Urease inhibitors: current advances, therapeutic potentials, and clinical challenges.

Authors: Alzoubi OH; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Khamees A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.; Princess Basma Teaching Hospital, Ministry of Health, Irbid, Jordan., Alzu'bi MB; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Freihat SF; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Attar A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Abo Sameed H; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alzubi R; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alsamarah AA; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Yassin RY; Faculty of Pharmacy, Yarmouk University, Irbid, Jordan., Al-Shami K; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Al-Trad B; Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia., Al-Zoubi RM; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.; Department of Chemistry, Jordan University of Science and Technology, Irbid, Jordan.; Department of Biomedical Sciences, QU-Health, College of Health Sciences, Qatar University, Doha, Qatar., Al Zoubi MS; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Source: Future medicinal chemistry [Future Med Chem] 2026 Jul; Vol. 18 (14), pp. 1907-1923. Date of Electronic Publication: 2026 Jun 15.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Helicobacter Infections/drug therapy ; Humans ; Animals

Newly synthesized 2-cyclopentylidenehydrazinylthiazoles as potential therapeutic agents against peptic ulcer.

Authors: Sehrish; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; Department of Chemistry, Jinnah University for Women, Karachi, Pakistan., Salar U; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Naz F; Department of Chemistry, Jinnah University for Women, Karachi, Pakistan., Ishaq A; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Naz F; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Iqbal J; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Khan KM; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Source: Future medicinal chemistry [Future Med Chem] 2026 Apr; Vol. 18 (8), pp. 865-880. Date of Electronic Publication: 2026 Mar 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Thiazoles*/chemistry , Thiazoles*/pharmacology , Thiazoles*/chemical synthesis , Thiazoles*/therapeutic use , Peptic Ulcer*/drug therapy , Anti-Ulcer Agents*/chemistry , Anti-Ulcer Agents*/pharmacology , Anti-Ulcer Agents*/chemical synthesis , Anti-Ulcer Agents*/therapeutic use , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Structure-Activity Relationship ; Molecular Docking Simulation ; Humans ; Molecular Structure

Urease-driven nanomotors loaded with sorafenib for magnetically-guided accumulation and deep tissue penetration towards hepatocellular carcinoma therapy via ferroptosis induction.

Authors: Hua C; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Lu Z; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Cui W; Postgraduate Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Ren W; The second Department of General Surgery, Second Hospital of Harbin, Harbin, Heilongjiang, 150056, China., Xu Y; Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Li J; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Zhao X; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Zhao S; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Kang P; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China. kang_pengcheng@126.com., Cui Y; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China. yfcui7@163.com.

Source: Mikrochimica acta [Mikrochim Acta] 2026 Jan 26; Vol. 193 (2), pp. 110. Date of Electronic Publication: 2026 Jan 26.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE

MeSH Terms: Sorafenib*/pharmacology , Sorafenib*/chemistry , Sorafenib*/therapeutic use , Sorafenib*/metabolism , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Urease*/metabolism , Urease*/chemistry , Ferroptosis*/drug effects, Silicon Dioxide/chemistry ; Drug Carriers/chemistry ; Magnetite Nanoparticles/chemistry ; Humans ; Animals ; Mice ; Drug Liberation ; Cell Line, Tumor

Droplet Digital PCR-Based Detection of Clarithromycin Resistance on Rapid Urease Test Samples Predicts Helicobacter pylori Eradication Success: A New Zealand Cohort Study.

Authors: Inns SJ; University of Otago, Wellington, New Zealand.; Capital Coast and Hutt Valley, Health New Zealand Te Whatu Ora, Wellington, New Zealand., Sowerbutts S; University of Otago, Wellington, New Zealand., Yumnam B; Malaghan Institute of Medical Research, Wellington, New Zealand., Payne K; Malaghan Institute of Medical Research, Wellington, New Zealand., Wheller G; Malaghan Institute of Medical Research, Wellington, New Zealand., Camberis M; Malaghan Institute of Medical Research, Wellington, New Zealand., Mules T; University of Otago, Wellington, New Zealand.; Capital Coast and Hutt Valley, Health New Zealand Te Whatu Ora, Wellington, New Zealand.; Malaghan Institute of Medical Research, Wellington, New Zealand.

