82: 301-310.doi:10.1111/j.1399-0004.2012.01923.x.; HuangP, ChenC, MagueSDet al. A common single nucleotide polymorphism A118G of the m-opioid receptor alters its N-glycosylation and protein stability. BiochemJ. 2012;441(1):379 - 386.doi:10.1042/BJ20111050.; Yiannakopoulou E. Pharmacogenomics and Opioid Analgesics: Clinical Implications. International Journal of Genomics. 2015:1. http://dx.doi.org/10.1155/2015/368979.; GregoriSde, GregoriMde, Guglielmina N R. et al. Morphine metabolism transport and brain disposition. Metab Brain Dis. 2012; (27):1 - 5.doi:10.1007/s11011-011-9274-6.; Knapman A, Connor M. Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human m-opioid receptor (OPRM1). Br J Pharmacol. 2015;(172): 349 - 363.doi:10.1111/bph.12644.; Laugsand EA, Skorpen F, Kaasa Set al. Genetic and non-genetic factors associated with constipation in cancer patients receiving opioids. Clinical and Translational Gastroenterology. 2015: 1 - 6.doi:10.1038/ctg.2015.19; Klepstad P, Fladvad T, Skorpen Fet al. Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients. Pain. 2011; 152(5): 1139 - 1145.doi:10.1016/j.pain.2011.01.040.; Argoff CE. Clinical Implications of opioid pharmacogenetics. Clinical journal of pain. 2010January ;26 (10) : 16 - 20.doi:10.1097/AJP.0b013e3181c49e11.; Женило ВМ, Махари ОА. Влияние полиморфизма гена oprm1 118a/g на перцепцию боли и фармакодинамику наркотических аналгетиков. Общая реаниматология. 2014 x; (1): 58-63.; Sato H, Droney J, Ross J, Olesen AE, Staahl C, Andresen T, Branford R, Riley J, Arendt-Nielsen L, Drewes AM. Gender, Variation in opiod receptor genes and sensitivity to experimental pain. Molecular Pain. 2013. 9:20.doi:10.1186/1744-8069-9-20; Jones JD, Luba RR, Vogelman JL et al. Searching for Evidence of Genetic Mediation of Opioid Withdrawal by opioid receptor gene polymorphisms. The American Journal on Addictions. 2016; (25): 41- 48.doi:10.1111/ajad.12316.; Knapman A, Santiago M, Connor M. A6V polymorphism of the human -opioid receptor decreases signalling of morphine and endogenous opioids in vitro. British Journal of Pharmacology. 2015;(172): 2258 - 2272.doi:10.1111/bph.13047.; Fenech AG and Grech G. Pharmacogenetics: the science of predictive clinical pharmacology. Xjenza Online - Journal of the Malta Chamber of Scientists.2013:15-32.doi: http://dx.medra.org/10.7423/xjenza.2014.1.03.; Janicki PK. Pharmacogenomics of Pain Management. American Academy of Pain Medicine, 2013.; Muralidharan A, Smith MT. Painanalgesia and genetics. J Pharm Pharmacol. 2011 Nov;63(11):1387 - 400.doi:10.1111/j.2042-7158.2011.01340.x.; Droney JM., Gretton SK, Sato H. et al. Analgesia and central side-effects: two separate dimensions of morphine response. Br J Clin Pharmacol. 2013 May; 75(5): 1340-1350. doi:10.1111/bcp.12008.; Lоtsch J, GeisslingerG.Pharmacogenetics of new analgesics.British Journal of Pharmacology. 2011;(163):447 - 460.doi:10.1111/j.1476-5381.2010.01074.x.; Zhang W, Chang YZ, Kan QC. et al. Association of human l-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecologicalpatients. Anaesthesia.2010;(65):130 - 135. doi:10.1111/j.1365-2044.2009.06193.x.; Lu Z, Xu J, Xu M. et al. Morphine regulates expression of m-opioid receptor MOR-1aan intron-retention carboxyl terminal splice variant of the m-opioid receptor (OPRM1) gene via miR - 103/miR-107s. Pan Mol Pharmacol. 2014 February; (85) :368 - 380.doi:10.1124/mol.113.089292.; Kasai S, Ikeda K. Pharmacogenomics of the human µ-opioid receptor. Pharmacogenomics. 2011; (12): 1305-1320.doi:10.1124/mol.113.089292.; Janicki PK. Pharmacogenomics of pain management.American Academy of Pain Medicine. 2013: 23 - 33.doi 10.1007/978-1-4614-1560-2_2.; Yao P, Ding Y-Y, Wang Z-Bet al. Effect of gene polymorphism of COMT and OPRM1 on the preoperative pain sensitivity in patients with cancer. Int J Clin Exp Med 2015;8(6):10036-10039.; Al-Hasani R, Bruchas MR. Molecular Mechanisms of opioid receptor-dependent Signaling and Behavior. Anesthesiology. 2011(115): 1363. doi:10.1097/ALN.0b013e318238bba6.; Nielsen LM, Olesen AE, Sato H, Christrup LL, Drewes AM. Association between gene polymorphisms and pain sensitivity assessed in a multi-modal multi-tissue human experimental model - an explorative study.BasicClinPharmacolToxicol. 2016 Oct;119(4):360-6. doi:10.1111/bcpt.12601.; Beer B, Erb R, Pavlic M, Ulmer H, Giacomuzzi S, Riemer Y, Oberacher H. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study.PLoS One. 2013 Sep 25;8(9):e75359. doi:10.1371/journal.pone.0075359.

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12

Academic Journal

Фармакологические эффекты и молекулярные механизмы действия лечебного фитопрепарата на основе Vitex Agnus-Castus

Source: Репродуктивна ендокринологія; № 40 (2018); 93-97
Репродуктивная эндокринология; № 40 (2018); 93-97
Reproductive Endocrinology; № 40 (2018); 93-97

Subject Terms: 03 medical and health sciences, дисгормональна дисплазія, масталгія, мастопатія, мастодінія, гіперпролактинемія, опіоїдні рецептори, рецептори естрогенів, дофамінові рецептори, Мастодинон, 0302 clinical medicine, dishormonal dysplasia, mastalgia, mastopathy, mastodynia, hyperprolactinemia, opioid receptors, receptors to estrogens, dopamine receptors, Mastodynon, дисгормональная дисплазия, масталгия, мастопатия, мастодиния, гиперпролактинемия, опиоидные рецепторы, рецепторы эстрогенов, дофаминовые рецепторы, 3. Good health