Urease inhibitors: current advances, therapeutic potentials, and clinical challenges.

Authors: Alzoubi OH; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Khamees A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.; Princess Basma Teaching Hospital, Ministry of Health, Irbid, Jordan., Alzu'bi MB; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Freihat SF; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Attar A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Abo Sameed H; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alzubi R; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alsamarah AA; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Yassin RY; Faculty of Pharmacy, Yarmouk University, Irbid, Jordan., Al-Shami K; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Al-Trad B; Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia., Al-Zoubi RM; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.; Department of Chemistry, Jordan University of Science and Technology, Irbid, Jordan.; Department of Biomedical Sciences, QU-Health, College of Health Sciences, Qatar University, Doha, Qatar., Al Zoubi MS; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Source: Future medicinal chemistry [Future Med Chem] 2026 Jul; Vol. 18 (14), pp. 1907-1923. Date of Electronic Publication: 2026 Jun 15.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Helicobacter Infections/drug therapy ; Humans ; Animals

Newly synthesized 2-cyclopentylidenehydrazinylthiazoles as potential therapeutic agents against peptic ulcer.

Authors: Sehrish; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; Department of Chemistry, Jinnah University for Women, Karachi, Pakistan., Salar U; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Naz F; Department of Chemistry, Jinnah University for Women, Karachi, Pakistan., Ishaq A; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Naz F; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Iqbal J; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Khan KM; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Source: Future medicinal chemistry [Future Med Chem] 2026 Apr; Vol. 18 (8), pp. 865-880. Date of Electronic Publication: 2026 Mar 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Thiazoles*/chemistry , Thiazoles*/pharmacology , Thiazoles*/chemical synthesis , Thiazoles*/therapeutic use , Peptic Ulcer*/drug therapy , Anti-Ulcer Agents*/chemistry , Anti-Ulcer Agents*/pharmacology , Anti-Ulcer Agents*/chemical synthesis , Anti-Ulcer Agents*/therapeutic use , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Structure-Activity Relationship ; Molecular Docking Simulation ; Humans ; Molecular Structure

Urease-driven nanomotors loaded with sorafenib for magnetically-guided accumulation and deep tissue penetration towards hepatocellular carcinoma therapy via ferroptosis induction.

Authors: Hua C; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Lu Z; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Cui W; Postgraduate Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Ren W; The second Department of General Surgery, Second Hospital of Harbin, Harbin, Heilongjiang, 150056, China., Xu Y; Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Li J; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Zhao X; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Zhao S; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Kang P; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China. kang_pengcheng@126.com., Cui Y; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China. yfcui7@163.com.

Source: Mikrochimica acta [Mikrochim Acta] 2026 Jan 26; Vol. 193 (2), pp. 110. Date of Electronic Publication: 2026 Jan 26.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE

MeSH Terms: Sorafenib*/pharmacology , Sorafenib*/chemistry , Sorafenib*/therapeutic use , Sorafenib*/metabolism , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Urease*/metabolism , Urease*/chemistry , Ferroptosis*/drug effects, Silicon Dioxide/chemistry ; Drug Carriers/chemistry ; Magnetite Nanoparticles/chemistry ; Humans ; Animals ; Mice ; Drug Liberation ; Cell Line, Tumor

Droplet Digital PCR-Based Detection of Clarithromycin Resistance on Rapid Urease Test Samples Predicts Helicobacter pylori Eradication Success: A New Zealand Cohort Study.

Authors: Inns SJ; University of Otago, Wellington, New Zealand.; Capital Coast and Hutt Valley, Health New Zealand Te Whatu Ora, Wellington, New Zealand., Sowerbutts S; University of Otago, Wellington, New Zealand., Yumnam B; Malaghan Institute of Medical Research, Wellington, New Zealand., Payne K; Malaghan Institute of Medical Research, Wellington, New Zealand., Wheller G; Malaghan Institute of Medical Research, Wellington, New Zealand., Camberis M; Malaghan Institute of Medical Research, Wellington, New Zealand., Mules T; University of Otago, Wellington, New Zealand.; Capital Coast and Hutt Valley, Health New Zealand Te Whatu Ora, Wellington, New Zealand.; Malaghan Institute of Medical Research, Wellington, New Zealand.

