Antifungal repurposing of clinical chelator DMSA against Cryptococcus neoformans via laccase and histidine biosynthesis inhibition.

Authors: Zhang C; Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China., Peng M; Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China., Hu Q; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, China., Huang S; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China., Zhang Q; Jinling Clinical Medical College, Nanjing Medical University, China., Zhu J; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China., Sang H; Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address: sanghong@nju.edu.cn., Kong Q; Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address: kongqingtao2008@163.com.

Source: Microbial pathogenesis [Microb Pathog] 2026 May; Vol. 214, pp. 108375. Date of Electronic Publication: 2026 Feb 10.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: Cryptococcus neoformans*/drug effects , Cryptococcus neoformans*/enzymology , Cryptococcus neoformans*/pathogenicity , Laccase*/antagonists & inhibitors , Laccase*/metabolism , Laccase*/drug effects , Antifungal Agents*/pharmacology , Chelating Agents*/pharmacology , Histidine*/biosynthesis , Histidine*/antagonists & inhibitors , Succimer*/pharmacology , Drug Repositioning*, Biofilms/drug effects ; Biofilms/growth & development ; Cryptococcosis/microbiology ; Cryptococcosis/drug therapy ; Moths/microbiology ; Urease/metabolism ; Fungal Capsules/drug effects ; Animals ; Microbial Sensitivity Tests ; Virulence Factors ; Humans ; Disease Models, Animal

Mechanistic insights into the inhibitory effect of epigallocatechin gallate on the production of virulence factors in Proteus mirabilis.

Authors: Xue Z; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Chen H; College of Marine Sciences, Ningde Normal University, Ningde, China., Qi Y; Clinical Laboratory, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Zeng Q; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Yan G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Fang G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.

Source: Medicine [Medicine (Baltimore)] 2026 Jan 02; Vol. 105 (1), pp. e46893.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Catechin*/analogs & derivatives , Catechin*/pharmacology , Catechin*/therapeutic use , Catechin*/analogs & derivatives , Catheter-Related Infections*/drug therapy , Catheter-Related Infections*/microbiology , Proteus Infections*/drug therapy , Proteus Infections*/microbiology , Proteus mirabilis*/drug effects , Proteus mirabilis*/genetics , Proteus mirabilis*/metabolism , Proteus mirabilis*/pathogenicity , Urinary Tract Infections*/drug therapy , Urinary Tract Infections*/microbiology , Virulence Factors*/antagonists & inhibitors , Virulence Factors*/biosynthesis, Biofilms/drug effects ; Biofilms/growth & development ; Gene Expression Regulation, Bacterial/drug effects ; Hemolysin Proteins/antagonists & inhibitors ; Hemolysin Proteins/biosynthesis ; Urease/antagonists & inhibitors ; Urease/biosynthesis ; Microbial Sensitivity Tests ; Humans

Fluorescent Probe for the pH-Independent Rapid and Sensitive Direct Detection of Urease-Producing Bacteria.

Authors: Albrich WC; Division of Infectious Diseases, Infection Prevention and Travel Medicine, Kantonsspital St. Gallen, Kantonsspital St. Gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland., Kahlert CR; Division of Infectious Diseases, Infection Prevention and Travel Medicine, Kantonsspital St. Gallen, Kantonsspital St. Gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland.; Infectious Diseases and Hospital Epidemiology, Children's Hospital St. Gallen, Claudiusstr. 6, St. Gallen 9006, Switzerland., Nigg S; Division of Infectious Diseases, Infection Prevention and Travel Medicine, Kantonsspital St. Gallen, Kantonsspital St. Gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland., Boesel LF; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland., Giovannini G; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland.

Source: Analytical chemistry [Anal Chem] 2024 Dec 31; Vol. 96 (52), pp. 20578-20586. Date of Electronic Publication: 2024 Dec 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

MeSH Terms: Urease*/metabolism , Urease*/analysis , Urease*/biosynthesis , Fluorescent Dyes*/chemistry , Klebsiella pneumoniae*/enzymology , Klebsiella pneumoniae*/isolation & purification , Enterobacter cloacae*/enzymology , Enterobacter cloacae*/isolation & purification, Hydrogen-Ion Concentration ; Limit of Detection ; Humans

Overproduction of glycolipopeptide bio-amphiphile by Pseudomonas aeruginosa mutant generated through three-tier cocktail random mutagenesis.

