Correlation Between the Proportion of Senescence-Associated β-Galactosidase-Stained CD8+ T Cells and Age: A Cross-Sectional Study in Japan.

Authors: Tsubokawa M; FANCL Research Institute, Yokohama 244-0806, Japan., Shimizu Y; FANCL Research Institute, Yokohama 244-0806, Japan., Yazaki M; FANCL Research Institute, Yokohama 244-0806, Japan., Shimodan S; FANCL Research Institute, Yokohama 244-0806, Japan., Noguchi M; FANCL Research Institute, Yokohama 244-0806, Japan., Yamazaki A; FANCL Research Institute, Yokohama 244-0806, Japan., Watanabe T; FANCL Research Institute, Yokohama 244-0806, Japan., Ocho M; FANCL Research Institute, Yokohama 244-0806, Japan., Sakurada T; FANCL Research Institute, Yokohama 244-0806, Japan., Hirose Y; Ginza Yoshie Clinic, Yukeikai Medical Corporation, V88 Building 5F, 2-5-11 Ginza, Chuo-ku, Tokyo 104-0061, Japan., Saito J; Medical Station Clinic, 3F Ichikawa Gakugei-dai Building, 3-12-8 Takaban, Meguro-ku, Tokyo 152-0004, Japan., Ishii Y; FANCL Research Institute, Yokohama 244-0806, Japan.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Sep 10; Vol. 26 (18). Date of Electronic Publication: 2025 Sep 10.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: T-Cell Senescence* , CD8-Positive T-Lymphocytes*/chemistry , CD8-Positive T-Lymphocytes*/enzymology , beta-Galactosidase*/analysis , beta-Galactosidase*/metabolism, Age Factors ; Japan/epidemiology ; Cross-Sectional Studies ; Humans ; Adult ; Middle Aged ; Memory T Cells/chemistry ; Memory T Cells/enzymology ; Biomarkers ; Male ; Female

Mitochondrial unfolded protein response in regulatory T cell function: a protective mechanism in immune aging.

Authors: Lewis L; Department of Surgery - Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, United States., Valvi D; Department of Surgery - Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, United States., Gedaly R; Department of Surgery - Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, United States.; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, United States.; Alliance Research Initiative (TILT Alliance), College of Medicine, University of Kentucky, Lexington, KY, United States., Marti F; Department of Surgery - Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, United States.; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, United States.; Alliance Research Initiative (TILT Alliance), College of Medicine, University of Kentucky, Lexington, KY, United States.

Source: Frontiers in immunology [Front Immunol] 2025 Jun 30; Vol. 16, pp. 1621759. Date of Electronic Publication: 2025 Jun 30 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Protein Unfolding* , Mitochondrial Proteins*/immunology , Mitochondrial Proteins*/metabolism , T-Lymphocytes, Regulatory*/immunology , T-Cell Senescence*, Humans ; Animals ; Stress, Physiological ; Unfolded Protein Response

Innate lymphoid cells prevent graft-versus-host disease via IL-9-driven T-cell senescence.

Authors: Tufa DM; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Hoffmeyer E; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Schaller KL; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Kooiman B; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Woods E; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Wang D; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Jones D; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Hall S; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Cruz JC; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO., Verneris MR; Department of Children's Cancer and Blood Disorders, University of Colorado and Children's Hospital of Colorado, Aurora, CO.

Source: Blood [Blood] 2025 Nov 27; Vol. 146 (22), pp. 2656-2669.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/immunology , Graft vs Host Disease*/immunology , Graft vs Host Disease*/prevention & control , Graft vs Host Disease*/pathology , Immunity, Innate* , T-Lymphocytes*/immunology , T-Lymphocytes*/pathology , Interleukin-9*/immunology , Lymphocytes*/immunology, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/cytology ; T-Cell Senescence

Accelerated T-cell senescence and persistent inflammation in older adults with rheumatoid arthritis.

