Computational design of a multi-epitope vaccine against Helicobacter pylori targeting CagA, FliD, urease, and OipA with cholera toxin B subunit (CTB) adjuvant.

Authors: Baniasadi Nejad N; Student Research Committee, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran., Shahbazi B; School of Pharmacy, Semnan University of Medical Sciences, Semnan, Iran.; Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran., Sarkoohi P; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran., Ahmadi N; School of Pharmacy, Semnan University of Medical Sciences, Semnan, Iran., Ahmadi K; The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. khadijeh_6482@yahoo.com.; Department of Medical Biotechnology, School of Paramedicine, Bushehr University of Medical Sciences, Bushehr, Iran. khadijeh_6482@yahoo.com.

Source: BMC microbiology [BMC Microbiol] 2026 Apr 25; Vol. 26 (1). Date of Electronic Publication: 2026 Apr 25.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180 (Electronic) Linking ISSN: 14712180 NLM ISO Abbreviation: BMC Microbiol Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/immunology , Helicobacter pylori*/genetics , Bacterial Proteins*/immunology , Bacterial Proteins*/genetics , Cholera Toxin*/immunology , Bacterial Vaccines*/immunology , Bacterial Vaccines*/genetics , Bacterial Vaccines*/chemistry , Helicobacter Infections*/prevention & control , Helicobacter Infections*/immunology , Helicobacter Infections*/microbiology, Antigens, Bacterial/immunology ; Antigens, Bacterial/genetics ; Urease/immunology ; Urease/genetics ; Epitopes, T-Lymphocyte/immunology ; Epitopes, B-Lymphocyte/immunology ; Toll-Like Receptor 2/immunology ; Toll-Like Receptor 4/immunology ; Virulence Factors/immunology ; Immunodominant Epitopes/immunology ; Molecular Dynamics Simulation ; Molecular Docking Simulation ; Immunoinformatics ; Protein Subunit Vaccines ; Humans ; Adjuvants, Immunologic ; Antibodies, Bacterial ; Computational Biology

The urease E subunit vaccine stimulate the immune response versus Helicobacter pylori in animal model.

Authors: Nikzad-Chaleshtori M; Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Asgari M; Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Rezaeizadeh G; Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran., Aali F; Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Doosti A; Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. doostiabbas2021@gmail.com.

Source: Immunologic research [Immunol Res] 2025 Apr 22; Vol. 73 (1), pp. 74. Date of Electronic Publication: 2025 Apr 22.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/immunology , Helicobacter pylori*/physiology , Helicobacter Infections*/immunology , Helicobacter Infections*/prevention & control , Urease*/genetics , Urease*/immunology , Vaccines, DNA*/immunology , Vaccines, DNA*/genetics , Bacterial Vaccines*/immunology , Bacterial Vaccines*/genetics , Bacterial Proteins*/genetics , Bacterial Proteins*/immunology, Antibodies, Bacterial/blood ; Vaccines, Subunit/immunology ; Cytokines/metabolism ; Cytokines/blood ; Immunoglobulin G/blood ; Animals ; Mice ; Mice, Inbred BALB C ; Disease Models, Animal ; Female ; Humans

Effectiveness of rapid urease, serum antibody, and histopathological detection of helicobacter pylori infection in children.

Authors: Yang D; Department of Clinical Laboratory, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110034, China., Mo T; Department of Faculty of Biology, Shenzhen MSU-BIT University, Shenzhen, Guangdong 518172, China., Chen Q; Department of Clinical Laboratory, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110034, China., Liang L; Department of Clinical Laboratory, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110034, China.

Source: African journal of reproductive health [Afr J Reprod Health] 2025 Oct 30; Vol. 29 (10), pp. 100-108.

Publication Type: Journal Article

Journal Info: Publisher: Women's Health and Action Research Centre Country of Publication: Nigeria NLM ID: 9712263 Publication Model: Print Cited Medium: Internet ISSN: 1118-4841 (Print) Linking ISSN: 11184841 NLM ISO Abbreviation: Afr J Reprod Health Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Helicobacter Infections*/pathology , Helicobacter Infections*/microbiology , Helicobacter Infections*/blood , Urease*/blood , Helicobacter pylori*/isolation & purification , Helicobacter pylori*/immunology , Antibodies, Bacterial*/blood, Humans ; Child ; Male ; Female ; Sensitivity and Specificity ; Child, Preschool ; Gastroscopy ; Adolescent

Use of Mendelian Randomization to Unveil Metabolic Markers in Helicobacter pylori Infection.

