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1Academic Journal
Authors: O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev, О. Н. Воронцова, А. Г. Аляева, К. Н. Колясникова, П. Ю. Поварнина, Т. А. Гудашева, В. Л. Дорофеев
Contributors: This study was conducted under the government contract of the Ministry of Science and Higher Education of the Russian Federation (Project FGFG-2022-0005)., Работа выполнена в рамках государственного задания Министерства науки и высшего образования Российской Федерации (тема FGFG-2022-0005).
Source: Pharmacokinetics and Pharmacodynamics; № 4 (2024); 55-62 ; Фармакокинетика и Фармакодинамика; № 4 (2024); 55-62 ; 2686-8830 ; 2587-7836
Subject Terms: Trk, nootropic activity, scopolamine amnesia, novel object recognition, К252а, ноотропная активность, скополаминовая амнезия, распознавание нового объекта
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Relation: https://www.pharmacokinetica.ru/jour/article/view/439/391; Gudasheva TA, Boyko SS, Akparov VKh, et al. Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain. FEBS Lett. 1996 Aug 5;391(1-2):149-52. doi:10.1016/0014-5793(96)00722-3.; Seredenin SB, Gudasheva TA, Boiko SS, et al. Endogenous dipeptide cycloprolylglycine shows selective anxiolytic activity in animals with manifest fear reaction. Bull Exp Biol Med. 2002 Apr;133(4):360-2. doi:10.1023/a:1016293904149.; Garibova TL, Gudasheva TA, Seredenin SB. A New Component in the Mechanism of Regulation of Endogenous Depressive-Like States. Dokl Biochem Biophys. 2019 Sep;488(1):324-326. doi:10.1134/S1607672919050107.; Колясникова К.Н., Гудашева Т.А., Назарова Г.А. и др. Сходство цикло-пролилглицина с пирацетамом по антигипоксическому и нейро-протекторному эффектам. Экспериментальная и клиническая фармакология. 2012;75(9):3-6.; Gudasheva TA, Grigoriev VV, Koliasnikova KN, et al. Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors. Dokl Biochem Biophys. 2016 Nov;471(1):387-389. doi:10.1134/S160767291606003X.; Gudasheva TA, Koliasnikova KN, Antipova TA, Seredenin SB. Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells. Dokl Biochem Biophys. 2016;469(1):273-6. doi:10.1134/S1607672916040104.; Akparov VKh, Timofeev VB, Koliasnikova KN. The neuropeptide cycloprolylglycine can form a complex with AMPA receptors. Mendeleev Communications. 2022;32(4):436-438. doi:10.1016/j.mencom.2022.07.003.; Гудашева Т.А., Колясникова К.Н., Аляева А.Г. и др. Нейропротекторный эффект нейропептида циклопролилглицина зависит от активации AMPA- и TRK-рецепторов. Доклады российской академии наук. Науки о жизни. 2022;507(1):483-487.; Gudasheva TA, Povarnina PYu, Koliasnikova KN, et al. The anxiolytic effect of the neuropeptide cycloprolylglycine is mediated by AMPA and TrkB receptors. Dokl Biochem Biophys. 2020;493(1):190-192. doi:10.1134/S1607672920040067. (In Russ.). doi:10.31857/S2686738920040113.; Колясникова К.Н., Григоркевич О.С., Аляева А.Г., Гудашева Т.А. Изучение вовлеченности TrkB-рецепторов в антигипоксическое действие нейропептида цикло-пролилглицина. Вопросы биологической, медицинской и фармацевтической химии. 2022;25(1):39-42.; Tang KS. The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers. Life Sci. 2019 Sep 15;233:116695. doi:10.1016/j.lfs.2019.116695.; Воронцова О.Н., Аляева А.Г., Колясникова К.Ю., и др. Нейропептид цикло-L-пролилглицин противодействует скополамин-индуцированному нарушению долговременной памяти у крыс в тесте «Распознавание нового объекта». Фармакокинетика и Фармакодинамика. 2023;(3):50-55.; Колясникова К.