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1Academic Journal
Authors: S. I. Rey, G. A. Berdnikov, N. V. Borovkova, M. A. Godkov, E. V. Klychnikova, T. E. Kuznetsova, A. A. Maksimov, I. A. Tyurin, С. И. Рей, Г. А. Бердников, Н. В. Боровкова, М. А. Годков, Е. В. Клычникова, Т. Е. Кузнецова, А. А. Максимов, И. А. Тюрин
Source: Russian Sklifosovsky Journal "Emergency Medical Care"; Том 14, № 3 (2025); 499-510 ; Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»; Том 14, № 3 (2025); 499-510 ; 2541-8017 ; 2223-9022
Subject Terms: β-гидроксимиристиновая кислота, blood purification, selective hemosorption of lipopolysaccharides, endotoxin, endotoxin activity assay (EAA), β-hydroxymyristic acid, экстракорпоральная гемокоррекция, селективная гемосорбция липополисахаридов, эндотоксин, активность эндотоксина (ЕАА-тест)
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Relation: https://www.jnmp.ru/jour/article/view/2202/1637; Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200–211. PMID: 31954465 https://doi.org/10.1016/S0140-6736(19)32989-7; Liu YC, Yao Y, Yu MM, Gao YL, Qi AL, Jiang TY, et al. Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis. BMC Infectious Diseases. 2022;22(1):564. PMID: 35729526 https://doi.org/10.1186/s12879-022-07543-8; Vincent JL, Jones G, David S, Olariu E, Cadwell KK. Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis. Crit Care. 2019;23(1):196. PMID: 31151462 https://doi.org/10.1186/s13054-019-2478-6; Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, et al. Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. JAMA. 2019;321(20):2003–2017. PMID: 31104070 https://doi.org/10.1001/jama.2019.5791; Kellum JA, Ronco C. The role of endotoxin in septic shock. Crit Care. 2023;27(1):400. PMID: 37858258 https://doi.org/10.1186/s13054-023-04690-5; Adamik B, Smiechowicz J, Jakubczyk D, Kübler A. Elevated Serum PCT in Septic Shock with Endotoxemia Is Associated with a Higher Mortality Rate. Medicine (Baltimore). 2015;94(27):e1085. PMID: 26166090 https://doi.org/10.1097/MD.0000000000001085; Hurley JC, Guidet B, Offenstad G, Maury E. Endotoxemia and mortality prediction in ICU and other settings: underlying risk and co-detection of gram negative bacteremia are confounders. Crit Care. 2012;16(4): R148. PMID: 22871090 https://doi.org/10.1186/cc11462; Лазанович В.А., Маркелова Е.В., Смирнов Г.А., Смолина Т.П. Клиническая значимость экспрессии Toll2, Toll4, CD14, HLA-DR на моноцитах у пациентов с сепсисом. Медицинская иммунология. 2015;17(3):221–228. https://doi.org/10.15789/1563-0625-2015-3-221-228; Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–810. PMID: 26903338 https://doi.org/10.1001/jama.2016.0287; Киров М.Ю., Кузьков В.В., Проценко Д.Н., Щеголев А.В., Бабаев М. А., Белоцерковский Б.З. и др. Септический шок у взрослых: клинические рекомендации Общероссийской общественной организации «Федерация анестезиологов и реаниматологов». Вестник интенсивной терапии им. А. И. Салтанова. 2023;(4):7–42. https://doi.org/10.21320/1818-474X-2023-4-7-42; Dellinger RP, Bagshaw SM, Antonelli M, Foster DM, Klein DJ, Marshall JC, et al.; EUPHRATES Trial Investigators. Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients with Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial. JAMA. 2018;320(14):1455–1463. PMID: 30304428 https://doi.org/10.1001/jama.2018.14618; Pais de Barros JP, Gautier T, Sali W, Adrie C, Choubley H, Charron E, et al.; Quantitative lipopolysaccharide analysis using HPLC/MS/MS and its combination with the limulus amebocyte lysate assay. J Lipid Res. 2015;56(7):1363–1369. PMID: 26023073 https://doi.org/10.1194/jlr. D059725.; Quadrini KJ, Patti-Diaz L, Maghsoudlou J, Cuomo J, Hedrick MN, McCloskey TW. A flow cytometric assay for HLA-DR expression on monocytes validated as a biomarker for enrollment in sepsis clinical trials. Cytometry B Clin Cytom. 