Authors: Cezar CD; Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Scholl JN; Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; National Institute of Science and Technology - Neuroimmunomodulation (INCT-NIM), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brasília, Brazil., Rabelo CF; Rheumatology Unit, Hospital São Lucas da PUCRS, Porto Alegre, Brazil., Madruga MP; Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., da Silva PL; Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Grun LK; Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Graduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University at Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Engroff P; Institute of Geriatrics and Gerontology, PUCRS, Porto Alegre, Brazil., Bressanim ACM; Institute of Geriatrics and Gerontology, PUCRS, Porto Alegre, Brazil., Scherer RT; Institute of Geriatrics and Gerontology, PUCRS, Porto Alegre, Brazil., Schwanke CHA; Institute of Geriatrics and Gerontology, PUCRS, Porto Alegre, Brazil; Graduate Programe in Biomedical Gerontology, School of Medicine, PUCRS, Porto Alegre, Brazil., Barbé-Tuana F; Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Graduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University at Rio Grande do Sul (PUCRS), Porto Alegre, Brazil., Sato DK; Institute of Geriatrics and Gerontology, PUCRS, Porto Alegre, Brazil; Instituto do Cérebro do Rio Grande do Sul (InsCer), PUCRS, Porto Alegre, Brazil., Bauer ME; Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Graduate Programe in Biomedical Gerontology, School of Medicine, PUCRS, Porto Alegre, Brazil; National Institute of Science and Technology - Neuroimmunomodulation (INCT-NIM), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brasília, Brazil. Electronic address: mebauer@pucrs.br.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Nov 14; Vol. 165, pp. 115518. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Arthritis, Rheumatoid*/immunology , Cellular Senescence*/immunology , T-Lymphocytes*/immunology , Inflammation*/immunology, Humans ; Aged ; Male ; Female ; Cytokines/blood ; Cytokines/metabolism ; Middle Aged ; Immunosenescence ; Cells, Cultured ; Aged, 80 and over ; T-Cell Senescence

An age-related decrease in leptin contributes to CD8 ⁺ T cell aging in the tumor microenvironment.

Authors: Wang F; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, China; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Bao R; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Xu S; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Li W; Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China., Huang H; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Li R; Department of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China., Ding X; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zhang Y; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Yu X; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Han Q; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Du X; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Wan J; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Li S; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Xiao Y; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Zhao R; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Cui X; Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China., Ye Y; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: youqiong.ye@shsmu.edu.cn., Sun J; Department of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. Electronic address: xkyyjysun@163.com., Zheng J; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: zhengjunke@shsmu.edu.cn., Chen GQ; Institute of Aging & Tissue Regeneration, Stress and Cancer Research Unit of Chinese Academy of Medical Sciences, State Key Laboratory of Systems Medicine for Cancer, Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; School of Basic Medicine and Life Science, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan 571199, China. Electronic address: chengq@shsmu.edu.cn., Zou Q; Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: qzou1984@sjtu.edu.cn.

Source: Cell reports. Medicine [Cell Rep Med] 2025 Sep 16; Vol. 6 (9), pp. 102310. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

MeSH Terms: Leptin*/metabolism , Leptin*/blood , Tumor Microenvironment*/immunology , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Cellular Senescence* , Aging*/immunology , Neoplasms*/pathology , Neoplasms*/immunology, Humans ; Animals ; Mice ; Mice, Inbred C57BL ; Adipocytes/metabolism ; Male ; Female ; Signal Transduction ; Aged ; T-Cell Senescence

T-cell senescence: Unlocking the tumor immune "Dark Box" - A multidimensional analysis from mechanism to tumor immunotherapeutic intervention.

Authors: Cheng J; Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China; Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Xiamen 361004, China; Xiamen Municipal Key Laboratory of Gastrointestinal Oncology, Xiamen 361004, China. Electronic address: chengjia@xmu.edu.cn., Zheng J; Department of Pathology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China., Ma C; Department of Emergency Internal Medicine, Zibo Central Hospital, Zibo 255024, China., Li Y; Department of Urology, Hebei Provincial Hospital of Chinese Medicine, Shijiazhuang 050017, China. Electronic address: iyz@hebcm.edu.cn., Hao H; Department of Pathology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China. Electronic address: haohua410@tongji.edu.cn.

