EXPRESSION OF PRO-INFLAMMATORY CYTOKINES IN PRIMARY HUMAN CORONARY ARTERY AND INTERNAL THORACIC ARTERY ENDOTHELIAL CELLS ; СРАВНИТЕЛЬНЫЙ АНАЛИЗ ЭКСПРЕССИИ ПРОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ В ПЕРВИЧНЫХ ЭНДОТЕЛИАЛЬНЫХ КЛЕТКАХ КОРОНАРНОЙ И ВНУТРЕННЕЙ ГРУДНОЙ АРТЕРИИ ЧЕЛОВЕКА

Authors: Victoria E. Markova, Daria K. Shishkova, Alexander D. Stepanov, Alexey V. Frolov, Marsel R. Kabilov, Alexey E. Tupikin, Maxim Yu. Sinitsky, Anna V. Sinitskaya, Yulia O. Yurieva, Anastasia I. Lazebnaya, Anton G. Kutikhin, Виктория Евгеньевна Маркова, Дарья Кирилловна Шишкова, Александр Денисович Степанов, Алексей Витальевич Фролов, Марсель Расимович Кабилов, Алексей Евгеньевич Тупикин, Максим Юрьевич Синицкий, Анна Викторовна Синицкая, Юлия Олеговна Юрьева, Анастасия Ивановна Лазебная, Антон Геннадьевич Кутихин

Contributors: Исследование выполнено за счет гранта Российского научного фонда № 24-65-00039 «Идентификация циркулирующего маркера провоспалительной дисфункции эндотелия в контексте гетерогенности эндотелиальных клеток», https://rscf.ru/project/24-65-00039/.

Source: Complex Issues of Cardiovascular Diseases; Том 14, № 5 (2025); 103-121 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 14, № 5 (2025); 103-121 ; 2587-9537 ; 2306-1278

Subject Terms: Внутренняя грудная артерия, Endothelial cells, Endothelial dysfunction, Pro-inflammatory cytokines, Cell adhesion molecules, Coronary artery, Internal thoracic artery, Эндотелиальные клетки, Дисфункция эндотелия, Провоспалительные цитокины, Молекулы клеточной адгезии, Коронарная артерия

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Relation: https://www.nii-kpssz.com/jour/article/view/1763/1103; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1763/2248; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1763/2249; Cahill PA, Redmond EM. Vascular endothelium - Gatekeeper of vessel health. Atherosclerosis. 2016;248:97-109. doi:10.1016/j.atherosclerosis.2016.03.007.; Amersfoort J, Eelen G, Carmeliet P. Immunomodulation by endothelial cells - partnering up with the immune system? Nat Rev Immunol. 2022; 22(9):576-588. doi:10.1038/s41577-022-00694-4.; Trimm E, Red-Horse K. Vascular endothelial cell development and diversity. Nat Rev Cardiol. 2023; 20(3):197-210. doi:10.1038/s41569-022-00770-1.; Kutikhin AG, Shishkova DK, Velikanova EA, Sinitsky MY, Sinitskaya AV, Markova VE. Endothelial Dysfunction in the Context of Blood-Brain Barrier Modeling. J Evol Biochem Physiol. 2022; 58(3):781-806. doi:10.1134/S0022093022030139.; Goncharov NV, Popova PI, Kudryavtsev IV, Golovkin AS, Savitskaya IV, Avdonin PP, Korf EA, Voitenko NG, Belinskaia DA, Serebryakova MK, Matveeva NV, Gerlakh NO, Anikievich NE, Gubatenko MA, Dobrylko IA, Trulioff AS, Aquino AD, Jenkins RO, Avdonin PV. Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments. Int J Mol Sci. 2024; 25(3):1888. doi:10.3390/ijms25031888.; Corban MT., Prasad A, Nesbitt L, Loeffler D, Herrmann J, Lerman LO, Lerman A. Local Production of Soluble Urokinase Plasminogen Activator Receptor and Plasminogen Activator Inhibitor-1 in the Coronary Circulation Is Associated With Coronary Endothelial Dysfunction in Humans. J Am Heart Assoc. 2018; 7(15):e009881. doi:10.1161/JAHA.118.009881.; Shishkova D, Markova V, Markova Y, Sinitsky M, Sinitskaya A, Matveeva V, Torgunakova E, Lazebnaya A, Stepanov A, Kutikhin A. Physiological Concentrations of Calciprotein Particles Trigger Activation and Pro-Inflammatory Response in Endothelial Cells and Monocytes. Biochemistry (Mosc). 2025; 90(1):132-160. doi:10.1134/S0006297924604064.; Stepanov A, Shishkova D, Markova V, Markova Y, Frolov A, Lazebnaya A, Oshchepkova K, Perepletchikova D, Smirnova D, Basovich L, Repkin E, Kutikhin A. Proteomic Profiling of Endothelial Cell Secretomes After Exposure to Calciprotein Particles Reveals Downregulation of Basement Membrane Assembly and Increased Release of Soluble CD59. Int J Mol Sci. 2024; 25(21):11382. doi:10.3390/ijms252111382.; Gomez Toledo A, Golden GJ, Cummings RD, Malmström J, Esko JD. Endothelial Glycocalyx Turnover in Vascular Health and Disease: Rethinking Endothelial Dysfunction. Annu Rev Biochem. 2025; 94(1):561-586. doi:10.1146/annurev-biochem-032620-104745.; Frolov A, Lobov A, Kabilov M, Zainullina B, Tupikin A, Shishkova D, Markova V, Sinitskaya A, Grigoriev E, Markova Y, Kutikhin A. Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity. Int J Mol Sci. 2023; 24(19):15032. doi:10.3390/ijms241915032.; Shishkova D, Lobov A, Zainullina B, Matveeva V, Markova V, Sinitskaya A, Velikanova E, Sinitsky M, Kanonykina A, Dyleva Y, Kutikhin A. Calciprotein Particles Cause Physiologically Significant Pro-Inflammatory Response in Endothelial Cells and Systemic Circulation. Int J Mol Sci. 2022; 23(23):14941. doi:10.3390/ijms232314941.; Sinitsky M, Repkin E, Sinitskaya A, Markova V, Shishkova D, Barbarash O. Proteomic Profiling of Endothelial Cells Exposed to Mitomycin C: Key Proteins and Pathways Underlying Genotoxic Stress-Induced Endothelial Dysfunction. Int J Mol Sci. 2024; 25(7):4044. doi:10.3390/ijms25074044.; Baaten CCFMJ, Vondenhoff S, Noels H. Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease. Circ Res. 2023; 132(8):970-992. doi:10.1161/CIRCRESAHA.123.321752.; Segers VFM, Bringmans T, De Keulenaer GW. Endothelial dysfunction at the cellular level in three dimensions: severity, acuteness, and distribution. Am J Physiol Heart Circ Physiol. 2023; 325(2):H398-H413. doi:10.1152/ajpheart.00256.2023.; Guzik TJ, Nosalski R, Maffia P, Drummond GR. Immune and inflammatory mechanisms in hypertension. Nat Rev Cardiol. 2024; 21(6):396-416. doi:10.1038/s41569-023-00964-1.

Availability: https://www.nii-kpssz.com/jour/article/view/1763
https://doi.org/10.17802//2306-1278-2025-14-5-103-121

COMPARISON OF MODIFIED ENDOTHELIAL NITRIC OXIDE SYNTHASE FORMS IN HYPERTENSIVE AND NORMOTENSIVE RATS ; СРАВНЕНИЕ ЭКСПРЕССИИ МОДИФИЦИРОВАННЫХ ФОРМ ЭНДОТЕЛИАЛЬНОЙ СИНТАЗЫ МОНООКСИДА АЗОТА У ГИПЕР- И НОРМОТЕНЗИВНЫХ КРЫС

Authors: Leo A. Bogdanov, Egor A. Kondratiev, Vladislav A. Koshelev, Rinat A. Mukhamadiyarov, Anastasia Yu. Kanonykina, Anastasia A. Lazebnaya, Arina E. Tyurina, Anton G. Kutikhin, Лев Александрович Богданов, Егор Андреевич Кондратьев, Владислав Александрович Кошелев, Ринат Авхадиевич Мухамадияров, Анастасия Юрьевна Каноныкина, Анастасия Ивановна Лазебная, Арина Евгеньевна Тюрина, Антон Геннадьевич Кутихин

Contributors: Исследование выполнено при поддержке гранта Российского научного фонда № 24-75-10057 «Идентификация клеточных маркеров дисфункции эндотелия», https://rscf.ru/project/24-75-10057/.

Source: Complex Issues of Cardiovascular Diseases; Том 14, № 2 (2025); 110-126 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 14, № 2 (2025); 110-126 ; 2587-9537 ; 2306-1278

Subject Terms: Фосфорилирование eNOS, Endothelial cells, Endothelial dysfunction, Hypertensive rats, Normotensive rats, Endothelial nitric oxide synthase, eNOS phosphorylation, Эндотелиальные клетки, Дисфункция эндотелия, Гипертензивные крысы, Нормотензивные крысы, Эндотелиальная NO-синтаза