2021;100(1):103–114. PMID: 33432735 https://doi.org/10.1002/cyto.b.21987; Cruz DN, Antonelli M, Fumagalli R, Foltran F, Brienza N, Donati A, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA. 2009;301(23):2445–2452. PMID: 19531784 https://doi.org/10.1001/jama.2009.856; Payen DM, Guilhot J, Launey Y, Lukaszewicz AC, Kaaki M, Veber B, et al.; ABDOMIX Group. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial. Intensive Care Med. 2015;41(6):975–984. PMID: 25862039 https://doi.org/10.1007/s00134-015-3751-z; Rey S, Kulabukhov VM, Popov A, Nikitina O, Berdnikov G, Magomedov M, et al. Hemoperfusion using the LPS-selective mesoporous polymeric adsorbent in septic shock: a multicenter randomized clinical trial. Shock. 2023;59(6):846–854. PMID: 37018802 https://doi.org/10.1097/SHK.0000000000002121; Nakamura К, Okazaki T, Tampo A, Mochizuki K, Kanda N, Ono T, et al. The polymyxin-B direct hemoperfusion OPTimal Initiation timing with Catecholamine PMX-OPTIC study: A multicenter retrospective observational study. Artif Organs. 2024 Sep 18. PMID: 39291793 https://doi.org/10.1111/aor.14865 Online ahead of print.; Lee JH, Han WH, Im H, Kim JH. Effects of Early Initiation of Polymyxin B Hemoperfusion Therapy in Patients with Cancer with Refractory Septic Shock. J Clin Med. 2024;13(4):1009. PMID: 38398322 https://doi.org/10.3390/jcm13041009; Fujimori К, Tarasawa К, Fushimi К. Effectiveness of polymyxin B hemoperfusion for sepsis depends on the baseline SOFA score: a nationwide observational study. Ann Intensive Care. 2021;11(1):141. PMID: 34568980 https://doi.org/10.1186/s13613-021-00928-z; Osawa I, Goto T, Kudo D, Hayakawa M, Yamakawa K, Kushimoto S, et al. Targeted therapy using polymyxin B hemadsorption in patients with sepsis: a post-hoc analysis of the JSEPTIC-DIC study and the EUPHRATES trial. Crit Care. 2023;27(1):245. PMID: 37344804 https://doi.org/10.1186/s13054-023-04533-3; Payen D, Dupuis C, Deckert V, Pais de Barros JP, Rérole AL, Lukaszewicz AC, et al. Endotoxin Mass Concentration in Plasma Is Associated with Mortality in a Multicentric Cohort of PeritonitisInduced Shock. Front Med (Lausanne). 2021:8:749405. PMID: 34778311 https://doi.org/10.3389/fmed.2021.749405 eCollection 2021; Cotoia A, Parisano V, Mariotti PS, Lizzi V, Netti GS, Ranieri E, et al. Kinetics of different blood biomarkers during Polymyxin-B extracorporeal hemoperfusion in abdominal sepsis. Blood Purif. 2024;53(7):574–582. PMID: 38653211 https://doi.org/10.1159/000538870; Mengos AE, Gastineau DA, Gustafson MP. The CD14+HLA-DRlo/ neg Monocyte: An Immunosuppressive Phenotype That Restrains Responses to Cancer Immunotherapy. Front Immunol. 2019:10:1147. PMID: 31191529 https://doi.org/10.3389/fimmu.2019.01147 eCollection 2019.; Papadopoulos P, Pistiki A, Theodorakopoulou M, Christodoulopoulou T, Damoraki G, Goukos D, et al. Immunoparalysis: Clinical and immunological associations in SIRS and severe sepsis patients. Cytokine. 2017;92:83–92. PMID: 28119177 https://doi.org/10.1016/j.cyto.2017.01.012; Volk HD, Reinke P, Krausch D, Zuckermann H, Asadullah K, Muller JM, et al. Monocyte deactivation–rationale for a new therapeutic strategy in sepsis. Intensive Care Med. 1996;22 (Suppl. 4):S474–481. PMID: 8923092 https://doi.org/10.1007/BF01743727; Лаврик И., Краммер П. Решение «Жизнь-или-смерть» в системе CD95: основные про- и антиапоптозные модуляторы. Acta Naturae (русскоязычная версия). 2009;(1):80–83.; Yoo H, Lee JY, Park J, Suh GY, Jeon K. Association of Plasma Levels of Fas Ligand with Severity and Outcome of Sepsis. Shock. 2021;56(4):544– 550. PMID: 33577245 https://doi.org/10.1097/SHK.0000000000001753; Asbun-Bojalil J, Huerta-Yepez S, Vega M. Correlation of the expression of YY1 and Fas cell surface death receptor with apoptosis of peripheral blood mononuclear cells, and the development of multiple organ dysfunction in children with sepsis. Mol Med Rep. 2017;15(5):2433– 2442. PMID: 28447715 https://doi.org/10.3892/mmr.2017.6310; https://www.jnmp.ru/jour/article/view/2202
