Gut microbial ammonia enhances colonic acetylcholine levels to regulate intestinal motility.

Authors: Chen H; Human Microbiome and Health Group, Department of Microbiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Wang Z; Human Microbiome and Health Group, Department of Microbiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Zhao Y; Human Microbiome and Health Group, Department of Microbiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Yang W; Human Microbiome and Health Group, Department of Parasitology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Huang J; Human Microbiome and Health Group, Department of Parasitology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China., Yu Z; Human Microbiome and Health Group, Department of Microbiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China. yuzheng@csu.edu.cn.

Source: Nature microbiology [Nat Microbiol] 2026 Apr; Vol. 11 (4), pp. 907-919. Date of Electronic Publication: 2026 Feb 20.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

MeSH Terms: Acetylcholine*/metabolism , Acetylcholine*/deficiency , Gastrointestinal Motility*/physiology , Ammonia*/metabolism , Colon*/metabolism , Gastrointestinal Microbiome*/physiology, Urease/metabolism ; Constipation/microbiology ; Constipation/physiopathology ; Animals ; Mice ; Humans ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Female

Unravelling the fate of foliar-applied nickel in soybean : a comprehensive investigation

Additional Titles: Background and aims: Nickel (Ni) deficiency has been reported to occur in soybean (Glycine max) grown on leached tropical soils in Brazil. We aimed to determine whether an internal or external Ni supply can compensate for low Ni within the seed by assessing whether the amount of Ni in the seed whether the foliar-application of aqueous NiSO4 influenced the uptake of Ni by the leaf, the nutritional status of the plant, urease activity and growth. Methods: We used Ni-depleted seeds (<0.35 μg Ni per g) and Ni-sufficient seeds (11.1 μg Ni g−1) for hydroponic experiments. Seedlings were grown either with or without an external Ni supply (0 or 0.85 μM Ni in nutrient solution) and either with or without an internal Ni supply (with or cotyledons removed). In addition, we used synchrotron-based micro-X-ray fluorescence analysis to examine the distribution of foliar-applied Ni (50 and 100 mg L-1). Key results: Leaf Ni concentration and urease activity were both enhanced by increasing either the internal (cotyledon seed store) or external (solution) Ni supply. In addition, plants derived from Ni-depleted seed that received external Ni supply had 9.2% higher biomass relative to plants derived from Ni-sufficient seeds which received Ni. When foliar-applied, Ni accumulated in the pedicles of the trichomes within 15 minutes of application, and then moved to the vascular bundles before dispersing further into tissues within 3 hours. Conclusions: Trichomes are an important pathway for foliar Ni absorption in soybean, but there are still major knowledge gaps our understanding of the physiological function of trichomes in the uptake of metal ions from foliar micro-nutrient treatments.

Authors: de Oliveira, Jessica Bezerra, Lavres, Jose, Kopittke, Peter M., Chaney, Rufus L., Harris, Hugh H., Erskine, Peter D., Howard, Daryl L., Rodrigues dos Reis, André, van der Ent, Antony

Source: ISSN: 0032-079X

Index Terms: Foliar nutrition, Leaf ion absorption, Nickel deficiency, Soybean; XFM, Article/Letter to editor

URL: https://edepot.wur.nl/653608
https://edepot.wur.nl/653608

Mosaic coexistence of two subalpine grassland types as a consequence of soil nutrient heterogeneity

Additional Titles: High-mountain areas often exhibit high soil heterogeneity, which allows for the close coexistence of plant species and communities with contrasting resource requirements. This study investigated the nutritional factors driving the mosaic distribution of Nardus stricta L. grasslands and chalk grasslands dominated by forbs in the subalpine southern Pyrenees (Spain). The concentrations of C, N, P, S, K, Ca and fiber fractions in herbage were analyzed in relation to soil nutrient availability; soil β-glucosidase, urease, phosphatase and arylsulfatase activities; and plant species and functional type compositions. The chalk grassland showed higher N:P ratios in herbage and higher enzyme demand for P relative to N in the soil, which indicates a greater limitation of P versus N compared to Nardus grassland. This limitation was related to the higher soil and plant Ca levels in the chalk grassland, where the calcareous bedrock lies close to the soil surface. In the Nardus grasslands, the alleviation of P limitation translated into increased productivity and the replacement of forbs with taller graminoids rich in structural carbohydrates, which was mirrored by greater β-D-glucosidase activity. The plant N:K and P:K ratios indicated potential K deficiency in both grasslands, which resulted from decreased uptake of K in competition with Ca, as indicated by the correlation between plant K and the soil K+:Ca2+ ratio. Our results highlight the effect of the heterogeneity of soil nutrient constraints, mediated by stoichiometry and dependent on microtopography, on the biodiversity of high-mountain ecosystems.

