Intrinsic mechanisms contributing to the biophysical signature of mouse gamma motoneurons.

Authors: Sharples SA; Division of Neurosurgery, Cincinnati Children's Hospital Medical Centre, Cincinnati, OH, USA.; School of Psychology and Neuroscience, University of St Andrews, Fife, UK., Nisbet SJ; School of Psychology and Neuroscience, University of St Andrews, Fife, UK., Broadhead MJ; School of Psychology and Neuroscience, University of St Andrews, Fife, UK., Bo Jensen D; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark., Sorrell FL; School of Psychology and Neuroscience, University of St Andrews, Fife, UK., Meehan CF; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark., Miles GB; School of Psychology and Neuroscience, University of St Andrews, Fife, UK.

Source: The Journal of physiology [J Physiol] 2025 Nov; Vol. 603 (22), pp. 7145-7170. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE

MeSH Terms: Motor Neurons, Gamma*/physiology , Motor Neurons*/physiology, Animals ; Mice ; Action Potentials ; Sodium-Potassium-Exchanging ATPase/metabolism ; Sodium-Potassium-Exchanging ATPase/physiology

POU6F1 promote lumbar motor circuit reorganization following spinal cord injury.

Authors: Wang S; Mudanjiang Collaborative Innovation Center for development and application of Northern Medicine Resources, Mudanjiang, PR China; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China., Li Y; Mudanjiang Collaborative Innovation Center for development and application of Northern Medicine Resources, Mudanjiang, PR China; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China., Liu D; Department of Neurology, Mudanjiang First People's Hospital, Mudanjiang, Heilongjiang, PR China., Lv Z; Department of General Surgery, Mudanjiang First People's Hospital, Mudanjiang, Heilongjiang, PR China., Sun G; Department of Neurology, Mudanjiang Second People's Hospital, Mudanjiang, Heilongjiang, PR China., Wang D; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China., Sun P; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China., Deng L; Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Jia H; Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, PR China. Electronic address: 201100111@nxmu.edu.cn., Li W; Mudanjiang Collaborative Innovation Center for development and application of Northern Medicine Resources, Mudanjiang, PR China; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China. Electronic address: yuanyuan19800413@163.com., Wang Y; Mudanjiang Collaborative Innovation Center for development and application of Northern Medicine Resources, Mudanjiang, PR China; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China. Electronic address: yingwang770224@163.com.

Source: Neurobiology of disease [Neurobiol Dis] 2025 Oct 15; Vol. 215, pp. 107080. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

MeSH Terms: Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/pathology , Spinal Cord Injuries*/physiopathology , Motor Neurons*/metabolism , Motor Neurons*/pathology , Octamer Transcription Factor-3*/metabolism , Octamer Transcription Factor-3*/genetics , Nerve Regeneration*/physiology, Animals ; Female ; Rats ; Mice ; Rats, Sprague-Dawley

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation.

Authors: Kobayashi H; Bio Science & Engineering Laboratories, FUJIFILM Corporation, Kanagawa, Japan., Suzuki-Masuyama H; Bio Science & Engineering Laboratories, FUJIFILM Corporation, Kanagawa, Japan., Tanabe H; Bio Science & Engineering Laboratories, FUJIFILM Corporation, Kanagawa, Japan., Kato H; Bio Science & Engineering Laboratories, FUJIFILM Corporation, Kanagawa, Japan., Endoh-Yamagami S; Bio Science & Engineering Laboratories, FUJIFILM Corporation, Kanagawa, Japan.

Source: Journal of neurochemistry [J Neurochem] 2025 Oct; Vol. 169 (10), pp. e70246.

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/physiology , Oxidative Stress*/drug effects , Oxidative Stress*/physiology , Induced Pluripotent Stem Cells*/drug effects , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/pathology , Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/pathology , Neurons*/drug effects , Neurons*/pathology , Neurons*/metabolism , Motor Neurons*/drug effects , Motor Neurons*/metabolism , Motor Neurons*/pathology, Animals ; Humans ; Neuroprotective Agents/pharmacology ; Mice ; Edaravone/pharmacology ; Cells, Cultured

Optogenetic methods to stimulate gamma motor neuron axons ex vivo.