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2Academic Journal
Authors: O. V. Nikitina, S. I. Rey, Y. V. Zabrodskaya, V. I. Avfukov, A. G. Lebedev, P. A. Yartsev, G. A. Berdnikov, A. M. Kaziyeva, E. A. Ostrogina, О. В. Никитина, С. И. Рей, Я. В. Забродская, В. И. Авфуков, А. Г. Лебедев, П. А. Ярцев, Г. А. Бердников, А. М. Казиева, Е. А. Острогина
Contributors: The study had no sponsorship, Исследование не имеет спонсорской поддержки
Source: Russian Sklifosovsky Journal "Emergency Medical Care"; Том 12, № 4 (2023); 552-567 ; Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»; Том 12, № 4 (2023); 552-567 ; 2541-8017 ; 2223-9022
Subject Terms: экстракорпоральная гемокоррекция, septic shock, mortality, long-term renal replacement therapy, selective hemosorption lipopolysaccharides, extracorporeal hemocorrection, септический шок, летальность, продолжительная заместительная почечная терапия, селективная гемосорбция липополисахаридов
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Relation: https://www.jnmp.ru/jour/article/view/1718/1353; https://www.jnmp.ru/jour/article/view/1718/1413; Monard С, Rimmelé T, Ronco C. Extracorporeal Blood Purification Therapies for Sepsis. Blood Purif. 2019;47 Suppl 3:1–14. PMID: 30974444 doi:10.1159/000499520; Putzu A, Schorer R, Lopez-Delgado JC, Cassina T, Landoni G. Blood Purification and Mortality in Sepsis and Septic Shock a Systematic Review and Metaanalysis of Randomized Trials. Anesthesiology. 2019;131(3):580–593. PMID: 31246600 doi:10.1097/ALN.0000000000002820; Girardot T, Schneider A, Rimmelé T. Blood Purification Techniques for Sepsis and Septic AKI. Semin Nephrol. 2019;39(5):505–514. PMID: 31514914 doi:10.1016/j.semnephrol.2019.06.010; Snow TAC, Littlewood S, Corredor C, Singer M, Arulkumaran N. Effect of Extracorporeal Blood Purification on Mortality in Sepsis: A Meta-Analysis and Trial Sequential Analysis. Blood Purif. 2021;50(4–5):462-472. PMID: 33113533 doi:10.1159/000510982; Romagnoli S, Ricci Z, Ronco C. CRRT for sepsis-induced acute kidney injury. Curr Opin Crit Care. 2018;24(6):483–492. PMID: 30239411 doi:10.1097/MCC.0000000000000544; Payen DM, Guilhot J, Launey Y, Lukaszewicz AC, Kaaki M, Veber B, et al. Early Use of Polymyxin B Hemoperfusion in Patients with Septic Shock Due to Peritonitis: a Multicenter Randomized Control Trial/. Intensive Care Med. 2015;41(6):975–984. PMID: 25862039 doi:10.1007/s00134-015-3751-z; Dellinger RP, Bagshaw SM, Antonelli M, Foster DM, Klein DJ, Marshall JC, et al. Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients with Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial. JAMA. 2018;320(14):1455–1463. PMID: 30304428 doi:10.1001/jama.2018.14618; Klein DJ, Foster D, Walker PM, Bagshaw SM, Mekonnen H, Antonelli M. Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial. Intensive Care Med. 2018;44(12):2205–2212. PMID: 30470853 doi:10.1007/s00134-018-5463-7; Zhang L, Feng Y, Fu P. Blood purification for sepsis: an overview. Precis Clin Med. 2021;4(1):45–55. PMID: 35693122 doi:10.1093/pcmedi/pbab005; Seeliger B, Stahl K, David S. Extracorporeal techniques for blood purification in sepsis: an update. Internist (Berl). 2020;61(10):1010–1016. (In German) PMID: 32897403 doi:10.1007/s00108-020-00862-5; Jarczak D, Kluge S, Nierhaus A. Sepsis-Pathophysiology and Therapeutic Concepts. Front Med (Lausanne). 2021;8:628302. PMID:34055825 doi:10.3389/fmed.2021.628302; Martin-Loeches I, Nunnally ME, Hellman J, Lat I, Martin GS, Jog S, et al. Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies. Crit Care Explor. 2021;3(9):e0511. PMID: 34514420 doi:10.1097/CCE.0000000000000511; Linder MM, Wacha H, Feldmann U, Wesch G, Streifensand RA, Gundlach E. [The Mannheim peritonitis index. An instrument for the intraoperative prognosis of peritonitis]. Chirurg. 1987;58(2):84–92. PMID: 3568820; Charlson ME, Pompei P, Ales KL, McKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40(5):373–383. PMID: 3558716 doi:10.1016/0021-9681(87)90171-8; Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–810. PMID: 26903338 doi:10.1001/jama.2016.0287; Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Available at: https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf [Accessed Jul 06, 2023]; Triantafilou M, Triantafilou K. Sepsis: molecular mechanisms underlying lipopolysaccharide recognition. Expert Rev Mol Med. 2004;6(4):1–18. PMID: 14987416 doi:10.1017/S1462399404007409; Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840–851. PMID: 23984731 doi:10.1056/NEJMra1208623; Moriyama К, Nishida О. Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification. Int J Mol Sci. 2021;22(16):8882. PMID: 34445610 doi:10.3390/ijms22168882; Ронко К., Пиччинни П., Рознер М.Г. (ред.) Эндотоксемия и эндотоксический шок. патогенез, диагностика и лечение : пер. с англ. Москва: Издатель И.Б. Балабанов; 2012.; Булава Г.В., Рей С.И., Бердников Г.А., Никитина О.В., Шабанов А. К., Боровкова Н.В., и др. Использование селективной гемосорбции липополисахаридов в комплексном лечении сепсиса. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2020;9(2):201–209. doi:10.23934/2223-9022-2020-9-2-201-209; https://www.jnmp.ru/jour/article/view/1718
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3Academic Journal
Authors: G. V. Bulava, S. I. Rey, G. A. Berdnikov, O. V. Nikitina, A. K. Shabanov, N. V. Borovkova, N. N. Salina, M. A. Godkov, Г. В. Булава, С. И. Рей, Г. А. Бердников, О. В. Никитина, А. К. Шабанов, Н. В. Боровкова, Н. Н. Салина, М. А. Годков
Source: Russian Sklifosovsky Journal "Emergency Medical Care"; Том 9, № 2 (2020); 201-209 ; Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»; Том 9, № 2 (2020); 201-209 ; 2541-8017 ; 2223-9022 ; 10.23934/2223-9022-2020-9-2
Subject Terms: экстракорпоральная гемокоррекция, septic shock, endotoxin lipopolysaccharide selective hemosorbtion, Polymyxin B hemoperfusion, LPS adsorber Alteco, extracorporeal hemocorrection, септический шок, эндотоксин, селективная гемосорбция липополисахаридов, Полимиксин-В, гемоперфузия, ЛПС-адсорбер Альтеко
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PMID: 25214990; Lewis DH, Chan DL, Pinheiro D, Armitage-Chan E, Garden OA. The immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response, and regulatory T cells. J Vet Intern Med. 2012;26:457–482. PMID: 22428780 https://doi.org/10.1111/j.1939-1676.2012.00905.x; Яковлев М.Ю. Кишечный липополисахарид: системная эндотоксинемия – эндотоксиновая агрессия – SIRS-полиорганная недостаточность как звенья одной цепи. Бюллетень ВНЦ СО РАМН. 2005;(1):15–18.; Triantafilou M, Triantafilou K. Sepsis: molecular mechanisms underlying lipopolysaccharide recognition. Expert Rev Mol Med. 2004;6(4):1–18. PMID: 14987416 https://doi.org/10.1017/S1462399404007409; Marshall JC, Foster D, Vincent JL, Cook DJ, Cohen J, Dellinger RP, et al. Diagnostic and Prognostic Implications of Endotoxemia in Critical Illness: Results of the MEDIC Study. J Infect Dis. 2004;190(3):527–534. PMID: 15243928 https://doi.org/10.1086/422254; Reade MC, Huang DT, Bell D, Coats TJ, Cross AM, Moran JL, et al. Variability in management of early severe sepsis. Emerg. Med. J. 2010;27(2):110–115. PMID: 20156862 https://doi.org/10.1136/emj.2008.070912; Solomkin JS, Bauman MR, Neeson RD, Simmons RL. Neutrophils dysfunction during the course of intra-abdominal infection. Ann Surg. 1981;194(1):9–17. PMID: 7247540 https://doi.org/10.1097/00000658-198107000-00003; Triantafilou M, Triantafilou K. Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol. 2002;23(6):301– 304. PMID: 12072369; Cruz DN, Perazella MA, Dellomo R, de Cal M, Polanco N, Corradi V, еt al. Effectivnes of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care. 2007;11(2);R 47 PMID: 17448226 https://doi.org/10.1186/cc5780; Ikeda T, Ikeda K, Nagura M, Taniuchi H, Matsushita M, Kiuchi S, et al. Clinical evaluation of PMX-DHP for hypercytokinemia caused by septic multiple organ failure. Ther Apher Dial. 2004;8(4):293–298. PMID: 15274680 https://doi.org/10.1111/j.1526-0968.2004.00167.x; Cruz DN, Antonelli M, Fumagalli R, Foltran F, Brienza N, Donati A, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA. 2009;301(23):2445–2452. PMID: 19531784 https://doi.org/10.1001/jama.2009.856; Payen DM, Guilhot J, Launey Y, Lukaszewicz AC, Kaaki M, Veber B, et al. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial. Intensive Care Med. 2015;41(6):975–984. PMID: 25862039 https://doi.org/10.1007/s00134-015-3751-z; Cutuli SL, Artigas A, Fumagalli R, Monti G, Ranieri VM, Ronco C, et al. EUPHAS 2 Collaborative Group. Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry. Ann Intensive Care. 2016;6(1):77. PMID: 27502196 https://doi.org/10.1186/s13613-016-0178-9; Dellinger RP, Bagshaw SM, Antonelli M, Foster DM, Klein DJ, Marshall JC, et al. EUPHRATES Trial Investigators. Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial. JAMA. 2018;320(14):1455–1463. PMID: 30304428 https://doi.org/10.1001/jama.2018.14618; Klein DJ, Foster D, Walker PM, Bagshaw SM, Mekonnen H, Antonelli M. Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial. Intensive Care Med. 2018;44(12):2205–2212. PMID: 30470853 https://doi.org/10.1007/s00134-018-5463-7; Adamik B, Zielinski S, Smiechowicz J, Kübler A. Endotoxin Elimination in Patients with Septic Shock: An Observation Study. Arch Immunol Ther Exp (Warsz). 2015;63(6):475–483. PMID: 26093653 https://doi.org/10.1007/s00005-015-0348-8; Zagli G, Bonizzoli M, Spina R, Cianchi G, Pasquini A, Anichini V, et al. Effects of hemoperfusion with an immobilized polymixin-B fibers column on cytokine plasma levels in patients with abdominal sepsis.; Nakamura T, Ebihara I, Shimada N, Koide H. Changes in plasma erythropoietin and interkeukin-6 concentranions in patients with septic shock after hemoperfusion with polymixin B- immobilized fibers. Intensive Care Med. 1998;24(12):1272–1276. PMID: 9885879; Крстич М., Зулькарнаев А.Б. Селективная адсорбция эндотоксина в лечении гнойно-септических осложнений у пациентов с урологическими заболеваниями после трансплантации почки. Вестник трансплантологии и искусственных органов. 2014;16(1):21–28.; Yaroustovsky M, Plyushch M, Popov D, Samsonova N, Abramyan M, Popok Z, et al. Prognostic value of endotoxin activity assay in patients with severe sepsis after cardiac surgery. J Inflamm (Lond). 2013;10(1):8. PMID: 23510603 https://doi.org/10.1186/1476-9255-10-8; Nakamura T, Sato E, Fujiwara N, Kawagoe Y, Maeda S, Yamagishi S. Suppression of high-mobility group box-1 and receptor for advanced glycation end-product axis by polymyxin B-immobilized fiber hemoperfusion in septic shock patients. J Crit Care. 2011;26(6):546–549. PMID: 21273029 https://doi.org/10.1016/j.jcrc.2010.11.010; Coudroy R, Payen D, Launey Y, Lukaszewicz AC, Kaaki M, Veber B, et al. Modulation by Polymyxin-B Hemoperfusion of Inflammatory Response Related to Severe Peritonitis. Shock. 2017;47(1):93-99. PMID: 27984535 https://doi.org/10.1097/SHK.0000000000000725; https://www.jnmp.ru/jour/article/view/929