Authors: Mora, Juan Luis, Armas-Herrera, Cecilia, Gómez, Daniel, Badía-Villas, David

Index Terms: info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion

URL: http://zaguan.unizar.es/record/135929
info:eu-repo/grantAgreement/ES/DGA/S51-23R

Sporosarcina pasteurii urease gene expression regulation mechanism overcomes urease inhibition by hydrocarbons

Authors: Comadran-Casas, Carla ^{a, ⁎}, Cholet, Fabien ^a, Ogundero, Ayo ^a, Poursat, Baptiste A.J. ^a, Smith, Cindy J. ^a, Sloan, William T. ^a, Bass, Adrian M. ^b, MacDonald, John ^b, Unluer, Cise ^c, Gauchotte-Lindsay, Caroline ^a

Source: In Journal of Hazardous Materials 15 June 2026 511

Genetic analysis of a suppressor of urease-deficiency in Neurospora crassa

Authors: K E, Buremalm, H G, Kolmark

Source: Hereditas. 69:249-261

Subject Terms: 0301 basic medicine, Neurospora, 0303 health sciences, 03 medical and health sciences, Phenotype, Suppression, Genetic, Neurospora crassa, Genetic Linkage, Mutation, Chromosome Mapping, Urease, Crosses, Genetic

Access URL: https://pubmed.ncbi.nlm.nih.gov/4281763

Root biological mechanisms of nitrogen deficiency and compensation effects in rice

Authors: Wang, Runnan ^{a, b}, Zhang, Hongcheng ^{a, b}, He, Haohua ^{c, ⁎}, Xiong, Qiangqiang ^{a, b, ⁎}

Source: In Applied Soil Ecology July 2026 223

Urease deficiency alters nitrogen metabolism and gene expression in urease-null soybean without affecting growth or productivity under nitrate supply

Authors: de Souza, Sarah Caroline Ribeiro^{Aff1, Aff2, IDs1173802030209_cor1}, Sodek, Ladaslav^Aff1, Polacco, Joe Carmine^Aff3, Mazzafera, Paulo^{Aff1, Aff4}

Source: Acta Physiologiae Plantarum. 42(3)

Rapid, simplified and sensitive method for screening fructose-1,6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography–mass spectrometry in the selected-ion monitoring mode

Authors: M, Iga, M, Kimura, T, Ohura, Y, Kikawa, S, Yamaguchi

Source: Journal of Chromatography B: Biomedical Sciences and Applications. 746:75-82

Subject Terms: Adult, Male, 0301 basic medicine, Reproducibility of Results, Sensitivity and Specificity, Urease, Gas Chromatography-Mass Spectrometry, Fructose-Bisphosphatase, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Child, Preschool, Humans, Female, Child, Metabolism, Inborn Errors

Access URL: https://pubmed.ncbi.nlm.nih.gov/11048742

Characteristics of Helicobacter pylori variants selected for urease deficiency

Authors: G I, Pérez-Pérez, A Z, Olivares, T L, Cover, M J, Blaser

Source: Infection and Immunity. 60:3658-3663

Subject Terms: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Bacterial Proteins, Helicobacter pylori, Cytotoxins, Vacuoles, Humans, Hydrogen-Ion Concentration, Urease, HeLa Cells

Access URL: https://iai.asm.org/content/iai/60/9/3658.full.pdf
https://pubmed.ncbi.nlm.nih.gov/1500174

Nickel Deficiency Affects Nitrogenous Forms and Urease Activity in Spring Xylem Sap of Pecan

Authors: Cheng Bai, Charles C. Reilly, Bruce W. Wood

Source: Journal of the American Society for Horticultural Science. 132:302-309

Subject Terms: 2. Zero hunger, 0106 biological sciences, 0401 agriculture, forestry, and fisheries, 04 agricultural and veterinary sciences, 15. Life on land, 01 natural sciences

