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    Academic Journal

    Contributors: Работа выполнена в рамках фундаментальной научной тематики FURS-2022-008 «Разработка персонализированной программы лечения рефрактерного ревматоидного артрита на основе изучения молекулярно-генетических и молекулярно-биологических предикторов. Создание и апробация регистра пациентов с ревматоидным артритом, резистентных к базисной противовоспалительной терапии» (номер государственного задания 1021051503137-7).

    Source: Rheumatology Science and Practice; Vol 62, No 5 (2024); 494-500 ; Научно-практическая ревматология; Vol 62, No 5 (2024); 494-500 ; 1995-4492 ; 1995-4484

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    Relation: https://rsp.mediar-press.net/rsp/article/view/3635/2403; Насонов ЕЛ (ред.). Ревматология. Российские клинические рекомендации. М.:ГЭОТАР-Медиа;2020.; GBD 2021 Rheumatoid Arthritis Collaborators. Global, regional, and national burden of rheumatoid arthritis, 1990–2020, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(10):e594-e610. doi:10.1016/S2665-9913(23)00211-4; Safiri S, Kolahi AA, Hoy D, Smith E, Bettampadi D, Mansournia MA, et al. Global, regional and national burden of rheumatoid arthritis 1990–2017: A systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis. 2019;78(11):1463-1471. doi:10.1136/annrheumdis-2019-215920; Зинчук ИЮ, Амирджанова ВН. Социальное бремя ревматоидного артрита. Научно-практическая ревматология. 2014;52(3):331-335.; Галушко ЕА, Насонов ЕЛ. Распространенность ревматических заболеваний в России. Альманах клинической медицины. 2018;46(1):32-39.; Rasch EK, Hirsch R, Paulose-Ram R, Hochberg MC. Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States. Arthritis Rheum. 2003;48:917-926. doi:10.1002/art.10897; Балабанова РМ, Эрдес ШФ. Динамика распространенности ревматических заболеваний, входящих в XIII класс МКБ-10, в популяции взрослого населения Российской Федерации за 2000–2010 гг. Научно-практическая ревматология. 2012;50(3):10-12.; Dyussenbayev A. Age periods of human life. Adv Soc Sci Res J. 2017;4(6):258-263. doi:10.14738/assrj.46.2924; WHO global strategy and action plan on ageing and health (2016– 2020). http://apps.who.int/gb/ebwha/pdf_files/WHA69/A69_17-en.pdf (Accessed: 8th August 2024).; Kobak S, Bes C. An autumn tale: Geriatric rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2018;10(1):3-11. doi:10.1177/1759720X17740075; Bechman K, Clarke BD, Rutherford AI, Yates M, Nikiphorou E, Molokhia M, et al. Polypharmacy is associated with treatment response and serious adverse events: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Rheumatology (Oxford). 2019;58(10):1767-1776. doi:10.1093/rheumatology/kez037; Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, van Gool WA. Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: A meta-analysis. JAMA. 2010;304(4):443-451. doi:10.1001/jama.2010.1013; Innala L, Berglin E, Möller B, Ljung L, Smedby T, Södergren A, et al. Age at onset determines severity and choice of treatment in early rheumatoid arthritis: A prospective study. Arthritis Res Ther. 2014;16(2):R94. doi:10.1186/ar4540; Murata K, Ito H, Hashimoto M, Nishitani K, Murakami K, Tanaka M, et al. Elderly onset of early rheumatoid arthritis is a risk factor for bone erosions, refractory to treatment: KURAMA cohort. Int J Rheum Dis. 2019;22(6):1084-1093. doi:10.1111/1756-185X.13428; Tan TC, Gao X, Thong BY, Leong KP, Lian TY, Law WG, et