Source: Helicobacter [Helicobacter] 2025 Sep-Oct; Vol. 30 (5), pp. e70075.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9605411 Publication Model: Print Cited Medium: Internet ISSN: 1523-5378 (Electronic) Linking ISSN: 10834389 NLM ISO Abbreviation: Helicobacter Subsets: MEDLINE

MeSH Terms: Clarithromycin*/pharmacology , Clarithromycin*/therapeutic use , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/diagnosis , Helicobacter pylori*/drug effects , Helicobacter pylori*/genetics , Helicobacter pylori*/enzymology , Helicobacter pylori*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Polymerase Chain Reaction*/methods , Urease*/analysis , Drug Resistance, Bacterial*, Humans ; New Zealand ; Female ; Male ; Middle Aged ; Aged ; Adult ; Cohort Studies ; Treatment Outcome

Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives.

Authors: Agabo-Martínez A; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Gomez-Chang E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Hernández-Hipólito E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Estrada-Muñiz E; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Escobedo-Martínez C; Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato 36050, Mexico., Obregón-Mendoza MA; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Enríquez RG; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Vega L; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Romero I; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico.

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Sep 23; Vol. 30 (19). Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Curcumin*/analogs & derivatives , Curcumin*/chemistry , Curcumin*/pharmacology , Curcumin*/therapeutic use , Curcumin*/analogs & derivatives , Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Stomach Ulcer*/chemically induced , Stomach Ulcer*/pathology , Stomach Ulcer*/prevention & control , Protective Agents*/chemistry , Protective Agents*/pharmacology , Protective Agents*/therapeutic use, Metals/chemistry ; Ethanol/toxicity ; Urease/antagonists & inhibitors ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology ; Topoisomerase II Inhibitors/therapeutic use ; Biological Availability ; Microbial Sensitivity Tests ; Disease Models, Animal ; Toxicity Tests, Subacute ; Animals ; Mice ; Male

Diuretic and Anti-hyperuricemic Effects of Geranyl Acetate in Rats.

Authors: Shah SN; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Younis W; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, , New York University Grossman School of Medicine, New York, USA., Junior AG; Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil., Manzoor W; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Malik MNH; Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan., Mushtaq MN; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Munir MU; Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, Brisbane, Australia., Bashir A; Riphah Institute of Pharmaceutical Sciences, Riphah International Univeristy, Lahore, Pakistan., Bibi S; Department of Biosciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Talha M; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Dos Reis Livero FA; Laboratory of Cardiometabolic Pharmacology, Federal University of Paraná, Curitiba, Brazil.; Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil.

Source: Current medicinal chemistry [Curr Med Chem] 2026; Vol. 33 (8), pp. 1551-1567.

Publication Type: Journal Article

Journal Info: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

MeSH Terms: Hyperuricemia*/drug therapy , Hyperuricemia*/metabolism , Diuretics*/pharmacology , Diuretics*/chemistry , Diuretics*/therapeutic use , Acetates*/pharmacology , Acetates*/chemistry , Acetates*/therapeutic use, Xanthine Oxidase/antagonists & inhibitors ; Xanthine Oxidase/metabolism ; Acetylcholinesterase/metabolism ; Urease/metabolism ; Urease/antagonists & inhibitors ; Animals ; Male ; Rats, Wistar ; Molecular Docking Simulation ; Rats

Preliminary assessment of the antioxidant, anti-inflammatory, antidiabetic, and anti-carcinogenic attributes of Australian red seaweeds

Additional Titles: Red seaweeds contain an assortment of valuable phytochemical; however, while their pharmaceutical and therapeutic potential has been previously recognized, many aspects of their bioactive properties remain underexplored, especially among the Australian species. An ultrasonic-assisted extraction method was used to obtain polyphenol-rich extracts from thirteen Australian red seaweeds. Antioxidant activity and anti-inflammatory potential, assessed through assays such as urease inhibition and nitric oxide scavenging, as well as anti-diabetic capacity through α-amylase and α-glucosidase inhibition, were evaluated. Rhodophyllis sp. demonstrated the greatest antioxidant capacity with relative antioxidant capacity index score of 1.43, while Crouania attenuata exhibited superior antidiabetic effects through α-glucosidase and α-amylase inhibition. Notable anti-inflammatory potential was observed in Plocamium and Asparagopsis samples, with A. armata excelling in protease inhibition. Moreover, LC-ESI-QTOF-MS/MS analysis of the extracts tentatively identified 26 polyphenols, indicating the rich bioactive profile of these marine resources. The in vitro assays and phenolic composition highlight the considerable biological potential of Australian Rhodophyta, emphasizing the need for further exploration of these red seaweeds as promising candidates for therapeutic and pharmaceutical applications.