Authors: Ekpenyong M; Environmental Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Biological Sciences, University of Calabar, Calabar, Nigeria. maurygg2002@yahoo.com.; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Calabar, Calabar, Nigeria. maurygg2002@yahoo.com.; University of Calabar Collection of Microorganisms (UCCM), University of Calabar, Calabar, Nigeria. maurygg2002@yahoo.com., Edet P; Department of Microbiology, Faculty of Biological Sciences, University of Cross River State, Calabar, Nigeria., Onwugbuta-Kingsley I; Environmental Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Biological Sciences, University of Calabar, Calabar, Nigeria., Agba L; Environmental Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Biological Sciences, University of Calabar, Calabar, Nigeria.; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Calabar, Calabar, Nigeria., Ekpo B; Environmental Geochemistry Unit, Department of Chemistry, Faculty of Physical Sciences, University of Calabar, Calabar, Nigeria.; Nigerian National Petroleum Corporation (NNPC), Port-Harcourt, Nigeria., Antai S; Environmental Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Biological Sciences, University of Calabar, Calabar, Nigeria.; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Calabar, Calabar, Nigeria.

Source: BMC microbiology [BMC Microbiol] 2026 Feb 14; Vol. 26 (1). Date of Electronic Publication: 2026 Feb 14.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180 (Electronic) Linking ISSN: 14712180 NLM ISO Abbreviation: BMC Microbiol Subsets: MEDLINE

MeSH Terms: Pseudomonas aeruginosa*/genetics , Pseudomonas aeruginosa*/metabolism , Pseudomonas aeruginosa*/drug effects , Pseudomonas aeruginosa*/radiation effects , Glycolipids*/biosynthesis , Glycolipids*/metabolism , Surface-Active Agents*/metabolism , Mutagenesis*, Nickel/metabolism ; Bioreactors/microbiology ; Urease/metabolism ; Methylnitronitrosoguanidine/pharmacology ; Biosurfactants ; Fermentation ; Mutation

Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives.

Authors: Mohammed SO; Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, Khartoum 11111, Sudan., El Ashry SHE; Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21568, Egypt., Khalid A; Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, Khartoum 11111, Sudan.; Substance Abuse and Toxicology Research Center, Jazan University, Jazan 45142, Saudi Arabia., Amer MR; Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21568, Egypt., Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.; Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Riyadh 13713, Saudi Arabia., Elshobaky A; Botany Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt., Hafez EE; Plant Protection and Biomolecular Diagnosis Department, City of Scientific Research and Technological Applications, ARADI, Alexandria 21934, Egypt.

Source: Molecules (Basel, Switzerland) [Molecules] 2022 Jan 27; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 27.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/biosynthesis , Urease*/genetics , Urease*/isolation & purification , Molecular Docking Simulation*, Benzimidazoles/*chemistry , Enzyme Inhibitors/*chemistry , Helicobacter pylori/*enzymology, Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Helicobacter pylori/genetics

Biosynthesis of gold nanoparticles using leaf extract of Salvadora persica and its role in boosting urease performance via immobilization

Authors: Rajnish Kumar Singh, null Jyoti, P. K. Srivastava, Om Prakash

Source: Journal of Plant Biochemistry and Biotechnology. 30:623-628

Subject Terms: 0106 biological sciences, 0301 basic medicine, 03 medical and health sciences, 01 natural sciences

Biosynthesis of microbial urease and its optimization for enhanced production

Authors: Yesra Arshad, Ikram Ul Haq, Muhammad Nauman Aftab, Ali Nawaz

Source: Pakistan Journal of Botany. 56

Biosynthesis of the Urease Metallocenter

Authors: Farrugia, Mark A. ^‡, Macomber, Lee ^§, Hausinger, Robert P. ^{‡, §, 1}

Source: In Journal of Biological Chemistry 10 May 2013 288(19):13178-13185

Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth and virulence.

Authors: Subramaniyan Y; Division of Microbiology and Biotechnology, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Mangalore, 575018, India., Mujeeburahiman M; Department of Urology, Yenepoya Medical College and Hospital, Yenepoya (Deemed to be University), University Road, Mangalore, 575018, India., Khan A; Department of Urology, Yenepoya Medical College and Hospital, Yenepoya (Deemed to be University), University Road, Mangalore, 575018, India., Rekha PD; Division of Microbiology and Biotechnology, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Mangalore, 575018, India. rekhapd@yenepoya.edu.in.