Source: Helicobacter [Helicobacter] 2025 Sep-Oct; Vol. 30 (5), pp. e70075.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9605411 Publication Model: Print Cited Medium: Internet ISSN: 1523-5378 (Electronic) Linking ISSN: 10834389 NLM ISO Abbreviation: Helicobacter Subsets: MEDLINE

MeSH Terms: Clarithromycin*/pharmacology , Clarithromycin*/therapeutic use , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/diagnosis , Helicobacter pylori*/drug effects , Helicobacter pylori*/genetics , Helicobacter pylori*/enzymology , Helicobacter pylori*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Polymerase Chain Reaction*/methods , Urease*/analysis , Drug Resistance, Bacterial*, Humans ; New Zealand ; Female ; Male ; Middle Aged ; Aged ; Adult ; Cohort Studies ; Treatment Outcome

Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives.

Authors: Agabo-Martínez A; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Gomez-Chang E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Hernández-Hipólito E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Estrada-Muñiz E; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Escobedo-Martínez C; Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato 36050, Mexico., Obregón-Mendoza MA; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Enríquez RG; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Vega L; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Romero I; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico.

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Sep 23; Vol. 30 (19). Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Curcumin*/analogs & derivatives , Curcumin*/chemistry , Curcumin*/pharmacology , Curcumin*/therapeutic use , Curcumin*/analogs & derivatives , Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Stomach Ulcer*/chemically induced , Stomach Ulcer*/pathology , Stomach Ulcer*/prevention & control , Protective Agents*/chemistry , Protective Agents*/pharmacology , Protective Agents*/therapeutic use, Metals/chemistry ; Ethanol/toxicity ; Urease/antagonists & inhibitors ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology ; Topoisomerase II Inhibitors/therapeutic use ; Biological Availability ; Microbial Sensitivity Tests ; Disease Models, Animal ; Toxicity Tests, Subacute ; Animals ; Mice ; Male

Diuretic and Anti-hyperuricemic Effects of Geranyl Acetate in Rats.

Authors: Shah SN; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Younis W; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, , New York University Grossman School of Medicine, New York, USA., Junior AG; Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil., Manzoor W; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Malik MNH; Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan., Mushtaq MN; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Munir MU; Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, Brisbane, Australia., Bashir A; Riphah Institute of Pharmaceutical Sciences, Riphah International Univeristy, Lahore, Pakistan., Bibi S; Department of Biosciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Talha M; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Dos Reis Livero FA; Laboratory of Cardiometabolic Pharmacology, Federal University of Paraná, Curitiba, Brazil.; Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil.

Source: Current medicinal chemistry [Curr Med Chem] 2026; Vol. 33 (8), pp. 1551-1567.

Publication Type: Journal Article

Journal Info: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

MeSH Terms: Hyperuricemia*/drug therapy , Hyperuricemia*/metabolism , Diuretics*/pharmacology , Diuretics*/chemistry , Diuretics*/therapeutic use , Acetates*/pharmacology , Acetates*/chemistry , Acetates*/therapeutic use, Xanthine Oxidase/antagonists & inhibitors ; Xanthine Oxidase/metabolism ; Acetylcholinesterase/metabolism ; Urease/metabolism ; Urease/antagonists & inhibitors ; Animals ; Male ; Rats, Wistar ; Molecular Docking Simulation ; Rats

Mechanistic insights into the inhibitory effect of epigallocatechin gallate on the production of virulence factors in Proteus mirabilis.

Authors: Xue Z; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Chen H; College of Marine Sciences, Ningde Normal University, Ningde, China., Qi Y; Clinical Laboratory, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Zeng Q; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Yan G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Fang G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.

Source: Medicine [Medicine (Baltimore)] 2026 Jan 02; Vol. 105 (1), pp. e46893.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Catechin*/analogs & derivatives , Catechin*/pharmacology , Catechin*/therapeutic use , Catechin*/analogs & derivatives , Catheter-Related Infections*/drug therapy , Catheter-Related Infections*/microbiology , Proteus Infections*/drug therapy , Proteus Infections*/microbiology , Proteus mirabilis*/drug effects , Proteus mirabilis*/genetics , Proteus mirabilis*/metabolism , Proteus mirabilis*/pathogenicity , Urinary Tract Infections*/drug therapy , Urinary Tract Infections*/microbiology , Virulence Factors*/antagonists & inhibitors , Virulence Factors*/biosynthesis, Biofilms/drug effects ; Biofilms/growth & development ; Gene Expression Regulation, Bacterial/drug effects ; Hemolysin Proteins/antagonists & inhibitors ; Hemolysin Proteins/biosynthesis ; Urease/antagonists & inhibitors ; Urease/biosynthesis ; Microbial Sensitivity Tests ; Humans

Urease inhibitory potential of pyridine-containing triazolothiadiazole and triazolothiadiazine scaffolds for the treatment of ulceration and kidney stone: in vitro screening, kinetics mechanism, and in silico computational analysis.