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Relation: https://www.nii-kpssz.com/jour/article/view/1669/1030; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2051; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2052; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2053; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2054; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2055; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2056; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2057; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2058; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2059; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2060; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2061; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2062; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2063; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2064; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1669/2065; Kutikhin AG, Shishkova DK, Velikanova EA, Sinitsky MY, Sinitskaya AV, Markova VE. Endothelial Dysfunction in the Context of Blood-Brain Barrier Modeling. J Evol Biochem Physiol. 2022;58(3):781-806. doi:10.1134/S0022093022030139.; Gimbrone MA Jr, García-Cardeña G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016;118(4):620-36. doi:10.1161/CIRCRESAHA.115.306301.; Шишкова Д.К., Фролов А.В., Маркова В.Е., Маркова Ю.О., Каноныкина А.Ю., Лазебная А.И., Матвеева В.Г., Торгунакова Е.А., Кутихин А.Г. Современные подходы к моделированию дисфункции эндотелия и системному поиску ее циркулирующих маркеров. Комплексные проблемы сердечно-сосудистых заболеваний. 2024. Т. 13. № S3. С. 173-190. doi:10.17802/2306-1278-2024-13-3S-173-190.; Богданов Л.А., Кошелев В.А., Мухамадияров Р.А., Каноныкина А.Ю., Лазебная А.И., Кондратьев Е.А., Степанов А.Д., Кутихин А.Г. Современные подходы к идентификации клеточных маркеров дисфункции эндотелия. Комплексные проблемы сердечно-сосудистых заболеваний. 2024. Т. 13. № S3. С. 191-207. doi:10.17802/2306-1278-2024-13-3S-191-207.; da Silva FC, de Araújo BJ, Cordeiro CS, Arruda VM, Faria BQ, Guerra JFDC, Araújo TG, Fürstenau CR. Endothelial dysfunction due to the inhibition of the synthesis of nitric oxide: Proposal and characterization of an in vitro cellular model. Front Physiol. 2022;13:978378. doi:10.3389/fphys.2022.978378.; Ghosh S, Gupta M, Xu W, Mavrakis DA, Janocha AJ, Comhair SA, Haque MM, Stuehr DJ, Yu J, Polgar P, Naga Prasad SV, Erzurum SC. Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2016;310(11):L1199-205. doi:10.1152/ajplung.00092.2016.; Li G, Zhang H, Zhao L, Zhang Y, Yan D, Liu Y. Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase. J Am Soc Hypertens. 2017;11(12):842-852. doi:10.1016/j.jash.2017.10.009.; Förstermann U, Xia N, Li H. Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis. Circ Res. 2017;120(4):713-735. doi:10.1161/CIRCRESAHA.116.309326.; Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(7):829-37, 837a-837d. doi:10.1093/eurheartj/ehr304.; Qian J, Fulton D. Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium. Front Physiol. 2013;4:347. doi:10.3389/fphys.2013.00347.; Heiss EH, Dirsch VM. Regulation of eNOS enzyme activity by posttranslational modification. Curr Pharm Des. 2014;20(22):3503-13. doi:10.2174/13816128113196660745.; Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019;129(7):2775-2791. doi:10.1172/JCI123825.; Michell BJ, Chen Zp, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, Kemp BE. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem. 2001;276(21):17625-8. doi:10.1074/jbc.C100122200.; Fleming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R. Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res. 2001;88(11):E68-75. doi:10.1161/hh1101.092677.; Lee CH, Wei YW, Huang YT, Lin YT, Lee YC, Lee KH, Lu PJ. CDK5 phosphorylates eNOS at Ser-113 and regulates NO production. J Cell Biochem. 2010;110(1):112-7. doi:10.1002/jcb.22515.; Kennard S, Ruan L, Buffett RJ, Fulton D, Venema RC. TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS. Vascul Pharmacol. 2016;81:61-8. doi:10.1016/j.vph.2016.04.003.; Li C, Ruan L, Sood SG, Papapetropoulos A, Fulton D, Venema RC. Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cells. Vascul Pharmacol. 2007;47(5-6):257-64. doi:10.1016/j.vph.2007.07.001.; Shishkova D, Markova V, Markova Y, Sinitsky M, Sinitskaya A, Matveeva V, Torgunakova E, Lazebnaya A, Stepanov A, Kutikhin A. Physiological Concentrations of Calciprotein Particles Trigger Activation and Pro-Inflammatory Response in Endothelial Cells and Monocytes. Biochemistry (Mosc). 2025;90(1):132-160. doi:10.1134/S0006297924604064.; Ku KH, Dubinsky MK, Sukumar AN, Subramaniam N, Feasson MYM, Nair R, Tran E, Steer BM, Knight BJ, Marsden PA. In Vivo Function of Flow-Responsive Cis-DNA Elements of eNOS Gene: A Role for Chromatin-Based Mechanisms. Circulation. 2021;144(5):365-381. doi:10.1161/CIRCULATIONAHA.120.051078.; Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. J Clin Invest. 2021;131(21):e145734. doi:10.1172/JCI145734.; Cattaneo MG, Vanetti C, Decimo I, Di Chio M, Martano G, Garrone G, Bifari F, Vicentini LM. Sex-specific eNOS activity and function in human endothelial cells. Sci Rep. 2017;7(1):9612. doi:10.1038/s41598-017-10139-x.; Smith AR, Visioli F, Frei B, Hagen TM. Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A. Aging Cell. 2006;5(5):391-400. doi:10.1111/j.1474-9726.2006.00232.x.; Sansbury BE, Cummins TD, Tang Y, Hellmann J, Holden CR, Harbeson MA, Chen Y, Patel RP, Spite M, Bhatnagar A, Hill BG. Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res. 2012 Oct 12;111(9):1176-89. doi:10.1161/CIRCRESAHA.112.266395.; Bu S, Nguyen HC, Nikfarjam S, Michels DCR, Rasheed B, Maheshkumar S, Singh S, Singh KK. Endothelial cell-specific loss of eNOS differentially affects endothelial function. PLoS One. 2022;17(9):e0274487. doi:10.1371/journal.pone.0274487.; Shu X, Keller TC 4th, Begandt D, Butcher JT, Biwer L, Keller AS, Columbus L, Isakson BE. Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci. 2015;72(23):4561-75. doi:10.1007/s00018-015-2021-0.; Fries DM, Paxinou E, Themistocleous M, Swanberg E, Griendling KK, Salvemini D, Slot JW, Heijnen HF, Hazen SL, Ischiropoulos H. Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species. J Biol Chem. 2003;278(25):22901-7. doi:10.1074/jbc.M210806200.; Singh A, Sventek P, Larivière R, Thibault G, Schiffrin EL. Inducible nitric oxide synthase in vascular smooth muscle cells from prehypertensive spontaneously hypertensive rats. Am J Hypertens. 1996;9(9):867-77. doi:10.1016/s0895-7061(96)00104-5.; Di Pietro N, Di Tomo P, Di Silvestre S, Giardinelli A, Pipino C, Morabito C, Formoso G, Mariggiò MA, Pandolfi A. Increased iNOS activity in vascular smooth muscle cells from diabetic rats: potential role of Ca(2+)/calmodulin-dependent protein kinase II delta 2 (CaMKIIdelta(2)). Atherosclerosis. 2013;226(1):88-94. doi:10.1016/j.atherosclerosis.2012.10.062.; Preeclampsia is associated with loss of neuronal nitric oxide synthase expression in vascular smooth muscle cells of the human umbilical cord. Schönfelder G, Fuhr N, Hadzidiakos D, John M, Hopp H, Paul M. Histopathology. 2004;44(2):116-28. doi:10.1111/j.1365-2559.2004.01806.x.; Boulanger CM, Heymes C, Benessiano J, Geske RS, Lévy BI, Vanhoutte PM. Neuronal nitric oxide synthase is expressed in rat vascular smooth muscle cells: activation by angiotensin II in hypertension. Circ Res. 1998;83(12):1271-8. doi:10.1161/01.res.83.12.1271.; Gomez-Alamillo C, Juncos LA, Cases A, Haas JA, Romero JC. Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds. Hypertension. 2003;42(4):831-6. doi:10.1161/01.HYP.0000088854.04562.DA.; Bruno RM, Ghiadoni L, Seravalle G, Dell'oro R, Taddei S, Grassi G. Sympathetic regulation of vascular function in health and disease. Front Physiol. 2012;3:284. doi:10.3389/fphys.2012.00284.; Sheng Y, Zhu L. The crosstalk between autonomic nervous system and blood vessels. Int J Physiol Pathophysiol Pharmacol. 2018;10(1):17-28.; Durand MJ, Gutterman DD. Diversity in mechanisms of endothelium-dependent vasodilation in health and disease. Microcirculation. 2013;20(3):239-47. doi:10.1111/micc.12040.; Maruhashi T, Kihara Y, Higashi Y. Assessment of endothelium-independent vasodilation: from methodology to clinical perspectives. J Hypertens. 2018;36(7):1460-1467. doi:10.1097/HJH.0000000000001750.

Availability: https://www.nii-kpssz.com/jour/article/view/1669
https://doi.org/10.17802/2306-1278-2025-14-2-110-126

SENSITIVITY OF VARIOUS METHODS FOR ASSESSING THE CYTOTOXICITY OF MEDICAL DEVICES ; ЧУВСТВИТЕЛЬНОСТЬ РАЗЛИЧНЫХ МЕТОДОВ ОЦЕНКИ ЦИТОТОКСИЧНОСТИ МЕДИЦИНСКИХ ИЗДЕЛИЙ

Authors: Larisa V. Antonova, Vera G. Matveeva, Evgenia A. Torgunakova, Maryam Yu. Khanova, Marina S. Kolomeets, Evgenia A. Senokosova, Лариса Валерьевна Антонова, Вера Геннадьевна Матвеева, Евгения Александровна Торгунакова, Марьям Юрисовна Ханова, Марина Сергеевна Коломеец, Евгения Андреевна Сенокосова

Contributors: Исследование выполнено в рамках фундаментальной темы НИИ КПССЗ № 0419-2022-0001 «Молекулярные, клеточные и биомеханические механизмы патогенеза сердечно-сосудистых заболеваний в разработке новых методов лечения заболеваний сердечно-сосудистой системы на основе персонифицированной фармакотерапии, внедрения малоинвазивных медицинских изделий, биоматериалов и тканеинженерных имплантатов».

Source: Complex Issues of Cardiovascular Diseases; Том 14, № 4 (2025); 91-101 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 14, № 4 (2025); 91-101 ; 2587-9537 ; 2306-1278

Subject Terms: xCelligence, Endothelial cells, Fibroblasts, MTT, Viability, Proliferation, Эндотелиальные клетки, Фибробласты, Жизнеспособность, Пролиферация

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Relation: https://www.nii-kpssz.com/jour/article/view/1607/1063; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1607/1918; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1607/1919; ГОСТ ISO 10993-5-2011. Изделия медицинские. Оценка биологического действия медицинских изделий. Часть 5. Исследования на цитотоксичность: методы in vitro. - Введ. 2013.01.01 – М.: Стандарт информ, 2014. – 10 с. – (Система стандартов по информации, библиотечному и издательскому делу).; Gruber S., Nickel A. Toxic or not toxic? The specifications of the standard ISO 10993-5 are not explicit enough to yield comparable results in the cytotoxicity assessment of an identical medical device. Front. Med. Technol. 2023;5:1195529. https://doi.org/10.3389/fmedt.2023.1195529.; Bellucci D., Salvatori R., Anesi A., Chiarini L., Cannillo V. SBF assays, direct and indirect cell culture tests to evaluate the biological performance of bioglasses and bioglass-based composites: Three paradigmatic cases. Materials Science and Engineering: C. 2019;96:757-764. https://doi.org/10.1016/j.msec.2018.12.006.; Braun K., Stürzel C.M., Biskupek J., Kaiser U., Kirchhoff F., Lindén M. Comparison of different cytotoxicity assays for in vitro evaluation of mesoporous silica nanoparticles. Toxicology in Vitro. 2018;52:214-221. https://doi.org/10.1016/j.tiv.2018.06.019.; Diemer F., Stark H., Helfgen E.H., Enkling N., Probstmeier R., Winter J., Kraus D. In vitro cytotoxicity of different dental resin-cements on human cell lines. J Mater Sci Mater Med. 2021;32(1):4. https://doi.org/10.1007/s10856-020-06471-w.; Wang Y., Ma B., Yin A., Zhang B., Luo R., Pan J., Wang Y. Polycaprolactone vascular graft with epigallocatechin gallate embedded sandwiched layer-by-layer functionalization for enhanced antithrombogenicity and anti-inflammation. J Control Release. 2020;320:226-238. https://doi.org/10.1016/j.jconrel.2020.01.043.; Zhou J., Wang M., Wei T., Bai L., Zhao J., Wang K., Feng Y. Endothelial cell-mediated gene delivery for in situ accelerated endothelialization of a vascular graft. ACS Appl Mater Interfaces. 2021;13(14):16097-16105. https://doi.org/10.1021/acsami.1c01869.; Kabirian F., Brouki Milan P., Zamanian A., Heying R., Mozafari M. Nitric oxide-releasing vascular grafts: A therapeutic strategy to promote angiogenic activity and endothelium regeneration. Acta Biomater. 2019;92:82-91. https://doi.org/10.1016/j.actbio.2019.05.002.; Lee S.J., Kim M.E., Nah H., Seok J.M., Jeong M.H., Park K., Kwon I.K., Lee J.S., Park S.A. Vascular endothelial growth factor immobilized on mussel-inspired three-dimensional bilayered scaffold for artificial vascular graft application: In vitro and in vivo evaluations. J Colloid Interface Sci. 2019;537:333-344. https://doi.org/10.1016/j.jcis.2018.11.039.; Daum R., Visser D., Wild C., Kutuzova L., Schneider M., Lorenz G., et al. Fibronectin adsorption on electrospun synthetic vascular grafts attracts endothelial progenitor cells and promotes endothelialization in dynamic in vitro culture. Cells. 2020;9(3):778. https://doi.org/10.3390/cells9030778.; Guan G., Yu C., Xing M., Wu Y., Hu X., Wang H., Wang L. Hydrogel small-diameter vascular graft reinforced with a braided fiber strut with improved mechanical properties. Polymers. 2019;11:810. https://doi.org/10.3390/polym11050810.; Jirofti N., Mohebbi-Kalhori D., Samimi A., Hadjizadeh A., Kazemzadeh G.H. Small-diameter vascular graft using co-electrospun composite PCL/PU nanofibers. Biomed Mater. 2018;13(5):055014. https://doi.org/10.1088/1748-605X/aad4b5.; Fiqrianti I.A., Widiyanti P., Manaf M.A., Savira C.Y., Cahyani N.R., Bella F.R. Poly-L-lactic Acid (PLLA)-chitosan-collagen electrospun tube for vascular graft Application. J Funct Biomater.2018;9(2):32. https://doi.org/10.3390/jfb9020032.; Rosellini E., Barbani N., Lazzeri L., Cascone M.G. Biomimetic and bioactive small diameter tubular scaffolds for vascular tissue engineering. Biomimetics (Basel). 2022;7(4):199. https://doi.org/10.3390/biomimetics7040199.; Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. Clin Invest. 1973; 52: 2745–2756. https://doi.org/10.1172/JCI107470.; Ghasemi M., Turnbull T., Sebastian S., Kempson I. The MTT Assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis. Int. J. Mol. Sci. 2021;22:12827. https://doi.org/10.3390/ijms222312827.; Великанова Е.А., Матвеева В.Г., Ханова М.Ю., Антонова Л.В. Влияние напряжения сдвига на свойства колониеформирующих эндотелиальных клеток в сравнении с эндотелиальными клетками коронарных артерий. Комплексные проблемы сердечно-сосудистых заболеваний. 2022; 11(4):90-97. https://doi.org/10.17802/2306-1278-2022-11-4-90-97.; Li W., Zhou J., Xu Y. Study of the in vitro cytotoxicity testing of medical devices. Biomed Rep. 2015;3(5):617-620. https://doi.org/10.3892/br.2015.481.

