Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development

Authors: Díaz del Moral, Sandra, Barrena, Silvia, Hernández-Torres, Francisco, Aránega, Amelia, Villaescusa, José Manuel, Gómez Doblas, Juan José, Franco, Diego, Jiménez-Navarro, Manuel, Muñoz-Chápuli, Ramón, Carmona, Rita

Contributors: Díaz del Moral,S, Barrena,S, Muñoz-Chápuli,R, Carmona,R Department of Animal Biology, University of Málaga, Málaga, Spain. Hernández-Torres,F Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Hernández-Torres,F, Aránega,A Medina Foundation, Technology Park of Health Sciences, Granada, Spain. Aránega,A, Franco,D Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, Jaén, Spain. Villaescusa,JM, Gómez Doblas,JJ, Jiménez-Navarro,M Heart Area Clinical Management Unit, University Hospìtal Virgen de la Victoria, CIBERCV Enfermedades Cardiovasculares Health Institute Carlos III, Biomedical Research Institute of Malaga (IBIMA), University of Málaga, Málaga, Spain., This work was supported by: Spanish Ministry of Economy, Industry and Competitivity (BFU2017-83907-P to RM-C and RC and PID2019-107492GB-I00 to AA and DF), Consejería de Salud, Junta de Andalucía (PC0066?2017/PC-0081-2017 to RC, JV, and JG), Instituto de Salud Carlos III-TERCEL network (RD16/0011/0030 to RM-C and RC), Instituto de Salud Carlos III-CIBERCV “Enfermedades Cardiovasculares” (CB16/11/00360 to MJ-N), and Consejería de Economía yConocimiento, Junta de Andalucía (UMA18-FEDERJA-146 to RM-C and RC and FEDER-UJA to AA and DF).

Subject Terms: Wilms’ tumor suppressor gene, Cardiomyocytes, Cardiac development, Calcium homeostasis, Potassium channels, Genes del tumor de Wilms, Genes supresores de tumores, Miocitos cardíacos, Crecimiento y desarrollo, Homeostasis, Calcio, Canales de potasio, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice, Medical Subject Headings::Anatomy::Cardiovascular System::Heart::Myocardium::Myocytes, Cardiac, Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Alkaline Earth::Calcium, Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Troponin::Troponin T, Medical Subject Headings::Anatomy::Musculoskeletal System::Muscles::Myocardium, Medical Subject Headings::Anatomy::Cardiovascular System::Heart::Pericardium, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors, Medical Subject Headings::Diseases::Neoplasms::Neoplastic Syndromes, Hereditary::Wilms Tumor, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Recessive::Genes, Tumor Suppressor

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.683861/full; Díaz Del Moral S, Barrena S, Hernández-Torres F, Aránega A, Villaescusa JM, Gómez Doblas JJ, et al. Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Front Cell Dev Biol. 2021 Jul 22;9:683861; http://hdl.handle.net/10668/4505; PMC8339973

Availability: http://hdl.handle.net/10668/4505
https://doi.org/10.3389/fcell.2021.683861

Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes

Authors: Santiago-Fernández, Concepción, Pérez-Belmonte, Luis M., Millán-Gómez, Mercedes, Moreno-Santos, Inmaculada, Carrasco-Chinchilla, Fernando, Ruiz-Salas, Amalio, Morcillo-Hidalgo, Luis, Melero, José M., Garrido-Sánchez, Lourdes, Jiménez-Navarro, Manuel

Contributors: Santiago-Fernández,C, Garrido-Sánchez,L Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital (IBIMA), Malaga University, Malaga, Spain. Santiago-Fernández,C, Garrido-Sánchez,L Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Malaga, Spain. Pérez-Belmonte,LM, Millán-Gómez,M, Moreno-Santos,I, Carrasco-Chinchilla,F, Ruiz-Salas,A, Morcillo-Hidalgo,L, Melero,JM, Jiménez-Navarro,M Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Malaga, Spain. Pérez-Belmonte,LM, Jiménez-Navarro,M Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Malaga, Spain., This work was supported by Grants from the Spanish Ministry of Health (FIS) (PI13/02542, PI11/01661) and Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV) (CB16/11/00360), Instituto de Salud Carlos III co-funded by the Fondo Europeo de Desarrollo Regional (FEDER).

Subject Terms: Scavenger receptors, Oxidized low-density, Epicardial adipose tissue, Diabetes mellitus, Ischemic heart disease, Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement, Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Coronary Disease::Coronary Artery Disease, Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2, Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Diabetic Cardiomyopathies, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL, Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Macrophages, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged, Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia, Medical Subject Headings::Anatomy::Cardiovascular System::Heart::Pericardium, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Scavenger, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Up-Regulation

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Relation: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-1842-2; Santiago-Fernández C, Pérez-Belmonte LM, Millán-Gómez M, Moreno-Santos I, Carrasco-Chinchilla F, Ruiz-Salas A, et al. Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes. J Transl Med. 2019 Mar 20;17(1):95.; http://hdl.handle.net/10668/3191; PMC6425581

Availability: http://hdl.handle.net/10668/3191
https://doi.org/10.1186/s12967-019-1842-2

Postoperative epidural hematoma contributes to delayed upper cord tethering after decompression of Chiari malformation type I.

Authors: López-González, Antonio, Plaza, Estela, Márquez-Rivas, Francisco Javier

Contributors: López-González,A, Márquez-Rivas,FJ Department of Neurosurgery, Virgen Macarena and Virgen del Rocío University Hospitals, Seville, Spain. Plaza,E Department of Neurosurgery, La Fe University and Polytechnic Hospital, Valencia, Spain.

Subject Terms: Arachnoiditis, Arnold-Chiary malformation, Dural graft, Posterior fossa, Tethering, Aracnoiditis, Estado de conciencia, Hematoma epidural craneal, Hematoma espinal epidural, Medical Subject Headings::Organisms::Eukaryota::Animals, Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Central Nervous System Infections::Meningitis::Arachnoiditis, Medical Subject Headings::Diseases::Nervous System Diseases::Nervous System Malformations::Neural Tube Defects::Arnold-Chiari Malformation, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Ruminants::Cattle, Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition::Consciousness, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Debridement, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Meninges::Dura Mater, Medical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Pain::Headache, Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Hemorrhages::Intracranial Hemorrhage, Traumatic::Hematoma, Epidural, Cranial, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage::Hematoma::Hematoma, Spinal, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Anatomy::Cardiovascular System::Heart::Pericardium, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Rhombencephalon

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Relation: http://surgicalneurologyint.com/surgicalint_articles/postoperative-epidural-hematoma-contributes-to-delayed-upper-cord-tethering-after-decompression-of-chiari-malformation-type-i/; López-González A, Plaza E, Márquez-Rivas FJ. Postoperative epidural hematoma contributes to delayed upper cord tethering after decompression of Chiari malformation type I. Surg Neurol Int. 2014; 5(Suppl 4):S278-81; http://hdl.handle.net/10668/2138; PMC4163907

Availability: http://hdl.handle.net/10668/2138
https://doi.org/10.4103/2152-7806.139384