Authors: Hoang T; Department of Cancer AI & Digital Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea.; Faculty of Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam., Kim J; Department of Cancer AI & Digital Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea. jskim@ncc.re.kr.

Source: Journal of Korean medical science [J Korean Med Sci] 2026 Jun 15; Vol. 41 (23), pp. e13. Date of Electronic Publication: 2026 Jun 15.

Publication Type: Journal Article; Meta-Analysis

Journal Info: Publisher: Korean Academy of Medical Science Country of Publication: Korea (South) NLM ID: 8703518 Publication Model: Electronic Cited Medium: Internet ISSN: 1598-6357 (Electronic) Linking ISSN: 10118934 NLM ISO Abbreviation: J Korean Med Sci Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/metabolism , Helicobacter Infections*/microbiology , Helicobacter Infections*/genetics , Helicobacter Infections*/pathology , Helicobacter Infections*/diagnosis , Helicobacter pylori*/immunology, Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/immunology ; Biomarkers/metabolism ; Urease/genetics ; Urease/metabolism ; Antigens, Bacterial/genetics ; Antigens, Bacterial/immunology ; Humans ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease

Urease-powered nanomotor containing STING agonist for bladder cancer immunotherapy.

Authors: Choi H; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; PHI BIOMED Co., Seocho-gu, Seoul, Korea., Jeong SH; Department of Urology, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.; Department of Urology, Seoul National University Hospital, Jongno-gu, Seoul, Korea., Simó C; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastian, Guipúzcoa, Spain., Bakenecker A; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Liop J; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastian, Guipúzcoa, Spain., Lee HS; Department of Urology, Seoul National University Hospital, Jongno-gu, Seoul, Korea., Kim TY; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Korea., Kwak C; Department of Urology, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea. mdrafael@snu.ac.kr.; Department of Urology, Seoul National University Hospital, Jongno-gu, Seoul, Korea. mdrafael@snu.ac.kr., Koh GY; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Korea. gykoh@kaist.ac.kr., Sánchez S; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. ssanchez@ibecbarcelona.eu.; Institució Catalana de Recerca i Estudis Avancats (ICREA), Passeig Lluís Companys 23, Barcelona, Spain. ssanchez@ibecbarcelona.eu., Hahn SK; PHI BIOMED Co., Seocho-gu, Seoul, Korea. skhanb@postech.ac.kr.; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Korea. skhanb@postech.ac.kr.

Source: Nature communications [Nat Commun] 2024 Nov 15; Vol. 15 (1), pp. 9934. Date of Electronic Publication: 2024 Nov 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Urinary Bladder Neoplasms*/therapy , Urinary Bladder Neoplasms*/immunology , Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/pathology , Membrane Proteins*/agonists , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Urease*/metabolism , Immunotherapy*/methods, CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; Programmed Cell Death 1 Receptor/metabolism ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Urinary Bladder/pathology ; Urinary Bladder/drug effects ; Urinary Bladder/immunology ; BCG Vaccine/therapeutic use ; Animals ; Mice ; Female ; Humans ; Cell Line, Tumor ; Mice, Inbred C57BL ; Administration, Intravesical ; Disease Models, Animal ; STING Protein

Investigation of the inhibitory effects of immunoglobulin Y antibody against key epitopes of Helicobacter pylori UreB recombinant protein.

Authors: Esmaeili Z; Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Kamal Shahsavar S; Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Ariannejad H; Institute of Biotechnology, Ferdowsi University of Mashhad, Iran., Hajinajaf N; Chemical Engineering Program, School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, USA., Menbari S; Department of Medical Laboratory Sciences, Faculty of Paramedical, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address: shahoo1020@gmail.com., Ghazvini K; Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: GhazviniK@mums.ac.ir.