Source: Seminars in cancer biology [Semin Cancer Biol] 2025 Aug; Vol. 113, pp. 190-209. Date of Electronic Publication: 2025 May 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9010218 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3650 (Electronic) Linking ISSN: 1044579X NLM ISO Abbreviation: Semin Cancer Biol Subsets: MEDLINE

MeSH Terms: Neoplasms*/immunology , Neoplasms*/therapy , Neoplasms*/pathology , Cellular Senescence*/immunology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Immunotherapy*/methods , Immunosenescence*/immunology, Humans ; Tumor Microenvironment/immunology ; Animals ; T-Cell Senescence

Impact of cellular composition and T-cell senescence of mononuclear cell concentrates on the manufacturing process of chimeric antigen receptor (CAR) T-cells.

Authors: Vučinić V; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Tumewu T; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Brückner M; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Kirchberg J; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Jentzsch M; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Buhmann R; Institute for Transfusion Medicine, University Leipzig Medical Center, Leipzig, Germany., Remane Y; Pharmacy, University Leipzig Medical Center, Leipzig, Germany., Hoffmann S; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Ramdohr F; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Merz M; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Metzeler KH; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Schwind S; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Herling C; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Krauß SM; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Herling M; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Franke GN; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Grieb N; Innovation Center Computer Assisted Surgery (ICCAS), University Leipzig, Leipzig, Germany., Stachel G; Medical Clinic and Policlinic for Cardiology, Leipzig University Medical Center, Leipzig, Germany., Janz M; Campus Benjamin-Franklin, University Berlin, Berlin, Germany., Penack O; Campus Virchow-Klinikum, University Berlin, Berlin, Germany., Bullinger L; Campus Virchow-Klinikum, University Berlin, Berlin, Germany., Keller U; Campus Benjamin-Franklin, University Berlin, Berlin, Germany., Cross M; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Henschler R; Institute for Transfusion Medicine, University Leipzig Medical Center, Leipzig, Germany., Bach E; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany., Platzbecker U; Medical Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig University Medical Center, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig, Germany.

Source: Transfusion [Transfusion] 2025 Sep; Vol. 65 (9), pp. 1650-1661. Date of Electronic Publication: 2025 Jul 29.

Publication Type: Journal Article

Journal Info: Publisher: American Association Of Blood Banks Country of Publication: United States NLM ID: 0417360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-2995 (Electronic) Linking ISSN: 00411132 NLM ISO Abbreviation: Transfusion Subsets: MEDLINE

MeSH Terms: Receptors, Chimeric Antigen*/metabolism , T-Lymphocytes*/cytology , T-Lymphocytes*/metabolism , T-Lymphocytes*/immunology , Immunotherapy, Adoptive*/methods , Cellular Senescence* , Leukocytes, Mononuclear*/cytology , Leukocytes, Mononuclear*/metabolism, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Aged ; Receptors, Antigen, T-Cell ; Adult ; T-Cell Senescence

Is T-cell senescence associated with inflammatory arthritis and disease burden? A systematic review.

Authors: Qooja S; National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK., Roberts MJ; National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK., Fakher N; Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Demashkieh M; National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK., Moorthy A; Department of Rheumatology, University Hospitals of Leicester NHS Trust, College of Life Sciences, University of Leicester, Leicester, UK., Bishop NC; National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. Electronic address: n.c.bishop@lboro.ac.uk.

Source: Seminars in arthritis and rheumatism [Semin Arthritis Rheum] 2025 Aug; Vol. 73, pp. 152757. Date of Electronic Publication: 2025 May 14.

Publication Type: Journal Article; Systematic Review

Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 1306053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-866X (Electronic) Linking ISSN: 00490172 NLM ISO Abbreviation: Semin Arthritis Rheum Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/immunology , T-Lymphocytes*/immunology , Arthritis, Rheumatoid*/immunology , Arthritis, Psoriatic*/immunology, Humans ; Cost of Illness ; T-Cell Senescence

CD49d promotes T-cell senescence in chronic lymphocytic leukaemia.