Availability: https://www.nii-kpssz.com/jour/article/view/1607
https://doi.org/10.17802/2306-1278-2025-14-4-91-101

Dynamics of development of the systemic inflammatory response and disruption of endothelium-dependent vasodilation of cerebral arteries ; Динамика развития системной воспалительной реакции и нарушение эндотелий-зависимой вазодилатации церебральных артерий

Authors: I. B. Sokolova, V. N. Shuvaeva, И. Б. Соколова, В. Н. Шуваева

Contributors: This study was supported by the State funding allocated to the Pavlov Institute of Physiology Russian Academy of Sciences (No. 1021062411784-3-3.1.8)., Работа поддержана средствами федерального бюджета в рамках государственного задания ФГБУН Институт физиологии им. И.П.Павлова РАН (№1021062411784-3-3.1.8).

Source: Vestnik Moskovskogo universiteta. Seriya 16. Biologiya; Том 79, № 4 (2024); 315-321 ; Вестник Московского университета. Серия 16. Биология; Том 79, № 4 (2024); 315-321 ; 0137-0952

Subject Terms: степень агрегации эритроцитов, brain, microcirculation, cerebral arteries, leukocytes, endothelial cells, erythrocyte aggregation, головной мозг, микроциркуляция, церебральные артерии, лейкоциты, эндотелиальные клетки

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Disord. 2024;24(1):266.; Otsuka S., Matsuzaki R., Kakimoto S., Tachibe Y., Kawatani T., Takada S., Tani A., Nakanishi K., Matsuoka T., Kato Y., Inadome M., Nojima N., Sakakima H., Mizuno K., Matsubara Y., Maruyama I. Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice. PLoS One. 2024;19(5):e0303833.; Белобородова Н.В., Острова И.В. Сепсис-ассоциированная энцефалопатия (обзор). Общая реаниматология. 2017;13(5):121–139. https://doi.org/10.15360/1813-9779-2017-5-121-139.; Fruekilde S.K., Bailey C.J., Lambertsen K.L., Clausen B.H., Carlsen J., Xu N-L., Drasbek K.R., Gutiérrez-Jiménez E. Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation. J. Cereb. 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HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy. J. Neuroinflammation. 2023;20(1):69.; Robledo-Montaña J., Díaz-García C., Martí- nez M., Ambrosio N., Montero E., Marín M.J., Virto L., Muñoz-López M., Herrera D., Sanz M., Leza J.C., García-Bueno B., Figuero E., Martín-Hernández D. Microglial morphological/inflammatory phenotypes and endocannabinoid signaling in a preclinical model of periodontitis and depression. J. Neuroinflammation. 2024;21(1):219.; Никифорова Л.Р., Крышень К.Л., Боровкова К.Е. Обзор доклинических моделей сепсиса и септического шока. Лабораторные животные для научных исследований. 2021;4:17–28.; Петрищев Н.Н., Беркевич О.А., Власов Т.Д., Волкова Е.В., Зуева Е.Е., Мозговая Е.В. Диагностическая ценность определения дескваминированных эндотелиальных клеток в крови. Клиническая лабораторная диагностика. 2001;1:50–52.; Вдовин В.А., Муравьев А.В., Певзнер А.А. Способ определения степени агрегации клеток крови. 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Availability: https://vestnik-bio-msu.elpub.ru/jour/article/view/1439
https://doi.org/10.55959/MSU0137-0952-16-79-4-9

KƏSKİN FİZİKİ YÜKDƏN SONRA KARDİOMİOSİTLƏRIN MORFOFUNKSİONAL XÜSUSİYYƏTLƏRİNİN DƏYİŞİKLİKLƏRİ: CHANGES IN THE MORPHOFUNCTIONAL PROPERTIES OF CARDIOMYOCYTES AFTER ACUTE PHYSICAL LOAD

Source: Azerbaijan Medical Journal. :166-171

Subject Terms: physical load, hypoxia, физическая нагрузка, кардиомиоцит, эндотелиальные клетки, kardiomiosit, endotel hüceyrələri, hipoksiya, гипоксия, cardiomyocyte, fiziki yük, endothelial cells

Biomimetic approach to the design of artificial small‑diameter blood vessels ; Биомиметический подход к разработке протезов кровеносных сосудов малого диаметра

Authors: E. A. Nemets, Yu. V. Belov, K. S. Kiryakov, N. V. Grudinin, V. K. Bogdanov, K. S. Filippov, A. O. Nikolskaya, I. Yu. Tyunyaeva, A. A. Vypryshko, V. M. Zaxarevich, Yu. B. Basok, V. I. Sevastianov, Е. А. Немец, В. Ю. Белов, К. С. Кирьяков, Н. В. Грудинин, В. К. Богданов, К. С. Филиппов, А. О. Никольская, И. Ю. Тюняева, А. А. Выпрышко, В. М. Захаревич, Ю. Б. Басок, В. И. Севастьянов

Source: Russian Journal of Transplantology and Artificial Organs; Том 26, № 2 (2024); 145-155 ; Вестник трансплантологии и искусственных органов; Том 26, № 2 (2024); 145-155 ; 1995-1191

Subject Terms: аорта крысы, electrospinning, tubular porous scaffold, polycaprolactone, gelatin, heparin, platelet lysate, endothelial cells, cytotoxicity, implantation, rat aorta, электроспиннинг, трубчатый пористый каркас, поликапролактон, желатин, гепарин, лизат тромбоцитов, эндотелиальные клетки, цитотоксичность, имплантация

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Relation: https://journal.transpl.ru/vtio/article/view/1789/1620; https://journal.transpl.ru/vtio/article/view/1789/1659; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1610; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1611; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1612; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1613; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1614; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1615; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1616; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1617; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1618; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1619; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1620; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1621; https://journal.transpl.ru/vtio/article/downloadSuppFile/1789/1622; Das D, Noh I. 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Availability: https://journal.transpl.ru/vtio/article/view/1789
https://doi.org/10.15825/1995-1191-2024-2-145-155

PATHOLOGICAL EFFECTS OF IONIZED CALCIUM, CALCIPROTEIN MONOMERS AND CALCIPROTEIN PARTICLES ON ARTERIAL ENDOTHELIAL CELLS ; ИССЛЕДОВАНИЕ ПАТОЛОГИЧЕСКОГО ВОЗДЕЙСТВИЯ ИОНИЗИРОВАННОГО КАЛЬЦИЯ, КАЛЬЦИПРОТЕИНОВЫХ МОНОМЕРОВ И КАЛЬЦИПРОТЕИНОВЫХ ЧАСТИЦ НА ПЕРВИЧНЫЕ АРТЕРИАЛЬНЫЕ ЭНДОТЕЛИАЛЬНЫЕ КЛЕТКИ

Authors: Daria K. Shishkova, Victoria E. Markova, Yulia O. Markova, Elena A. Velikanova, Anna V. Sinitskaya, Maxim Yu. Sinitsky, Arina E. Tyurina, Alexander D. Stepanov, Yulia A. Dyleva, Vera G. Matveeva, Anton G. Kutikhin, Дарья Кирилловна Шишкова, Виктория Евгеньевна Маркова, Юлия Олеговна Маркова, Елена Анатольевна Великанова, Анна Викторовна Синицкая, Максим Юрьевич Синицкий, Арина Евгеньевна Тюрина, Александр Денисович Степанов, Юлия Александровна Дылева, Вера Геннадьевна Матвеева, Антон Геннадьевич Кутихин

Contributors: Исследование выполнено при поддержке гранта Российского научного фонда № 22-15-00107 «Патологические последствия и молекулярные механизмы воздействия кальций-фосфатных бионов (кальципротеиновых частиц) на форменные элементы крови», https://rscf.ru/project/22-15-00107/.

Source: Complex Issues of Cardiovascular Diseases; Том 13, № 3 (2024); 167-181 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 13, № 3 (2024); 167-181 ; 2587-9537 ; 2306-1278

Subject Terms: Дисфункция эндотелия, Ionized calcium, Calciprotein monomers, Calciprotein particles, Mineral stress, Endothelial cells, Endothelial dysfunction, Ионизированный кальций, Кальципротеиновые мономеры, Кальципротеиновые частицы, Минеральный стресс, Эндотелиальные клетки