Н., Голубятникова А.К., Ребеко А.Г., и др. Синтез цикло-L-пролилглицина и изучение его антипаркинсонической активности. Фармакокинетика и Фармакодинамика. 2019;(3):19-26.; Auld DS, Mennicken F, Day JC, Quirion R. Neurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons. J Neurochem. 2001 Apr;77(1):253-62. doi:10.1046/j.1471-4159.2001.t01-1-00234.x.; Kim SK, Kwon DA, Kim YS, et al. Standardized Extract (HemoHIM) Protects against Scopolamine-Induced Amnesia in a Murine Model. Evid Based Complement Alternat Med. 2021 Mar 17;2021:8884243. doi:10.1155/2021/8884243.; Ennaceur A, Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav Brain Res. 1988 Nov 1;31(1):47-59. doi:10.1016/0166-4328(88)90157-x.; Ennaceur A. Chapter 1 - Object Novelty Recognition Memor. Handbook of Behavioral Neuroscience. 2018:27;1-22. doi:10.1016/b978-0-12-812012-5.00001-x.; Vogel-Ciernia A, Wood MA. Examining object location and object recognition memory in mice. Curr Protoc Neurosci. 2014 Oct 8;69:8.31.1-17. doi:10.1002/0471142301.ns0831s69.; Ozawa T, Yamada K, Ichitani Y. d-Cycloserine reverses scopolamineinduced object and place memory deficits in a spontaneous recognition paradigm in rats. Pharmacol Biochem Behav. 2019 Dec;187:172798. doi:10.1016/j.pbb.2019.172798.; Knüsel B, Hefti F. K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons. J Neurochem. 1991 Sep;57(3): 955-62. doi:10.1111/j.1471-4159.1991.tb08243.x.; Knüsel B, Hefti F. K-252 compounds: modulators of neurotrophin signal transduction. J Neurochem. 1992 Dec;59(6):1987-96. doi:10.1111/j.1471-4159.1992.tb10085.x.; Antunes M, Biala G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process. 2012 May;13(2):93-110. doi:10.1007/s10339-011-0430-z.; https://www.pharmacokinetica.ru/jour/article/view/439
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2Academic Journal
Authors: Anton Semenets, Marharyta Suleiman, Victoriya Georgiyants, Sergiy Kovalenko, Natalia Kobzar, Lina Grinevich, Mikhail Pokrovskii, Mikhail Korokin, Vladislav Soldatov, Vera Bunyatyan, Lina Perekhoda
Source: ScienceRise: Pharmaceutical Science; № 4 (26) (2020); 4-17
Subject Terms: производные 1-бензил-4-пирролидин-2-она, виртуальный скрининг, ноотропная активность, молекулярный докинг, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 0404 agricultural biotechnology, похідні 1-бензил-4-піролідин-2-ону, віртуальний скринінг, ноотропна активність, молекулярний докінг, 04 agricultural and veterinary sciences, 0405 other agricultural sciences, UDC 615.217.34: 547.745: 547.792.1, 1-benzyl-4-pyrrolidin-2-one derivatives, virtual screening, nootropic action, molecular docking
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3Academic Journal
Authors: O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, E. A. Valdman, P. Yu. Povarnina, О. Н. Воронцова, А. Г. Аляева, К. Ю. Колясникова, Е. А. Вальдман, П. Ю. Поварнина
Source: Pharmacokinetics and Pharmacodynamics; № 3 (2023); 50-55 ; Фармакокинетика и Фармакодинамика; № 3 (2023); 50-55 ; 2686-8830 ; 2587-7836
Subject Terms: тест распознавания нового объекта, nootropic activity, scopolamine amnesia, novel object recognition test, ноотропная активность, скополаминовая амнезия