Authors: Karekal A; Department of Biological Sciences, One Washington Square, San José State University, San Jose, California, USA., Mandawe R; Department of Biological Sciences, One Washington Square, San José State University, San Jose, California, USA., Chun C; Department of Biological Sciences, One Washington Square, San José State University, San Jose, California, USA., Byri SK; Department of Biological Sciences, One Washington Square, San José State University, San Jose, California, USA., Cheline D; Department of Biological Sciences, One Washington Square, San José State University, San Jose, California, USA., Ortiz S; Department of Biological Sciences, One Washington Square, San José State University, San Jose, California, USA., Hochman S; Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA., Wilkinson KA; Department of Biological Sciences, One Washington Square, San José State University, San Jose, California, USA.

Source: Experimental physiology [Exp Physiol] 2025 Oct; Vol. 110 (10), pp. 1531-1541. Date of Electronic Publication: 2025 Feb 03.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9002940 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-445X (Electronic) Linking ISSN: 09580670 NLM ISO Abbreviation: Exp Physiol Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Axons*/physiology , Motor Neurons, Gamma*/physiology , Motor Neurons, Gamma*/metabolism , Motor Neurons*/physiology, Animals ; Mice ; Mice, Transgenic ; Muscle Spindles/physiology ; Muscle Contraction/physiology ; Sciatic Nerve/physiology ; Muscle, Skeletal/physiology ; Male ; Mice, Inbred C57BL

The Vap33 signaling axis precisely coordinates the timing of motoneuron dendritogenesis in neural map development.

Authors: Kamiyama D; Department of Cellular Biology, University of Georgia, Athens, GA, USA. daichi.kamiyama@uga.edu.; Neuroscience Program, University of Georgia, Athens, GA, USA. daichi.kamiyama@uga.edu., Kamiyama R; Department of Cellular Biology, University of Georgia, Athens, GA, USA., Nishida Y; Department of Cellular Biology, University of Georgia, Athens, GA, USA., Sego A; Department of Cellular Biology, University of Georgia, Athens, GA, USA.; Neuroscience Program, University of Georgia, Athens, GA, USA., Vining GB; Department of Cellular Biology, University of Georgia, Athens, GA, USA., Bui KC; Department of Cellular Biology, University of Georgia, Athens, GA, USA.; Neuroscience Program, University of Georgia, Athens, GA, USA., Fitch M; Department of Cellular Biology, University of Georgia, Athens, GA, USA., Do HGT; Department of Cellular Biology, University of Georgia, Athens, GA, USA., Avraham O; Department of Cellular Biology, University of Georgia, Athens, GA, USA.; Neuroscience Program, University of Georgia, Athens, GA, USA., Chihara T; Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.; Program of Basic Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.

Source: Nature communications [Nat Commun] 2025 Dec 04; Vol. 16 (1), pp. 10893. Date of Electronic Publication: 2025 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Motor Neurons*/metabolism , Motor Neurons*/cytology , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Dendrites*/metabolism , Neurogenesis*/physiology, Animals ; Signal Transduction ; cdc42 GTP-Binding Protein/metabolism ; Drosophila melanogaster/metabolism ; Humans ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Cell Membrane/metabolism ; GTP-Binding Proteins

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.

Authors: Joseph BJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Departments of Pathology & Cell Biology, Neuroscience, and Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Departments of Systems Biology, Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Marshall KA; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Harley P; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Mann JR; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Alessandrini F; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Vanoye CG; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Chi W; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Prudencio M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Simkin D; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kao TT; Department of Neurology, Center for Motor Neuron Biology and Disease, Eleanor and Lou Gehrig ALS Center, Columbia University, New York, NY, USA., Desai RR; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Keuss MJ; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Barattucci S; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Zanovello M; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Mehta PR; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., DeKeyser JM; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Limone F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Lee J; RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, USA., Brown AL; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Leyton-Jaimes MF; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Nash LA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Juan IGS; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Aronica E; Amsterdam UMC, University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, The Netherlands., Wainger BJ; Department of Neurology, Mass General Brigham and Harvard Medical School, Boston, MA, USA., Shah M; UCL School of Pharmacy, University College London, London, UK., Goswami A; Department of Neurology, Center for Motor Neuron Biology and Disease, Eleanor and Lou Gehrig ALS Center, Columbia University, New York, NY, USA., Shneider NA; Department of Neurology, Center for Motor Neuron Biology and Disease, Eleanor and Lou Gehrig ALS Center, Columbia University, New York, NY, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Burrone J; Centre for Developmental Neurobiology, MRC Centre for Neurodevelopmental Disorders, Kings College London, London, UK., Zhang C; Departments of Systems Biology, Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Wichterle H; Departments of Pathology & Cell Biology, Neuroscience, and Neurology, Columbia University Irving Medical Center, New York, NY, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Watts JK; RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA, USA., George AL Jr; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Fratta P; UCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK. p.fratta@ucl.ac.uk., Eggan K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Kevin.Eggan@bmrn.com., Kiskinis E; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. evangelos.kiskinis@northwestern.edu.; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. evangelos.kiskinis@northwestern.edu.