Authors: Ebrahimi, F, Subbiah, V, Agar, OT, Legione, AR, Ahmadi, F, Suleria, HAR

Index Terms: Journal Article

URL: https://hdl.handle.net/11343/365053

Mechanistic insights into the inhibitory effect of epigallocatechin gallate on the production of virulence factors in Proteus mirabilis.

Authors: Xue Z; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Chen H; College of Marine Sciences, Ningde Normal University, Ningde, China., Qi Y; Clinical Laboratory, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Zeng Q; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Yan G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Fang G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.

Source: Medicine [Medicine (Baltimore)] 2026 Jan 02; Vol. 105 (1), pp. e46893.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Catechin*/analogs & derivatives , Catechin*/pharmacology , Catechin*/therapeutic use , Catechin*/analogs & derivatives , Catheter-Related Infections*/drug therapy , Catheter-Related Infections*/microbiology , Proteus Infections*/drug therapy , Proteus Infections*/microbiology , Proteus mirabilis*/drug effects , Proteus mirabilis*/genetics , Proteus mirabilis*/metabolism , Proteus mirabilis*/pathogenicity , Urinary Tract Infections*/drug therapy , Urinary Tract Infections*/microbiology , Virulence Factors*/antagonists & inhibitors , Virulence Factors*/biosynthesis, Biofilms/drug effects ; Biofilms/growth & development ; Gene Expression Regulation, Bacterial/drug effects ; Hemolysin Proteins/antagonists & inhibitors ; Hemolysin Proteins/biosynthesis ; Urease/antagonists & inhibitors ; Urease/biosynthesis ; Microbial Sensitivity Tests ; Humans

Urease inhibitory potential of pyridine-containing triazolothiadiazole and triazolothiadiazine scaffolds for the treatment of ulceration and kidney stone: in vitro screening, kinetics mechanism, and in silico computational analysis.

Authors: Ullah S; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Halim SA; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Ibrar A; Department of Chemistry, Faculty of Natural Sciences, The University of Haripur, Haripur, Pakistan., Khan I; Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK., Ataya FS; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Fouad D; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, Egypt., Khan A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Al-Harrasi A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.

Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Feb; Vol. 43 (3), pp. 1249-1258. Date of Electronic Publication: 2023 Dec 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/chemistry , Thiadiazoles*/chemistry , Thiadiazoles*/pharmacology , Pyridines*/chemistry , Pyridines*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use , Thiadiazines*/chemistry , Thiadiazines*/pharmacology , Ulcer*/drug therapy, Molecular Docking Simulation ; Kinetics ; Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Dynamics Simulation

Multimodal anti-Helicobacter pylori effects of Lactobacillus casei HY001: Evidence from in vitro and in vivo studies.

Authors: Lv Z; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Yu J; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang X; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang L; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang C; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Liu X; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Chang Y; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Yin H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Wang W; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhao H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Li H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China.

Source: PloS one [PLoS One] 2026 May 14; Vol. 21 (5), pp. e0349099. Date of Electronic Publication: 2026 May 14 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Lacticaseibacillus casei*/physiology , Helicobacter pylori*/physiology , Helicobacter Infections*/microbiology , Helicobacter Infections*/therapy , Probiotics*/pharmacology , Probiotics*/therapeutic use, Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Urease/metabolism ; RNA, Ribosomal, 16S/genetics ; NF-kappa B/metabolism ; Animals ; Humans ; Mice ; Bacterial Adhesion ; Male ; Gastrointestinal Microbiome

Kidney Stone Dissolution By Tetherless, Enzyme-Loaded, Soft Magnetic Miniature Robots.

Authors: Khabbazian A; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Kwong L; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Lewis A; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Liu E; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Abdelrazec N; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Bakenecker AC; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Medical Engineering, Technical University of Darmstadt, Merckstr. 25, 64283, Darmstadt, Germany., Fontanals N; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Lopez G; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Sánchez S; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Catalan Institute for Research and Advanced Studies, ICREA, Barcelona, 08028, Spain., Lopez JM; Department of Urology, University of Barcelona Clinic Hospital, Barcelona, 08036, Spain., Carrillo B; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Farcas M; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Kallweit C; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada., Yu ACH; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada., Behrad Khamesee M; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Magdanz V; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada.; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada.