Authors: Ullah S; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Halim SA; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Ibrar A; Department of Chemistry, Faculty of Natural Sciences, The University of Haripur, Haripur, Pakistan., Khan I; Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK., Ataya FS; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Fouad D; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, Egypt., Khan A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Al-Harrasi A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.

Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Feb; Vol. 43 (3), pp. 1249-1258. Date of Electronic Publication: 2023 Dec 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/chemistry , Thiadiazoles*/chemistry , Thiadiazoles*/pharmacology , Pyridines*/chemistry , Pyridines*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use , Thiadiazines*/chemistry , Thiadiazines*/pharmacology , Ulcer*/drug therapy, Molecular Docking Simulation ; Kinetics ; Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Dynamics Simulation

Multimodal anti-Helicobacter pylori effects of Lactobacillus casei HY001: Evidence from in vitro and in vivo studies.

Authors: Lv Z; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Yu J; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang X; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang L; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang C; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Liu X; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Chang Y; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Yin H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Wang W; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhao H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Li H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China.

Source: PloS one [PLoS One] 2026 May 14; Vol. 21 (5), pp. e0349099. Date of Electronic Publication: 2026 May 14 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Lacticaseibacillus casei*/physiology , Helicobacter pylori*/physiology , Helicobacter Infections*/microbiology , Helicobacter Infections*/therapy , Probiotics*/pharmacology , Probiotics*/therapeutic use, Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Urease/metabolism ; RNA, Ribosomal, 16S/genetics ; NF-kappa B/metabolism ; Animals ; Humans ; Mice ; Bacterial Adhesion ; Male ; Gastrointestinal Microbiome

Kidney Stone Dissolution By Tetherless, Enzyme-Loaded, Soft Magnetic Miniature Robots.

Authors: Khabbazian A; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Kwong L; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Lewis A; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Liu E; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Abdelrazec N; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Bakenecker AC; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Medical Engineering, Technical University of Darmstadt, Merckstr. 25, 64283, Darmstadt, Germany., Fontanals N; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Lopez G; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Sánchez S; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Catalan Institute for Research and Advanced Studies, ICREA, Barcelona, 08028, Spain., Lopez JM; Department of Urology, University of Barcelona Clinic Hospital, Barcelona, 08036, Spain., Carrillo B; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Farcas M; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Kallweit C; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada., Yu ACH; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada., Behrad Khamesee M; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Magdanz V; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada.; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada.

Source: Advanced healthcare materials [Adv Healthc Mater] 2025 Sep; Vol. 14 (23), pp. e2403423. Date of Electronic Publication: 2025 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

MeSH Terms: Kidney Calculi*/therapy , Urease*/therapeutic use , Robotics*, Wireless Technology ; Magnetics ; Urinary Tract ; Humans ; Models, Anatomic ; Printing, Three-Dimensional ; Ultrasonography

Anti-biopassivated Reticular Micromotors for Bladder Cancer Therapy.

Authors: Sun J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Chu R; Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan 250021, China., Wu X; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Yu Q; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Xiao W; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ao H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wang Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu T; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ju H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Lei J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 May 28; Vol. 147 (21), pp. 17936-17945. Date of Electronic Publication: 2025 May 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH Terms: Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/pathology , Urease*/metabolism , Urease*/chemistry , Metal-Organic Frameworks*/chemistry , Metal-Organic Frameworks*/pharmacology , Metal-Organic Frameworks*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Urea/metabolism ; Urea/chemistry ; Humans ; Hydrogen Bonding ; Cell Line, Tumor

Combined therapeutic strategy through antioxidant and urease inhibitory activities of Algerian Crataegus monogyna ethanolic fraction: UAE extraction, RP-HPLC-PDA metabolite profiling, and molecular Insights

Authors: Goudjil, Sabrina ^{a, ⁎}, Boussekine, Samira ^a, Goudjil, Sarra ^b, Goudjil, Hanane ^c, Kolaylı, Sevgi ^d, Kara, Yakup ^d, Zegheb, Nadjiba ^e

Source: In South African Journal of Botany January 2026 188:207-218

Phytochemicals as Natural Therapeutics Against Helicobacter pylori: A Comprehensive Review.