Source: Nature neuroscience [Nat Neurosci] 2025 Dec; Vol. 28 (12), pp. 2476-2492. Date of Electronic Publication: 2025 Oct 31.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/physiopathology , KCNQ2 Potassium Channel*/genetics , KCNQ2 Potassium Channel*/metabolism , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/metabolism , Frontotemporal Dementia*/pathology , Frontotemporal Dementia*/physiopathology , Motor Neurons*/metabolism , Motor Neurons*/physiology , RNA Splicing*, Humans ; Induced Pluripotent Stem Cells ; Neurons ; Male ; Female ; Animals

A critical affinity window for IgSF proteins DIP-α and Dpr10 is required for proper motor neuron arborization.

Authors: Lopez DH; Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York 10032, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA., Rostam KD; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA., Zamurrad S; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA., Xu S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA., Mann RS; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA; rsm10@columbia.edu.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.

Source: Genes & development [Genes Dev] 2025 Dec 01; Vol. 39 (23-24), pp. 1426-1433. Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

MeSH Terms: Motor Neurons*/cytology , Motor Neurons*/metabolism , Motor Neurons*/physiology , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Drosophila melanogaster*/embryology , Drosophila melanogaster*/metabolism , Drosophila melanogaster*/genetics , Cell Adhesion Molecules*/metabolism, Animals ; Pseudopodia/metabolism ; Protein Binding ; Neuromuscular Junction

Over-expression microRNA-218 induces differentiation of neural stem cells into functional motor neuron-like cells with differential expression of PI3K/Akt/mTOR, PTEN and GSK3ß signaling proteins.

Authors: Khalil W; Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: vm.khalil@modares.ac.ir., Tiraihi T; Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; College of Medicine, University of Warith Al-Anbiyaa, Kerbala, Iraq. Electronic address: takialtr@modares.ac.ir., Shojaei A; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: am.shojaei@modares.ac.ir., Hassoun HK; Clinical Neurology, Middle Euphrates Neuroscience Center, Faculty of Medicine, Kufa University, Kufa, Iraq. Electronic address: hayder.alkaabi@uokufa.edu.iq.

Source: Life sciences [Life Sci] 2025 Dec 01; Vol. 382, pp. 124015. Date of Electronic Publication: 2025 Oct 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH Terms: Neural Stem Cells*/cytology , Neural Stem Cells*/metabolism , Motor Neurons*/cytology , Motor Neurons*/metabolism , MicroRNAs*/genetics , MicroRNAs*/biosynthesis , Cell Differentiation*/genetics, TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/genetics ; PTEN Phosphohydrolase/metabolism ; PTEN Phosphohydrolase/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Signal Transduction ; Animals ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Cells, Cultured ; Rats

Electrophysiological characterization of sourced human iPSC-derived motor neurons.

Authors: Jurkovicova-Tarabova B; Institute of Molecular Physiology and Genetics, Center of Biosciences, Slovak Academy of Sciences, Bratislava, Slovakia.; Department of Biology, Faculty of Education, Trnava University, Trnava, Slovakia., Stringer RN; Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic., Sevcikova Tomaskova Z; Institute of Molecular Physiology and Genetics, Center of Biosciences, Slovak Academy of Sciences, Bratislava, Slovakia., Weiss N; Institute of Molecular Physiology and Genetics, Center of Biosciences, Slovak Academy of Sciences, Bratislava, Slovakia.; Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Source: Channels (Austin, Tex.) [Channels (Austin)] 2025 Dec; Vol. 19 (1), pp. 2480713. Date of Electronic Publication: 2025 Mar 25.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101321614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6969 (Electronic) Linking ISSN: 19336950 NLM ISO Abbreviation: Channels (Austin) Subsets: MEDLINE

MeSH Terms: Induced Pluripotent Stem Cells*/cytology , Induced Pluripotent Stem Cells*/metabolism , Motor Neurons*/cytology , Motor Neurons*/metabolism , Motor Neurons*/physiology, Humans ; Cell Differentiation ; Electrophysiological Phenomena ; Action Potentials

A stochastic RNA editing process targets a select number of sites in individual Drosophila glutamatergic motoneurons.