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Relation: https://www.nii-kpssz.com/jour/article/view/1399/926; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1476; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1477; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1478; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1479; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1486; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1487; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1490; Kutikhin A.G., Feenstra L., Kostyunin A.E., Yuzhalin A.E., Hillebrands J.L., Krenning G. Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology. Arterioscler Thromb Vasc Biol. 2021;41(5):1607-1624. doi:10.1161/ATVBAHA.120.315697.; Heiss A., Eckert T., Aretz A., Richtering W., van Dorp W., Schäfer C., Jahnen-Dechent W. Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 2008;283(21):14815-25. doi:10.1074/jbc.M709938200.; Heiss A., DuChesne A., Denecke B., Grötzinger J., Yamamoto K., Renné T., Jahnen-Dechent W. Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem. 2003;278(15):13333-41. doi:10.1074/jbc.M210868200.; Shishkova D.K., Velikanova E.A., Bogdanov L.A., Sinitsky M.Y., Kostyunin A.E., Tsepokina A.V., Gruzdeva O.V., Mironov A.V., Mukhamadiyarov R.A., Glushkova T.V., Krivkina E.O., Matveeva V.G., Hryachkova O.N., Markova V.E., Dyleva Y.A., Belik E.V., Frolov A.V., Shabaev A.R., Efimova O.S., Popova A.N., Malysheva V.Y., Kolmykov R.P., Sevostyanov O.G., Russakov D.M., Dolganyuk V.F., Gutakovsky A.K., Zhivodkov Y.A., Kozhukhov A.S., Brusina E.B., Ismagilov Z.R., Barbarash O.L., Yuzhalin A.E., Kutikhin A.G. Calciprotein Particles Link Disturbed Mineral Homeostasis with Cardiovascular Disease by Causing Endothelial Dysfunction and Vascular Inflammation. Int J Mol Sci. 2021;22(22):12458. doi:10.3390/ijms222212458.; Shishkova D., Markova V., Sinitsky M., Tsepokina A., Velikanova E., Bogdanov L., Glushkova T., Kutikhin A. Calciprotein Particles Cause Endothelial Dysfunction under Flow. Int J Mol Sci. 2020;21(22):8802. doi:10.3390/ijms21228802.; Kutikhin A.G., Velikanova E.A., Mukhamadiyarov R.A., Glushkova T.V., Borisov V.V., Matveeva V.G., Antonova L.V., Filip'ev D.E., Golovkin A.S., Shishkova D.K., Burago A.Y., Frolov A.V., Dolgov V.Y., Efimova O.S., Popova A.N., Malysheva V.Y., Vladimirov A.A., Sozinov S.A., Ismagilov Z.R., Russakov D.M., Lomzov A.A., Pyshnyi D.V., Gutakovsky A.K., Zhivodkov Y.A., Demidov E.A., Peltek S.E., Dolganyuk V.F., Babich O.O., Grigoriev E.V., Brusina E.B., Barbarash O.L., Yuzhalin A.E. Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions. Sci Rep. 2016;6:27255. doi:10.1038/srep27255.; Feenstra L., Kutikhin A.G., Shishkova D.K., Buikema H., Zeper L.W., Bourgonje A.R., Krenning G., Hillebrands J.L. Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism. Arterioscler Thromb Vasc Biol. 2023;43(3):443-455. doi:10.1161/ATVBAHA.122.318420.; Shishkova D., Lobov A., Zainullina B., Matveeva V., Markova V., Sinitskaya A., Velikanova E., Sinitsky M., Kanonykina A., Dyleva Y., Kutikhin A. Calciprotein Particles Cause Physiologically Significant Pro-Inflammatory Response in Endothelial Cells and Systemic Circulation. Int J Mol Sci. 2022;23(23):14941. doi:10.3390/ijms232314941.; Kutikhin A.G. Pathophysiological and clinical significance of mineral homeostasis disorders in the development of cardiovascular disease. Fundamental and Clinical Medicine. 2021;6(2):82-102. doi:10.23946/2500-0764-2021-6-1-82-102. (In Russian); Lutsey P.L., Alonso A., Michos E.D., Loehr L.R., Astor B.C., Coresh J., Folsom A.R. Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2014;100(3):756-64. doi:10.3945/ajcn.114.085167.; Rohrmann S., Garmo H., Malmstrom H., Hammar N., Jungner I., Walldius G., Van Hemelrijck M. Association between serum calcium concentration and risk of incident and fatal cardiovascular disease in the prospective AMORIS study. Atherosclerosis. 2016;251:85-93. doi:10.1016/j.atherosclerosis.2016.06.004.; Reid I.R., Gamble G.D., Bolland M.J. Circulating calcium concentrations, vascular disease and mortality: a systematic review. J Intern Med. 2016;279(6):524-40. doi:10.1111/joim.12464.; Kobylecki C.J., Nordestgaard B.G., Afzal S. Plasma Ionized Calcium and Risk of Cardiovascular Disease: 106 774 Individuals from the Copenhagen General Population Study. Clin Chem. 2021;67(1):265-275. doi:10.1093/clinchem/hvaa245.; Shishkova D.K., Matveeva V.G., Markova V.E., Khryachkova O.N., Indukaeva E.V., Shabaev А.R., Frolov A.V., Kutikhin A.G. Quantification of the initial levels of calciprotein particles as a screening marker of mineral homeostasis in patients with cardiovascular disease and in patients with chronic kidney disease. Russian Journal of Cardiology. 2022;27(12):5064. doi:10.15829/1560-4071-2022-5064. (In Russioan); Kutikhin A.G., Shishkova D.K., Khryachkova O.N., Frolov A.V., Osyaev N.Yu., Indukaeva E.V., Gruzdeva O.V., Shabaev A.R., Zagorodnikov N.I., Markova V.E., Bogdanov L.А. Formation of calcium phosphate bions in patients with carotid and coronary atherosclerosis. Russian Journal of Cardiology. 2020;25(12):3881. (In Russian); Xie W.M., Ran L.S., Jiang J., Chen Y.S., Ji H.Y., Quan X.Q. Association between fetuin-A and prognosis of CAD: A systematic review and meta-analysis. Eur J Clin Invest. 2019;49(5):e13091. doi:10.1111/eci.13091.; Ronit A., Kirkegaard-Klitbo D.M., Dohlmann T.L., Lundgren J., Sabin C.A., Phillips A.N., Nordestgaard B.G., Afzal S. Plasma Albumin and Incident Cardiovascular Disease: Results From the CGPS and an Updated Meta-Analysis. Arterioscler Thromb Vasc Biol. 2020;40(2):473-482. doi:10.1161/ATVBAHA.119.313681.; Seidu S., Kunutsor S.K., Khunti K. Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants. Scand Cardiovasc J. 2020;54(5):280-293. doi:10.1080/14017431.2020.1762918.; Heiss A., Pipich V., Jahnen-Dechent W., Schwahn D. Fetuin-A is a mineral carrier protein: small angle neutron scattering provides new insight on Fetuin-A controlled calcification inhibition. Biophys J. 2010;99(12):3986-95. doi:10.1016/j.bpj.2010.10.030.; Koeppert S., Ghallab A., Peglow S., Winkler C.F., Graeber S., Büscher A., Hengstler J.G., Jahnen-Dechent W. Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers. Front Cell Dev Biol. 2021;9:633925. doi:10.3389/fcell.2021.633925.; Herrmann M., Schäfer C., Heiss A., Gräber S., Kinkeldey A., Büscher A., Schmitt M.M., Bornemann J., Nimmerjahn F., Herrmann M., Helming L., Gordon S., Jahnen-Dechent W. Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A. Circ Res. 2012;111(5):575-84. doi:10.1161/CIRCRESAHA.111.261479.; Köppert S., Büscher A., Babler A., Ghallab A., Buhl E.M., Latz E., Hengstler J.G., Smith E.R., Jahnen-Dechent W. Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity. Front Immunol. 2018;9:1991. doi:10.3389/fimmu.2018.01991.; Kutikhin A.G., Shishkova D.K., Velikanova E.A., Sinitsky M.Y., Sinitskaya A.V., Markova V.E. Endothelial Dysfunction in the Context of Blood-Brain Barrier Modeling. J Evol Biochem Physiol. 2022;58(3):781-806. doi:10.1134/S0022093022030139.; Shishkova D.K., Sinitskaya A.V., Sinitsky M.Yu., Matveeva V.G., Velikanova E.A., Markova V.E., Kutikhin A.G. Spontaneous endothelial-to-mesenchymal transition in human primary umbilical vein endothelial cells. Complex Issues of Cardiovascular Diseases. 2022;11(3):97-114. doi:10.17802/2306-1278-2022-11-3-97-114 (In Russian)]; Liberale L., Montecucco F., Tardif J.C, Libby P., Camici G.G. Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. Eur Heart J. 2020;41(31):2974-2982. doi:10.1093/eurheartj/ehz961.

Availability: https://www.nii-kpssz.com/jour/article/view/1399
https://doi.org/10.17802/2306-1278-2024-13-3-167-181

ROLE OF ADIPONECTIN IN ATHEROGENESIS: FUNDAMENTAL ASPECTS AND PERSPECTIVES IN TRANSLATION INTO CLINICAL PRACTICE ; РОЛЬ АДИПОНЕКТИНА В АТЕРОГЕНЕЗЕ: ФУНДАМЕНТАЛЬНЫЕ АСПЕКТЫ И ПЕРСПЕКТИВЫ ТРАНСЛЯЦИИ В КЛИНИЧЕСКУЮ ПРАКТИКУ

Authors: Dmitriy A. Tanyanskiy, Дмитрий Андреевич Танянский

Contributors: Исследования по влиянию адипонектина на функцию эндотелиальных клеток и макрофагов выполнены при поддержке гранта РНФ (проект № 22-25-00366).

Source: Complex Issues of Cardiovascular Diseases; Том 13, № 1 (2024); 179-195 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 13, № 1 (2024); 179-195 ; 2587-9537 ; 2306-1278

Subject Terms: Макрофаги, Atherosclerosis, Low-density lipoproteins, Endothelial cells, Macrophages, Атеросклероз, Липопротеины низкой плотности, Эндотелиальные клетки

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Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes. 2003;52(7):1779-85. doi:10.2337/diabetes.52.7.1779.; Fu Y., Luo N., Klein R.L., Garvey W.T. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res. 2005;46(7):1369-79. doi:10.1194/jlr.M400373-JLR200.; Kim J.Y., van de Wall E., Laplante M., Azzara A., Trujillo M.E., Hofmann S.M., Schraw T., Durand J.L., Li H., Li G., Jelicks L.A., Mehler M.F., Hui D.Y., Deshaies Y., Shulman G.I., Schwartz G.J., Scherer P.E. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. 2007;117(9):2621-37. doi:10.1172/JCI31021.; Matsuura F., Oku H., Koseki M., Sandoval J.C., Yuasa-Kawase M., Tsubakio-Yamamoto K., Masuda D., Maeda N., Tsujii K., Ishigami M., Nishida M., Hirano K., Kihara S., Hori M., Shimomura I., Yamashita S. Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver. Biochem Biophys Res Commun. 2007;358(4):1091-5. doi:10.1016/j.bbrc.2007.05.040.; Wang X., Chen Q., Pu H., Wei Q., Duan M., Zhang C., Jiang T., Shou X., Zhang J., Yang Y. Adiponectin improves NF-κB-mediated inflammation and abates atherosclerosis progression in apolipoprotein E-deficient mice. Lipids Health Dis. 2016;15:33. doi:10.1186/s12944-016-0202-y.; Tsao T.S. Assembly of adiponectin oligomers. Rev Endocr Metab Disord. 2014;15(2):125-36. doi:10.1007/s11154-013-9256-6.; Takemura Y., Ouchi N., Shibata R., Aprahamian T., Kirber M.T., Summer R.S., Kihara S., Walsh K. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest. 2007;117(2):375-86. doi:10.1172/JCI29709.; Yamauchi T., Iwabu M., Okada-Iwabu M., Kadowaki T. Adiponectin receptors: a review of their structure, function and how they work. Best Pract Res Clin Endocrinol Metab. 2014;28(1):15-23. doi:10.1016/j.beem.2013.09.003.; Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995;270(45):26746-9. doi:10.1074/jbc.270.45.26746.; Ding M., Carrão A.C., Wagner R.J., Xie Y., Jin Y., Rzucidlo E.M., Yu J., Li W., Tellides G., Hwa J., Aprahamian T.R., Martin K.A. Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype. J Mol Cell Cardiol. 2012;52(2):474-84. doi:10.1016/j.yjmcc.2011.09.008.; Wong W.T., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L., Wang Y., Lee V.W., Lam K.S., Vanhoutte P.M., Huang Y. Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab. 2011;14(1):104-15. doi:10.1016/j.cmet.2011.05.009.; Wedellová Z., Dietrich J., Siklová-Vítková M., Kološtová K., Kováčiková M., Dušková M., Brož J., Vedral T., Stich V., Polák J. 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Circulation. 2002;106(22):2767-70. doi:10.1161/01.cir.0000042707.50032.19.; Yamauchi T., Kamon J., Waki H., Imai Y., Shimozawa N., Hioki K., Uchida S., Ito Y., Takakuwa K., Matsui J., Takata M., Eto K., Terauchi Y., Komeda K., Tsunoda M., Murakami K., Ohnishi Y., Naitoh T., Yamamura K., Ueyama Y., Froguel P., Kimura S., Nagai R., Kadowaki T. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem. 2003;278(4):2461-8. doi:10.1074/jbc.M209033200.; van Stijn C.M., Kim J., Barish G.D., Tietge U.J., Tangirala R.K. Adiponectin expression protects against angiotensin II-mediated inflammation and accelerated atherosclerosis. PLoS One. 2014;9(1):e86404. doi:10.1371/journal.pone.0086404.; Li L., Cai X.J., Feng M., Rong Y.Y., Zhang Y., Zhang M. Effect of adiponectin overexpression on stability of preexisting plaques by inducing prolyl-4-hydroxylase expression. 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Effects of shear stress on the properties of colonyforming endothelial cells in comparison with coronary artery endothelial cells ; Влияние напряжения сдвига на свойства колониеформирующих эндотелиальных клеток в сравнении с эндотелиальными клетками коронарных артерий

Authors: E. A. Velikanova, V. G. Matveeva, M. Yu. Khanova, L. V. Antonova, Е. А. Великанова, В. Г. Матвеева, М. Ю. Ханова, Л. В. Антонова

Contributors: Работа выполнена при поддержке комплексной программы фундаментальных научных исследований СО РАН в рамках фундаментальной темы НИИ КПССЗ № 0546-2019-0002 «Патогенетическое обоснование разработки имплантатов для сердечно-сосудистой хирургии на основе биосовместимых материалов, с реализацией пациент-ориентированного подхода с использованием математического моделирования, тканевой инженерии и геномных предикторов».

