THE ROLE OF VEGF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASES ; РОЛЬ ОЛИГОНУКЛЕОТИДНЫХ ПОЛИМОРФИЗМОВ VEGF В РАЗВИТИИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ

Συγγραφείς: Anife Sevrievna Gaffarova, Igor Anatolievich Yatskov, Vladimir Alekseevich Beloglazov, Elizaveta Sergeevna Ageyeva, Elena Mikhailovna Dolya, Анифе Севриевна Гаффарова, Игорь Анатольевич Яцков, Владимир Алексеевич Белоглазов, Елизавета Сергеевна Агеева, Елена Михайловна Доля

Πηγή: Medical Immunology (Russia); Online First ; Медицинская иммунология; Online First ; 2313-741X ; 1563-0625 ; 10.15789/1563-0625-0-0

Θεματικοί όροι: ишемическкая болезнь сердца, cardiovascular diseases, single nucleotide polymorphisms, vascular endothelial growth factor, angiogenesis, chronic coronary syndrome, сердечно-сосудистые заболевания, олигонуклеотидные полиморфизмы, фактор роста эндотелия сосудов, ангиогенез

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Relation: https://www.mimmun.ru/mimmun/article/view/3320/2221; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/15950; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/15951; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/15952; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/15953; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/15954; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/15955; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/15964; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3320/16015; McNamara K., Alzubaidi H., Jackson J.K. Cardiovascular disease as a leading cause of death: how are pharmacists getting involved? J. Integr. Pharm. Res. Pract., 2019, Vol. 8, pp. 1-11.; Libby P. Inflammation and cardiovascular disease mechanisms. Am. J. Clin. Nutr., 2006, Vol. 83, pp. 456-460.; Alfaddagh A., Martin S.S., Leucker T.M., Michos E.D., Blaha M.J., Lowenstein C.J., Jones S.R., Toth P.P. Inflammation and cardiovascular disease: from mechanisms to therapeutics. Am. J. Prev. Cardiol., 2020, Vol. 4, pp. 100-130.; Sun H.J., Wu Z.Y., Nie X.W., Bian J.S. Role of endothelial dysfunction in cardiovascular diseases: the link between inflammation and hydrogen sulfide. Front. Pharmacol., 2020; Vol. 10, pp. 1568-1583.; Cervantes Gracia K., Llanas-Cornejo D., Husi H. CVD and oxidative stress. J. Clin. Med., 2017, Vol. 6, no. 2, no. 1-22.; Artiach G., Sarajlic P., Bäck M. Inflammation and its resolution in coronary artery disease: a tightrope walk between omega-6 and omega-3 polyunsaturated fatty acids. Kardiol. Pol., 2020, Vol. 78, no. 2, pp. 93-95.; Sarajlic P., Artiach G., Larsson S., Bäck M. Dose-dependent risk reduction for myocardial infarction with eicosapentaenoic acid: a meta-analysis and meta-regression including STRENGTH trial. Cardiovasc. Drugs Ther., 2021, Vol. 35, pp. 1079-1081.; Watson C.J., Webb N.J., Bottomley M.J., Brenchley P.E. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine, 2000, Vol. 12, no. 8, pp. 1232-1235. https://doi.org/10.1006/cyto.2000.0692.; Renner W., Kotschan S., Hoffmann C., Obermayer-Pietsch B., Pilger E. A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. Journal of vascular research, 2000, Vol. 37, no. 6, pp. 443-448. https://doi.org/10.1159/000054076.; Pare-Brunet L., Glubb D., Evans P., Berenguer-Llergo A., Etheridge A.S., Skol A.D., et al. Discovery and functional assessment of gene variants in the vascular endothelial growth factor pathway. Human mutation, 2014, Vol. 35, no. 2, pp. 227–235. https://doi.org/10.1002/humu.22475.; Choi S.H., Ruggiero D., Sorice R., Song C., Nutile T., Vernon Smith A., et al. Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. PLoS Genet., 2016, Vol. 12, no. 2, e1005874. https://doi.org/10.1371/journal.pgen.1005874.; Ku D.D., Zaleski J.K., Liu S., Brock T.A. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am. J. Physiol. 1993, Vol. 265, no. 2, pp. 586-592.; Ghazizadeh H., Avan A., Fazilati M., Azimi-Nezhad M., Tayefi M., Ghasemi F, et al. Association of rs6921438 A; Eaton C.B., Gramling R., Parker D.R., Roberts M.B., Lu B., Ridker P.M. Prospective association of vascular endothelial growth factor-A (VEGF-A) with coronary heart disease mortality in southeastern New England. Atherosclerosis, 2008, Vol. 200, no. 1, pp, 221-227. https://doi.org/10.1016/j.atherosclerosis.2007.12.027.; Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 1989, Vol. 246, no. 4935, pp. 1306–1309. https://doi.org/10.1126/science.2479986.; Marks E.C.A., Wilkinson T.M., Frampton C.M., Skelton L., Pilbrow A.P., Yandle T.G., et al. Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovasc. Disord., 2018, Vol. 18, no. 1, pp. 169. https://doi.org/10.1186/s12872-018-0894-1.; Matsumoto K., Ema M. Roles of VEGF-A signalling in development, regeneration, and tumours. J. Biochem., 2014, Vol. 156, no. 1, pp. 1-10. https://doi.org/10.1093/jb/mvu031.; Yla-Herttuala S., Rissanen T.T., Vajanto I., Hartikainen J. Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. Journal of the American College of Cardiology, 2007, Vol. 49, no. 10, pp. 1015-1026. https://doi.org/10.1016/j.jacc.2006.09.053.; Han X., Liu L., Niu J., Yang J., Zhang Z. Association between VEGF polymorphisms (936c/t, -460t/c and -634g/c) with haplotypes and coronary heart disease susceptibility. Int. J. Clin. Exp. Pathol., 2015, Vol. 8, no. 1, pp. 922-927.; Kalayi Nia S., Ziaee S., Boroumand M.A., Sotudeh Anvari M., Pourgholi L., Jalali A. The impact of vascular endothelial growth factor +405 C/G polymorphism on long-term outcome and severity of coronary artery disease. J. Clin. Lab. Anal., 2017, Vol. 31, no. 4, pp. 1-8. https://doi.org/10.1002/jcla.22066.; Matsumoto T., Mugishima H. Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis. J. Atheroscler. Thromb., 2006, Vol. 13, no. 3, pp. 130-135. https://doi.org/10.5551/jat.13.130,16.; Inoue M., Itoh H., Ueda M., Naruko T., Kojima A., Komatsu R., et al. Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation, 1998, Vol. 98, no. 20, pp. 2108-2116. https://doi.org/10.1161/01.cir.98.20.2108.; Howell W.M., Ali S., Rose-Zerilli M.J., Ye S. VEGF polymorphisms and severity of atherosclerosis. Journal of medical genetics, 2005, Vol. 42, no. 6, pp. 485-490. https://doi.org/10.1136/jmg.2004.025734.; ErZen B., Silar M., Sabovic M. Stable phase post-MI patients have elevated VEGF levels correlated with inflammation markers, but not with atherosclerotic burden. BMC Cardiovasc Disord. 2014, Vol. 14, p. 166. https://doi.org/10.1186/1471-2261-14-166.; Meier P., Gloekler S., Zbinden R., Beckh S., de Marchi S.F., Zbinden S., et al. Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements. Circulation, 2007, Vol. 116, no. 9, pp. 975-983. https://doi.org/10.1161/CIRCULATIONAHA.107.703959.; Ma W.Q., Wang Y., Han X.Q., Zhu Y, Liu N.F. Association of genetic polymorphisms in vascular endothelial growth factor with susceptibility to coronary artery disease: a meta-analysis. BMC medical genetics, 2018, Vol. 19, no. 1, p. 108. https://doi.org/10.1186/s12881-018-0628-3.; Zhao X., Meng L., Jiang J., Wu X. Vascular endothelial growth factor gene polymorphisms and coronary heart disease: a systematic review and meta-analysis. Growth Factors, 2018, Vol. 36, no. 3-4, pp. 153-63.; Cui Q.T., Li Y., Duan C.H., Zhang W., Guo X.L. Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility. Gene, 2013, Vol. 521, no. 2, pp. 217–221. https://doi.org/10.1016/j.gene.2013.03.091; Dong P.P. Association of vascular endothelial growth factor expression and polymorphisms with the risk of gestational diabetes mellitus. J. Clin. Lab. Anal., 2019, Vol. 33, no. 2, e22686. https://doi.org/10.1002/jcla.22686.; Al-Habboubi H.H., Sater M.S., Almawi A.W., Al-Khateeb G.M., Almawi W.Y. Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population. Eur. Cytokine Netw., 2011, Vol. 22, no. 3, pp. 154-158. https://doi.org/10.1684/ecn.2011.0289.; Osadnik T., Strzelczyk J.K., Regula R., Bujak K., Fronczek M., Gonera M., et al. The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-beta1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent. PloS one, 2016, Vol. 11, no. 3, e0150500. https://doi.org/10.1371/journal.pone 0150500.; Yadav B.K., Yadav R., Chang H., Choi K., Kim J.T., Park M.S., et al. Genetic Polymorphisms rs699947, rs1570360, and rs3025039 on the VEGF Gene Are Correlated with Extracranial Internal Carotid ArteryStenosis and Ischemic Stroke. Ann. Clin. Lab. Sci., 2017; Vol. 47, no. 2, pp. 144-155.; Liu D., et al. Medicine, 2016, Vol. 95, p. 19, DOI:10.1097/MD.0000000000003413.; Wang E., Wang Z., Liu S., et al. Polymorphisms of VEGF, TGFbeta1, TGFbetaR2 and conotruncal heart defects in a Chinese population. Mol. Biol. Rep., 2014, Vol. 41, pp. 1763-1770.; Griffin H.R., Hall D.H., Topf A., et al. Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation. PLoSOne, 2009, Vol. 4, e4978.; Palmer B.R., Paterson M.A., Frampton C.M., Pilbrow A.P., Skelton L., Pemberton C.J., et al. (2021) Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 2021, Vol. 16, no. 7, e0254206. https://doi.org/10.1371/journal.pone.0254206.; Li H., Kantoff P.W., Ma J., Stampfer M.J., George D.J. Prediagnostic plasma vascular endothelial growth factor levels and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev., 2005; Vol. 14, no. 6, pp. 1557-1561. https://doi.org/10.1158/1055-9965.EPI-04-0456.; Carilho R., de Carvalho M., Swash M., Pinto S., Pinto A., Costa J. Vascular endothelial growth factor and amyotrophic lateral sclerosis: the interplay with exercise and noninvasive ventilation. Muscle Nerve, 2014, Vol. 49, no. 4, pp. 545-550. https://doi.org/10.1002/mus.23955.; Eaton C.B., Gramling R., Parker D.R., Roberts M.B., Lu B., Ridker P.M. Prospective association of vascular endothelial growth factor-A (VEGF-A) with coronary heart disease mortality in southeastern New England. Atherosclerosis, 2008, Vol. 200, no. 1, pp. 221-227. https://doi.org/10.1016/j.atherosclerosis.2007.12.027.; Pia Davidsson, Susanna Eketjäll, Niclas Eriksson, Anna Walentinsson, Richard C. Becker, Anders Cavallin, Anna Bogstedt, Anna Collén, Claes Held, Stefan James, Agneta Siegbahn, Ralph Stewart, Robert F. Storey8, Harvey White, and Lars Wallentin. Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease. Cardiovascular Research, 2023, Vol. 119, pp. 1596-1605. https://doi.org/10.1093/cvr/cvad039.; Gudjonsson A., Gudmundsdottir V., Axelsson G.T., Gudmundsson E.F., Jonsson B.G., Launer L.J., Lamb J.R., Jennings L.L., Aspelund T., Emilsson V., Gudnason V. A genome-wide association study of serum proteins reveals shared loci with common diseases. Nat. Commun., 2022, Vol. 13, no. 1, p. 480.; Meng F., Jing X., Song G., Jie L., Shen F. Prox1 induces new lymphatic vessel formation and promotes nerve reconstruction in a mouse model of sciatic nerve crush injury. J. Anat., 2020, Vol. 237, pp. 933-940.; Ahmed S., Ahmed A., Säleby J., Bouzina H., Lundgren J., Rådegran G. Elevated plasma tyrosine kinases VEGF-D and HER4 in heart failure patients decrease after heart transplantation in association with improved haemodynamics. Heart Vessels, 2020, Vol. 35, no. 6, pp. 786-799.; Mountain D.J., Singh M., Singh K. Downregulation of VEGF-D expression by interleukin-1beta in cardiac microvascular endothelial cells is mediated by MAPKs and PKCalpha/beta1. J. Cell. Physiol., 2008, Vol. 215, pp. 337-343.; Zhao T., Zhao W., Meng W., Liu C., Chen Y., Bhattacharya S.K., Sun Y. Vascular endothelial growth factor-D mediates fibrogenic response in myofibroblasts. Mol. Cell. Biochem. 2016, Vol. 413, pp. 127-135.; Borné Y., Gränsbo K., Nilsson J., Melander O., Orho-Melander M., Smith J.G., Engström G. Vascular endothelial growth factor D, pulmonary congestion, and incidence of heart failure. J. Am. Coll. Cardiol., 2018, Vol. 71, pp. 580-582.; Berntsson J., Smith J.G., Johnson L.S.B., Söderholm M., Borné Y., Melander O., Orho-Melander M., Nilsson J., Engström G. Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke. Heart, 2019, Vol. 105, pp. 553-558.; Säleby J., Bouzina H., Lundgren J., Rådegran G. Angiogenic and inflammatory biomarkers in the differentiation of pulmonary hypertension. Scand. Cardiovasc. J., 2017, Vol. 51, pp. 261-270.; Säleby J., Bouzina H., Ahmed S., Lundgren J., Rådegran G. Plasma receptor tyrosine kinase RET in pulmonary arterial hypertension diagnosis and differentiation. ERJ Open. Res., 2019, Vol. 5, e00037–02019.; Seyama K., Kumasaka T., Souma S., Sato T., Kurihara M., Mitani K., Tominaga S., Fukuchi Y. Vascular endothelial growth factor-D is increased in serum of patients with lymphangioleiomyomatosis. Lymphat. Res. Biol., 2006, Vol. 4, no. 3, pp. 143-152.; https://www.mimmun.ru/mimmun/article/view/3320