Authors: Crane AB; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States., Inouye MO; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States., Jetti SK; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States., Littleton JT; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.

Source: ELife [Elife] 2025 Nov 20; Vol. 14. Date of Electronic Publication: 2025 Nov 20.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH Terms: RNA Editing* , Motor Neurons*/metabolism , Motor Neurons*/physiology , Drosophila melanogaster*/genetics, Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Larva/genetics ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Drosophila/genetics

Role of 2-[ ¹⁸ F]FDG-PET as a biomarker of upper motor neuron involvement in amyotrophic lateral sclerosis.

Authors: Cabras S; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy. sara.cabras@unito.it.; School of Advanced Studies, Centre for Neuroscience, University of Camerino, Camerino, Italy. sara.cabras@unito.it., Manera U; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.; Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza Di Torino, Neurology Unit 1U, Turin, Italy., Di Pede F; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Zocco G; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Vasta R; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Novara A; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Minerva E; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Matteoni E; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., De Mattei F; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Pellegrino G; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Grassano M; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Iazzolino B; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Palumbo F; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Callegaro S; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy., Polverari G; Positron Emission Tomography Centre AFFIDEA-IRMET S.P.A, Turin, Italy., Morbelli SD; Department of Medical Sciences, University of Turin, Turin, Italy.; Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza Di Torino, Nuclear Medicine Unit, Turin, Italy., Pardini M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Chiaravalloti A; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy.; IRCCS Neuromed, Pozzilli, Italy., Schillaci O; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy., Leenders KL; Department of Neurology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Kogan RV; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Moglia C; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.; Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza Di Torino, Neurology Unit 1U, Turin, Italy., Calvo A; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.; Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza Di Torino, Neurology Unit 1U, Turin, Italy.; Neuroscience Institute of Turin (NIT), Turin, Italy., Chiò A; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.; Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza Di Torino, Neurology Unit 1U, Turin, Italy.; Neuroscience Institute of Turin (NIT), Turin, Italy.; Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy., Pagani M; Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy.; Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden., Canosa A; ALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.; Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza Di Torino, Neurology Unit 1U, Turin, Italy.; Neuroscience Institute of Turin (NIT), Turin, Italy.; Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy.

Source: Journal of neurology [J Neurol] 2025 Nov 17; Vol. 272 (12), pp. 766. Date of Electronic Publication: 2025 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/diagnostic imaging , Amyotrophic Lateral Sclerosis*/metabolism , Fluorodeoxyglucose F18* , Positron-Emission Tomography*/methods , Motor Cortex*/diagnostic imaging , Motor Cortex*/metabolism , Motor Neurons*/metabolism , Motor Neurons*/pathology, Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Aged ; Adult ; Biomarkers/metabolism ; Radiopharmaceuticals

Examining iPSC derived motor neuron variability and genome stability monitoring as a solution.

Authors: Gaffey F; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK. finbar.gaffey@lifearc.org., McCoull D; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Vaitone E; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Hedges E; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Lovejoy C; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Yao Z; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Wright PD; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Mead RJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK., Stebbeds W; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.

Source: Scientific reports [Sci Rep] 2025 Nov 12; Vol. 15 (1), pp. 39670. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Induced Pluripotent Stem Cells*/cytology , Induced Pluripotent Stem Cells*/metabolism , Motor Neurons*/cytology , Motor Neurons*/metabolism , Genomic Instability*, Humans ; Cell Differentiation/genetics ; Cell Line

Performing Compound Motor Action Potential Measurement in Zebrafish: A Description of Methodology and a Comparison Between Healthy and ALS-Affected Animals.

Authors: Rutkove S; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Tiwari G; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Nath AK; Harvard Medical School, Boston, Massachusetts, USA.; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Broad Institute, Cambridge, Massachusetts, USA.