Source: Microbial pathogenesis [Microb Pathog] 2025 Jul; Vol. 204, pp. 107613. Date of Electronic Publication: 2025 Apr 17.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/immunology , Helicobacter pylori*/genetics , Helicobacter pylori*/growth & development , Helicobacter pylori*/drug effects , Antibodies, Bacterial*/immunology , Antibodies, Bacterial*/isolation & purification , Epitopes*/immunology , Epitopes*/genetics , Urease*/immunology , Urease*/genetics , Bacterial Proteins*/immunology , Bacterial Proteins*/genetics , Immunoglobulins*/immunology , Immunoglobulins*/isolation & purification, Recombinant Proteins/immunology ; Recombinant Proteins/genetics ; Helicobacter Infections/immunology ; Helicobacter Infections/microbiology ; Escherichia coli/genetics ; Virulence Factors/immunology ; Animals ; Chickens ; Female ; Cloning, Molecular

Portable pH meter-based competitive immunoassay of E-selectin using urease-encapsulated metal-organic frameworks.

Authors: Xie Y; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, PR China., He X; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, PR China., Yu R; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, PR China., Jin Y; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, PR China., Tan L; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, PR China. Electronic address: liangtan@hunnu.edu.cn.

Source: Talanta [Talanta] 2025 May 15; Vol. 287, pp. 127613. Date of Electronic Publication: 2025 Jan 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

MeSH Terms: Urease*/chemistry , Urease*/metabolism , Metal-Organic Frameworks*/chemistry , Enzymes, Immobilized*/chemistry , Enzymes, Immobilized*/metabolism , E-Selectin*/analysis , E-Selectin*/immunology, Immunoassay/methods ; Immunoassay/instrumentation ; Nanocomposites/chemistry ; Hydrogen-Ion Concentration ; Humans

Tough and waterproof microneedles overcome mucosal immunotolerance by modulating antigen release patterns.

Authors: He P; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., He C; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Guo R; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Ou Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Chang Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Xie Z; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Tang X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Xu Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Zhao Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Wang H; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Guo Z; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Bai S; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Chen Z; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Fan F; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Du G; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Sun X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: sunxun@scu.edu.cn.

Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Jun 10; Vol. 382, pp. 113740. Date of Electronic Publication: 2025 Apr 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH Terms: Urease*/administration & dosage , Urease*/immunology , Helicobacter Infections*/prevention & control , Helicobacter Infections*/immunology , Bacterial Vaccines*/administration & dosage , Bacterial Vaccines*/immunology , Antigens*/administration & dosage , Antigens, Bacterial*/administration & dosage , Antigens, Bacterial*/immunology, Mouth Mucosa/immunology ; Helicobacter pylori/immunology ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Animals ; Needles ; Immunity, Mucosal ; Female ; Mice, Inbred BALB C ; Immune Tolerance ; Mice ; Drug Delivery Systems ; Mice, Inbred C57BL

Oral Live-Carrier Vaccine of Recombinant Lactococcus lactis Inducing Prophylactic Protective Immunity Against Helicobacter pylori Infection.

Authors: Ni X; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China., Liu Y; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China., Sun M; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China., Jiang Y; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China., Wang Y; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China., Ke D; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China., Guo G; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China. guogang7001@163.com., Liu K; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, China. liukaiyun@wchscu.edu.cn.

Source: Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2025 Dec; Vol. 17 (6), pp. 4111-4123. Date of Electronic Publication: 2024 Sep 10.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101484100 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1867-1314 (Electronic) Linking ISSN: 18671306 NLM ISO Abbreviation: Probiotics Antimicrob Proteins Subsets: MEDLINE

MeSH Terms: Lactococcus lactis*/genetics , Lactococcus lactis*/immunology , Helicobacter pylori*/immunology , Helicobacter pylori*/genetics , Helicobacter Infections*/prevention & control , Helicobacter Infections*/immunology , Helicobacter Infections*/microbiology , Bacterial Vaccines*/immunology , Bacterial Vaccines*/administration & dosage , Bacterial Vaccines*/genetics, Urease/immunology ; Urease/genetics ; Bacterial Toxins/genetics ; Bacterial Toxins/immunology ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/immunology ; Enterotoxins/genetics ; Enterotoxins/immunology ; Cytokines/immunology ; Bacterial Proteins/immunology ; Bacterial Proteins/genetics ; Animals ; Mice, Inbred BALB C ; Mice ; Administration, Oral ; Female

Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter Pylori.