Authors: Wang M; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China., Guo Z; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China., Zhao S; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China., Liu L; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China., Shi Y; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China., Li H; Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Su J; Department of Hematology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China., Zhang N; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China., Li J; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China., Wu Y; Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China.; Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Source: British journal of haematology [Br J Haematol] 2025 Jul; Vol. 207 (1), pp. 80-91. Date of Electronic Publication: 2025 May 15.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

MeSH Terms: Leukemia, Lymphocytic, Chronic, B-Cell*/immunology , Leukemia, Lymphocytic, Chronic, B-Cell*/pathology , Leukemia, Lymphocytic, Chronic, B-Cell*/genetics , Leukemia, Lymphocytic, Chronic, B-Cell*/metabolism , Cellular Senescence*/immunology , Integrin alpha4*/genetics , Integrin alpha4*/immunology , Integrin alpha4*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , CD8-Positive T-Lymphocytes*/pathology , CD4-Positive T-Lymphocytes*/immunology , CD4-Positive T-Lymphocytes*/metabolism , CD4-Positive T-Lymphocytes*/pathology, Humans ; Female ; Male ; Middle Aged ; Aged ; T-Cell Senescence

CD4 ⁺ T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets.

Authors: Gao Y; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China., Lu Y; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China., Liang X; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China., Zhao M; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China., Yu X; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China., Fu H; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China., Yang W; Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.

Source: Cells [Cells] 2024 Apr 25; Vol. 13 (9). Date of Electronic Publication: 2024 Apr 25.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: CD4-Positive T-Lymphocytes*/immunology , Neurodegenerative Diseases*/immunology , Neurodegenerative Diseases*/pathology , Neurodegenerative Diseases*/therapy , T-Cell Senescence*, Animals ; Humans ; Aging/immunology ; Aging/pathology

Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy.

Authors: Admasu TD; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA., Yu JS; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Kairos Pharma, Los Angeles, California, USA.

Source: Aging cell [Aging Cell] 2025 May; Vol. 24 (5), pp. e70055. Date of Electronic Publication: 2025 Apr 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

MeSH Terms: Neoplasms*/immunology , Neoplasms*/therapy , Immunotherapy*/methods , Cellular Senescence*/immunology , T-Lymphocytes*/immunology , Rejuvenation*, Humans ; Animals ; T-Cell Senescence

LAMA4 ⁺ CD90 ⁺ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8 ⁺ T cell senescence.

Authors: Zhang J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China.; Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei, 230031, China., Li Z; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China.; Department of Genetics, School of Life Science, Anhui Medical University, Hefei, 230031, China., Zhang Q; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Ma W; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Fan W; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Dong J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Tian J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Liao H; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China., Guo J; Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University, Hefei, 230031, China., Cao Y; Kiang Wu Hospital, Macao SAR, Macao, China., Yin J; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China. yinjiang20@gzhmu.edu.cn., Zheng G; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China. zhengguopei@126.com., Li N; Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Hengzhigang Road 78#, Guangzhou, 510095, China. Linan_gz2013@163.com.

Source: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Apr 28; Vol. 23 (1), pp. 203. Date of Electronic Publication: 2025 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE

MeSH Terms: Liver Neoplasms*/immunology , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , CD8-Positive T-Lymphocytes*/immunology , Tumor Microenvironment*/immunology , Thy-1 Antigens*/metabolism , Cellular Senescence* , Laminin*/metabolism , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/immunology , Cancer-Associated Fibroblasts*/pathology , Extracellular Matrix*/metabolism, Animals ; Mice ; Humans ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/immunology ; Mice, Inbred C57BL ; Cell Line, Tumor ; Male ; T-Cell Senescence

T cell aging and exhaustion: Mechanisms and clinical implications.