Authors: Shah SAR; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan. ali.raza@imbb.uol.edu.pk., Jamil H; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Mustafa I; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Sharif S; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Zahid Z; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Yasir A; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Nayila I; Department of Pharmacy, The University of Lahore, Sargodha Campus, Sargodha, Pakistan.

Source: Current microbiology [Curr Microbiol] 2026 Jul 23; Vol. 83 (9). Date of Electronic Publication: 2026 Jul 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/drug effects , Helicobacter pylori*/physiology , Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Phytochemicals*/chemistry , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/chemistry, Biofilms/drug effects ; Plants, Medicinal/chemistry ; Humans ; Drug Resistance, Bacterial

Anti-inflammatory and urease inhibitory iridoid glycosides from Nyctanthes arbor-tristis Linn.

Authors: Sana T; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Khan M; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Siddiqui BS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Pakistan Academy of Sciences, 3-Constitution Avenue, G-5/2, Islamabad, Pakistan. Electronic address: siddiqui_bina@yahoo.com., Baig TA; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Jabeen A; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Begum S; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Hadda TB; Laboratoire de Chimie des Matériaux, Facultédes Sciences, Université Mohammed Premier, 60000, Oujda, Morocco., Shah L; Hazara University, Mansehra, 21300, Pakistan.

Source: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jan 30; Vol. 319 (Pt 3), pp. 117368. Date of Electronic Publication: 2023 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

MeSH Terms: Plant Extracts*/therapeutic use , Urease*, Iridoid Glycosides/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Mice ; Animals ; Kinetics ; Molecular Docking Simulation ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha

Evidence-Based Guidelines for the Diagnosis and Treatment of Helicobacter pylori Infection in Korea: 2025 Revised Edition.

Authors: Bang CS; Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea., Kang SJ; Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea., Lim H; Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea., Kim SH; Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea., Lee MW; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea., Nam SY; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea., Tae CH; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea., Kim SE; Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea., Kim SY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Korea., Jung HK; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea., Kim BJ; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Choi M; Division of Healthcare Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea., Jung HY; Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea., Kim BW; Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea.

Corporate Authors: Korean College of Helicobacter and Upper Gastrointestinal Research

Source: Helicobacter [Helicobacter] 2026 Jul-Aug; Vol. 31 (4), pp. e70149.

Publication Type: Journal Article; Practice Guideline

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9605411 Publication Model: Print Cited Medium: Internet ISSN: 1523-5378 (Electronic) Linking ISSN: 10834389 NLM ISO Abbreviation: Helicobacter Subsets: MEDLINE

MeSH Terms: Anti-Bacterial Agents*/therapeutic use , Helicobacter Infections*/diagnosis , Helicobacter Infections*/drug therapy , Helicobacter pylori*/drug effects, Clarithromycin/therapeutic use ; Humans ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Republic of Korea ; Systematic Reviews as Topic ; Meta-Analysis as Topic

Exploring the phytochemical composition, ethnomedicinal uses, and therapeutic potential of Prunus species: a comprehensive review.

Authors: Nambooze J; Department of Chemistry, University of the Free State, Bloemfontein, South Africa., Mishra AP; Cosmetics and Natural Products Research Center (CosNat), Naresuan University, Tha Pho, Phitsanulok, Thailand. mishra.ap@nu.ac.th., Nigam M; Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, Uttarakhand, India., Seidel V; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK., Bonnet SL; Department of Chemistry, University of the Free State, Bloemfontein, South Africa.

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jun; Vol. 399 (9), pp. 13063-13100. Date of Electronic Publication: 2026 Apr 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH Terms: Prunus*/chemistry , Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology , Phytochemicals*/isolation & purification , Plant Extracts*/therapeutic use , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Medicine, Traditional*, Humans ; Animals ; Phytotherapy ; Ethnopharmacology

The Unfinished Agenda in Helicobacter pylori Treatment: Resistance, Microbiome Effects, and Future Directions.