Source: Muscle & nerve [Muscle Nerve] 2025 Nov; Vol. 72 (5), pp. 1168-1177. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 7803146 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4598 (Electronic) Linking ISSN: 0148639X NLM ISO Abbreviation: Muscle Nerve Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/physiopathology , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/diagnosis , Action Potentials*/physiology , Motor Neurons*/physiology, Animals ; Zebrafish ; Disease Models, Animal ; Animals, Genetically Modified ; Electric Stimulation ; Superoxide Dismutase/genetics

Induced long-term potentiation improves synaptic stability and restores network function in ALS motor neurons.

Authors: Kollstrøm AM; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway. Electronic address: anna.m.kollstrom@ntnu.no., Grønlie MB; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway., Christiansen N; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway., Sandvig A; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway; Department of Clinical Neurosciences, Division of Neuro, Head and Neck, Umeå University Hospital, Umeå, Sweden; Department of Community Medicine and Rehabilitation, Umeå University Hospital, Umeå, Sweden., Sandvig I; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Norway. Electronic address: ioanna.sandvig@ntnu.no.

Source: Neurobiology of disease [Neurobiol Dis] 2025 Nov; Vol. 216, pp. 107077. Date of Electronic Publication: 2025 Sep 11.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/physiopathology , Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/metabolism , Motor Neurons*/drug effects , Motor Neurons*/physiology , Motor Neurons*/pathology , Synapses*/drug effects , Synapses*/physiology , Long-Term Potentiation*/physiology , Long-Term Potentiation*/drug effects , Nerve Net*/drug effects , Nerve Net*/physiopathology, Humans ; Male ; Tetraethylammonium/pharmacology ; Female ; Potassium Channel Blockers/pharmacology ; Middle Aged

Considering Big tau as a novel and specific biomarker for spinal motor neuron pathology.

Authors: Fischer I; Drexel University, College of Medicine, Department of Neurobiology and Anatomy, Philadelphia, PA 19129, USA. Electronic address: If24@drexel.edu.

Source: Neurobiology of disease [Neurobiol Dis] 2025 Nov; Vol. 216, pp. 107118. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

MeSH Terms: tau Proteins*/metabolism , Motor Neurons*/pathology , Motor Neurons*/metabolism , Spinal Cord*/pathology , Spinal Cord*/metabolism , Motor Neuron Disease*/metabolism , Motor Neuron Disease*/pathology , Motor Neuron Disease*/diagnosis, Humans ; Biomarkers/metabolism ; Animals ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology

Axonal injury signaling is restrained by a spared synaptic branch.

Authors: Smithson LJ; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States., Zang JL; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States., Junginger L; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States., Waller TJ; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States., Reilly-Jankowiak L; Department of Neurosciences, Case Western Reserve University, Cleveland, United States., Khan SA; Department of Neurosciences, Case Western Reserve University, Cleveland, United States., Li Y; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States., Cai D; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States., Collins CA; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.; Department of Neurosciences, Case Western Reserve University, Cleveland, United States.

Source: ELife [Elife] 2025 Oct 29; Vol. 13. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH Terms: Signal Transduction* , Drosophila Proteins*/metabolism , Axons*/physiology , Axons*/pathology , Axons*/metabolism , Motor Neurons*/physiology , Motor Neurons*/metabolism , MAP Kinase Kinase Kinases*/metabolism , Synapses*/metabolism , Drosophila melanogaster*, Animals ; Larva ; Drosophila ; Nerve Tissue Proteins

Intrinsically accelerated cellular degradation is amplified by TDP-43 loss in ALS-vulnerable motor neurons in a zebrafish model.

Authors: Asakawa K; Neurobiology and Pathology Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Shizuoka, Japan. kasakawa@nig.ac.jp.; The Graduate University for Advanced Studies (SOKENDAI), Department of Genetics, Mishima, Shizuoka, Japan. kasakawa@nig.ac.jp., Tomita T; Division of Protein Metabolism, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Shioya S; Neurobiology and Pathology Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Shizuoka, Japan., Handa H; Department of Molecular Pharmacology, Center for Future Medical Research, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan., Saeki Y; Division of Protein Metabolism, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kawakami K; The Graduate University for Advanced Studies (SOKENDAI), Department of Genetics, Mishima, Shizuoka, Japan.; Laboratory of Molecular and Developmental Biology, Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Shizuoka, Japan.

Source: Nature communications [Nat Commun] 2025 Oct 27; Vol. 16 (1), pp. 9213. Date of Electronic Publication: 2025 Oct 27.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Motor Neurons*/metabolism , Motor Neurons*/pathology , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/genetics , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics, Animals ; Zebrafish ; Disease Models, Animal ; Spinal Cord/metabolism ; Spinal Cord/pathology ; Autophagy ; Humans ; Proteasome Endopeptidase Complex/metabolism ; Unfolded Protein Response ; Proteolysis

Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations.