Source: Complex Issues of Cardiovascular Diseases; Том 11, № 4 (2022); 90-97 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 11, № 4 (2022); 90-97 ; 2587-9537 ; 2306-1278

Subject Terms: Эндотелиальные клетки коронарных артерий, Shear stress, Colony-forming endothelial cells, Coronary artery endothelial cells, Напряжение сдвига, Колониеформирующие эндотелиальные клетки

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https://doi.org/10.17802/2306-1278-2022-11-4-90-97

PRODUCTION OF GROWTH FACTORS AND DESQUAMATION OF ENDOTHELIOCYTES IN THE HEART IN ISCHEMIC CARDIOMYOPATHY ; ПРОДУКЦИЯ ФАКТОРОВ РОСТА И ДЕСКВАМАЦИЯ ЭНДОТЕЛИОЦИТОВ В СЕРДЦЕ ПРИ ИШЕМИЧЕСКОЙ КАРДИОМИОПАТИИ

Authors: Olga A. Denisenko, Svetlana P. Chumakova, Olga I. Urazova, Margarita V. Gladkovskaya, Vladimir M. Shipulin, Sergey L. Andreev, Ksenia V. Nevskaya, Abboshon Gayrat ugli Gulomzhenov, Ольга Анатольевна Денисенко, Светлана Петровна Чумакова, Ольга Ивановн Уразова, Маргарита Владимировна Гладковская, Владимир Митрофанович Шипулин, Сергей Леонидович Андреев, Ксения Владимировна Невская, Аббосхон Гайрат угли Гуломженов

Contributors: Исследование выполнено при поддержке гранта Российского научного фонда № 22-25-00821, https://rscf.ru/project/22-25-00821/.

Source: Complex Issues of Cardiovascular Diseases; Том 12, № 4 (2023); 120-132 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 12, № 4 (2023); 120-132 ; 2587-9537 ; 2306-1278

Subject Terms: Факторы роста, Ischemic cardiomyopathy, Desquamated endothelial cells, Progenitor endothelial cells, Growth factors, Ишемическая кардиомиопатия, Десквамированные эндотелиальные клетки, Прогениторные эндотелиальные клетки

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Relation: https://www.nii-kpssz.com/jour/article/view/1324/841; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1324/1320; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1324/1321; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1324/1322; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1324/1323; Dang H., Ye Y., Zhao X., Zeng Y. Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database. BMC Cardiovasc Disord. 2020; 20(1): 320. doi:10.1186/s12872-020-01596-w; Cabac-Pogorevici I., Muk B., Rustamova Y., Kalogeropoulos A., Tzeis S., Vardas P. Ischaemic cardiomyopathy. Pathophysiological insights, diagnostic management and the roles of revascularisation and device treatment. Gaps and dilemmas in the era of advanced technology Eur J Heart Fail. 2020; 22(5): 789-799. doi:10.1002/ejhf.1747; Ali H.R., Michel C.R., Lin Y.H., McKinsey T.A., Jeong M.Y., Ambardekar A.V., et all. Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. Mol Cell Cardiol. 2020; 138: 304-317. doi:10.1016/j.yjmcc.2019.11.159; Mallick R., Ylä-Herttuala S. Therapeutic Potential of VEGF-B in Coronary heart disease and heart failure: dream or vision? Cells. 2022; 11(24): 4134. doi:10.3390/cells11244134; Cavalcante S.L., Lopes S., Bohn L., Cavero-Redondo I., Álvarez-Bueno C., Viamonte S., Santos M., Oliveira J., Ribeiro F. Effects of exercise on endothelial progenitor cells in patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis Rev Port Cardiol (Engl Ed). 2019; 38(11): 817-827. doi:10.1016/j.repc.2019.02.016; Botts S.R., Fish J.E., Howe K.L. Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment. Front Pharmacol. 2021; 12: 787541. doi:10.3389/fphar.2021.787541; Ungvari Z., Tarantini S., Kiss T., Wren J.D., Giles C.B., Griffin C.T., Murfee W.L., Pacher P., Csiszar A. Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Nat Rev Cardiol. 2018; 15(9): 555–565. doi:10.1038/s41569-018-0030-z; Zhang J. Biomarkers of endothelial activation and dysfunction in cardiovascular diseases. Rev Cardiovasc Med. 2022; 23(2): 73. doi:10.31083/j.rcm2302073; Gimbrone M.A., García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 2016; 118(4): 620–636. doi:10.1161/CIRCRESAHA.115.306301; Топузова М.П., Алексеева Т.М., Вавилова Т.В., Сироткина О.В., Клочева Е.Г. Циркулирующие эндотелиоциты и их предшественники как маркер дисфункции эндотелия у больных артериальной гипертензией, перенесших ишемический инсульт (Обзор). Артериальная гипертензия. 2018; 24(1): 57-64. doi:10.18705/1607-419X-2018-24-1-57-64; Lopes J., Teixeira M., Cavalcante S., Gouveia M., Duarte A., Ferreira M.,et al. Reduced levels of circulating endothelial cells and endothelial progenitor cells in patients with heart failure with reduced ejection fraction. Arch Med Res. 2022; 53(3): 289-295. doi:10.1016/j.arcmed.2022.02.001; Jaipersad A.S., Lip G.Y.H., Silverman S., Shantsila E. The role of monocytes in angiogenesis and atherosclerosis. J Am Coll Cardiol. 2014; 63(1): 1-11. doi:10.1016/j.jacc.2013.09.019; Elsheikh E., Uzunel M., He Z., Holgersson J., Nowak G., Sumitran-Holgersson S. Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity. Blood. 2005; 106(7): 2347-55. doi:10.1182/blood-2005-04-1407; Yan F., Liu X., Ding H., Zhang W. Paracrine mechanisms of endothelial progenitor cells in vascular repair. Acta Histochem. 2022; 124(1): 151833. doi:10.1016/j.acthis.2021.151833; Куртукова М.О., Бугаева И.О., Иванов А.Н. Факторы, регулирующие ангиогенез. Современные проблемы науки и образования. 2015; 5: 246.; Braile M., Marcella S., Cristinziano L., Galdiero M.R., Modestino L., Ferrara A.L., Varricchi G., Marone G., Loffredo S. VEGF-A in Cardiomyocytes and Heart Diseases. Int J Mol Sci. 2020; 21(15): 5294. doi:10.3390/ijms21155294; Grismaldo A., Sobrevia L., Morales L. Role of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases. Biochim Biophys Acta Gen Subj. 2022; 1866(10): 130188. doi:10.1016/j.bbagen.2022.130188; Oprescu N., Micheu M.M., Scafa-Udriste A., Popa-Fotea N-M., Dorobantu M. Inflammatory markers in acute myocardial infarction and the correlation with the severity of coronary heart disease. Ann Med. 2021; 53(1): 1040–1046. doi:10.1080/07853890.2021.1916070; Гордеева К., Каде А.Х. Изменение цитокинового статуса при стабильной стенокардии напряжения напряжения. Медицинский вестник Юга России. Обзоры. 2016; 1: 15-21. doi:10.21886/2219-8075-2016-1-15-21; Felker G.M., Shaw G.M., O’Connor C.M. A standardized definition of ischemic cardiomyopathy for use in clinical research. Journal of the American College of Cardiology. 2002; 39 (2): 208–210. doi:10.1016/s0735-1097(01)01738-7; Shantsila E., Blann A.D., Lip G.Y.H. Circulating endothelial cells: from bench to clinical practice. J Thromb Haemost. 2008; 6(5): 865-868. doi:10.1111/j.1538-7836.2008.02918.x; Valgimigli M., Rigolin G.M., Fucili A., Porta M.D., Soukhomovskaia O., Malagutti P., Bugli A.M., Bragotti L.Z., Francolini G., Mauro E., Castoldi G., Ferrari R. CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation. 2004; 110: 1209–1212. doi:10.1161/01.CIR.0000136813.89036.21; Morrone D., Picoi M.E.L., Felice F., Martino A.D., Scatena C., Spontoni P., Naccarato A.G., Di Stefano R., Bortolotti U., Dal Monte M., Pini S., Abelli M., Balbarini A. Endothelial progenitor cells: an appraisal of relevant data from bench to bedside. Int. J. Mol. Sci. 2021; 22: 12874. doi:10.3390/ijms222312874; Melincovici C.S., Boşca A.B., Şuşman S., Mărginean M., Mihu C., Istrate M., Moldovan I.M., Roman A.L., Mihu C.M. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 2018, 59(2): 455–467; Zhou Y., Zhu X, Cui H., Shi J., Yuan G., Shi S., Hu Y. The Role of the VEGF Family in Coronary Heart Disease. Front Cardiovasc Med. 2021; 8: 738325. doi:10.3389/fcvm.2021.738325.; Сергеенко И.В., Семенова А.Е., Масенко В.П., Хабибуллина Л.И., Габрусенко С.А., Кухарчук В.В., Беленков Ю.Н. Влияние реваскуляризации миокарда на динамику сосудистого эндотелиального и трансформирующего факторов роста у больных ишемической болезнью сердца. Кардиоваскуляр-ная терапия и профилактика. 2007; 6(5); 12-17.; Прасолов А.В., Князева Л.А., Князева Л.И., Жукова Л.А. Изменение показателей цитокинового статуса у больных ИБС: стабильной стенокардией напряжения II-III функционального класса в зависимости от терапии. Вестник новых медицинских технологий. 2009; 14(2); 146-147.; Goumans M-J., Dijke P.T. TGF-β Signaling in Control of Cardiovascular Function. Cold Spring Harb Perspect Biol. 2018; 10(2): a022210. doi:10.1101/cshperspect.a022210; Rajendran S., Shen X., Glawe J., Kolluru G.K., Kevil C.G. Nitric oxide and hydrogen sulfide regulation of ischemic vascular growth and remodeling. Compr Physiol. 2019; 9(3): 1213–1247. doi:10.1002/cphy.c180026; Li J-H., Li Y., Huang D., Yao M. Role of stromal cell-derived factor-1 in endothelial progenitor cell-mediated vascular repair and regeneration. Tissue Eng Regen Med. 2021; 18(5): 747–758. doi:10.1007/s13770-021-00366-9

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https://doi.org/10.17802/2306-1278-2023-12-4-120-132

The role of the Notch signaling pathway in liver fibrogenesis

Authors: Lebedeva, E. I.