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Relation: https://www.pharmacokinetica.ru/jour/article/view/381/344; Гудашева Т.А., Островская Р.У., Максимова Ф.В. и др. Топологические аналоги пирацетама на основе пролина и их ноотропная активность. Химико-фармацевтический журнал. 1989;23(3):276–281.; Gudasheva TA, Boyko SS, Akparov VKh, et al. Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain. FEBS Letters. 1996;391:149–152. DOI:10.1016/0014-5793(96)00722-3.; Kang D, Waldvogel HJ, Wang A, et al. The autocrine regulation of insulin-like growth factor-1 in human brain of Alzheimer's disease. Psychoneuroendocrinology. 2021;127:105191. DOI:10.1016/j.psyneuen.2021.105191.; Островская Р.У., Мирзоев Т.Х., Романова Г.А. и др. Пролин содержащий дипептид ГВС-111 сохраняет ноотропную активность при пероральном введении. Бюллетень экспериментальной биологии и медицины. 2001;132(10):404–408. DOI:10.1023/a:1013663126973.; Гудашева Т.А., Константинопольский М.А., Островская Р.У., Середенин С.Б. Анксиолитическая активность эндогенного ноотропа цикло-пролилглицина в тесте приподнятого крестообразного лабиринта стереоселективна. Бюллетень экспериментальной биологии и медицины. 2001;131(5):547–550. DOI:10.1023/a:1017928116025.; Povarnina PY, Kolyasnikova KN, Nikolaev SV, et al. Neuropeptide cycloprolylglycine exhibits neuroprotective activity after systemic administration to rats with modeled incomplete global ischemia and in in vitro modeled glutamate eurotoxicity. Bull Exp Biol Med. 2016 Mar;160(5):653–655. DOI:10.1007/s10517-016-3241-5.; Колясникова К.Н., Гудашева Т.А., Назарова Г.А. и др. Сходство цикло-пролилглицина с пирацетамом по антигипоксическому и нейропротекторному эффектам. Экспериментальная и клиническая фармакология. 2012;75(9):3–6.; Sambeth A, Riedel WJ, Smits LT, Blokland A. Cholinergic drugs affect novel object recognition in rats: relation with hippocampal EEG? Eur J Pharmacol. 2007;572(2–3):151–159. DOI:10.1016/j.ejphar.2007.06.018.; Zhang R, Lao K, Lu B, et al. (m)RVD-hemopressin (α) and (m)VD-hemopressin (m) improve the memory-impairing effect of scopolamine in novel object and object location recognition tasks in mice. Peptides. 2021;136:170442. DOI:10.1016/j.peptides.2020.170442.; Ennaceur A. One-trial object recognition in rats and mice: methodological and theoretical issues. Behav Brain Res. 2010;215(2):244–254. DOI:10.1016/j.bbr.2009.12.036.; Волкова А.А., Поварнина П.Ю., Никифоров Д.М. и др. Сравнительное изучение мнемотропной активности димерных дипептидных миметиков отдельных петель NGF и BDNF в тесте распознавания нового объекта у крыс. Химико-фармацевтический журнал. 2022;56(4): 3–6. DOI:10.30906/0023-1134-2022-56-4-3-6.; Ozawa T, Yamada K, Ichitani Y. d-Cycloserine reverses scopolamineinduced object and place memory deficits in a spontaneous recognition paradigm in rats. Pharmacol Biochem Behav. 2019 Dec;187:172798. DOI:10.1016/j.pbb.2019.172798.; Dix SL, Aggleton JP. Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. Behav Brain Res. 1999 Mar;99(2):191–200. DOI:10.1016/s0166-4328(98)00079-5.; Malikowska-Racia N, Podkowa A, Sałat K. Phencyclidine and scopolamine for modeling amnesia in rodents: direct comparison with the use of barnes maze test and contextual fear conditioning test in mice. Neurotox Res. 2018;34(3):431–441. DOI:10.1007/s12640-018-9901-7.; Tanimizu T, Kono K, Kida S. Brain networks activated to form object recognition memory. Brain Res Bull. 2018;141:27–34. DOI:10.1016/j.brainresbull.2017.05.017.; Miranda M, Morici JF, Zanoni MB, Bekinschtein P. Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Front Cell Neurosci. 2019;13:363. DOI:10.3389/fncel.2019.00363.; Bekinschtein P, Cammarota M, Medina JH. BDNF and memory processing. Neuropharmacology. 2014;76 Pt C:677–683. DOI:10.1016/j.neuropharm.2013.04.024.; Гудашева Т.А., Колясникова К.Н., Антипова Т.А., Середенин С.