Authors: Ma GM; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China., Xia CC; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China., Lyu BY; Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA., Liu J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China., Luo F; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China., Guan MF; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China., Wang JY; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China., Sun L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China., Zhang L; The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China., Chen Y; Research Center for Aging and Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Jing'an District, Shanghai 200040, China; Department of Neurology & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address: chenyanhs@fudan.edu.cn., Mao YW; Penn State University, 214 Life Sciences Building, University Park, PA 16802, USA. Electronic address: yzm1@psu.edu., Yu GQ; Department of Automation, Tsinghua University, Beijing 100084, China. Electronic address: yug@tsinghua.edu.cn., Wang WY; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, China; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: wywang@sioc.ac.cn.

Source: Stem cell reports [Stem Cell Reports] 2025 Oct 14; Vol. 20 (10), pp. 102649. Date of Electronic Publication: 2025 Oct 02.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE

MeSH Terms: Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Motor Neurons*/metabolism , Motor Neurons*/cytology , C9orf72 Protein*/genetics , RNA-Binding Protein FUS*/genetics , Mutation* , Superoxide Dismutase-1*/genetics , DNA-Binding Proteins*/genetics, Humans ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Amyotrophic Lateral Sclerosis/metabolism ; Cell Differentiation/genetics ; Alternative Splicing ; Gene Expression Profiling

Exposure to the organochlorine pesticide cis-chlordane induces ALS-like mitochondrial perturbations in stem cell-derived motor neurons.

Authors: Clackson O; Department of Molecular Biology & Biochemistry, Wesleyan University, Middletown, Connecticut, United States of America., Hamid MR; Neuroscience and Behavior Program, Wesleyan University, Middletown, Connecticut, United States of America., Wijesekera A; Department of Molecular Biology & Biochemistry, Wesleyan University, Middletown, Connecticut, United States of America., Kulick D; Neuroscience and Behavior Program, Wesleyan University, Middletown, Connecticut, United States of America., O'Neil AL; Department of Chemistry, Neuroscience and Behavior Program, College of Integrated Sciences, Wesleyan University, Middletown, Connecticut, United States of America.

Source: PloS one [PLoS One] 2025 Oct 14; Vol. 20 (10), pp. e0332422. Date of Electronic Publication: 2025 Oct 14 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Motor Neurons*/drug effects , Motor Neurons*/metabolism , Motor Neurons*/pathology , Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/chemically induced , Mitochondria*/drug effects , Mitochondria*/metabolism , Mitochondria*/pathology , Pesticides*/toxicity , Chlordan*/toxicity, Humans ; Reactive Oxygen Species/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Animals ; Adenosine Triphosphate/metabolism ; Oxygen Consumption/drug effects

Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons.

Authors: Lowry ER; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. el2139@cumc.columbia.edu., Patel T; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA., Costa JA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Chang E; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Tariq S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Melikyan H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Davis I; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Aziz S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Ntermentzaki G; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Lotti F; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Wichterle H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. hw350@cumc.columbia.edu.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. hw350@cumc.columbia.edu.; Department of Neuroscience, Columbia University Irving Medical Center, New York, NY, USA. hw350@cumc.columbia.edu.; Department of Rehabilitation and Regenerative Medicine, Columbia University Irving Medical Center, New York, NY, USA. hw350@cumc.columbia.edu.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA. hw350@cumc.columbia.edu.; Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY, USA. hw350@cumc.columbia.edu.

Source: Nature neuroscience [Nat Neurosci] 2025 Oct; Vol. 28 (10), pp. 2044-2053. Date of Electronic Publication: 2025 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , Motor Neurons*/metabolism , Motor Neurons*/pathology , Motor Neurons*/physiology , Transcription Factors*/genetics , Transcription Factors*/metabolism , LIM-Homeodomain Proteins*/genetics , LIM-Homeodomain Proteins*/metabolism , Gene Expression Regulation, Developmental*/genetics, Animals ; Mice ; Mice, Transgenic ; Disease Models, Animal ; Superoxide Dismutase/genetics ; Superoxide Dismutase-1 ; Animals, Newborn ; Humans ; Spinal Cord