al.; TTSH Rheumatoid Arthritis Study Group. Comparison of elderlyand young-onset rheumatoid arthritis in an Asian cohort. Int J Rheum Dis. 2017;20(6):737-745. doi:10.1111/1756-185X.12861; Li X, Cesta A, Movahedi M, Bombardier C. Late-onset rheumatoid arthritis has a similar time to remission as younger-onset rheumatoid arthritis: Results from the Ontario Best Practices Research Initiative. Arthrit Res Ther. 2022;24(1):255. doi:10.1186/s13075-022-02952-1; Romão VC, Humby F, Kelly S, Di Cicco M, Mahto A, Lazarou I, et al. Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: Findings from a prospective observational longitudinal early arthritis cohort study. Semin Arthritis Rheum. 2020;50(4):735-743. doi:10.1016/j.semarthrit.2020.03.018; Zhang JF, Ye XL, Duan M, Zhou XL, Yao ZZ, Zhao JX. [Clinical characteristics of elderly and younger onset rheumatoid arthritis. Zhonghua Yi Xue Za Zhi. 2020;100(47):3788-3792 (In Chinese). doi:10.3760/cma.j.cn112137-20200506-01439; Huscher D, Sengler C, Gromnica-Ihle E, Bischoff S, Eidner T, Ochs W, et al. Clinical presentation, burden of disease and treatment in young-onset and late-onset rheumatoid arthritis: A matched-pairs analysis taking age and disease duration into account. Clin Exp Rheumatol. 2013;31(2):256-262.; Lahaye C, Tatar Z, Dubost J-J, Tournadre A, Soubrier M. Management of inflammatory rheumatic conditions in the elderly. Rheumatology (Oxford). 2019;58:748-764.; Сатыбалдыев АМ, Демидова НВ, Гриднева ГИ, Никишина НЮ, Герасимова ЕВ, Гукасян ДА, и др. Клиническая характеристика трех когорт раннего ревматоидного артрита с поздним началом (в возрасте 50 лет и старше). Обобщение 40-летнего опыта. Научно-практическая ревматология. 2020;58(2):140-146.; Arnold MB, Bykerk VP, Boire G, Haraoui BP, Hitchon C, Thorne C, et al.; CATCH Investigators. Are there differences between young- and older-onset early inflammatory arthritis and do these impact outcomes? An analysis from the CATCH cohort. Rheumatology (Oxford). 2014;53(6):1075-1086. doi:10.1093/rheumatology/ket449; van der Heijde DM, van Riel PL, van Leeuwen MA, van’t Hof MA, van Rijswijk MH, van de Putte LB. Older versus younger onset rheumatoid arthritis: Results at onset and after 2 years of a prospective followup study of early rheumatoid arthritis. J Rheumatol. 1991;18(9):1285-1289.; Mueller RB, Kaegi T, Finckh A, Haile SR, Schulze-Koops H, von Kempis J; SCQM physicians. Is radiographic progression of late-onset rheumatoid arthritis different from young-onset rheumatoid arthritis? Results from the Swiss prospective observational cohort. Rheumatology (Oxford). 2014;53(4):671-677. doi:10.1093/rheumatology/ket399; Aiello A, Farzaneh F, Candore G, Caruso C, Davinelli S, Gambino CM, et al. Immunosenescence and its hallmarks: How to oppose aging strategically? A review of potential options for therapeutic intervention. Front Immunol. 2019;10:2247. doi:10.3389/fimmu.2019.02247; Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908:244-254. doi:10.1111/j.1749-6632.2000.tb06651.x; Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Immunosenescence and inflamm-aging as two sides of the same coin: Friends or foes? Front Immunol. 2018;8:1960. doi:10.3389/fimmu.2017.01960; Boots AM, Maier AB, Stinissen P, Masson P, Lories RJ, De Keyser F. The influence of ageing on the development and management of rheumatoid arthritis. Nat Rev Rheumatol. 2013;9(10):604-613. doi:10.1038/nrrheum.2013.92; Goronzy JJ, Weyand CM. Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation. Arthr Res Ther. 2003;5:225-234. doi:10.1186/ar974; Chalan P, Van den Berg A, Kroesen B, Brouwer L, Boots A. Rheumatoid arthritis, immunosenescence and the hallmarks of aging. Curr Aging Sci. 2015;8:131-146. doi:10.2174/1874609808666150727110744; Lindstrom T, Robinson W. Rheumatoid arthritis: A role for immunosenescence? J Am Geriatr Soc. 2010;58:1565-1575. doi:10.1111/j.1532-5415.2010. 02965.x; Weyand CM, Yang Z, Goronzy JJ. T-cell aging in rheumatoid arthritis. Curr Opin Rheumatol. 2014;26(1):93-100. doi:10.1097/BOR.0000000000000011; Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013;14(12):877-782. doi:10.1016/j.jamda.2013.05.009; Lorenzo J, Horowitz M, Choi Y. Osteoimmunology: interactions of the bone and immune system. Endocr Rev. 2008;29(4):403-440. doi:10.1210/er.2007-0038; Weyand C, Goronzy J. Aging of the immune system. Annals ATS. 2016;13:422-428. doi:10.1513/AnnalsATS.201602-095AW; Chen JM, Cui GH, Jiang GX, Xu RF, Tang HD, Wang G, et al. Cognitive impairment among elderly individuals in Shanghai suburb, China: Association of C-reactive protein and its interactions with other relevant factors. Am J Alzheimers Dis Other Demen. 2014;29(8):712-717. doi:10.1177/1533317514534758; Van Onna M, Boonen A. The challenging interplay between rheumatoid arthritis, ageing and comorbidities. BMC Musculoskeletal Disorders. 2016;17:184. doi:10.1186/s12891-016-1038-3; Ruban TN, Jacob B, Pope JE, Keystone EC, Bombardier C, Kuriya B. The influence of age at disease onset on disease activity and disability: Results from the Ontario Best Practices Research Initiative. Clin Rheumatol. 2016;35(3):759-763. doi:10.1007/s10067-015-3031-x; Dougados M, Soubrier M, Antunez A, Balint P, Balsa A, Buch MH, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: Results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2014;73(1):62-68. doi:10.1136/annrheumdis-2013-204223; Baghdadi L, Woodman R, Shanahan E, Mangoni A. The impact of traditional cardiovascular risk factors on cardiovascular outcomes in patients with rheumatoid arthritis: A systematic review and meta-analysis. PLoS One. 2015;10:e0117952. doi:10.1371/journal.pone; Meissner Y, Zink A, Kekow J, Rockwitz K, Liebhaber A, Zinke S, et al. Impact of disease activity and treatment of comorbidities on the risk of myocardial infarction in rheumatoid arthritis. Arthritis Res Ther. 2016;18(1):183. doi:10.1186/s13075-016-1077-z; Gullick NJ, Scott DL. Co-morbidities in established rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2011;25:469-483. doi:10.1016/j.berh.2011.10.009; Roubille C, Richer V, Starnino T, McCourt C, McFarlane A, Fleming P, et al. The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: A systematic review and meta-analysis. Ann Rheum Dis. 2015;74(3):480-489. doi:10.1136/annrheumdis-2014-206624; Lindhardsen J, Ahlehoff O, Gislason GH, Madsen OR, Olesen JB, Torp-Pedersen C, et al. The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: A Danish nationwide cohort study. Ann Rheum Dis. 2011;70(6):929-934. doi:10.1136/ard.2010.143396; Listing J, Gerhold K, Zink A. The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment. Rheumatology (Oxford). 