Source: Advanced healthcare materials [Adv Healthc Mater] 2025 Sep; Vol. 14 (23), pp. e2403423. Date of Electronic Publication: 2025 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

MeSH Terms: Kidney Calculi*/therapy , Urease*/therapeutic use , Robotics*, Wireless Technology ; Magnetics ; Urinary Tract ; Humans ; Models, Anatomic ; Printing, Three-Dimensional ; Ultrasonography

Anti-biopassivated Reticular Micromotors for Bladder Cancer Therapy.

Authors: Sun J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Chu R; Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan 250021, China., Wu X; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Yu Q; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Xiao W; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ao H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wang Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu T; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ju H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Lei J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 May 28; Vol. 147 (21), pp. 17936-17945. Date of Electronic Publication: 2025 May 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH Terms: Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/pathology , Urease*/metabolism , Urease*/chemistry , Metal-Organic Frameworks*/chemistry , Metal-Organic Frameworks*/pharmacology , Metal-Organic Frameworks*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Urea/metabolism ; Urea/chemistry ; Humans ; Hydrogen Bonding ; Cell Line, Tumor

Combined therapeutic strategy through antioxidant and urease inhibitory activities of Algerian Crataegus monogyna ethanolic fraction: UAE extraction, RP-HPLC-PDA metabolite profiling, and molecular Insights

Authors: Goudjil, Sabrina ^{a, ⁎}, Boussekine, Samira ^a, Goudjil, Sarra ^b, Goudjil, Hanane ^c, Kolaylı, Sevgi ^d, Kara, Yakup ^d, Zegheb, Nadjiba ^e

Source: In South African Journal of Botany January 2026 188:207-218

Therapeutic potential of Cydonia oblonga extracts for anti-urease and antibacterial activities to cure urinary tract infections

Authors: Sharif, Aneeqa ^a, Ali, Anser ^{a, ⁎⁎}, Amjad, Muhammad ^b, Ismatullah, Humaira ^c, Latief, Noreen ^d, Javaid, Binish ^e, Tariq, Muhammad ^{e, ⁎}, Yasin, Rabia ^e, Rafiq, Muhammad ^f

Source: In Journal of Agriculture and Food Research March 2025 19

Anti-inflammatory and urease inhibitory iridoid glycosides from Nyctanthes arbor-tristis Linn.

Authors: Sana T; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Khan M; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Siddiqui BS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Pakistan Academy of Sciences, 3-Constitution Avenue, G-5/2, Islamabad, Pakistan. Electronic address: siddiqui_bina@yahoo.com., Baig TA; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Jabeen A; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Begum S; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Hadda TB; Laboratoire de Chimie des Matériaux, Facultédes Sciences, Université Mohammed Premier, 60000, Oujda, Morocco., Shah L; Hazara University, Mansehra, 21300, Pakistan.

Source: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jan 30; Vol. 319 (Pt 3), pp. 117368. Date of Electronic Publication: 2023 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

MeSH Terms: Plant Extracts*/therapeutic use , Urease*, Iridoid Glycosides/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Mice ; Animals ; Kinetics ; Molecular Docking Simulation ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha

Phytochemicals as Natural Therapeutics Against Helicobacter pylori: A Comprehensive Review.

Authors: Shah SAR; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan. ali.raza@imbb.uol.edu.pk., Jamil H; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Mustafa I; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Sharif S; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Zahid Z; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Yasir A; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Nayila I; Department of Pharmacy, The University of Lahore, Sargodha Campus, Sargodha, Pakistan.

Source: Current microbiology [Curr Microbiol] 2026 Jul 23; Vol. 83 (9). Date of Electronic Publication: 2026 Jul 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/drug effects , Helicobacter pylori*/physiology , Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Phytochemicals*/chemistry , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/chemistry, Biofilms/drug effects ; Plants, Medicinal/chemistry ; Humans ; Drug Resistance, Bacterial

Evidence-Based Guidelines for the Diagnosis and Treatment of Helicobacter pylori Infection in Korea: 2025 Revised Edition.