Source: Medical microbiology and immunology [Med Microbiol Immunol] 2025 Aug 05; Vol. 214 (1), pp. 35. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0314524 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1831 (Electronic) Linking ISSN: 03008584 NLM ISO Abbreviation: Med Microbiol Immunol Subsets: MEDLINE

MeSH Terms: Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/biosynthesis , Staphylococcus aureus*/pathogenicity , Staphylococcus aureus*/growth & development , Staphylococcus aureus*/genetics , Staphylococcus aureus*/physiology , Urinary Tract Infections*/microbiology , Trans-Activators*/genetics , Trans-Activators*/metabolism , Trans-Activators*/biosynthesis , Urine*/chemistry , Urine*/microbiology , Quorum Sensing*, Urease/genetics ; Urease/metabolism ; Biofilms/growth & development ; Staphylococcal Infections/microbiology ; Virulence Factors/genetics ; Virulence ; Humans ; Gene Expression Regulation, Bacterial ; Hydrogen-Ion Concentration

Biosynthesis of nano-inorganic materials by urease and phosphatase positive probiotic bacteria

Authors: Sabere Nouri, Rasoul Roghanian, Giti Emtiazi, Rasoul Shafiei

Aspartate Biosynthesis Is Essential for the Growth of Streptococcus thermophilus in Milk, and Aspartate Availability Modulates the Level of Urease Activity

Authors: S. Arioli, C. Monnet, S. Guglielmetti, C. Parini, I. De Noni, J. Hogenboom, P. M. Halami, D. Mora

Contributors: ProdInra, Archive Ouverte, Department of Food Science and Microbiology, Università degli Studi di Milano = University of Milan (UNIMI), Génie et Microbiologie des Procédés Alimentaires (GMPA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Central Food Technological Research Institute

Source: Applied and Environmental Microbiology 18 (73), 5789-5796. (2007)

Subject Terms: 0301 basic medicine, PHOSPHOENOLPYRUVATE CARBOXYLASE, CARBON DIOXIDE METABOLISM, 03 medical and health sciences, MILK, [SDV.EE]Life Sciences [q-bio]/Ecology, Animals, Streptococcus thermophilus, ASPARTATE, bactérie, PPC GENE, Aspartic Acid, 0303 health sciences, streptococcus thermophilus, Lactococcus-lactis, nitrogen-metabolism, acid, bacteria, sequence, proteinase, gene, UREASE ACTIVITY, Streptococcus, Gene Expression Regulation, Bacterial, Yogurt, lait, Urease, [SDV.EE] Life Sciences [q-bio]/Ecology, environment, Milk, Genes, Bacterial, Food Microbiology, environment, Metabolic Networks and Pathways

File Description: application/pdf

Access URL: https://europepmc.org/articles/pmc2074928?pdf=render
https://pubmed.ncbi.nlm.nih.gov/17660309
https://hal.science/hal-01195413v1
https://hal.science/hal-01195413v1/document
https://doi.org/10.1128/aem.00533-07
https://hdl.handle.net/2434/36308
https://doi.org/10.1128/AEM.00533-07
https://hdl.handle.net/10281/459101
https://doi.org/10.1128/AEM.00533-07
http://prodinra.inra.fr/record/11408

Mycofabrication of selenium and tellurium nanoparticles by using Penicillium rubens: In-vitro physicochemical, antimicrobial, antioxidant, urease inhibitory, thrombolytic and anticoagulant performance

Authors: Hamed Barabadi, Fatemeh Ashouri, Kamyar Jounaki, Reza Jahani, Salimeh Amidi, Omid Hosseini, Melika Kamali

Source: Nanomedicine Journal, Vol 12, Iss 1, Pp 70-84 (2025)

Subject Terms: biosynthesis, nanoparticles, penicillium rubens, pharmaceutical research, Medicine (General), R5-920

File Description: electronic resource

Relation: https://nmj.mums.ac.ir/article_25104_af8eb1771fb86c379735007b02326bc2.pdf; https://doaj.org/toc/2322-3049; https://doaj.org/toc/2322-5904

Access URL: https://doaj.org/article/8274d6fcea4043e3a0aa3a88afc6454f

A model‐based proposal for the role of UreF as a GTPase‐activating protein in the urease active site biosynthesis

Authors: M. Salomone Stagni, ZAMBELLI, BARBARA, MUSIANI, FRANCESCO, CIURLI, STEFANO LUCIANO

Source: Proteins: Structure, Function, and Bioinformatics. 68:749-761

Subject Terms: 0301 basic medicine, Protein Folding, 0303 health sciences, Binding Sites, Sequence Homology, Amino Acid, Protein Conformation, Hydrolysis, GTPase-Activating Proteins, Molecular Sequence Data, Bacillus, Urease, 03 medical and health sciences, Bacterial Proteins, Amino Acid Sequence, Phylogeny

Access URL: https://pubmed.ncbi.nlm.nih.gov/17510959

Biosynthesis of Active Bacillus subtilis Urease in the Absence of Known Urease Accessory Proteins

Authors: Jong Kyong, Kim, Scott B, Mulrooney, Robert P, Hausinger

Source: Journal of Bacteriology. 187:7150-7154

Subject Terms: 0301 basic medicine, 0303 health sciences, Hydrolases, Gene Expression Regulation, Bacterial, Urease, Gene Expression Regulation, Enzymologic, Recombinant Proteins, 3. Good health, Enzyme Activation, 03 medical and health sciences, Bacterial Proteins, Nickel, Klebsiella, Guanosine Triphosphate, Bacillus subtilis

