Protein-inorganic hybrid nanoflowers with enhanced laccase-like activity for optical analysis of urease.

Authors: Feng S; Changchun Veterinary Research Institude, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China. Electronic address: 17839959954@163.com., Wang X; Changchun Veterinary Research Institude, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, School of Public Health, Jilin University, Changchun, 130012, China., Li Y; Changchun Veterinary Research Institude, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, School of Public Health, Jilin University, Changchun, 130012, China., Li J; Changchun Veterinary Research Institude, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China; School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, China., An X; Changchun Veterinary Research Institude, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China., Zhou B; Changchun Veterinary Research Institude, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China. Electronic address: hottank3210@126.com., Sun J; College of Pharmacy, Xinjiang Key Laboratory of Biopharmaceuticals and Medical Devices, Xinjiang Medical University, Urumqi, 830017, China. Electronic address: sun@xjmu.edu.cn.

Source: Analytica chimica acta [Anal Chim Acta] 2026 May 15; Vol. 1399, pp. 345315. Date of Electronic Publication: 2026 Feb 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

MeSH Terms: Urease*/analysis , Urease*/metabolism , Copper*/chemistry , Serum Albumin, Bovine*/chemistry , Serum Albumin, Bovine*/metabolism , Laccase*/chemistry , Laccase*/metabolism , Nanostructures*/chemistry, Colorimetry/methods ; Animals ; Cattle ; Limit of Detection

Cyclopentyl-linked N-Acylthioureas as Promising Urease Inhibitors: Insights from in vitro Bioassay, Structure-activity Relationships and Computational Analysis

Authors: Khansa, Mumtaz, Sumera, Zaib, Aamer, Saeed, Atteeque, Ahmed, Afifa Tur, Rehman, Aneeza Asghar, Imtiaz, Khan

Source: Acta Chimica Slovenica. 72:798-809

Subject Terms: Molecular Docking Simulation, Structure-Activity Relationship, Helicobacter pylori, Thiourea, Biological Assay, Cyclopentanes, Enzyme Inhibitors, Molecular Dynamics Simulation, Urease

Access URL: https://pubmed.ncbi.nlm.nih.gov/41408815

Synthesis of thiosemicarbazone derivatives of thiophene-2-carboxylic acid as potent urease inhibitors: in vitro evaluation, molecular docking, and density functional theory analysis.

Authors: Khan W; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Laiba; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Ahmad I; Programa de Pós-Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Pelotas, Brazil., Elhenawy AA; Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt., Shah SAA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA Puncak Alam Campus, Bandar Puncak Alam, Malaysia.; Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Malaysia., Alanazi AS; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Shakoor A; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Alam A; Department of Chemistry, Rawalpindi Women University, Rawalpindi, Pakistan., Khan M; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Source: Future medicinal chemistry [Future Med Chem] 2026 Aug; Vol. 18 (16), pp. 2147-2159. Date of Electronic Publication: 2026 Jul 13.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Thiosemicarbazones*/chemistry , Thiosemicarbazones*/chemical synthesis , Thiosemicarbazones*/pharmacology , Thiophenes*/chemistry , Thiophenes*/pharmacology , Thiophenes*/chemical synthesis , Density Functional Theory*, Molecular Docking Simulation ; Structure-Activity Relationship ; Molecular Structure ; Molecular Dynamics Simulation ; Carboxylic Acids

Double-site rapid urease test versus histopathology for the diagnosis of Helicobacter pylori among patients with dyspepsia on proton pump inhibitors-A diagnostic accuracy study.

Authors: Yadav AI; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Jearth V; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India. vaneet.jearth@gmail.com., Sharma AK; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Singh AK; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Chauhan P; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Patial P; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Sekar A; Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Shah J; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Mandavdhare H; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Rana SS; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Dutta U; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India.