Authors: Pasha AVK; Department of Medicinal Chemistry, TeMS.C., Islamic Azad University, Tehran, Iran., Esfandiyari M; Department of Medicinal Chemistry, TeMS.C., Islamic Azad University, Tehran, Iran., Parnian A; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran., Mahboubi-Rabbani M; Department of Medicinal Chemistry, TeMS.C., Islamic Azad University, Tehran, Iran., Bayanati M; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Source: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2026 Jan; Vol. 9 (1), pp. e70441.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101747728 Publication Model: Print Cited Medium: Internet ISSN: 2573-8348 (Electronic) Linking ISSN: 25738348 NLM ISO Abbreviation: Cancer Rep (Hoboken) Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/immunology , Bacterial Vaccines*/immunology , Computational Biology*/methods , Helicobacter Infections*/prevention & control , Helicobacter Infections*/immunology , Helicobacter Infections*/microbiology , Epitopes*/immunology, Vaccines, Subunit/immunology ; Flagellin/immunology ; Flagellin/chemistry ; Urease/immunology ; Urease/chemistry ; Cholera Toxin/immunology ; Epitopes, T-Lymphocyte/immunology ; Humans ; Molecular Docking Simulation ; Adjuvants, Immunologic ; Immunoinformatics

Intramuscular All-Trans Retinoic Acid-Adjuvanted Nanovaccine Elicits Robust Mucosal and Systemic Immunity Against Helicobacter pylori.

Authors: Xu J; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Sun M; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Wang N; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Shi Y; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Liu Y; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Tan R; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Zhou S; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Guo G; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China., Liu K; Institute of Biopharmaceuticals, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Source: International journal of nanomedicine [Int J Nanomedicine] 2025 Dec 28; Vol. 20, pp. 15847-15861. Date of Electronic Publication: 2025 Dec 28 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/immunology , Helicobacter Infections*/prevention & control , Helicobacter Infections*/immunology , Tretinoin*/administration & dosage , Tretinoin*/chemistry , Bacterial Vaccines*/immunology , Bacterial Vaccines*/administration & dosage , Bacterial Vaccines*/chemistry , Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , Adjuvants, Immunologic*/administration & dosage , Adjuvants, Immunologic*/chemistry, Immunity, Mucosal/drug effects ; Dendritic Cells/immunology ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Urease/immunology ; Urease/administration & dosage ; Antibodies, Bacterial/blood ; Animals ; Mice, Inbred BALB C ; Mice ; Female ; Injections, Intramuscular ; Nanovaccines ; Receptors, CCR

Chitosan-based Oral DNA vaccine elicits mucosal immunity and reduces Helicobacter pylori colonization in mice.

Authors: Chan YL; Department of Chemistry, Chinese Culture University, Taipei, Taiwan. Electronic address: zyl13@ulive.pccu.edu.tw., Chao YP; Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan., Li TL; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Liao KW; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.

Source: Vaccine [Vaccine] 2025 Oct 03; Vol. 64, pp. 127692. Date of Electronic Publication: 2025 Sep 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

MeSH Terms: Chitosan*/administration & dosage , Vaccines, DNA*/immunology , Vaccines, DNA*/administration & dosage , Helicobacter pylori*/immunology , Helicobacter pylori*/genetics , Helicobacter Infections*/prevention & control , Helicobacter Infections*/immunology , Bacterial Vaccines*/immunology , Bacterial Vaccines*/administration & dosage , Immunity, Mucosal*, Urease/immunology ; Urease/genetics ; Nanoparticles/administration & dosage ; Interferon-gamma/metabolism ; Antibodies, Bacterial/blood ; Interleukin-17/metabolism ; Interleukin-17/immunology ; Animals ; Administration, Oral ; Mice ; Female ; Immunoglobulin G ; Immunoglobulin A ; Mice, Inbred BALB C

Inhibitory Effect of Fucoidan Combined with Bifidobacteria on Helicobacter pylori.