2013;52:53-61. doi:10.1093/rheumatology/kes305; Ramiro S, Sepriano A, Chatzidionysiou K, Nam JL, Smolen JS, van der Heijde D, et al. Safety of synthetic and biological DMARDs: A systematic literature review informing the 2016 update of the EULAR recommendations for management of rheumatoid arthritis. Ann Rheum Dis. 2017;76(6):1101-1136. doi:10.1136/annrheumdis-2016-210708; Simon T, Thompson A, Gandhi K, Hochberg M, Suissa S. Incidence of malignancy in adult patients with rheumatoid arthritis: A meta-analysis. Arthr Res Ther. 2015;17:212. doi:10.1186/s13075-015-0728-9; Listing J, Kekow J, Manger B, Burmester GR, Pattloch D, Zink A, et al. Mortality in rheumatoid arthritis: The impact of disease activity, treatment with glucocorticoids, TNFα inhibitors and rituximab. Ann Rheum Dis. 2015;74(2):415-421. doi:10.1136/annrheumdis-2013-204021; Maassen JM, Bergstra SA, Chopra A, Govind N, Murphy EA, Vega-Morales D, et al. Phenotype and treatment of elderly onset compared with younger onset rheumatoid arthritis patients in international daily practice. Rheumatology (Oxford). 2021;60(10):4801-4810. doi:10.1093/rheumatology/keab102; Smolen JS, Landewé R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76(6):960-977. doi:10.1136/annrheumdis-2016-210715; Singh JA, Saag KG, Bridges SL Jr, Akl EA, Bannuru RR, Sullivan MC, et al. 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2016;68(1):1-26. doi:10.1002/art.39480; Tkacheva ON, Runikhina NK, Ostapenko VS, Sharashkina NV, Mkhitaryan EA, Onuchina JS, et al. Prevalence of geriatric syndromes among people aged 65 years and older at four community clinics in Moscow. Clin Interv Aging. 2018;13:251-259. doi:10.2147/CIA.S153389; Niksolat F, Zandieh Z, Roshani F, Larijani SS, Mirfakhraee H, Bahadori F, et al. Geriatric syndromes among patients with rheumatoid arthritis: A comparison between young and elderly patients. Ethiop J Health Sci. 2022;32(4):791-798. doi:10.4314/ejhs.v32i4.16; Ward KT, Reuben DB. Comprehensive geriatric assessment. URL: https://www.uptodate.com/contents/comprehensive-geriatric-assessment (Accessed: 25th July 2024).; Van Moerbeke A, Magdelijns F, Cleutjens F, Boonen A, van Onna M. Development and evaluation of a clinic for elderly patients with rheumatoid arthritis and multimorbidity: A pilot study. ACR Open Rheum J. 2021;3:34-40. doi:10.1002/acr2.11213; van Leendert JAA, Linkens AEMJH, Poeze M, Pijpers E, Magdelijns F, Ten Broeke RHM, et al. Mortality in hip fracture patients after implementation of a nurse practitioner-led orthogeriatric care program: Results of a 1-year follow-up. Age Ageing. 2021;50(5):1744-1750. doi:10.1093/ageing/afab031; Radner H, Yoshida K, Smolen JS, Solomon DH. Multimorbidity and rheumatic conditions-enhancing the concept of comorbidity. Nat Rev Rheum. 2014;10:252-256. doi:10.1038/nrrheum.2013.212; Jogerst GJ. Geriatrics assessment is not just for geriatricians. Advances in Gerontology. 2006;19:120-128.; Kastner M, Hayden L, Wong G, Lai Y, Makarski J, Treister V, et al. Underlying mechanisms of complex interventions addressing the care of older adults with multimorbidity: A realist review. BMJ Open. 2019;9(4):e025009. doi:10.1136/bmjopen-2018-025009

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    Academic Journal

    Contributors: The investigation has been conducted as part of government program "Optimization of diagnosis and management of combined diseases of the musculoskeletal system in elderly and senile patients in order to maintain autonomy" №69.7-2021., Исследование выполнено в рамках Государственного задания «Оптимизация диагностики и ведения сочетанных заболеваний опорно-двигательного аппарата у пациентов пожилого и старческого возраста с целью сохранения автономности» №69.7-2021.