Source: Морфологія, Vol 14, Iss 1, Pp 7-15 (2020)
Morphologia; Том 14, № 1 (2020); 7-15

Subject Terms: фіброз печінки, макрофаги, QH301-705.5, сигнальный путь Notch, фиброз печени, звездчатые клетки, синусоидальные эндотелиальные клетки, сигнальний шлях notch, сигнальний шлях Notch, зірчасті клітини, синусоїдальні ендотеліальні клітини, Notch signaling pathway, liver fibrosis, stellate cells, macrophages, sinusoidal endothelial cells, Biology (General), 3. Good health

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Access URL: http://morphology.dma.dp.ua/article/download/201023/201095
https://doaj.org/article/41c0e7398c4e44cf834a6263fbba7a11
http://morphology.dma.dp.ua/article/view/201023
http://morphology.dma.dp.ua/article/download/201023/201095
http://morphology.dma.dp.ua/article/view/201023

Technique for reducing the surgical porosity of small-diameter vascular grafts ; Способ уменьшения хирургической пористости протезов кровеносных сосудов малого диаметра

Authors: E. A. Nemets, A. I. Khairullina, V. Yu. Belov, V. A. Surguchenko, V. N. Vasilets, V. I. Sevastianov, E. A. Volkova, Yu. B. Basok, Е. А. Немец, А. И. Хайруллина, В. Ю. Белов, В. А. Сургученко, В. Н. Василец, Е. А. Волкова, Ю. Б. Басок, В. И. Севастьянов

Source: Russian Journal of Transplantology and Artificial Organs; Том 25, № 3 (2023); 87-96 ; Вестник трансплантологии и искусственных органов; Том 25, № 3 (2023); 87-96 ; 1995-1191

Subject Terms: эндотелиальные клетки, polycaprolactone, gelatin, surgical porosity, mechanical properties, endothelial cells, поликапролактон, желатин, хирургическая пористость, механические свойства

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Relation: https://journal.transpl.ru/vtio/article/view/1669/1512; https://journal.transpl.ru/vtio/article/view/1669/1528; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1382; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1383; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1384; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1385; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1386; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1387; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1388; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1389; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1390; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1391; https://journal.transpl.ru/vtio/article/downloadSuppFile/1669/1392; Протезы кровеносных сосудов. Общие технические требования. Методы испытаний: ГОСТ 31514-2012. Дата введения 01.01.2015. М.: Стандартинформ, 2015.; Szentivanyi A, Chakradeo T, Zernetsch H, Glasmacher B. Electrospun cellular microenvironments: understanding controlled release and scaffold structure. Adv Drug Deliv Rev. 2011; 63: 209–220.; Новикова СП, Салохединова РР, Лосева СВ, Николашина ЛН, Левкина АЮ. Анализ физико-механических и структурных характеристик протезов кровеносных сосудов. Грудная и сердечно-сосудистая хирургия. 2012; 54: 27–33.; Wesolowski SA, Fries CC, Karlson KE, De Bakey M, Sawyer PN. Porosity: primary determinant of ultimate fate of synthetic vascular grafts. Surgery. 1961; 50: 91–96.; Лебедев ЛВ, Плотник ЛЛ, Смирнов АД. Протезы кровеносных сосудов. Л.: Медицина, 1981; 192.; Guan G, Yu C, Fang X, Guidoin R, King MW, Wang H, Wang L. Exploration into practical significance of integral water permeability of textile vascular grafts. J Appl Biomater Funct Mater. 2021; 19: 22808000211014007. doi:10.1177/22808000211014007.; Yates SG, Barros D’Sa AA, Berger K, Fernandez LG, Wood SJ, Rittenhouse EA et al. The preclotting of porous arterial prostheses. Ann Surg. 1978; 188: 611–622.; Joseph J, Domenico Bruno V, Sulaiman N, Ward A, Johnson TW, Baby HM et al. A novel small diameter nanotextile arterial graft is associated with surgical feasibility and safety and increased transmural endothelial ingrowth in pig. J Nanobiotechnology. 2022; 20: 71. doi:10.1186/s12951-022-01268-1.; Hisagi M, Nishimura T, Ono M, Gojo S, Nawata K, Kyo S. New pre-clotting method for fibrin glue in a nonsealed graft used in an LVAD: the KYO method. J Artif Organs. 2010; 13: 174–177. doi:10.1007/s10047-010- 0504-1.; Weadock KS, Goggins JA. Vascular graft sealants. J Long Term Eff Med Implants. 1993; 3: 207–22.; Copes F, Pien N, Van Vlierberghe S, Boccafoschi F, Mantovani D. Collagen-Based Tissue Engineering Strategies for Vascular Medicine. Front Bioeng Biotechnol. 2019; 7: 166. doi:10.3389/fbioe.2019.00166.; Zdrahala RJ. Small caliber vascular grafts. Part I: state of the art. J Biomater Appl. 1996; 10: 309–329. doi:10.1177/088532829601000402.; Drury JK, Ashton TR, Cunningham JD, Maini R, Pollock JG. Experimental and clinical experience with a gelatin impregnated Dacron prosthesis. Ann Vasc Surg. 1987; 1: 542–547.; Fortin W, Bouchet M, Therasse E, Maire M, Héon H, Ajji A et al. Negative In Vivo Results Despite Promising In vitro Data With a Coated Compliant Electrospun Polyurethane Vascular Graft. J Surg Res. 2022; 279: 491– 504. doi:10.1016/j.jss.2022.05.032.; Huang F, Sun L, Zheng J. In vitro and in vivo characterization of a silk fibroin-coated polyester vascular prosthesis. Artif Organs. 2008; 12: 932–941. doi:10.1111/j.1525- 1594.2008.00655.x.; Lee JH, Kim WG, Kim SS, Lee JH, Lee HB. Development and characterization of an alginate-impregnated polyester vascular graft. J Biomed Mater Res. 1997; 36: 200–208. doi:10.1002/(sici)1097-4636(199708)36:23.0.co;2-o.; Lisman A, Butruk B, Wasiak I, Ciach T. Dextran/Albumin hydrogel sealant for Dacron(R) vascular prosthesis. J Biomater Appl. 2014; 28: 1386–1396. doi:10.1177/0885328213509676.; Madhavan K, Elliott WH, Bonani W, Monnet E, Tan W. Mechanical and biocompatible characterizations of a readily available multilayer vascular graft. J Biomed Mater Res B Appl Biomater. 2013; 101: 506–519. doi:10.1002/jbm.b.32851.; Немец ЕА, Панкина АП, Сургученко ВА, Севастьянов ВИ. Биостабильность и цитотоксичность медицинских изделий на основе сшитых биополимеров. Вестник трансплантологии и искусственных органов. 2018; 20 (1): 79–85. doi:10.15825/1995-1191-2018-1-79-85.; Глушкова ТВ, Овчаренко ЕА, Рогулина НВ, Клышников КЮ, Кудрявцева ЮА, Барбараш ЛС. Дисфункции эпоксиобработанных биопротезов клапанов сердца. Кардиология. 2019; 59 (10): 49–59. doi:10.18087/cardio.2019.10.n327.; Hennink WE, van Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev. 2002; 54: 13–36. doi:10.1016/s0169-409x(01)00240-x.; Chernonosova VS, Laktionov PP. Structural Aspects of Electrospun Scaffolds Intended for Prosthetics of Blood Vessels. Polymers (Basel). 2022; 14: 1698. doi:10.3390/polym14091698.; Fioretta ES, Simonet M, Smits AI, Baaijens FP, Bouten CV. Differential response of endothelial and endothelial colony forming cells on electrospun scaffolds with distinct microfiber diameters. Biomacromolecules. 2014; 15: 821–829. doi:10.1021/bm4016418.; Azimi B, Nourpanah P, Rabiee M, Arbab SJ. Poly (ε-caprolactone) Fiber: An Overview. Engineered Fibers Fabrics. 2014; 9: 74–90. doi:10.1177/155892501400900309.; Reid JA, McDonald A, Callanan A. Electrospun fibre diameter and its effects on vascular smooth muscle cells. J Mater Sci Mater Med. 2021; 32: 131. doi:10.1007/s10856-021-06605-8.; Nemets EA, Surguchenko VA, Belov VYu, Xajrullina AI, Sevastyanov VI. Porous Tubular Scaffolds for Tissue Engineering Structures of Small Diameter Blood Vessels. Inorganic Materials: Applied Research. 2023; 14: 400– 407. doi:10.1134/S2075113323020338.; Лебедев АВ, Бойко АИ. Зависимость прочности сваренных кровеносных сосудов от диаметра, толщины и модуля Юнга стенки. Биомедицинская инженерия и электроника. 2014; 2: 54–61.; https://journal.transpl.ru/vtio/article/view/1669

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https://doi.org/10.15825/1995-1191-2023-3-87-96

Analysis of the effectiveness of various protein coatings for optimizing the endothelialization of polymer matrices ; Анализ эффективности различных белковых покрытий для оптимизации эндотелизации полимерных матриксов

Authors: E. A. Velikanova, V. G. Matveeva, E. A. Senokosova, M. U. Khanova, E. O. Krivkina, L. V. Antonova, Е. А. Великанова, В. Г. Матвеева, Е. А. Сенокосова, М. Ю. Ханова, Е. О. Кривкина, Л. В. Антонова

Contributors: The study was supported by the Ministry of Science and Higher Education of the Russian Federation within the framework of the Agreement on the provision of grants from the federal budget in the form of subsidies in accordance with paragraph 4 of Article 78.1 of the Budget Code of the Russian Federation № 075-15-2022-1202 dated September 30, 2022, concluded to implement the Order of the Russian Federation Government dated May 11, 2022 No. 1144-r., Исследование выполнено при финансовой поддержке Министерства науки и высшего образования Российской Федерации в рамках Соглашения о предоставлении из федерального бюджета грантов в форме субсидий в соответствии с п. 4 ст. 78.1 Бюджетного кодекса Российской Федерации № 075-15-2022-1202 от 30 сентября 2022 г., заключенного в целях реализации Распоряжения Правительства Российской Федерации от 11 мая 2022 г. № 1144-р.

Source: Siberian Journal of Clinical and Experimental Medicine; Том 38, № 1 (2023); 160-166 ; Сибирский журнал клинической и экспериментальной медицины; Том 38, № 1 (2023); 160-166 ; 2713-265X ; 2713-2927

Subject Terms: эндотелиальные клетки, small-diameter vessel prostheses, electrospinning, fibrin, endothelial cells, протезы сосудов малого диаметра, электроспиннинг, фибрин