Διαθεσιμότητα: https://www.mimmun.ru/mimmun/article/view/3320
https://doi.org/10.15789/1563-0625-TRO-3320

THE EFFECT OF TGF-BETA ARG25PRO POLYMORPHISM ON MARKERS OF SYSTEMIC INFLAMMATION, INTESTINAL PERMEABILITY, AND VASCULAR REGULATION IN PATIENTS WITH BRONCHIAL ASTHMA IN THE POSTCOVID PERIOD ; ВЛИЯНИЕ ПОЛИМОРФИЗМА TGF-BETA ARG25PRO НА МАРКЕРЫ СИСТЕМНОГО ВОСПАЛЕНИЯ, КИШЕЧНОЙ ПРОНИЦАЕМОСТИ И СОСУДИСТОЙ РЕГУЛЯЦИИ У ПАЦИЕНТОВ C БРОНХИАЛЬНОЙ АСТМОЙ В ПОСТКОВИДНОМ ПЕРИОДЕ

Συγγραφείς: Igor Anatolievich Yatskov, Vladimir Alekseevich Beloglazov, Elizaveta Sergeevna Ageeva, Evgeny Dmitrievich Kumelsky, Yulia Olegovna Popenko, Игорь Анатольевич Яцков, Владимир Алексеевич Белоглазов, Елизавета Сергеевна Агеева, Евгений Дмитриевич Кумельский, Юлия Олеговна Попенко

Συνεισφορές: This work was supported by the Russian Science Foundation under grant no. 23-15-20021, https://rscf.ru/project/23-15-20021/., Исследование выполнено за счет гранта Российского научного фонда № 23-15-20021, https://rscf.ru/project/23-15-20021/.