    Source: Modern Rheumatology Journal; Том 16, № 3 (2022); 50-59 ; Современная ревматология; Том 16, № 3 (2022); 50-59 ; 2310-158X ; 1996-7012

    File Description: application/pdf

    Relation: https://mrj.ima-press.net/mrj/article/view/1297/1249; Hawker GA. Osteoarthritis is a serious disease. Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):3-6. Epub 2019 Oct 14.; Naumov AV, Vorob'eva NM, Khovasova NO, et al. The prevalence of osteoarthritis and its association with geriatric syndromes in people over 65 years of age: data from the Russian epidemiological study EUCALYPTUS. Terapevticheskii arkhiv. 2021;93(12):1482-90. (In Russ.).; Hana S, Aicha BT, Selim D, et al. Clinical and Radiographic Features of Knee Osteoarthritis of Elderly Patients. Curr Rheumatol Rev. 2018;14(2):181-7. doi:10.2174/1573397113666170425150133.; Johnson M, Collett B, Castro-Lopes J. The challenges of pain management in primary care: a pan-European survey. J Pain Res. 2013 May 22;6:393-401. doi:10.2147/JPR.S41883. Print 2013.; Bjordal JM, Ljunggren AE, Klovning A, et al. Non-Steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials. BMJ. 2004 Dec 4;329(7478):1317. doi:10.1136/bmj.38273.626655.63. Epub 2004 Nov 23.; Bharde S, Caxaria S, Dell'Accio F, Sikandar S. Update on pain in arthritis. Curr Opin Support Palliat Care. 2021 Jun 1;15(2):99-107. doi:10.1097/SPC.0000000000000551.; Bijlsma JWJ, Berenbaum F, Lafeber FPJG. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011 Jun 18; 377(9783):2115-26. doi:10.1016/S0140-6736(11)60243-2.; Demir UG, Demir AN, Toraman NF. Neuropathic pain in knee osteoarthritis. Adv Rheumatol. 2021 Nov 7;61(1):67. doi:10.1186/s42358-021-00225-0.; Thakur M, Dickenson AH, Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol. 2014 Jun;10(6):374-80. doi:10.1038/nrrheum.2014.47. Epub 2014 Apr 1.; Torrance N, Ferguson JA, Afolabi E, et al. Neuropathic pain in the community: more under-treated than refractory? Pain. 2013 May; 154(5):690-9. doi:10.1016/j.pain.2012.12.022. Epub 2013 Jan 23.; Vertkin AL. Comorbidity: history, current understanding, prevention and treatment. Kardiovaskulyarnaya terapiya i profilaktika. 2015;14(2):74-9. (In Russ.).; Davydov OS, Yakhno NN, Kukushkin ML, et al. Neuropathic pain: clinical guidelines for the diagnosis and treatment of the Russian Society for the Study of Pain. Rossiiskii zhurnal boli. 2018;(4):5-41. (In Russ.).; Bouhassira D, Attal N, Alchaar H, et al. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain. 2005 Mar;114 (1-2):29-36. doi:10.1016/j.pain.2004.12.010. Epub 2005 Jan 26.; Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical recommendations "Senile asthenia". Part 1. Rossiiskii zhurnal geriatricheskoi meditsiny. 2020;(1):11-46. (In Russ.).; Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical recommendations "Senile asthenia". Part 2. Rossiiskii zhurnal geriatricheskoi meditsiny. 2020;(2):115-30. (In Russ.).; Vorob'eva NM, Tkacheva ON, Kotovskaya YuV, et al. Russian epidemiological study of EUCALYPT: protocol and basic characteristics of participants. Rossiiskii zhurnal geriatricheskoi meditsiny. 2021;(1):35-43. (In Russ.).; Terry EL, Booker SQ, Cardoso JS, et al. Neuropathic-Like Pain Symptoms in a Community-Dwelling Sample with or at Risk for Knee Osteoarthritis. Pain Med. 2020 Jan 1; 21(1):125-37. doi:10.1093/pm/pnz112.; Van Helvoort EM, Welsing PMJ, Jansen MP, et al. Neuropathic pain in the IMIAPPROACH knee osteoarthritis cohort: prevalence and phenotyping. RMD Open. 2021 Dec;7(3):e002025. doi:10.1136/rmdopen-2021-002025.; Moss P, Benson HA, Will R, Wright A. Patients with knee osteoarthritis who score highly on the PainDETECT questionnaire present with multimodality hyperalgesia, increased pain, and impaired physical function. Clin J Pain. 2018 Jan;34(1):15-21. doi:10.1097/AJP.0000000000000504.; French HP, Smart KM, Doyle F. Prevalence of neuropathic pain in knee or hip osteoarthritis: A systematic review and metaanalysis. Semin Arthritis Rheum. 