Access URL: https://journals.ashs.org/downloadpdf/journals/jashs/132/3/article-p302.pdf

Carbamoly-phosphate synthetase 1 (CPS1) deficiency: A tertiary center retrospective cohort study and literature review

Authors: Noori, Mahmood ^a, Jarrah, Omar ^a, Al Shamsi, Aisha ^{b, ⁎}

Source: In Molecular Genetics and Metabolism Reports December 2024 41

Experimental study on bio-treatment effect of the dredged Yellow River silt based on soybean urease induced calcium carbonate precipitation

Authors: Wang, Yuke ^a, Wang, Zhenhai ^a, Chen, Yuyuan ^{b, ∗}, Cao, Tiancai ^a, Yu, Xiang ^a, Rui, Pang ^c

Source: In Journal of Building Engineering 15 September 2023 75

The critical role of urease in yogurt fermentation with various combinations of Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus.

Authors: Yamauchi R; Graduate School of Agriculture, University of Meiji, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan. Electronic address: cf60128@meiji.ac.jp., Maguin E; INRA UMR1319 Micalis Allée de Vilvert Bat. 440, R-1, Pce 420, 78352 Jouy-en-Josas Cedex, Ile de France, France., Horiuchi H; Food Development Laboratories, R&D Division, Meiji Co., Ltd., 1-29-1 Nanakuni, Hachioji, Tokyo 192-0919, Japan., Hosokawa M; Chuo University of Junior and High School, 3-22-1 Nukuikitamachi, Koganei, Tokyo, 184-8575, Japan., Sasaki Y; Graduate School of Agriculture, University of Meiji, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.

Source: Journal of dairy science [J Dairy Sci] 2019 Feb; Vol. 102 (2), pp. 1033-1043. Date of Electronic Publication: 2018 Dec 26.

Publication Type: Journal Article

Journal Info: Publisher: American Dairy Science Association Country of Publication: United States NLM ID: 2985126R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3198 (Electronic) Linking ISSN: 00220302 NLM ISO Abbreviation: J Dairy Sci Subsets: MEDLINE

MeSH Terms: Fermentation* , Yogurt*, Lactobacillus delbrueckii/*enzymology , Streptococcus thermophilus/*enzymology , Urease/*metabolism, Lactobacillus delbrueckii/genetics ; Lactobacillus delbrueckii/metabolism ; Streptococcus thermophilus/genetics ; Streptococcus thermophilus/metabolism ; Urease/deficiency ; Urease/genetics ; Animals ; Mutation

Frequency of iron deficiency anemia (IDA) among patients with Helicobacter pylori infection

Authors: Adeel Rahat, Lubna Kamani

Source: Pak J Med Sci

Subject Terms: Immunology, Transferrin saturation, Helicobacter pylori infection, 03 medical and health sciences, 0302 clinical medicine, Health Sciences, Pathology, Rapid urease test, Micronutrient, Internal medicine, Immunology and Microbiology, Iron-deficiency anemia, Ferritin, Role of Galectins in Immunity and Disease, Helicobacter pylori, FOS: Clinical medicine, Iron deficiency, Gastroenterology, Serum iron, Life Sciences, Anemia, 3. Good health, Helicobacter pylori Infection and Gastric Cancer, Medicine, Original Article, Surgery, Etiology and Management of Peritoneal Adhesions, Urea breath test

Access URL: https://www.pjms.org.pk/index.php/pjms/article/download/3944/882
https://pubmed.ncbi.nlm.nih.gov/34104164

20-hydroxyecdysone regulated exosomal transport of mulberry urease drives nitrogen recycling and silkworm development.

Authors: Li M; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China., Liang J; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China., Lu H; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China., Liu H; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China., Chen L; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China., Chen K; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China., Zhang S; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China., He N; State Key Laboratory of Resource Insects, Institute of Sericulture and Systems Biology, Southwest University, Chongqing400715, People's Republic of China.