Б. Нейропептид циклопролилглицин увеличивает содержание мозгового нейротрофического фактора в нейрональных клетках. Доклады Академии наук. 2016;4:469(1):492–495. DOI:10.7868/S0869565216220254. .; Гудашева Т.А., Колясникова К.Н., Аляева А.Г. и др. Нейропротекторный эффект нейропептида циклопролилглицина зависит от активации AMPA- и TRK-рецепторов. Доклады российской академии наук. Науки о жизни. 2022;507:483–487. DOI:10.31857/S2686738922060099.; Гудашева Т.А., Поварнина П.Ю., Колясникова К.Н. и др. Анксиолитический эффект нейропептида циклопролилглицина опосредован АМРА- и TrkB-рецепторами. Доклады российской академии наук. Науки о жизни. 2020;493(1):364–366. DOI:10.31857/S2686738920040113.; Колясникова К.Н. Григоркевич О.С., Аляева А.Г., Гудашева Т.А. Изучение вовлеченности TrkB-рецепторов в антигипоксическое действие нейропептида цикло-пролилглицина. Вопросы биологической, медицинской и фармацевтической химии. 2022:25(1); 39–42. DOI:10.29296/25877313-2022-01-06; https://www.pharmacokinetica.ru/jour/article/view/381
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4Academic Journal
Authors: I. P. Kodonidi, D. S. Anenko, D. I. Pozdnyakov, И. П. Кодониди, Д. С. Аненко, Д. И. Поздняков
Source: Drug development & registration; Том 11, № 1 (2022); 40-49 ; Разработка и регистрация лекарственных средств; Том 11, № 1 (2022); 40-49 ; 2658-5049 ; 2305-2066
Subject Terms: пирацетам, N-acyl-β-ketoamides, pyrimidin-4(1H)-one, nootropic activity, chiral center, diastereotopic protons, piracetam, N-ацил-β-кетоамиды, пиримидин-4(1H)-оны, ноотропная активность, хиральный центр, диастеротопные протоны
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Relation: https://www.pharmjournal.ru/jour/article/view/1160/944; https://www.pharmjournal.ru/jour/article/downloadSuppFile/1160/1034; Машковский М. Д. Лекарственные средства. 15-е изд. М.: ООО «Издательство Новая Волна»; 2005. 169 c.; Вартанян Р. С. Синтез основных лекарственных средств. М.: Медицинское информационное агенство; 2004. 233 с.; Орлов В. Д., Липсон В. В., Иванов В. В. Медицинская химия. Харьков: Фолио; 2005. 193 с.; Воронков А. В., Поздняков Д. И., Мирошниченко К. А., Потапова А. А., Кодониди И. П., Аненко Д. С. Производные пиримидина – перспективные корректоры метаболических и функциональных нарушений головного мозга в условиях хронической травматической энцефалопатии. Вестник смоленской государственной медицинской академии. 2019;18(3):18–24.; Кодониди И. П., Аненко Д. С., Терехов А. Ю., Сидорская С. Ю., Григорянц Э. Г. Синтез 2,6-диалкильных производных пиримидин-4(1h)-она, обладающих противовоспалительным действием. Фармация. 2021;70(1):11–17. DOI:10.29296/25419218-2021-01-02.; Kim K., Kim D., Lee H., Lee T. H., Kim K-Y., Kim H. New Pyrimidinone-Fused 1,4-Naphthoquinone Derivatives Inhibit the Growth of Drug Resistant Oral Bacteria. Biomedicines. 2020;8(6)160. DOI:10.3390/biomedicines8060160.; Kelada M., Walsh J. M. D., Devine R. W., McArdle P., Stephens J. C. Synthesis of pyrazolopyrimidinones using a "one-pot" approach under microwave irradiation. Beilstein Journal of Organic Chemistry. 2018;14:1222–1228. DOI:10.3762/bjoc.14.104.; MacDonald J. A., Sutherland C., Carlson D. A., Bhaidani S., Al-Ghabkari A., Sward K., Haystead T. A. J., Walsh M. P. A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Molecular Pharmacology. 2016;89(1):105–117. DOI:10.1124/mol.115.100529.; Elsharif A. M. Synthesis of New Pyrimidinone Derivatives and Their Respective Biological Structure Assessment. Orient Journal of Chemistry. 