2017 Aug; 47(1):1-8. doi:10.1016/j.semarthrit.2017.02.008. Epub 2017 Feb 20.; Blikman T, Rienstra W, van Raay JJ, et al. Neuropathic-like symptoms and the association with joint-specific function and quality of life in patients with hip and knee osteoarthritis. PLoS One. 2018 Jun 14;13(6):e0199165. doi:10.1371/journal.pone.0199165.eCollection 2018.; Cruz-Almeida Y, King CD, Goodin BR, et al. Psychological profiles and pain characteristics of older adults with knee osteoarthritis. Arthritis Care Res (Hoboken). 2013 Nov; 65(11):1786-94. doi:10.1002/acr.22070.; Moore RA, Straube S, Wiffen PJ, et al. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009 Jul 8; 3):CD007076. doi:10.1002/14651858.CD007076.pub2.; Reisner L. Pharmacological management of persistent pain in older persons. J Pain. 2011 Mar;12(3 Suppl 1):S21-9. doi:10.1016/j.jpain.2011.01.001.; Oneschuk D, al-Shahri MZ. The pattern of gabapentin use in a tertiary palliative care unit. J Palliat Care. Fall 2003;19(3):185-7.; Wiffen PJ, Derry S, Bell RF, et al. Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017 Jun 9;6(6): CD007938. doi:10.1002/14651858.CD 007938.pub4.; Sindrup SH, Otto M, Finnerup NB, Jensen TS. Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. doi:10.1111/j.1742-7843.2005.pto_96696601.x.; Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015 Feb;14(2):162-73. doi:10.1016/S1474-4422(14)70251-0. Epub 2015 Jan 7.; Mu A, Weinberg E, Moulin DE, Clarke H. Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement. Can Fam Physician. 2017 Nov;63(11):844-52.; Tkacheva ON, Naumov AV, Kotovskaya YuV, et al. Chronic pain in elderly and senile patients. Clinical recommendations. Rossiiskii zhurnal geriatricheskoi meditsiny. 2021;(3): 275-320. (In Russ.).; Bruyere O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec;49(3): 337-50. doi:10.1016/j.semarthrit.2019.04.008. Epub 2019 Apr 30.; Stabler TV, Huang Z, Montell E, et al. Chondroitin sulphate inhibits NF- κB activity induced by interaction of pathogenic and damage associated molecules. Osteoarthritis Cartilage. 2017 Jan;25(1):166-74. doi:10.1016/j.joca.2016.08.012. Epub 2016 Sep 7.; Kim HK, Park SK, Zhou JL, et al. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain. 2004 Sep;111(1-2):116-24. doi:10.1016/j.pain.2004.06.008.; Taves S, Berta T, Chen G, Ji RR. Microglia and spinal cord synaptic plasticity in persistent pain. Neural Plast. 2013;2013:753656. doi:10.1155/2013/753656. Epub 2013 Aug 18.; Ma W, Bisby MA. Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries. Brain Res. 1998 Jun 29;797(2): 243-54. doi:10.1016/s0006-8993(98)00380-1.; Olaseinde OF, Owoyele BV. Chondroitin sulfate produces antinociception and neuroprotection in chronic constriction injury-induced neuropathic pain in rats by increasing anti-inflammatory molecules and reducing oxidative stress. Int J Health Sci (Qassim). Sep-Oct 2021;15(5):3-17.; Hochberg MC, Martel-Pelletier J, Monfort J, et al; MOVES Investigation Group. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Ann Rheum Dis. 2016 Jan;75(1):37-44. doi:10.1136/annrheumdis-2014-206792. Epub 2015 Jan 14.

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