Source: Open biology [Open Biol] 2026 Feb 18; Vol. 16 (2).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society Pub Country of Publication: England NLM ID: 101580419 Publication Model: Print Cited Medium: Internet ISSN: 2046-2441 (Electronic) Linking ISSN: 20462441 NLM ISO Abbreviation: Open Biol Subsets: MEDLINE

MeSH Terms: Bombyx*/growth & development , Bombyx*/metabolism , Morus*/enzymology , Ecdysterone*/metabolism , Ecdysterone*/pharmacology , Urease*/metabolism , Nitrogen*/metabolism , Exosomes*/metabolism, Hemolymph/metabolism ; Larva/growth & development ; Larva/metabolism ; Animals ; Biological Transport

Rapid,simplified and sensitive method for screening fructose-1,6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography-mass spectrometry in the selected-ion monitoring mode

In-situ monitoring bacteria-based crack sealing process in mortar

Authors: Hou, Fuxing, Shen, Di, Guo, Hanyu, Yao, Tian, Ma, Aowei, Wang, Jianyun ^⁎

Source: In Cement and Concrete Composites March 2026 167

Impact of Artificial Feed-Infused Nickel Nanoparticles Functionalized with Urease (Ni-Urease) on the Growth and Properties of Silkworms (Bombyx mori)

Authors: Zhang, Zhan-Peng^aff1, Khurshid, Marriam^aff1, Li, Shi-Hua^aff1, Li, Yi-Jiang-Cheng^aff1, Quaye, Lydia^aff1, Herman, Richard Ansah^{aff1, aff2}, Wang, Jun^{aff1, aff2, aff3}

Source: ACS Applied Nano Materials. 8(6):3129-3140

Availability: https://pubs.acs.org/doi/10.1021/acsanm.4c06931

Therapeutic potential of N4-substituted thiosemicarbazones as new urease inhibitors: Biochemical and in silico approach

Authors: Islam, Muhammad ^{a, b, c}, Khan, Ajmal ^b, Shehzad, Muhammad Tariq ^a, Khiat, Mohammed ^b, Halim, Sobia Ahsan ^b, Hameed, Abdul ^d, Shah, Syed Raza ^{b, e}, Basri, Rabia ^a, Anwar, Muhammad U. ^b, Hussain, Javid ^f, Csuk, René ^g, Al-Harrasi, Ahmed ^{b, ⁎}, Shafiq, Zahid ^{a, ⁎}

Source: In Bioorganic Chemistry April 2021 109

Neutralizing antibodies for Helicobacter pylori urease inhibit bacterial colonization in the murine stomach in vivo.

Authors: Takeshita H; Department of Microbiology and Immunology, Nippon Medical School.; Department of Pediatrics, Nippon Medical School., Watanabe E; Department of Microbiology and Immunology, Nippon Medical School., Norose Y; Department of Microbiology and Immunology, Nippon Medical School., Ito Y; Department of Pediatrics, Nippon Medical School., Takahashi H; Department of Microbiology and Immunology, Nippon Medical School.

Source: Biomedical research (Tokyo, Japan) [Biomed Res] 2019; Vol. 40 (2), pp. 87-95.

Publication Type: Journal Article

Journal Info: Publisher: Biomedical Research Foundation Country of Publication: Japan NLM ID: 8100317 Publication Model: Print Cited Medium: Internet ISSN: 1880-313X (Electronic) Linking ISSN: 03886107 NLM ISO Abbreviation: Biomed Res

MeSH Terms: Antibodies, Bacterial/*biosynthesis , Antibodies, Neutralizing/*biosynthesis , Bacterial Proteins/*immunology , Helicobacter Infections/*prevention & control , Immunization/*methods , Peptides/*immunology , Urease/*immunology, Bacterial Proteins/genetics ; Epitopes/chemistry ; Epitopes/immunology ; Gastric Mucosa/drug effects ; Gastric Mucosa/immunology ; Gastric Mucosa/microbiology ; Helicobacter Infections/genetics ; Helicobacter Infections/immunology ; Helicobacter Infections/microbiology ; Helicobacter pylori/drug effects ; Helicobacter pylori/growth & development ; Helicobacter pylori/immunology ; Immune Sera/administration & dosage ; Peptides/administration & dosage ; Peptides/chemical synthesis ; Stomach/drug effects ; Stomach/immunology ; Stomach/microbiology ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/immunology ; Urease/deficiency ; Urease/genetics ; Amino Acid Sequence ; Animals ; Female ; Gene Deletion ; Gene Expression ; Mice ; Mice, Inbred BALB C