Authors: Guo L; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Xuan J; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Bao S; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Yang L; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Li Y; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Jiang B; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Wang J; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Ren D; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Jan 14; Vol. 74 (1), pp. 1525-1537. Date of Electronic Publication: 2025 Dec 22.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/drug effects , Helicobacter pylori*/physiology , Helicobacter pylori*/genetics , Polysaccharides*/administration & dosage , Helicobacter Infections*/microbiology , Helicobacter Infections*/drug therapy , Helicobacter Infections*/genetics , Helicobacter Infections*/immunology , Bifidobacterium animalis*/growth & development , Bifidobacterium animalis*/physiology , Probiotics*/administration & dosage , Anti-Bacterial Agents*/administration & dosage, NF-kappa B/genetics ; NF-kappa B/metabolism ; Gastric Mucosa/microbiology ; Gastric Mucosa/drug effects ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/metabolism ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Bacterial Adhesion/drug effects ; Urease/metabolism ; Epithelial Cells/microbiology ; Epithelial Cells/drug effects ; Animals ; Mice ; Humans ; Male ; Mice, Inbred BALB C ; Cell Line

Intraperitoneal immunization with Urease loaded N-trimethyl Chitosan nanoparticles elicits high protection against Brucella melitensis and Brucella abortus infections.

Authors: Abkar M; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mortezaabkar@gmail.com., Fasihi-Ramandi M; Molecular Biology Research Center, System Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: fasihi.m@gmail.com., Kooshki H; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: hmdkooshki@gmail.com., Lotfi AS; Department of Clinical Biochemistry, Faculty of Medical Sciences Tarbiat Modares University, Tehran, Iran. Electronic address: lotfi_ab@owa.modares.ac.ir.

Source: Immunology letters [Immunol Lett] 2018 Jul; Vol. 199, pp. 53-60. Date of Electronic Publication: 2018 Mar 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7910006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0542 (Electronic) Linking ISSN: 01652478 NLM ISO Abbreviation: Immunol Lett Subsets: MEDLINE

MeSH Terms: Brucellosis*/drug therapy , Brucellosis*/immunology , Brucellosis*/prevention & control, Brucella Vaccine/*immunology , Chitosan/*therapeutic use , Nanoparticles/*therapeutic use , Urease/*immunology , Urease/*therapeutic use, Brucella abortus/immunology ; Brucella melitensis/immunology ; Immunoglobulin G/metabolism ; Animals ; Humans ; Injections, Intraperitoneal ; Mice ; Mice, Inbred BALB C ; Models, Animal ; Vaccination

Outer membrane vesicles from genetically engineered Salmonella enterica serovar Typhimurium presenting Helicobacter pylori antigens UreB and CagA induce protection against Helicobacter pylori infection in mice.

Authors: Liu Q; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University., Shang Y; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University., Shen L; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University., Yu X; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University., Cao Y; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University., Zeng L; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University., Zhang H; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University.; The Second Clinical Medical College, Nanchang University, Nanchang, China., Rao Z; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University.; HuanKui Academy, Nanchang University, Nanchang, China., Li Y; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University.; The First Clinical Medical College, Nanchang University, Nanchang, China., Tao Z; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University., Liu Z; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University.; HuanKui Academy, Nanchang University, Nanchang, China., Huang X; The First Affiliated Hospital, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University.

Source: Virulence [Virulence] 2024 Dec; Vol. 15 (1), pp. 2367783. Date of Electronic Publication: 2024 Jun 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/prevention & control , Helicobacter Infections*/immunology , Helicobacter Infections*/microbiology , Bacterial Proteins*/genetics , Bacterial Proteins*/immunology , Helicobacter pylori*/immunology , Helicobacter pylori*/genetics , Salmonella typhimurium*/immunology , Salmonella typhimurium*/genetics , Antigens, Bacterial*/immunology , Antigens, Bacterial*/genetics, Bacterial Vaccines/immunology ; Bacterial Vaccines/genetics ; Antibodies, Bacterial/immunology ; Antibodies, Bacterial/blood ; Urease/immunology ; Urease/genetics ; Animals ; Mice ; Female ; Immunoglobulin G ; Genetic Engineering ; Disease Models, Animal

Immunoinformatics design and synthesis of a multi-epitope vaccine against Helicobacter pylori based on lipid nanoparticles.