Authors: Zhang W; School of Medicine, Nankai University, Tianjin, China; Research Institute of Transplant Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory for Organ Transplantation, Tianjin, China. Electronic address: drzwq2022@mail.nankai.edu.cn., Kong D; School of Medicine, Nankai University, Tianjin, China; Research Institute of Transplant Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory for Organ Transplantation, Tianjin, China. Electronic address: dejunk@tmu.edu.cn., Zhang X; School of Medicine, Nankai University, Tianjin, China; Research Institute of Transplant Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory for Organ Transplantation, Tianjin, China. Electronic address: zhangxiaohan1212@126.com., Hu L; Tianjin Medical University First Central Clinical College, Tianjin, China. Electronic address: hl7711@tmu.edu.cn., Nian Y; School of Medicine, Nankai University, Tianjin, China; Research Institute of Transplant Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory for Organ Transplantation, Tianjin, China; Key Laboratory of Transplant Medicine, Chinese Academy of Medical Science, Tianjin, China; Department of Kidney Transplant, Tianjin First Central Hospital, Tianjin, China. Electronic address: nianyeqi0314@hotmail.com., Shen Z; School of Medicine, Nankai University, Tianjin, China; Research Institute of Transplant Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory for Organ Transplantation, Tianjin, China; Key Laboratory of Transplant Medicine, Chinese Academy of Medical Science, Tianjin, China. Electronic address: zhongyangshen@nankai.edu.cn.

Source: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2025 Jun; Vol. 275, pp. 110486. Date of Electronic Publication: 2025 Mar 20.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE

MeSH Terms: Cellular Senescence*/immunology , T-Lymphocytes*/immunology, Humans ; Animals ; Adaptive Immunity/immunology ; T-Cell Senescence

Dual roles of IRE1α inhibition in reversing mitochondrial ROS-induced CD8 ⁺ T-cell senescence and exerting direct antitumor effects in multiple myeloma.

Authors: Wan Y; Department of Hematology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang J; Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China., Chen M; Department of Hematology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang J; Department of Hematology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Nan F; The Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Huang H; Department of Hematology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu Z; Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China houjian@medmail.com.cn zqliu@sdfmu.edu.cn., Hou J; Department of Hematology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China houjian@medmail.com.cn zqliu@sdfmu.edu.cn.

Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 May 26; Vol. 13 (5). Date of Electronic Publication: 2025 May 26.

Publication Type: Journal Article

Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

MeSH Terms: Multiple Myeloma*/drug therapy , Multiple Myeloma*/pathology , Multiple Myeloma*/immunology , Multiple Myeloma*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , CD8-Positive T-Lymphocytes*/drug effects , Reactive Oxygen Species*/metabolism , Endoribonucleases*/antagonists & inhibitors , Endoribonucleases*/metabolism , Mitochondria*/metabolism , Mitochondria*/drug effects , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Cellular Senescence*/drug effects, Animals ; Humans ; Mice ; Cell Line, Tumor ; T-Cell Senescence

Meta-epigenetic shifts in T cell aging and aging-related dysfunction.

Authors: Rousseau L; Department of Fundamental Oncology, University of Lausanne, 155 Ch. Des Boveresses, 1066, Epalinges, Switzerland.; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland., Hajdu KL; Department of Fundamental Oncology, University of Lausanne, 155 Ch. Des Boveresses, 1066, Epalinges, Switzerland.; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland., Ho PC; Department of Fundamental Oncology, University of Lausanne, 155 Ch. Des Boveresses, 1066, Epalinges, Switzerland. ping-chih.ho@unil.ch.; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland. ping-chih.ho@unil.ch.

Source: Journal of biomedical science [J Biomed Sci] 2025 May 23; Vol. 32 (1), pp. 51. Date of Electronic Publication: 2025 May 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE

MeSH Terms: Epigenesis, Genetic* , Aging*/genetics , Aging*/immunology , T-Lymphocytes*/immunology , T-Lymphocytes*/physiology , Cellular Senescence*/genetics , Cellular Senescence*/immunology, Humans ; DNA Methylation ; Animals ; T-Cell Senescence

T-cell Senescence in the Tumor Microenvironment.

Authors: Huang L; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China., Zhang C; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China., Jiang A; Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China., Lin A; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.; Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China., Zhu L; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China., Mou W; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zeng D; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Cancer Center, the Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, China., Liu Z; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Tang B; Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China., Zhang J; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China., Cheng Q; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China., Miao K; Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China., Wei T; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China., Luo P; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.; Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.

Source: Cancer immunology research [Cancer Immunol Res] 2025 May 02; Vol. 13 (5), pp. 618-632.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Cellular Senescence*/immunology , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/therapy , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism, Humans ; Animals ; Immunotherapy/methods ; Prognosis ; T-Cell Senescence

T Cell Aging: An Important Target for Perioperative Immunomodulation.