Source: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2026 Aug; Vol. 45 (4), pp. 706-714. Date of Electronic Publication: 2025 Jun 12.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Springer India Country of Publication: India NLM ID: 8409436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0975-0711 (Electronic) Linking ISSN: 02548860 NLM ISO Abbreviation: Indian J Gastroenterol Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Helicobacter Infections*/pathology , Helicobacter Infections*/complications , Helicobacter pylori*/isolation & purification , Helicobacter pylori*/genetics , Proton Pump Inhibitors*/adverse effects , Proton Pump Inhibitors*/administration & dosage , Dyspepsia*/etiology , Dyspepsia*/microbiology , Dyspepsia*/drug therapy , Urease*/analysis, Humans ; Prospective Studies ; Female ; Biopsy ; Sensitivity and Specificity ; Polymerase Chain Reaction ; Male ; Predictive Value of Tests ; Middle Aged ; Rapid Diagnostic Tests ; Adult

Predictive Analysis of Dental Caries Risk via Rapid Urease Activity Evaluation in Saliva Using a ZIF‑8 Nanoporous Membrane

Authors: Zhou, Bao-Yi^aff1, Shi, Xiao-Yan^aff2, Luo, Zhao-Ying^aff1, Pan, Zhong-Qin^aff1, Gu, Hai-Ying^aff1, Liu, Yang^aff1, Shi, Xin-He^aff3, Wu, Zeng-Qiang^aff1

Source: ACS Sensors. 10(6):3888-3897

Availability: https://pubs.acs.org/doi/10.1021/acssensors.4c03091

Comparative Data Analysis of Virtual Screening Methodologies for Predicting Urease Inhibitory Activity

Authors: Valdés-Muñoz, Elizabeth^{aff1, aff2}, Olguín-Orellana, Gabriel J.^aff3, Ríos-Rozas, Sofía E.^aff2, Alegría-Arcos, Melissa^aff4, Morales, Natalia^{aff2, aff5}, Rojas-Santander, Vicente^aff2, Farías-Abarca, Javier^aff2, Palma, Jonathan M.^aff6, Hernández-Rodríguez, Erix W.^aff2, Suardíaz, Reynier^aff7, Bustos, Daniel^aff2

Source: ACS Omega. 10(42):49641-49658

Availability: https://pubs.acs.org/doi/10.1021/acsomega.5c04457

Pyridine Bistriazole and Its Metal Complexes: Synthesis, Optical Analysis, Urease Inhibition, and Molecular Docking

Authors: Zahid, Muhammad^Aff1, Tahir, Tehreem^Aff2, Rafiq, Muhammad^Aff3, Paracha, Rizwan Nasir^{Aff4, IDS1070363226601080_cor1}, Zhang, Jian^{Aff1, IDS1070363226601080_cor2}, Saleem, Muhammad^{Aff4, IDS1070363226601080_cor3}

Source: Russian Journal of General Chemistry. 96(8)

Green synthesis of silver nanoparticles using Citrullus colocynthis fruit: phytochemical analysis, antioxidant, and urease, carbonic anhydrase, and xanthine oxidase inhibition activities

Authors: Tayyeba, Rehman, Aymen Owais, Ghauri, Laila, Sumreen, Ume, Habiba, Shehla, Akbar

Source: Natural Product Research. :1-6

Access URL: https://pubmed.ncbi.nlm.nih.gov/41342358

Synthesis, characterizations, structural elucidation, computational analysis, and urease inhibitory activity of vitamin B6–derived Schiff base complexes

Authors: Karim, Amir ^{a, b}, Jabbar, Abdul ^a, Ullah, Atta ^a, Halim, Sobia Ahsan ^a, Malekshah, Rahime Eshaghi ^b, Khan, Ajmal ^a, Al-Harrasi, Ahmed ^{a, ⁎}, Anwar, Muhammad U. ^{a, ⁎}

Source: In Inorganic Chemistry Communications June 2026 188 Part 1

Design, synthesis, anti-urease activity, molecular docking, molecular dynamics, DFT analysis, and ADMET profiling of new barbiturate-phenylhydrazone-acetamide derivatives

Authors: Sayahi, Mohammad Hosein ^{a, 1}, Zareei, Samira ^{b, 1}, Ahmad, Iqrar ^{c, d}, Moazzam, Ali ^e, Khademian, Aynaz ^f, Amanlou, Massoud ^{g, h}, Larijani, Bagher ^e, Mohammadi-Khanaposhtani, Maryam ^{i, ⁎}, Mahdavi, Mohammad ^{e, ⁎}

Source: In Results in Chemistry September 2026 29

Synthesis, crystal structure, hirshfeld surface analysis, and inhibition of urease and carbonic anhydrase by azomethine compounds

Authors: Latif, Saba ^a, Khan, Bilal Ahmad ^{a, ⁎}, Sayed, Mardia T. El ^b, Ahmad, Balal ^a, Khushal, Aneela ^c, Yousuf, Sammer ^d, Ashfaq, Muhammad ^e, Khan, Sara ^c, Munawar, Khurram Shahzad ^{f, g}, Farooq, Umar ^c, Ragab, Ahmed H. ^h, Gumaah, Najla F. ⁱ