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Relation: https://www.sibjcem.ru/jour/article/view/1724/800; Mathers C.D., Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442. DOI:10.1371/journal.pmed.0030442.; Pashneh-Tala S., MacNeil S., Claeyssens F. The tissue-engineered vascular graft – past, present, and future. Tissue Eng. Part. B.: Rev. 2016;22(1):68–100. DOI:10.1089/ten.teb.2015.0100.; Elliott M.B., Ginn B., Fukunishi T., Bedja D., Suresh A., Chen T. et al. Regenerative and durable small-diameter graft as an arterial conduit. Proc. Natl. Acad. Sci. USA. 2019;116(26):12710–12719. DOI:10.1073/pnas.1905966116.; Shoji T., Shinoka T. Tissue engineered vascular grafts for pediatric cardiac surgery. Transl. Pediatr. 2018;7(2):188–195. DOI:10.21037/tp.2018.02.01.; Abdulhannan P., Russell D.A., Homer-Vanniasinkam S. Peripheral arterial disease: a literature review. Br. Med. Bull. 2012;104:21–39. DOI:10.1093/bmb/lds027.; Ardila D.C., Liou J.J., Maestas D., Slepian M.J., Badowski M., Wagner W.R. et al. Surface Modification of Electrospun Scaffolds for Endothelialization of Tissue-Engineered Vascular Grafts Using Human Cord Blood-Derived Endothelial Cells. J. Clin. Med. 2019;8(2):185. DOI:10.3390/jcm8020185.; Assmann A., Delfs C., Munakata H., Schiffer F., Horstkötter K., Huynh K. et al. Acceleration of autologous in vivo recellularization of decellularized aortic conduits by fibronectin surface coating. Biomaterials. 2013;34:6015–6026. DOI:10.1016/j.biomaterials.2013.04.037.; Conklin B.S., Wu H., Lin P.H., Lumsden A.B., Chen C. Basic fibroblast growth factor coating and endothelial cell seeding of a decellularized heparin-coated vascular graft. Artif. Organs. 2004;28:668–675. DOI:10.1111/j.1525-1594.2004.00062.x.; Flameng W., De Visscher G., Mesure L., Hermans H., Jashari R., Meuris B. Coating with fibronectin and stromal cell–derived factor-1α of decellularized homografts used for right ventricular outflow tract reconstruction eliminates immune response–related degeneration. J. Thorac. Cardiovasc. Surg. 2014;147(4):1398–1404.e2. DOI:10.1016/j.jtcvs.2013.06.022.; Ханова М.Ю., Великанова Е.А., Глушкова Т.В., Матвеева В.Г. Создание персонифицированного клеточно-заселенного сосудистого протеза in vitro. Комплексные проблемы сердечно-сосудистых заболеваний. 2021;10(2):89–93. DOI:10.17802/2306-1278-2021-10-2S-89-93.; Copes F., Pien N., Vlierberghe S.V., Boccafoschi F., Mantovani D. Collagen-Based Tissue Engineering Strategies for Vascular Medicine. Front. Bioeng. Biotechnol. 2019;7:166. DOI:10.3389/fbioe.2019.00166.; Lynn A.K., Yannas I.V., Bonfield W. Antigenicity and immunogenicity of collagen. J. Biomed. Mater. Res. Part B. Appl. Biomater. 2004; 71:343–354. DOI:10.1002/jbm.b.30096.; Smethurst P.A., Onley D J., Jarvis G.E., O’Connor M.N., Knight C.G., Herr A. B. et al. Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet glycoprotein VI contains two glycine-proline-hydroxyproline triplets. J. Biol. Chem. 2007;282(2):1296–1304. DOI:10.1074/jbc.M606479200.; Dietrich M., Heselhaus J., Wozniak J., Weinandy S., Mela P., Tschoeke B. et al. Fibrin-based tissue engineering: Comparison of different methods of autologous fibrinogen isolation. Tissue Engineering. Part C: Methods. 2013;19(3):216–226. DOI:10.1089/ten.tec.2011.0473.; Park C.H., Woo K.M. Fibrin-Based Biomaterial Applications in Tissue Engineering and Regenerative Medicine. Adv. Exp. Med. Biol. 2018;1064:253–261. DOI:10.1007/978-981-13-0445-3_16.; Podolnikova N.P., Yakovlev S., Yakubenko V.P., Wang X., Gorkun O.V., Ugarova T.P. The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. J. Biol. Chem. 2014;289(4):2371–2383. DOI:10.1074/jbc.M113.518126.; https://www.sibjcem.ru/jour/article/view/1724

Availability: https://www.sibjcem.ru/jour/article/view/1724
https://doi.org/10.29001/2073-8552-2023-38-1-160-166

SPECIFIC TOXICITY OF CALCIUM PHOSPHATE BIONS FOR HUMAN VENOUS AND ARTERIAL ENDOTHELIAL CELLS

Source: ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia». :53-61

Subject Terms: 0301 basic medicine, bions, 0303 health sciences, гидроксиапатит, endothelium, бионы, эндотелиальные клетки, apoptosis, hydroxyapatite, триггеры, triggers, endothelial cells, 3. Good health, 03 medical and health sciences, атеросклероз, апоптоз, cytotoxicity, цитотоксичность, atherosclerosis, эндотелий

Access URL: https://pfiet.ru/article/download/2232/1656
https://pfiet.ru/index.php/pfiet/article/view/2232

Blood monocytes in maintaining the balance of vascular endothelial injury and repair process in ischemic cardiomyopathy ; Моноциты крови в поддержании баланса деструктивных и репаративных процессов в сосудистом эндотелии при ишемической кардиомиопатии

Authors: S. P. Chumakova, O. I. Urazova, O. A. Denisenko, D. A. Pogonchenkova, V. M. Shipulin, A. S. Pryakhin, K. V. Nevskaya, M. V. Gladkovskaya, С. П. Чумакова, О. И. Уразова, О. А. Денисенко, Д. A. Погонченкова, В. М. Шипулин, А. С. Пряхин, К. В. Невская, М. В. Гладковская

Contributors: Исследование выполнено за счет гранта Российского научного фонда № 22-25-20038 (https://rscf.ru/project/22-25-20038/), а так же средств Администрации Томской области (договор с РОО «ТПС» № 22-04 от 28.06.2022 в рамках реализации регионального проекта РНФ № 22-25-20038).

Source: Complex Issues of Cardiovascular Diseases; Том 11, № 3 (2022); 84-96 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 11, № 3 (2022); 84-96 ; 2587-9537 ; 2306-1278

Subject Terms: моноциты, ischemic cardiomyopathy, endothelial desquamation, progenitor endothelial cells, hypoxia-inducible factor, monocytes, ишемическая кардиомиопатия, десквамация эндотелия, прогениторные эндотелиальные клетки, индуцируемый гипоксией фактор

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Relation: https://www.nii-kpssz.com/jour/article/view/1164/698; Adhyapak S.M., Parachuri V.R. Tailoring therapy for ischemic cardiomyopathy: is Laplace's law enough? Ther Adv Cardiovasc Dis. 2017; 11 (9): 231–234. doi:10.1177/1753944717718719.; Шипулин В.М., Пряхин А.С., Андреев С.Л., Шипулин В.В., Чумакова С.П., Рябова Т.Р., Стельмашенко А.И., Беляева С.А., Лелик Е.В. Современные клинико-фундаментальные аспекты в диагностике и лечении пациентов с ишемической кардиомиопатией (обзор). Сибирский журнал клинической и экспериментальной медицины. 2021; 36 (1): 20–29. doi:10.29001/2073-8552-2021-36-1-20-29.; Dang H, Ye Y, Zhao X, Zeng Y. Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database. BMC Cardiovasc Disord. 2020; 20 (1): 320. doi:10.1186/s12872-020-01596-w.; Gyöngyösi M., Winkler J., Ramos I., Do QT., Firat H., McDonald K., González A., Thum T., Díez J., Jaisser F., Pizard A., Zannad F. Myocardial fibrosis: biomedical research from bench to bedside. Eur J Heart Fail. 2017; 19 (2): 177–191. doi:10.1002/ejhf.696.; Kaski J.-C., Crea F., Gersh B. J., Camici P.G. Reappraisal of Ischemic Heart Disease. Fundamental Role of Coronary Microvascular Dysfunction in the Pathogenesis of Angina Pectoris. Circulation. 2018; 138: 1463-1480 doi:10.1161/CIRCULATIONAHA.118.031373; Poston R.N. Atherosclerosis: integration of its pathogenesis as a self-perpetuating propagating inflammation: a review. Cardiovasc Endocrinol Metab. 2019; 8 (2): 51–61. doi:10.1097/XCE.0000000000000172.; Мельникова Ю.С., Макарова Т.П. Эндотелиальная дисфункция как центральное звено патогенеза хронических болезней. Казан.мед.жур. 2015; 96 (4): 659–665. doi:10.17750/KMJ2015-65.; Eligini S., Cosentino N., Fiorelli S., Fabbiocchi F., Niccoli G., Refaat H., Camera M., Calligaris G., De Martini S., Bonomi A., Veglia F., Fracassi F., Crea F., Marenzi G., Tremoli E. Biological profile of monocyte-derived macrophages in coronary heart disease patients: implications for plaque morphology. Sci Rep. 2019; 9 (1): 8680. doi:10.1038/s41598-019-44847-3.; Xu H., Jiang J., Chen W., Li W., Chen Z. Vascular Macrophages in Atherosclerosis. J Immunol Res. 2019: 4354786. doi:10.1155/2019/4354786.; Moroni F., Ammirati E., Norata G.D., Magnoni M., Camici P.G. The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis. Mediators Inflamm. 2019: 7434376. doi:10.1155/2019/7434376.; Dick S.A., Zaman R. Epelman S. Using High-Dimensional Approaches to Probe Monocytes and Macrophages in Cardiovascular Disease. Front Immunol. 2019; 10: 2146. doi:10.3389/fimmu.2019.02146; Hamers A.A.J., Dinh H.Q., Thomas G.D., Marcovecchio P., Blatchley A., Nakao C.S., Kim C., McSkimming C., Taylor A.M., Nguyen A.T., McNamara C.A., Hedrick C.C. Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry. Arterioscler Thromb Vasc Biol. 2019; 39 (1): 25–36. doi:10.1161/ATVBAHA.118.311022; Rojas J., Salazar J., Martínez M.S., Palmar J., Bautista J., Chávez-Castillo M., Gómez A., Bermúdez V. Macrophage heterogeneity and plasticity: impact of macrophage biomarkers on atherosclerosis. Scientifica (Cairo). 2015; 2015: 851252. doi:10.1155/2015/851252.; Jaipersad A.S., Lip G.Y., Silverman S, Shantsila E. The role of monocytes in angiogenesis and atherosclerosis. J Am Coll Cardiol. 2014; 63 (1): 1–11. doi:10.1016/j.jacc.2013.09.019; Li D.W., Liu Z.Q., Wei J., Liu Y., Hu L.S. Contribution of endothelial progenitor cells to neovascularization (Review). Int J Mol Med. 2012; 30 (5): 1000-1006. doi:10.3892/ijmm.2012.1108; Esquiva G., Grayston A., Rosell A. Revascularization and endothelial progenitor cells in stroke. Am J Physiol Cell Physiol. 2018; 315 (5): 664–674. doi:10.1152/ajpcell.00200.2018.; Ozkok A., Yildiz A. Endothelial Progenitor Cells and Kidney Diseases. Kidney Blood Press Res. 2018; 43 (3): 701–718. doi:10.1159/000489745.; Денисенко О.А., Чумакова С.П., Уразова О.И. Эндотелиальные прогениторные клетки: происхождение и роль в ангиогенезе при сердечно-сосудистой патологии. Сибирский журнал клинической и экспериментальной медицины. 2021; 36 (2): 23–29. doi:10.29001/2073-8552-2021-36-2-23-29.; Felker G.M., Shaw G.M., O’Connor C.M. A standardized definition of ischemic cardiomyopathy for use in clinical research. Journal of the American College of Cardiology. 2002; 39 (2): 208–210. doi:10.1016/s0735-1097(01)01738-7.; Mitruţ R., Stepan A.E., Mărgăritescu C., Andreiana B.C., Kesse A.M., Simionescu C.E., Militaru C. Immunoexpression of MMP-8, MMP-9 and TIMP-2 in dilated cardiomyopathy. Rom J Morphol Embryol. 2019; 60 (1): 119–124.; Shahid F., Gregory Y., Lip H., Shantsila E. Role of Monocytes in Heart Failure and Atrial Fibrillation J Am Heart Assoc. 2018; 7 (3) doi:10.1161/JAHA.117.007849.; Lin N., Simon M.C. Hypoxia-inducible factors: key regulators of myeloid cells during inflammation. J Clin Invest. 2016; 126 (10): 3661–3671. doi:10.1172/JCI84426.; Чумакова С.П., Уразова О.И., Винс М.В., Шипулин В.М., Пряхин А.С., Букреева Е.Б., Буланова А.А., Кошель А.П., Новицкий В.В. Содержание гипоксия-индуцируемых факторов и медиаторов иммуносупрессии в крови при заболеваниях, ассоциированных с гипоксией. Бюллетень сибирской медицины. 2020; 19 (3): 105–112. doi:10.20538/1682-0363-2020-3-105-112.; Lafuse W.P., Wozniak D.J., Rajaram M.V.S. Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair. Cells. 2020; 10 (1): 51. doi:10.3390/cells10010051.; Колотов К.А., Распутин П.Г. Моноцитарный хемотаксический протеин-1 в физиологии и медицине. Пермский медицинский журнал. 2018; 35 (4): 99–105. doi:10.17816/pmj35399-105.