Authors: Rokkas T; Gastroenterology Clinic, Henry Dunant Hospital, Athens, Greece; Medical School, European University of Cyprus, Nicosia, Cyprus and. Electronic address: sakkor@otenet.gr., Graham DY; Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas.

Source: Gastroenterology [Gastroenterology] 2026 Aug; Vol. 171 (2), pp. 271-284. Date of Electronic Publication: 2026 Mar 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/drug effects , Helicobacter pylori*/pathogenicity , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/diagnosis , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/adverse effects , Anti-Bacterial Agents*/pharmacology , Gastrointestinal Microbiome*/drug effects , Drug Resistance, Bacterial*, Proton Pump Inhibitors/therapeutic use ; Probiotics/therapeutic use ; Humans ; Treatment Outcome

Therapeutic potential of Cydonia oblonga extracts for anti-urease and antibacterial activities to cure urinary tract infections

Authors: Sharif, Aneeqa ^a, Ali, Anser ^{a, ⁎⁎}, Amjad, Muhammad ^b, Ismatullah, Humaira ^c, Latief, Noreen ^d, Javaid, Binish ^e, Tariq, Muhammad ^{e, ⁎}, Yasin, Rabia ^e, Rafiq, Muhammad ^f

Source: In Journal of Agriculture and Food Research March 2025 19

Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance.

Authors: Zhang Z; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Lin J; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Dai X; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Li X; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Huang F; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Qin S; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Song E; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China. Electronic address: eqsong@swu.edu.cn., Tan W; The Key Laboratory of Zhejiang Province for Nucleic Acids, Hangzhou Institute of Medicine, Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.

Source: Acta biomaterialia [Acta Biomater] 2025 Jul 01; Vol. 201, pp. 534-544. Date of Electronic Publication: 2025 Jun 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH Terms: Theranostic Nanomedicine*/methods , Helicobacter pylori*/drug effects , Helicobacter Infections*/diagnostic imaging , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/therapy , Helicobacter Infections*/metabolism , Nanoparticles*/chemistry , Nanoparticles*/therapeutic use , Photoacoustic Techniques*, Hematoporphyrins/chemistry ; Hematoporphyrins/pharmacology ; Urease/metabolism ; Animals ; Mice ; Humans

Neochlorogenic acid targets caseinolytic protease P to Suppress MRSA pathogenicity and Unlocks a novel therapeutic avenue for osteomyelitis.

Authors: Wang Y; Yanbian University Medical College, Yanji 133002, PR China., Lin X; The Affiliated Hospital of Yanbian University, Yanji 133000, PR China., Du Y; Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji 133002, PR China., Jiang H; Yanbian University Medical College, Yanji 133002, PR China., Xu P; Yanbian University Medical College, Yanji 133002, PR China., Sun Y; Changchun University of Chinese Medicine, Changchun 130117, PR China., Liu X; Changchun University of Chinese Medicine, Changchun 130117, PR China., Gao H; Changchun University of Chinese Medicine, Changchun 130117, PR China., Gao Y; Changchun University of Chinese Medicine, Changchun 130117, PR China., Wang B; Changchun University of Chinese Medicine, Changchun 130117, PR China., Li L; Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji 133002, PR China; Department of Anatomy, Histology and Embryology, Yanbian University Medical College, Yanji 133002, PR China. Electronic address: lclee@ybu.edu.cn., Zhou X; The Affiliated Hospital of Yanbian University, Yanji 133000, PR China. Electronic address: xczhou@ybu.edu.cn.

Source: Biochemical pharmacology [Biochem Pharmacol] 2026 Jun; Vol. 248, pp. 117811. Date of Electronic Publication: 2026 Feb 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Methicillin-Resistant Staphylococcus aureus*/drug effects , Methicillin-Resistant Staphylococcus aureus*/pathogenicity , Methicillin-Resistant Staphylococcus aureus*/enzymology , Osteomyelitis*/drug therapy , Osteomyelitis*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Endopeptidase Clp*/antagonists & inhibitors , Endopeptidase Clp*/metabolism, Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Virulence/drug effects ; Virulence/physiology ; Animals ; Rats ; Mice ; Rats, Sprague-Dawley