Πηγή: Medical Immunology (Russia); Online First ; Медицинская иммунология; Online First ; 2313-741X ; 1563-0625 ; 10.15789/1563-0625-0-0

Θεματικοί όροι: проницаемость, new coronavirus infection, Arg25Pro, TGFb, SARS-CoV-2, CRP, permeability, новая коронавирусная инфекция, СРБ

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Relation: https://www.mimmun.ru/mimmun/article/view/3198/2101; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3198/15006; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3198/15007; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3198/15008; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3198/15009; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3198/15010; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3198/15011; https://www.mimmun.ru/mimmun/article/downloadSuppFile/3198/15196; Яцков И.А., Белоглазов В.А., Агеева Е.С. Полиморфизм Arg25Pro гена TGFβ как фактор дифференцированного подхода к профилактике у пациентов с сахарным диабетом 1-го типа // Физиотерапевт. – 2024. – № 6. – С. 114-120.; Agondi R.C., Menechino N., Marinho A.K.B.B., Kalil J., Giavina-Bianchi P. Worsening of asthma control after COVID-19. Front Med (Lausanne), 2022, Vol. 9, p. 882665.; Crowley S.D., Rudemiller N.P. Immunologic Effects of the Renin-Angiotensin System. J Am Soc Nephrol., 2017, Vol. 28, no. 5, pp. 1350-1361.; Deng Z., Fan T., Xiao C., Tian H., Zheng Y., Li C., He J. TGF-β signaling in health, disease, and therapeutics. Signal Transduct Target Ther., 2024, Vol. 9, no. 1, p. 61.; Goerlich E., Chung T.H., Hong G.H., Metkus T.S., Gilotra N.A., Post W.S., Hays A.G. Cardiovascular effects of the post-COVID-19 condition. Nat Cardiovasc Res., 2024, Vol. 3, no. 2, pp. 118-129.; Majidpour M., Azizi S.G., Davodabadi F., Sabeti Akbar-Abad M., Abdollahi Z., Sargazi S., Shahriari H. Recent advances in TGF-β signaling pathway in COVID-19 pathogenesis: A review. Microb Pathog., 2025, Vol. 199, p. 107236.; Michał P., Konrad S., Piotr K. TGF-β gene polimorphisms as risk factors for asthma control among clinic patients. J Inflamm (Lond)., 2021, Vol. 18, no. 1, p. 28.; Rönnbäck C., Hansson E. The Importance and Control of Low-Grade Inflammation Due to Damage of Cellular Barrier Systems That May Lead to Systemic Inflammation. Front Neurol., 2019, Vol. 10, p. 533.; Scholkmann F, May CA. COVID-19, post-acute COVID-19 syndrome (PACS, "long COVID") and post-COVID-19 vaccination syndrome (PCVS, "post-COVIDvac-syndrome"): Similarities and differences. Pathol Res Pract., 2023, Vol. 246, p. 154497.; Sharif S., Van der Graaf Y., Cramer M.J., Kapelle L.J., de Borst G.J., Visseren F.L.J., Westerink J.; SMART study group. Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes. Cardiovasc Diabetol., 2021, Vol. 20, no. 1, p. 220.; Travis M.A., Sheppard D. TGF-β activation and function in immunity. Annu Rev Immunol., 2014, Vol. 32, pp. 51-82.; Xiao K., Cao S., Jiao L., Song Z., Lu J., Hu C. TGF-β1 protects intestinal integrity and influences Smads and MAPK signal pathways in IPEC-J2 after TNF-α challenge. Innate Immun., 2017, Vol. 23, no. 3, pp. 276-284.; https://www.mimmun.ru/mimmun/article/view/3198

Διαθεσιμότητα: https://www.mimmun.ru/mimmun/article/view/3198