Availability: https://www.nii-kpssz.com/jour/article/view/1164
https://doi.org/10.17802/2306-1278-2022-11-3-84-96

Cytokines and HIF-1α as dysregulation factors of migration and differentiation of monocyte progenitor cells of endotheliocytes in the pathogenesis of ischemic cardiomyopathy ; Цитокины и HIF-1α как факторы дисрегуляции миграции и дифференцировки моноцитарных клеток-предшественниц эндотелиоцитов в патогенезе ишемической кардиомиопатии

Authors: O. A. Denisenko, S. P. Chumakova, O. I. Urazova, V. M. Shipulin, A. S. Pryakhin, О. А. Денисенко, С. П. Чумакова, О. И. Уразова, В. М. Шипулин, А. С. Пряхин

Contributors: Исследование выполнено за счёт гранта Российского научного фонда № 22-25-00821 (https://rscf.ru/project/22-25-00821/).

Source: Acta Biomedica Scientifica; Том 7, № 5-2 (2022); 21-30 ; 2587-9596 ; 2541-9420

Subject Terms: костный мозг, ischemic cardiomyopathy, coronary heart disease, progenitor endothelial cells, hypoxia-inducible factor, bone marrow, ишемическая кардиомиопатия, ишемическая болезнь сердца, прогениторные эндотелиальные клетки, индуцируемый гипоксией фактор

File Description: application/pdf

Relation: https://www.actabiomedica.ru/jour/article/view/3822/2424; Chen C, Tian J, He Z, Xiong W, He Y, Liu S. Identified three interferon induced proteins as novel biomarkers of human ischemic cardiomyopathy. Int J Mol Sci. 2021; 22(23): 13116. doi:10.3390/ijms222313116; Dang H, Ye Y, Zhao X, Zeng Y. Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database. BMC Cardiovasc Disord. 2020; 20(1): 320. doi:10.1186/s12872-020-01596-w; Зюзенков М.В. Ишемическая кардиомиопатия. Военная медицина. 2013; 1: 35-36.; Medina-Leyte DJ, Zepeda-García O, Domínguez-Pérez M, González-Garrido A, Villarreal-Molina T, Jacobo-Albavera L. Endothelial dysfunction, inflammation and coronary artery disease: Potential biomarkers and promising therapeutical approaches. Int J Mol Sci. 2021; 22(8): 3850. doi:10.3390/ijms22083850; Xue M, Qiqige C, Zhang Q, Zhao H, Su L, Sun P, et al. Effects of tumor necrosis factor α (TNF-α) and interleukina 10 (IL-10) on intercellular cell adhesion molecule-1 (ICAM-1) and cluster of differentiation 31 (CD31) in human coronary artery endothelial cells. Med Sci Monit. 2018; 24: 4433-4439. doi:10.12659/MSM.906838; Cui S, Men L, Li Y, Zhong Y, Yu S, Li F, et al. Selenoprotein S attenuates tumor necrosis factor-α-induced dysfunction in endothelial cells. Mediators Inflamm. 2018; 2018: 1625414. doi:10.1155/2018/1625414; Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, et al. Monocytes as endothelial progenitor cells (EPCs), another brick in the wall to disentangle tumor angiogenesis. Cells. 2020; 9(1): 107. doi:10.3390/cells9010107; Peplow PV. Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization. Neural Regen Res. 2014; 9(15): 1425-1429. doi:10.4103/1673-5374.139457; Prisco AR, Prisco MR, Carlson BE, Greene AS. TNF-α increases endothelial progenitor cell adhesion to the endothelium by increasing bond expression and affinity. Am J Physiol Heart Circ Physiol. 2015; 308(11): 1368-1381. doi:10.1152/ajpheart.00496.2014; Qiu Y, Zhang C, Zhang G, Tao J. Endothelial progenitor cells in cardiovascular diseases. Aging Med (Milton). 2018; 1(2): 204-208. doi:10.1002/agm2.12041; Li D-W, Liu Z-Q, Wei J, Liu Y, Hu L-S. Contribution of endothelial progenitor cells to neovascularization (Review). Int J Mol Med. 2012; 30(5): 1000-1006. doi:10.3892/ijmm.2012.1108; Singh S, Anshita D, Ravichandiran V. MCP-1: Function, regulation, and involvement in disease. Int Immunopharmacol. 2021; 101(Pt B): 107598. doi:10.1016/j.intimp.2021.107598; Коваль С.Н., Милославский Д.К., Снегурская И.А., Щенявская Е.Н. Факторы ангиогенеза при заболеваниях внутренних органов (обзор литературы). Вiсник проблем бiологii i медицини. 2012; 3, 2(95): 11-15.; Sinha SK, Miikeda A, Fouladian Z, Mehrabian M, Edillor C, Shih D, et al. Local macrophage colony-stimulating factor expression regulates macrophage proliferation and apoptosis in atherosclerosis. Arterioscler Thromb Vasc Biol. 2021; 41(1): 220-233. doi:10.1161/ATVBAHA.120.315255; Денисенко O.A., Чумакова С.П., Уразова О.И. Эндотелиальные прогениторные клетки: происхождение и роль в ангиогенезе при сердечно-сосудистой патологии. Сибирский журнал клинической и экспериментальной медицины. 2021; 36(2): 23-29. doi:10.29001/2073-8552-2021-36-2-23-29; Felker GM, Shaw LK, O’Connor CM. A standardized definition of ischemic cardiomyopathy for use in clinical research. J Am Coll Cardiol. 2002; 39(2): 210-218. doi:10.1016/s0735-1097(01)01738-7; Mudyanadzo TA. Endothelial progenitor cells and cardiovascular correlates. Cureus. 2018; 10(9): e3342. doi:10.7759/cureus.3342; Lin C-P, Lin F-Y, Huang P-H, Chen Y-L, Chen W-C, Chen H-Y, et al. Endothelial progenitor cell dysfunction in cardiovascular diseases: Role of reactive oxygen species and inflammation. Biomed Res Int. 2013; 2013: 845037. doi:10.1155/2013/845037; Nova-Lamperti E, Zúñiga F, Ormazábal V, Escudero C, Aguayo C. Vascular regeneration by endothelial progenitor cells in health and diseases. In: Lenasi H (ed.). Microcirculation Revisited. From Molecules to Clinical Practice. 2016: 231-258.; Ha X-Q, Li J, Mai C-P, Cai X-L, Yan C-Y, Jia C-X, et al. The decrease of endothelial progenitor cells caused by high altitude may lead to coronary heart disease. Eur Rev Med Pharmacol Sci. 2021; 25(19): 6101-6108. doi:10.26355/eurrev_202110_26888; George AL, Bangalore-Prakash P, Rajoria S, Suriano R, Shanmugam A, Mittelman A, et al. Endothelial progenitor cell biology in disease and tissue regeneration. J Hematol Oncol. 2011; 4: 24. doi:10.1186/1756-8722-4-24; Bartoszewski R, Moszyńska A, Serocki M, Cabaj A, Polten A, Ochocka R, et al. Primary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia. FASEB J. 2019; 33(7): 7929-7941. doi:10.1096/fj.201802650RR; Naserian S, Abdelgawad ME, Bakshloo MA, Ha G, Arouche N, Cohen JL, et al. The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effect. Cell Commun Signal. 2020; 18(1): 94. doi:10.1186/s12964-020-00564-3; Goukassian DA, Qin G, Dolan C, Murayama T, Silver M, Curry C, et al. Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation. 2007; 115(6): 752-762. doi:10.1161/CIRCULATIONAHA.106.647255; https://www.actabiomedica.ru/jour/article/view/3822

Availability: https://www.actabiomedica.ru/jour/article/view/3822
https://doi.org/10.29413/ABS.2022-7.5-2.3

Sisteme tehnologice inovaționale în prelevarea și procesarea corneei

Authors: Cociug, A.M., Macagonova, O.I., Dumbrăveanu, L.G., Думбрэвяну, Л., Cuşnir, V.N., Cushnir, V.N., Nacu, V.E.

Source: Sănătate Publică, Economie şi Management în Medicină 92 (1) 32-37

Subject Terms: celule endoteliale, mediu de cultură, presiune intraoculară, celule epiteliale, stroma, bioreactor, bancă de ochi, Endothelial cells, culture medium, intraocular pressure, Epithelial cells, Eye bank, эндотелиальные клетки, питательная среда, внутриглазное давление, эпителиальные клетки, строма, биореактор, глазной банк

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Relation: https://ibn.idsi.md/vizualizare_articol/171122; urn:issn:17298687

Availability: https://ibn.idsi.md/vizualizare_articol/171122
https://doi.org/10.52556/2587-3873.2022.1(92).05

Differentiation and subpopulation composition of VEGFR2+ cells in the blood and bone marrow in ischemic cardiomyopathy

Authors: S. P. Chumakova, O. I. Urazova, V. M. Shipulin, O. A. Denisenko, T. E. Kononova, K. V. Nevskaya, S. L. Andreev

Source: Бюллетень сибирской медицины, Vol 21, Iss 3, Pp 120-131 (2022)

Subject Terms: моноциты, прогениторные эндотелиальные клетки, репарация сосудов, костный мозг, цитокины, ишемическая кардиомиопатия, ишемическая болезнь сердца, Medicine

Relation: https://bulletin.ssmu.ru/jour/article/view/4915; https://doaj.org/toc/1682-0363; https://doaj.org/toc/1819-3684; https://doaj.org/article/4cf73052d7c347c29a6a4d87ba8db769

Availability: https://doi.org/10.20538/1682-0363-2022-3-120-131
https://doaj.org/article/4cf73052d7c347c29a6a4d87ba8db769

Ультрамикроскопические особенности эндотелиоцитов капилляров щитовидной железы крыс после 60-дневного введения бензоата натрия

Authors: Морозов, В. Н., Морозова, Е. Н.

Subject Terms: медицина, клиническая эндокринология, щитовидная железа, капилляры, эндотелиальные клетки, пищевые добавки, бензоат натрия, крысы, экспериментальные исследования

Relation: http://dspace.bsu.edu.ru/handle/123456789/52360

Availability: http://dspace.bsu.edu.ru/handle/123456789/52360

Endothelial cell monolayer formation on a small-diameter vascular graft surface under pulsatile flow conditions ; Формирование монослоя эндотелиальных клеток на поверхности сосудистого протеза малого диаметра в условиях потока

Authors: M. Yu. Khanova, E. A. Velikanova, V. G. Matveeva, E. O. Krivkina, T. V. Glushkova, V. V. Sevostianova, A. G. Kutikhin, L. V. Antonova, М. Ю. Ханова, Е. А. Великанова, В. Г. Матвеева, Е. О. Кривкина, Т. В. Глушкова, В. В. Севостьянова, А. Г. Кутихин, Л. В. Антонова

Source: Russian Journal of Transplantology and Artificial Organs; Том 23, № 3 (2021); 101-114 ; Вестник трансплантологии и искусственных органов; Том 23, № 3 (2021); 101-114 ; 1995-1191

Subject Terms: персонифицированный сосудистый протез, autologous endothelial cells, pulsatile flow, personalized vascular graft, аутологичные эндотелиальные клетки, пульсирующий поток

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https://doi.org/10.15825/1995-1191-2021-3-101-114