Source: In Journal of Molecular Structure 5 November 2025 1344

Reinforcement of urease through encapsulation with β-Cyclodextrin-based bioconjugates: A comparative analysis and kinetic assessment

Authors: Rai, Shailja ^a, Pande, Poorn Prakash ^a, Kumar, Krishna ^{b, ⁎}, Tungala, Kranthikumar ^c, Tiwari, Rudramani ^d, Parwati, Km ^e, Krishnamoorthi, S. ^e, Chaudhary, Aradhana ^a, Dutta, Arunava ^f, Prasad, Tarkeshwar ^a, Singh, Vinai Kumar ^g

Source: In Reactive and Functional Polymers January 2026 218

Nitrification and urease inhibitors (NUIs) in soil and water: Environmental fate, distribution, and risk assessment.

Authors: Wang X; School of Biosystems and Food Engineering, Agriculture and Food Science Centre, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: xin.wang@ucd.ie., Forrestal PJ; Teagasc, Soils, Environment and Land Use Department, Crops Environment and Land Use Programme, Johnstown Castle, Co. Wexford, Ireland. Electronic address: Patrick.Forrestal@teagasc.ie., Richards K; Teagasc Climate Centre, Johnstown Castle, Co. Wexford, Ireland. Electronic address: Karl.Richards@teagasc.ie., Matse DT; Teagasc, Soils, Environment and Land Use Department, Crops Environment and Land Use Programme, Johnstown Castle, Co. Wexford, Ireland. Electronic address: Dumsane.Matse@teagasc.ie., Cummins E; School of Biosystems and Food Engineering, Agriculture and Food Science Centre, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: enda.cummins@ucd.ie.

Source: The Science of the total environment [Sci Total Environ] 2025 Nov 15; Vol. 1004, pp. 180796. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Soil Pollutants*/analysis , Water Pollutants, Chemical*/analysis , Enzyme Inhibitors*/analysis , Nitrification* , Environmental Monitoring*, Soil/chemistry ; Fertilizers/analysis ; Risk Assessment

A Study on the Combined Application of Gastroscopy and the Rapid Urease Test in Paediatric Gastric Disorders.

Authors: Song X; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Lu H; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Zhao C; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Ma T; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Tian D; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Zhang G; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China.

Source: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2026 Apr; Vol. 36 (4), pp. 489-492.

Publication Type: Journal Article

Journal Info: Publisher: College of Physicians and Surgeons Pakistan Country of Publication: Pakistan NLM ID: 9606447 Publication Model: Print Cited Medium: Internet ISSN: 1681-7168 (Electronic) Linking ISSN: 1022386X NLM ISO Abbreviation: J Coll Physicians Surg Pak Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Gastroscopy*/methods , Urease*/analysis , Urease*/metabolism , Helicobacter pylori*/isolation & purification , Stomach Diseases*/diagnosis , Stomach Diseases*/microbiology, Breath Tests/methods ; Humans ; Female ; Child ; Male ; Adolescent ; Child, Preschool ; Sensitivity and Specificity ; Biopsy ; China ; Rapid Diagnostic Tests ; ROC Curve

Synthesis, characterization, DFT calculations, comparative in vitro and in silico screening of anti-bacterial, anti-urease and α-amylase inhibition activities of indole derivatives with hirshfeld surface analysis and crystal structure explorations of Bis(4,6-dimethoxy-2,3-diphenyl-1H-7,7΄-indolylmethane

Authors: Rubab, Syeda Laila ^{a, ⁎}, Rehman, Muhammad Fayyaz ur ^b, Raza, Abdul Rauf ^b, Ashfaq, Muhammad ^c, Al-Hussain, Sami A. ^d, Akhter, Shahzaib ^b, Tahir, Muhammad Nawaz ^c, Mustafvi, Isra ^a, Irfan, Ali ^{e, ⁎}, Zaki, Magdi E.A. ^{d, ⁎}

Source: In Journal of Molecular Structure 15 September 2025 1340

Computational Study of Amino Acid-Transition Metal Complexes as potential Helicobacter pylori Urease Enzyme Inhibitors: DFT, Molecular Docking and ADMET analysis

Authors: Muhammad Mustapha Abdullahi, Safiya Abdulsalam, Sa’adatu Auwal Hamza, Medina Imam

The Environmental Afterlife of Nitrification and Urease Inhibitors: A meta-analysis of Transformation and Fate

Authors: Eva Weidemann, Matthias Gassmann

Oral urease rapid test serve as an effective complement to the detection of Helicobacter pylori infection through urea breath test.