2019;35(2):658–667. DOI:10.13005/ojc/350221.; Bederson J. B., Pitts L. H., Tsuji M., Nishimura M. C., Davis R. L., Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 1986;17:472–476.; Cohen P. A., Zakharevich I., Gerona R. Presence of Piracetam in Cognitive Enhancement Dietary Supplements. JAMA Internal Medicine. 2019;180(3):458–459. DOI:10.1001/jamainternmed.2019.5507.; Keil U., Scherping I., Hauptmann S., Schuessel K., Eckert A., Müller W. E. Piracetam improves mitochondrial dysfunction following oxidative stress. British Journal of Pharmacology. 2005;147(2):199–208. DOI:10.1038/sj.bjp.0706459.; Миронов А. Н., ред. Руководство по проведению доклинических исследований лекарственных средств. Часть первая. М.: Гриф и К; 2012. 944 с.; Fleming S. M, Ekhator O. R., Ghisays V. Assessment of Sensorimotor Function in Mouse Models of Parkinson’s Disease. Journal of Visualized Experiments. 2013;76:50303. DOI:10.3791/50303.; Плотникова Е. Ю., Грачева Т. Ю., Синьков М. А., Сухих А. С. Анализ ошибок при проведении сравнительных исследований клинической и экономической эффективности на примере дженериков урсодезоксихолевой кислоты. РМЖ. 2019;27(5):3–7.; Hayashi M., Bachman S., Hashimoto S., Eichman C. C., Stoltz B. M. Ni-Catalysed Enantioselective C-Acylation of α-substituted Lactams. Journal of the American Chemical Society. 2016;138(29):8997–9000. DOI:10.1021/jacs.6b02120.; Moradian M., Amini A., Naeimi H. Zncl2@MWCNTs nanocomposite as an efficient and reusable catalyst for direct regioselective ortho C-acylation of phenolic compounds under solvent-free and microwave conditions. Green Chemistry Letters and Reviews. 2017;10(4):228–234. DOI:10.1080/17518253.2017.1349194.; Lee J., Hong M., Jung Y., Cho E., Rhee H. Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides. Tetrahedron. 2012;68(8):2045–2051.; Li W., Zheng Y., Qu E., Bai J. β-Keto Amides: A Jack-of-All-Trades Building Block in Organic Chemistry. European Journal of Organic Chemistry. 2021;37:5151–5192. DOI:10.1002/ejoc.202100692.; Оспанов М. А., Турмуханова М. Ж., Мурзагулова К. Б., Абилов Ж. А. Стереохимические особенности непредельных аминодиэфиров – полупродуктов в синтезе рихлокаина. Вестник КазНУ. Серия химическая. 2014;3(75):361–368. DOI:10.15328/chemb_2014_361-68.; Терней А. Л. Современная органическая химия. Пер. с англ. В 2 томах. 2 том. М.: Мир; 1981. C. 559–561.; Пакальнис В. В., Зерова И. В., Якимович С. И. Взаимодействие ароил- и гетероароилтрифторацетонов с ацилгидразинами: регионаправленность и таутомерия продуктов конденсации. ЖОХ. 2007;77:1665–1676.; Мещерякова С. А. Синтез, свойства, структура и биологическая активность новых S и N-производных пиримидина. Дис. . докт. фарм. наук. Уфа; 2015. 205 с. Доступно по: https://www.dissercat.com/content/sintez-svoistva-struktura-i-biologicheskaya-aktivnost-novykh-s-i-n-proizvodnykh-pirimidina. Ссылка активна на 29.12.2021.; https://www.pharmjournal.ru/jour/article/view/1160
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5Academic Journal
Authors: A. L. Budantsev, V. A. Prikhodko, I. V. Varganova, S. V. Okovityi, А. Л. Буданцев, В. А. Приходько, И. В. Варганова, С. В. Оковитый
Contributors: The study was carried out within the framework of the institutional research project N АААА-А19-119031290052-1 (Vascular plants of Eurasia: systematic, flora, plant resources) of the Komarov Botanical Institute of the Russian Academy of Sciences., Работа выполнена по плановой теме Ботанического института им. В. Л. Комарова РАН ААА-А19-119031290052-1 «Сосудистые растения Евразии: систематика, флора, растительные ресурсы».