Authors: Bang CS; Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea., Kang SJ; Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea., Lim H; Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea., Kim SH; Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea., Lee MW; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea., Nam SY; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea., Tae CH; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea., Kim SE; Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea., Kim SY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Korea., Jung HK; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea., Kim BJ; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Choi M; Division of Healthcare Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea., Jung HY; Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea., Kim BW; Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea.

Corporate Authors: Korean College of Helicobacter and Upper Gastrointestinal Research

Source: Helicobacter [Helicobacter] 2026 Jul-Aug; Vol. 31 (4), pp. e70149.

Publication Type: Journal Article; Practice Guideline

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9605411 Publication Model: Print Cited Medium: Internet ISSN: 1523-5378 (Electronic) Linking ISSN: 10834389 NLM ISO Abbreviation: Helicobacter Subsets: MEDLINE

MeSH Terms: Anti-Bacterial Agents*/therapeutic use , Helicobacter Infections*/diagnosis , Helicobacter Infections*/drug therapy , Helicobacter pylori*/drug effects, Clarithromycin/therapeutic use ; Humans ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Republic of Korea ; Systematic Reviews as Topic ; Meta-Analysis as Topic

Exploring the phytochemical composition, ethnomedicinal uses, and therapeutic potential of Prunus species: a comprehensive review.

Authors: Nambooze J; Department of Chemistry, University of the Free State, Bloemfontein, South Africa., Mishra AP; Cosmetics and Natural Products Research Center (CosNat), Naresuan University, Tha Pho, Phitsanulok, Thailand. mishra.ap@nu.ac.th., Nigam M; Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, Uttarakhand, India., Seidel V; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK., Bonnet SL; Department of Chemistry, University of the Free State, Bloemfontein, South Africa.

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jun; Vol. 399 (9), pp. 13063-13100. Date of Electronic Publication: 2026 Apr 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH Terms: Prunus*/chemistry , Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology , Phytochemicals*/isolation & purification , Plant Extracts*/therapeutic use , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Medicine, Traditional*, Humans ; Animals ; Phytotherapy ; Ethnopharmacology

The Unfinished Agenda in Helicobacter pylori Treatment: Resistance, Microbiome Effects, and Future Directions.

Authors: Rokkas T; Gastroenterology Clinic, Henry Dunant Hospital, Athens, Greece; Medical School, European University of Cyprus, Nicosia, Cyprus and. Electronic address: sakkor@otenet.gr., Graham DY; Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas.

Source: Gastroenterology [Gastroenterology] 2026 Aug; Vol. 171 (2), pp. 271-284. Date of Electronic Publication: 2026 Mar 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/drug effects , Helicobacter pylori*/pathogenicity , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/diagnosis , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/adverse effects , Anti-Bacterial Agents*/pharmacology , Gastrointestinal Microbiome*/drug effects , Drug Resistance, Bacterial*, Proton Pump Inhibitors/therapeutic use ; Probiotics/therapeutic use ; Humans ; Treatment Outcome

Modeling the Impact of Dynamic Gastric pH on Helicobacter pylori Eradication and Antibiotic Resistance Emergence.

Authors: Sockeng Koussok AH; Department of Mathematics, Pan African University Institute for Basic Sciences, Technology and Innovation, Nairobi, 00200, Kenya. hsockeng@yahoo.com., Onyango ER; Department of Pure and Applied Mathematics, Jomo Kenyatta University of Agriculture and Technology, Nairobi, 00200, Kenya., Fujimoto K; Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, 739-8528, Hiroshima, Japan., Tewa JJ; National Advanced School of Engineering of Yaounde, University of Yaoundé I, Yaoundé, P.O. Box 8390, Cameroon.

Source: Bulletin of mathematical biology [Bull Math Biol] 2026 Jun 14; Vol. 88 (7). Date of Electronic Publication: 2026 Jun 14.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 0401404 Publication Model: Electronic Cited Medium: Internet ISSN: 1522-9602 (Electronic) Linking ISSN: 00928240 NLM ISO Abbreviation: Bull Math Biol Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/drug effects , Helicobacter pylori*/pathogenicity , Helicobacter pylori*/growth & development , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Models, Biological*, Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Urease/metabolism ; Gastric Acid/metabolism ; Hydrogen-Ion Concentration ; Drug Resistance, Bacterial ; Humans ; Mathematical Concepts ; Computer Simulation ; Host-Pathogen Interactions