Access URL: https://europepmc.org/articles/pmc1251626?pdf=render
https://pubmed.ncbi.nlm.nih.gov/16199586

Isolation, identification, and plant growth-promoting mechanisms of strain BN5, with a focus on exogenously Trp-independent IAA biosynthesis, and its impact on cucumber cultivation

Authors: Cui, Qiannan ^a, Wang, Jie ^a, Huang, Yujie ^{a, ⁎}, Zhou, Fangyuan ^a, Wu, Jinjuan ^b, Song, Fanyong ^a, Zhao, Qingqing ^a, Feng, Rulong ^b, Zhang, Xinjian ^{a, ⁎}

Source: In Current Research in Microbial Sciences 2026 10

Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation.

Authors: Akash, Muhammad¹, Rana, Nehal², Aslam, Sana³ dr.sana@gcwuf.edu.pk, Ahmad, Matloob¹ matloob.ahmad@gcuf.edu.pk, Saif, Muhammad Jawwad⁴, Asghar, Aneeza², Sultan, Sadia^5,6, Al-Hussain, Sami A.⁷, Liaqat, Afifa², Zaib, Sumera² sumera.zaib@ucp.edu.pk, Zaki, Magdi E. A.⁷ mezaki@imamu.edu.sa, Osmaniye, Derya, Sari, Keriman Ozadali, Kafarski, Pawel

Source: Frontiers in Chemistry. 2024, p1-19. 19p.

Subject Terms: *Biosynthesis, *Gastric mucosa, *Urease, *Gas chromatography/Mass spectrometry (GC-MS), *Helicobacter pylori, *Molecular docking

A link between urease and polyamine metabolism in Cryptococcus neoformans

Authors: Toplis, Barbra ^{a, 1}, Bosch, Caylin ^a, Stander, Marietjie ^b, Taylor, Malcolm ^b, Perfect, John R. ^c, Botha, Alfred ^{a, ∗}

Source: In Microbial Pathogenesis September 2021 158

Nic1p, a Relative of Bacterial Transition Metal Permeases inSchizosaccharomyces pombe, Provides Nickel Ion for Urease Biosynthesis

Authors: T, Eitinger, O, Degen, U, Bohnke, M, Muller

Source: Journal of Biological Chemistry. 275:18029-18033

Subject Terms: 0301 basic medicine, 0303 health sciences, Molecular Sequence Data, Biological Transport, Active, Membrane Proteins, Cobalt, Urease, Open Reading Frames, 03 medical and health sciences, Nickel, Mutation, Schizosaccharomyces, Amino Acid Sequence, Schizosaccharomyces pombe Proteins, Carrier Proteins, Cation Transport Proteins, Sequence Alignment

Access URL: http://www.jbc.org/content/275/24/18029.full.pdf
https://pubmed.ncbi.nlm.nih.gov/10748059

Biosynthesis of Calcite Nanocrystal by a Novel Polyextremophile Bhargavaea cecembensis-Related Strain Isolated from Sandy Soil

Authors: Fatemeh Elmi, Zahra Etemadifar, Giti Emtiazi

Source: Microbial Ecology. 85:698-707

Subject Terms: 0301 basic medicine, Soil, 0303 health sciences, 03 medical and health sciences, Bacteria, Sand, RNA, Ribosomal, 16S, Planococcaceae, Nanoparticles, Chemical Precipitation, Urease, Calcium Carbonate

Access URL: https://pubmed.ncbi.nlm.nih.gov/35190857

Klebsiella aerogenes urease gene cluster: sequence of ureD and demonstration that four accessory genes (ureD, ureE, ureF, and ureG) are involved in nickel metallocenter biosynthesis

Authors: M H, Lee, S B, Mulrooney, M J, Renner, Y, Markowicz, R P, Hausinger

Source: Journal of Bacteriology. 174:4324-4330

Subject Terms: DNA, Bacterial, 0301 basic medicine, 0303 health sciences, Base Sequence, Molecular Sequence Data, Restriction Mapping, Urease, 3. Good health, Kinetics, Klebsiella pneumoniae, Open Reading Frames, 03 medical and health sciences, Bacterial Proteins, Genes, Bacterial, Nickel, Multigene Family, Sequence Homology, Nucleic Acid, Metalloproteins, Escherichia coli, Amino Acid Sequence, Chromosome Deletion, Cloning, Molecular, Proteus mirabilis, Plasmids

Access URL: http://jb.asm.org/content/174/13/4324.full.pdf
https://pubmed.ncbi.nlm.nih.gov/1624427