Authors: Lan H; Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China., Xu S; Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China., Li H; Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China., Guo R; Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China., Feng Z; Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China., Wang Y; Department of Anaesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.

Source: Clinical interventions in aging [Clin Interv Aging] 2025 May 01; Vol. 20, pp. 537-557. Date of Electronic Publication: 2025 May 01 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101273480 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-1998 (Electronic) Linking ISSN: 11769092 NLM ISO Abbreviation: Clin Interv Aging Subsets: MEDLINE

MeSH Terms: T-Lymphocytes*/immunology , T-Lymphocytes*/physiology , Immunomodulation* , Aging*/immunology , Cellular Senescence*/immunology , Perioperative Care*/methods, Humans ; Perioperative Period ; Aged ; Postoperative Complications/immunology ; T-Cell Senescence

Proteostasis in T cell aging.

Authors: Gressler AE; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany., Leng H; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA., Zinecker H; Ascenion GmbH, Am Zirkus 1, Bertold-Brecht-Platz 3, 10117 Berlin, Germany., Simon AK; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom. Electronic address: katja.simon@ndm.ox.ac.uk.

Source: Seminars in immunology [Semin Immunol] 2023 Nov; Vol. 70, pp. 101838. Date of Electronic Publication: 2023 Sep 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9009458 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3618 (Electronic) Linking ISSN: 10445323 NLM ISO Abbreviation: Semin Immunol Subsets: MEDLINE

MeSH Terms: Proteostasis* , T-Cell Senescence*, Humans ; Aged ; Aging ; Proteasome Endopeptidase Complex/metabolism ; Autophagy

The immunology and cell biology of T cell aging.

Authors: Goronzy JJ; Departments of Immunology and Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA. Electronic address: goronzy.jorg@mayo.edu., Weng NP; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: Wengn@nih.gov.

Source: Seminars in immunology [Semin Immunol] 2023 Nov; Vol. 70, pp. 101843. Date of Electronic Publication: 2023 Sep 28.

Publication Type: Editorial

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9009458 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3618 (Electronic) Linking ISSN: 10445323 NLM ISO Abbreviation: Semin Immunol Subsets: MEDLINE

MeSH Terms: T-Cell Senescence* , Allergy and Immunology*, Humans ; Aging

Developing and experimental validating a T cell senescence-related gene signature to predict prognosis and immunotherapeutic sensitivity in non-small cell lung cancer.

Authors: Chen P; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou 350011 Fujian Province, PR China; Fujian Provincial Key Laboratory of Tumor Biotherapy, Fuzhou 350011 Fujian Province, PR China. Electronic address: cp15060086615@163.com., Yang X; Department of Nephrology, Fujian Provincial Hospital South Branch, Fuzhou 350007 Fujian Province, PR China. Electronic address: yxharsy@163.com., Chen W; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China. Electronic address: 2279570023@qq.com., Wei W; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China. Electronic address: 496912949@qq.com., Chen Y; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China. Electronic address: 71165024@qq.com., Wang P; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China. Electronic address: wangpeiyuan18@163.com., He H; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China. Electronic address: 273739022@qq.com., Liu S; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China. Electronic address: shuoyanliu2010@163.com., Zheng Y; Department of Thoracic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000 Guangdong Province, PR China. Electronic address: Zhengyzhen26@mail.sysu.edu.cn., Wang F; Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350011 Fujian Province, PR China. Electronic address: wfmd120@163.com.

Source: Gene [Gene] 2025 Mar 15; Vol. 941, pp. 149233. Date of Electronic Publication: 2025 Jan 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE

MeSH Terms: Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/immunology , Carcinoma, Non-Small-Cell Lung*/therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/immunology , Lung Neoplasms*/therapy , Lung Neoplasms*/pathology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Cellular Senescence*/genetics, Humans ; Prognosis ; Immunotherapy/methods ; Tumor Microenvironment/immunology ; Tumor Microenvironment/genetics ; Female ; Male ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor/genetics ; Transcriptome ; Middle Aged ; T-Cell Senescence