Source: Pharmacy & Pharmacology; Том 9, № 1 (2021); 17-31 ; Фармация и фармакология; Том 9, № 1 (2021); 17-31 ; 2413-2241 ; 2307-9266 ; 10.19163/2307-9266-2021-9-1
Subject Terms: аментофлавон, antidepressant, neuroprotective, nootropic, anxiolytic, antibacterial, cytotoxic, hypoglycemic activity, hypericin, hyperforin, amentoflavone, H. perforatum, антидепрессивная активность, нейропротекторная активность, ноотропная активность, анксиолитическая активность, антибактериальная активность, цитотоксическая активность, гипогликемическая активность, гиперицин, гиперфорин
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Macromol. - 2017. - Vol. 104, Pt A. - P. 287–293. DOI:10.1016/j.ijbiomac.2017.06.049.; Meinke M.C., Schanzer S., Haag S.F., Casetti F., Müller M.L., Wölfle U., Kleemann A., Lademann J., Schempp C.M. In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo // Eur. J. Pharm. Biopharm. - 2012. - Vol. 81, No.2. - P. 346–350. DOI:10.1016/j.ejpb.2012.03.002.; Micioni Di Bonaventura MV, Vitale G, Massi M, Cifani C. Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats // J Obes. – 2012. Vol.2012. – P.956137. DOI:10.1155/2012/956137.; Peron A.P., Mariucci R.G., de Almeida I.V., Düsman E., Mantovani M.S., Vicentini V.E. Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems // BMC Complement. Altern. Med. - 2013. - Vol. 13. – P. 97. Doi:10.1186/1472-6882-13-97.; Imreova P., Feruszova J., Kyzek S., Bodnarova K., Zduriencikova M., Kozics K., Mucaji P., Galova E., Sevcovicova A., Miadokova E., Chalupa I. Hyperforin exhibits antigenotoxic activity on human and bacterial cells // Molecules. - 2017. - Vol. 22, No.1. - Pii: E167. DOI:10.3390/molecules22010167.; Ševčovičová A., Šemeláková M., Plšíková J., Loderer D., Imreová P., Gálová E., Kožurková M., Miadoková E., Fedoročko P. DNA-protective activities of hyperforin and aristoforin // Toxicol. In Vitro. - 2015. - Vol. 29, No.3. - P. 631–637. DOI:10.1016/j.tiv.2015.01.016.; You M.K., Kim D.W., Jeong K.S., Bang M.A., Kim H.S., Rhuy J., Kim H.A. St. John’s Wort (Hypericum perforatum) stimulates human osteoblastic MG-63 cell proliferation and attenuates trabecular bone loss induced by ovariectomy // Nutr. Res. Pract. - 2015. - Vol. 9, No.5. - P. 459–465. DOI:10.4162/nrp.2015.9.5.459.; Abtahi Froushani S.M., Esmaili Gouvarchin Galee H., Khamisabadi M., Lotfallahzade B. Immunomudulatory effects of hydroalcoholic extract of Hypericum perforatum // Avicenna J. Phytomed. - 2015. - Vol. 5, No.1. - P. 62–68.; Eğilmez O.K., Kökten N., Ekici A.I., Kalcıoğlu M.T., Yesilada E., Tekin M. The effect of Hypericum perforatum L. (St. John’s Wort) on prevention of myringosclerosis after myringotomy in a rat model // Int. J. Pediatr. Otorhinolaryngol. - 2015. - Vol. 79, No.7. - P. 1128–1134. DOI:10.1016/j.ijporl.2015.05.009.; Radulović N.S., Genčić M.S., Stojanović N.M., Randjelović P.J., Baldovini N., Kurteva V. Prenylated β-diketones, two new additions to the family of biologically active Hypericum perforatum L. (Hypericaceae) secondary metabolites // Food Chem. Toxicol. - 2018. - Vol. 118. - P. 505–513. DOI:10.1016/j.fct.2018.05.009.; Guo Y., Zhang N., Sun W., Duan X., Zhang Q., Zhou Q., Chen C., Zhu H., Luo Z., Liu J., Li X. N., Xue Y., Zhang Y. Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum // Org. Biomol. 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6Academic Journal
Source: Current issues in pharmacy and medicine: science and practice; Vol. 12 No. 3 (2019) ; Актуальные вопросы фармацевтической и медицинской науки и практики; Том 12 № 3 (2019) ; Актуальні питання фармацевтичної і медичної науки та практики; Том 12 № 3 (2019) ; 2409-2932 ; 2306-8094
Subject Terms: вазопрессин, пленки буккальные, основа-носитель, ноотропная активность, введение лекарств трансбуккальное, vasopressin, buccal films, base-vehicle, nootropic activity, administration buccal, вазопресин, плівки букальні, основа-носій, ноотропна активність, введення ліків трансбукальне