Authors: He Y; Gastrointestinal Surgery Department of Jiangmen Central Hospital, Jiangmen, Guangdong, China.; Digestive Disease Research Center of Jiangmen Central Hospital, Jiangmen, Guangdong, China., Wang C; Gastrointestinal Surgery Department of Jiangmen Central Hospital, Jiangmen, Guangdong, China.; Digestive Disease Research Center of Jiangmen Central Hospital, Jiangmen, Guangdong, China., Luo W; Gastroenterology Department of Panyu District Central Hospital, Guangzhou, Guangdong, China., Lin W; Gastrointestinal Surgery Department of Jiangmen Central Hospital, Jiangmen, Guangdong, China.; Digestive Disease Research Center of Jiangmen Central Hospital, Jiangmen, Guangdong, China., Li S; Gastrointestinal Surgery Department of Jiangmen Central Hospital, Jiangmen, Guangdong, China.; Digestive Disease Research Center of Jiangmen Central Hospital, Jiangmen, Guangdong, China., Xie F; Gastroenterology Department of Panyu District Central Hospital, Guangzhou, Guangdong, China., Zhou C; Gastrointestinal Surgery Department of Jiangmen Central Hospital, Jiangmen, Guangdong, China.; Digestive Disease Research Center of Jiangmen Central Hospital, Jiangmen, Guangdong, China., Shen J; Gastroenterology Department of Panyu District Central Hospital, Guangzhou, Guangdong, China., Zou W; Nuclear Medicine Department of Jiangmen Central Hospital, Jiangmen, Guangdong, China., Zhong J; Digestive Disease Research Center of Jiangmen Central Hospital, Jiangmen, Guangdong, China., Wan Y; Gastroenterology Department of Panyu District Central Hospital, Guangzhou, Guangdong, China. wanyur@163.com., Zhao J; Gastrointestinal Surgery Department of Jiangmen Central Hospital, Jiangmen, Guangdong, China. zhaojinglin@jmszxyy.com.cn.; Digestive Disease Research Center of Jiangmen Central Hospital, Jiangmen, Guangdong, China. zhaojinglin@jmszxyy.com.cn.

Source: BMC gastroenterology [BMC Gastroenterol] 2025 Nov 28; Vol. 25 (1), pp. 846. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Urease*/analysis , Helicobacter pylori*/isolation & purification, Breath Tests/methods ; Urea/analysis ; Dental Plaque/microbiology ; Tongue/microbiology ; Humans ; Sensitivity and Specificity ; Female ; Double-Blind Method ; Male ; Adult ; Predictive Value of Tests ; Middle Aged ; Rapid Diagnostic Tests ; Young Adult

Design, structural analysis, and biological evaluation of four mononuclear copper(II) complexes as potent urease inhibitors: Insights from experimental and theoretical studies

Authors: Wang, Hu ^{a, c}, Guo, Pengxiao ^{a, c}, Yin, Chaochuang ^a, Zhou, Yadong ^d, Lei, Yizhu ^a, Wu, Tingting ^a, Wang, Yinyan ^a, Chen, Kang ^a, Sun, Li ^a, Zong, Ziao ^{b, ⁎}, Luo, Huaijun ^{e, f, ⁎}

Source: In Journal of Molecular Structure 5 November 2025 1344

Structural Analysis and Molecular Dynamics Simulations of Urease From Ureaplasma parvum

Authors: Wu, Heng Ning ¹, Fujita, Junso ^{2, 3, 4}, Nakura, Yukiko ¹, Inoue, Masao ⁵, Suzuki, Koichiro ^{6, 7}, Ekimoto, Toru ⁵, Yin, Bingjie ^{1, 10}, Fukuda, Yohta ^{4, 8}, Harada, Kazuo ⁴, Inoue, Tsuyoshi ^{4, 8}, Ikeguchi, Mitsunori ^{5, 9}, Namba, Keiichi ^{2, 3}, Yanagihara, Itaru ^{1, 10, ⁎}

Source: In Journal of Molecular Biology 1 November 2025 437(21)