Authors: Jebali A; Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran.; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Esmaeilzadeh A; Department of Nanobiomimetics, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. esmaeilzadeh2016@gmail.com., Esmaeilzadeh MK; Eeducational and Hospital Pharmacies Complex, Isfahan University of Medical Sciences, Isfahan, Iran., Shabani S; Department of Biological Sciences, Bio-molecular Science Institute, Florida International University, Miami, FL, USA.

Source: Scientific reports [Sci Rep] 2024 Aug 02; Vol. 14 (1), pp. 17910. Date of Electronic Publication: 2024 Aug 02.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/immunology , Nanoparticles*/chemistry , Bacterial Vaccines*/immunology , Bacterial Vaccines*/chemistry , Computational Biology*/methods, Bacterial Proteins/immunology ; Bacterial Proteins/chemistry ; Epitopes/immunology ; Epitopes/chemistry ; Antigens, Bacterial/immunology ; Antigens, Bacterial/chemistry ; Helicobacter Infections/prevention & control ; Helicobacter Infections/immunology ; Toll-Like Receptor 4/immunology ; Urease/immunology ; Urease/chemistry ; Humans ; Molecular Docking Simulation ; Immunoinformatics ; Liposomes

Are anti-Helicobacter pylori urease antibodies involved in atherosclerotic diseases?

Authors: Arabski M; Department of Microbiology, Institute of Biology, Jan Kochanowski University, ul Swietokrzyska 15, 25-406 Kielce, Poland. arabski@ujk.kielce.pl, Konieczna I, Sołowiej D, Rogoń A, Kolesińska B, Kamiński Z, Kaca W

Source: Clinical biochemistry [Clin Biochem] 2010 Jan; Vol. 43 (1-2), pp. 115-23. Date of Electronic Publication: 2009 Sep 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0133660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2933 (Electronic) Linking ISSN: 00099120 NLM ISO Abbreviation: Clin Biochem Subsets: MEDLINE

MeSH Terms: Atherosclerosis*/enzymology , Atherosclerosis*/immunology, Antibodies, Bacterial/*immunology , Bacterial Proteins/*immunology , Helicobacter pylori/*enzymology , Urease/*immunology, Bacterial Proteins/genetics ; Epitopes/immunology ; Helicobacter Infections/enzymology ; Helicobacter Infections/immunology ; Peptides/chemistry ; Peptides/genetics ; Peptides/immunology ; Urease/genetics ; Adult ; Aged ; Aged, 80 and over ; Amino Acid Sequence ; Antibody Specificity ; Female ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Molecular Structure ; Young Adult

Comparative Analysis of Diagnostic Techniques for Helicobacter pylori Infection: Insights for Effective Therapy.

Authors: Mujtaba A; Department of Food Science and Technology, Faculty of Engineering Sciences and Technology, Hamdard University Islamabad Campus, Islamabad, Pakistan.; Institute of Food and Nutritional Sciences, PMAS-Arid Agriculture University, Rawalpindi, Pakistan., Ibrahim MS; Institute of Food and Nutritional Sciences, PMAS-Arid Agriculture University, Rawalpindi, Pakistan., Parveen S; Institute of Food and Nutritional Sciences, PMAS-Arid Agriculture University, Rawalpindi, Pakistan., Sarwar N; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan., Alsagaby SA; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi Arabia., Raza MA; Department of Zoology, Govt. Graduate College for Boys, Gujranwala, Pakistan., Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia., Ghoneim MM; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia., El-Ghorab AH; Department of Chemistry, College of Science, Jouf University, Sakaka, Saudi Arabia., Selim S; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia., Al Abdulmonem W; Department of Pathology, College of Medicine, Qassim University, Buraidah, Kingdom of Saudi Arabia., Hussain M; Department of Food Science, Government College University Faisalabad, Faisalabad, Pakistan., Fenta Yehuala T; Faculty of Chemical and Food Engineering, Bahir Dar Institute of Technology, Bahir Dar University, Bahir Dar City, Ethiopia.