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Relation: http://pharmed.zsmu.edu.ua/article/view/184199/186259; http://pharmed.zsmu.edu.ua/article/view/184199
Availability: http://pharmed.zsmu.edu.ua/article/view/184199
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7Academic Journal
Authors: T. A. Sapozhnikova, N. S. Makara, S. F. Gabdrakhmanova, R. Yu. Khisamutdinova, Т. А. Сапожникова, Н. С. Макара, С. Ф. Габдрахманова, Р. Ю. Хисамутдинова
Source: Drug development & registration; Том 8, № 1 (2019); 86-90 ; Разработка и регистрация лекарственных средств; Том 8, № 1 (2019); 86-90 ; 2658-5049 ; 2305-2066
Subject Terms: нормобарическая гипоксия, activity, nootropic activity, passive avoidance task, antihypoxic activity, normobaric hypoxia, ноотропная активность, условный рефлекс пассивного избегания, антигипоксическая активность
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Relation: https://www.pharmjournal.ru/jour/article/view/652/647; Вахитова Ю. В., Антипина Е. И., Ямиданов Р. С., Хисамутдинова Р.Ю. Идентификация генов-мишеней 5-аминоэкзо-3-азатрицикло[5.2.1.02,6]декан-4-она на модели аритмии in vivo. Биоорганическая химия. 2011; 6(37): 9–11. Doi.org/10.1134/S1068162011060148.; Миронов А. Н., Бунатян Н. Д. Руководство по проведению доклинических исследований лекарственных средств. – М.: Гриф и К, 2012; 944 с.; Современные методы в биохимии / Под. ред. акад. В. Н. Ореховича. – М.: Медицина. 1977; С. 66–68.; Хисамутдинова Р. Ю., Сапожникова Т. А., Макара Н. ., Габдрахманова С. Ф., Зарудий Ф. С. Экспериментальное изучение антиаритмической активности и хронической токсичности 5-аминоэкзо-3-азатрицикло[5.2.1.02,6]декан-4-она. Разработка и регистрация лекарственных средств. 2015; 2(11): 90–93.; Цыпышева И. П., Ковальская А. В., Макара Н. С., Лобов А. Н., Петренко И. А., Галкин Е. Г., Сапожникова Т. А., Зарудий Ф. С., Юнусов М. С. Синтез и специфическая ноотропная активность производных (-)-цитизина, имеющих в структуре фрагменты карбамидов и тиокарбамидов. Химия природных соединений. 2012; 4: 565. Doi.org/10.1007/s10600-012-0329-7.; Martino M. V., Guandalini L., Mannelli L. C. Di, Menicatti M., Bartolucci G., Dei S., Manetti D., Teodori E., Ghelardini C., Romanelli M. Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents. Bioorganic and Medicinal Chemistry. 2017; 25: 1795–1803. DOI:10.1016/j.bmc.2017.02.019.; Tsypysheva I. P., Koval’skaya A. V., Lobov A. N., Makara N. S., Petrova P. R., Farafontova E. I., Zainullina L. F., Vakhitova Yu. V., Zarudii F. S. Synthesis and nootropic activity of new 3-amino-12-nmethylcytisine derivatives. Chemistry of Natural Compounds. 2015; 5(51): 910–915. Doi.org/10.1007/s10600-015-1446-x.; Zveiniece L., Svalbe B., Veinberg G., Grinberga S., Vorona M., Kalvinsh I., Dambrova M. Investigation into stereoselective pharmacological activity of phenotropil. Basic and Clinical Pharmacology and Toxicology. 2011; 109: 407–412. Doi.org/10.1111/j.1742-7843.2011.00742.x.; https://www.pharmjournal.ru/jour/article/view/652
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8Academic Journal
Authors: ПОВАРНИНА П.Ю., ГУДАШЕВА Т.А., ДЕЕВА О.А., ЯРКОВ С.А., ЯРКОВА М.А., СЕРЕДЕНИН С.Б.
Subject Terms: ТРАНСЛОКАТОРНЫЙ БЕЛОК,ДИПЕПТИД,ГД-23,АНКСИОЛИТИЧЕСКАЯ АКТИВНОСТЬ,НООТРОПНАЯ АКТИВНОСТЬ
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9Academic Journal
Authors: Куркин Владимир Александрович, Авдеева Елена Владимировна, Куркина Анна Владимировна, Петрухина Ирина Константиновна
Subject Terms: гинкго двулопастный, Ginkgo biloba L., листья, лекарственные препараты, настойка, флавоноиды, гинкгетин, никотифлорин, нарциссин, рутин, ноотропная активность, спектрофотометрия, тонкослойная хроматография, стандартизация
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10Academic Journal
Subject Terms: СЕРПУХА ВАСИЛЬКОВАЯ, SERRATULA CENTAUROIDES L. ПРОТИВОСУДОРОЖНАЯ АКТИВНОСТЬ, НООТРОПНАЯ АКТИВНОСТЬ
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11Academic Journal
Authors: Корчагина, Д., Куркина, А., Дубищев, А., Кочнева, О., Гусев, Д.
Subject Terms: ГИНКГО ДВУЛОПАСТНЫЙ, GINKGO BILOBA L., ЛИСТЬЯ, ЛЕКАРСТВЕННЫЕ ПРЕПАРАТЫ, НАСТОЙКА, ФЛАВОНОИДЫ, НЕЙРОТРОПАЯ АКТИВНОСТЬ, НООТРОПНАЯ АКТИВНОСТЬ, АНКСИОЛИТИЧЕСКАЯ АКТИВНОСТЬ
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12Academic Journal
Authors: Колісник, С.
Subject Terms: N-[2-(БЕНЗОїЛАМіНО)(2-ОКСО-1, 2-ДИГіДРО-3Н-іНДОЛ-3-іЛіДЕН)АЦЕТИЛ]АМіНОКИСЛОТИ, НООТРОПНА АКТИВНіСТЬ, N-[2-(БЕНЗОИЛАМИНО)(2-ОКСО-1, 2-ДИГИДРО-3Н-ИНДОЛ-3-ИЛИДЕН)АЦЕТИЛ]АМИНОКИСЛОТЫ, НООТРОПНАЯ АКТИВНОСТЬ, N-[2-(BENZOYLAMINO)(2-OXO-1, 2-DIHYDRO-3H-INDOL-3-YLIDENE)ACETYL]AMINOACIDS
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13Academic Journal
Authors: Давлятова, Г., Валеева, Л.
Subject Terms: ПРОИЗВОДНЫЕ КСАНТИНА, ПСИХОСТИМУЛИРУЮЩАЯ АКТИВНОСТЬ, ПСИХОСЕДАТИВНАЯ АКТИВНОСТЬ, НООТРОПНАЯ АКТИВНОСТЬ
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14Academic Journal
Authors: Багметова, В., Багметов, М., Тюренков, Иван, Васильева, О., Берестовицка, В.
Subject Terms: ПРОИЗВОДНЫЕ ГЛУТАМИНОВОЙ КИСЛОТЫ, ПОВЕДЕНИЕ, НЕЙРОПСИХОФАРМАКОЛОГИЧЕСКИЕ ЭФФЕКТЫ, АНКСИОЛИТИЧЕСКАЯ АКТИВНОСТЬ, НООТРОПНАЯ АКТИВНОСТЬ, АНТИДЕПРЕССАНТНАЯ АКТИВНОСТЬ
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15Academic Journal
Authors: Тюренков, И., Меркушенкова, О., Багметова, В.
Subject Terms: ПСИХОФАРМАКОЛОГИЧЕСКИЕ СВОЙСТВА, ПРОИЗВОДНЫЕ ГАММА-АМИНОМАСЛЯНОЙ КИСЛОТЫ (ГАМК), НООТРОПНАЯ АКТИВНОСТЬ, АНКСИОЛИТИЧЕСКОЕ ДЕЙСТВИЕ, DERIVATIVES OF GAMMA-AMINOBUTYRIC ACID (GABA)
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16Academic Journal
Source: Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук.
Subject Terms: СЕРПУХА ВАСИЛЬКОВАЯ, SERRATULA CENTAUROIDES L. ПРОТИВОСУДОРОЖНАЯ АКТИВНОСТЬ, НООТРОПНАЯ АКТИВНОСТЬ, 3. Good health
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17Academic Journal
Source: Acta Naturae (русскоязычная версия).
Subject Terms: ТРАНСЛОКАТОРНЫЙ БЕЛОК,ДИПЕПТИД,ГД-23,АНКСИОЛИТИЧЕСКАЯ АКТИВНОСТЬ,НООТРОПНАЯ АКТИВНОСТЬ
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18Academic Journal
Authors: Намсараева, Г., Даждинова, Г.
Subject Terms: SCUTELLARIA BAICALENSIS G., ШЛЕМНИК БАЙКАЛЬСКИЙ, ЭКСПЕРИМЕНТ, СОСУДИСТО-МОЗГОВАЯ НЕДОСТАТОЧНОСТЬ, НООТРОПНАЯ АКТИВНОСТЬ
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19Academic Journal
Authors: I. V. Shilova
Source: Бюллетень сибирской медицины, Vol 1, Iss 2, Pp 55-59 (2002)
Subject Terms: лекарственные растения, ноотропная активность, химический состав, Medicine
Relation: https://bulletin.ssmu.ru/jour/article/view/3952; https://doaj.org/toc/1682-0363; https://doaj.org/toc/1819-3684; https://doaj.org/article/e7967413f12846f98f994b6f5ce7c680
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20Academic Journal
Source: Фундаментальные исследования.
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