Source: Journal of cellular and molecular medicine [J Cell Mol Med] 2025 Mar; Vol. 29 (6), pp. e70487.

Publication Type: Journal Article; Comparative Study; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Helicobacter Infections*/microbiology , Helicobacter Infections*/drug therapy , Helicobacter pylori*/drug effects , Helicobacter pylori*/genetics , Helicobacter pylori*/isolation & purification , Helicobacter pylori*/immunology, Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Urease/metabolism ; Immunoglobulin G/blood ; Bacterial Proteins/genetics ; Antigens, Bacterial/genetics ; Antibodies, Bacterial/blood ; Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Sensitivity and Specificity

Development of an easy-to-use urease kit for detecting Helicobacter pylori in canine gastric mucosa

Authors: Chularat Hlaoperm, Kiattawee Choowongkomon, Chantima Pruksakorn, Jatuporn Rattanasrisomporn

Source: Vet World
Veterinary World, Vol 14, Iss 7, Pp 1977-1987 (2021)

Subject Terms: Pulmonary and Respiratory Medicine, 0301 basic medicine, Veterinary medicine, Immunology, rapid urease test, SF1-1100, Microbiology, Biochemistry, Gene, 03 medical and health sciences, Helicobacter, SF600-1100, Health Sciences, Genetics, Rapid urease test, Urea, Biology, Immunology and Microbiology, 0303 health sciences, Role of Galectins in Immunity and Disease, Helicobacter pylori, Bacteria, FOS: Clinical medicine, Stomach, Gastroenterology, Life Sciences, Chronic gastritis, Gastric Cancer Research and Treatment, Urease, Animal culture, Polymerase chain reaction, 3. Good health, Gastric mucosa, Microbiological culture, Helicobacter pylori Infection and Gastric Cancer, FOS: Biological sciences, Gastritis, dog, helicobacter pylori, Medicine, Surgery, Research Article

Access URL: http://www.veterinaryworld.org/Vol.14/July-2021/36.pdf
https://pubmed.ncbi.nlm.nih.gov/34475726
https://doaj.org/article/701d74c69bd6499892aab6fd195e883d

Neutralizing antibodies for Helicobacter pylori urease inhibit bacterial colonization in the murine stomach in vivo.

Authors: Takeshita H; Department of Microbiology and Immunology, Nippon Medical School.; Department of Pediatrics, Nippon Medical School., Watanabe E; Department of Microbiology and Immunology, Nippon Medical School., Norose Y; Department of Microbiology and Immunology, Nippon Medical School., Ito Y; Department of Pediatrics, Nippon Medical School., Takahashi H; Department of Microbiology and Immunology, Nippon Medical School.

Source: Biomedical research (Tokyo, Japan) [Biomed Res] 2019; Vol. 40 (2), pp. 87-95.

Publication Type: Journal Article

Journal Info: Publisher: Biomedical Research Foundation Country of Publication: Japan NLM ID: 8100317 Publication Model: Print Cited Medium: Internet ISSN: 1880-313X (Electronic) Linking ISSN: 03886107 NLM ISO Abbreviation: Biomed Res

MeSH Terms: Antibodies, Bacterial/*biosynthesis , Antibodies, Neutralizing/*biosynthesis , Bacterial Proteins/*immunology , Helicobacter Infections/*prevention & control , Immunization/*methods , Peptides/*immunology , Urease/*immunology, Bacterial Proteins/genetics ; Epitopes/chemistry ; Epitopes/immunology ; Gastric Mucosa/drug effects ; Gastric Mucosa/immunology ; Gastric Mucosa/microbiology ; Helicobacter Infections/genetics ; Helicobacter Infections/immunology ; Helicobacter Infections/microbiology ; Helicobacter pylori/drug effects ; Helicobacter pylori/growth & development ; Helicobacter pylori/immunology ; Immune Sera/administration & dosage ; Peptides/administration & dosage ; Peptides/chemical synthesis ; Stomach/drug effects ; Stomach/immunology ; Stomach/microbiology ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/immunology ; Urease/deficiency ; Urease/genetics ; Amino Acid Sequence ; Animals ; Female ; Gene Deletion ; Gene Expression ; Mice ; Mice, Inbred BALB C