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1Academic Journal
Authors: Daria K. Shishkova, Victoria E. Markova, Yulia O. Markova, Elena A. Velikanova, Anna V. Sinitskaya, Maxim Yu. Sinitsky, Arina E. Tyurina, Alexander D. Stepanov, Yulia A. Dyleva, Vera G. Matveeva, Anton G. Kutikhin, Дарья Кирилловна Шишкова, Виктория Евгеньевна Маркова, Юлия Олеговна Маркова, Елена Анатольевна Великанова, Анна Викторовна Синицкая, Максим Юрьевич Синицкий, Арина Евгеньевна Тюрина, Александр Денисович Степанов, Юлия Александровна Дылева, Вера Геннадьевна Матвеева, Антон Геннадьевич Кутихин
Contributors: Исследование выполнено при поддержке гранта Российского научного фонда № 22-15-00107 «Патологические последствия и молекулярные механизмы воздействия кальций-фосфатных бионов (кальципротеиновых частиц) на форменные элементы крови», https://rscf.ru/project/22-15-00107/.
Source: Complex Issues of Cardiovascular Diseases; Том 13, № 3 (2024); 167-181 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 13, № 3 (2024); 167-181 ; 2587-9537 ; 2306-1278
Subject Terms: Дисфункция эндотелия, Ionized calcium, Calciprotein monomers, Calciprotein particles, Mineral stress, Endothelial cells, Endothelial dysfunction, Ионизированный кальций, Кальципротеиновые мономеры, Кальципротеиновые частицы, Минеральный стресс, Эндотелиальные клетки
File Description: application/pdf
Relation: https://www.nii-kpssz.com/jour/article/view/1399/926; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1476; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1477; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1478; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1479; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1486; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1487; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1399/1490; Kutikhin A.G., Feenstra L., Kostyunin A.E., Yuzhalin A.E., Hillebrands J.L., Krenning G. Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology. Arterioscler Thromb Vasc Biol. 2021;41(5):1607-1624. doi:10.1161/ATVBAHA.120.315697.; Heiss A., Eckert T., Aretz A., Richtering W., van Dorp W., Schäfer C., Jahnen-Dechent W. Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 2008;283(21):14815-25. doi:10.1074/jbc.M709938200.; Heiss A., DuChesne A., Denecke B., Grötzinger J., Yamamoto K., Renné T., Jahnen-Dechent W. Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem. 2003;278(15):13333-41. doi:10.1074/jbc.M210868200.; Shishkova D.K., Velikanova E.A., Bogdanov L.A., Sinitsky M.Y., Kostyunin A.E., Tsepokina A.V., Gruzdeva O.V., Mironov A.V., Mukhamadiyarov R.A., Glushkova T.V., Krivkina E.O., Matveeva V.G., Hryachkova O.N., Markova V.E., Dyleva Y.A., Belik E.V., Frolov A.V., Shabaev A.R., Efimova O.S., Popova A.N., Malysheva V.Y., Kolmykov R.P., Sevostyanov O.G., Russakov D.M., Dolganyuk V.F., Gutakovsky A.K., Zhivodkov Y.A., Kozhukhov A.S., Brusina E.B., Ismagilov Z.R., Barbarash O.L., Yuzhalin A.E., Kutikhin A.G. Calciprotein Particles Link Disturbed Mineral Homeostasis with Cardiovascular Disease by Causing Endothelial Dysfunction and Vascular Inflammation. Int J Mol Sci. 2021;22(22):12458. doi:10.3390/ijms222212458.; Shishkova D., Markova V., Sinitsky M., Tsepokina A., Velikanova E., Bogdanov L., Glushkova T., Kutikhin A. Calciprotein Particles Cause Endothelial Dysfunction under Flow. Int J Mol Sci. 2020;21(22):8802. doi:10.3390/ijms21228802.; Kutikhin A.G., Velikanova E.A., Mukhamadiyarov R.A., Glushkova T.V., Borisov V.V., Matveeva V.G., Antonova L.V., Filip'ev D.E., Golovkin A.S., Shishkova D.K., Burago A.Y., Frolov A.V., Dolgov V.Y., Efimova O.S., Popova A.N., Malysheva V.Y., Vladimirov A.A., Sozinov S.A., Ismagilov Z.R., Russakov D.M., Lomzov A.A., Pyshnyi D.V., Gutakovsky A.K., Zhivodkov Y.A., Demidov E.A., Peltek S.E., Dolganyuk V.F., Babich O.O., Grigoriev E.V., Brusina E.B., Barbarash O.L., Yuzhalin A.E. Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions. Sci Rep. 2016;6:27255. doi:10.1038/srep27255.; Feenstra L., Kutikhin A.G., Shishkova D.K., Buikema H., Zeper L.W., Bourgonje A.R., Krenning G., Hillebrands J.L. Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism. Arterioscler Thromb Vasc Biol. 2023;43(3):443-455. doi:10.1161/ATVBAHA.122.318420.; Shishkova D., Lobov A., Zainullina B., Matveeva V., Markova V., Sinitskaya A., Velikanova E., Sinitsky M., Kanonykina A., Dyleva Y., Kutikhin A. Calciprotein Particles Cause Physiologically Significant Pro-Inflammatory Response in Endothelial Cells and Systemic Circulation. Int J Mol Sci. 2022;23(23):14941. doi:10.3390/ijms232314941.; Kutikhin A.G. Pathophysiological and clinical significance of mineral homeostasis disorders in the development of cardiovascular disease. Fundamental and Clinical Medicine. 2021;6(2):82-102. doi:10.23946/2500-0764-2021-6-1-82-102. (In Russian); Lutsey P.L., Alonso A., Michos E.D., Loehr L.R., Astor B.C., Coresh J., Folsom A.R. Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2014;100(3):756-64. doi:10.3945/ajcn.114.085167.; Rohrmann S., Garmo H., Malmstrom H., Hammar N., Jungner I., Walldius G., Van Hemelrijck M. Association between serum calcium concentration and risk of incident and fatal cardiovascular disease in the prospective AMORIS study. Atherosclerosis. 2016;251:85-93. doi:10.1016/j.atherosclerosis.2016.06.004.; Reid I.R., Gamble G.D., Bolland M.J. Circulating calcium concentrations, vascular disease and mortality: a systematic review. J Intern Med. 2016;279(6):524-40. doi:10.1111/joim.12464.; Kobylecki C.J., Nordestgaard B.G., Afzal S. Plasma Ionized Calcium and Risk of Cardiovascular Disease: 106 774 Individuals from the Copenhagen General Population Study. Clin Chem. 2021;67(1):265-275. doi:10.1093/clinchem/hvaa245.; Shishkova D.K., Matveeva V.G., Markova V.E., Khryachkova O.N., Indukaeva E.V., Shabaev А.R., Frolov A.V., Kutikhin A.G. Quantification of the initial levels of calciprotein particles as a screening marker of mineral homeostasis in patients with cardiovascular disease and in patients with chronic kidney disease. Russian Journal of Cardiology. 2022;27(12):5064. doi:10.15829/1560-4071-2022-5064. (In Russioan); Kutikhin A.G., Shishkova D.K., Khryachkova O.N., Frolov A.V., Osyaev N.Yu., Indukaeva E.V., Gruzdeva O.V., Shabaev A.R., Zagorodnikov N.I., Markova V.E., Bogdanov L.А. Formation of calcium phosphate bions in patients with carotid and coronary atherosclerosis. Russian Journal of Cardiology. 2020;25(12):3881. (In Russian); Xie W.M., Ran L.S., Jiang J., Chen Y.S., Ji H.Y., Quan X.Q. Association between fetuin-A and prognosis of CAD: A systematic review and meta-analysis. Eur J Clin Invest. 2019;49(5):e13091. doi:10.1111/eci.13091.; Ronit A., Kirkegaard-Klitbo D.M., Dohlmann T.L., Lundgren J., Sabin C.A., Phillips A.N., Nordestgaard B.G., Afzal S. Plasma Albumin and Incident Cardiovascular Disease: Results From the CGPS and an Updated Meta-Analysis. Arterioscler Thromb Vasc Biol. 2020;40(2):473-482. doi:10.1161/ATVBAHA.119.313681.; Seidu S., Kunutsor S.K., Khunti K. Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants. Scand Cardiovasc J. 2020;54(5):280-293. doi:10.1080/14017431.2020.1762918.; Heiss A., Pipich V., Jahnen-Dechent W., Schwahn D. Fetuin-A is a mineral carrier protein: small angle neutron scattering provides new insight on Fetuin-A controlled calcification inhibition. Biophys J. 2010;99(12):3986-95. doi:10.1016/j.bpj.2010.10.030.; Koeppert S., Ghallab A., Peglow S., Winkler C.F., Graeber S., Büscher A., Hengstler J.G., Jahnen-Dechent W. Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers. Front Cell Dev Biol. 2021;9:633925. doi:10.3389/fcell.2021.633925.; Herrmann M., Schäfer C., Heiss A., Gräber S., Kinkeldey A., Büscher A., Schmitt M.M., Bornemann J., Nimmerjahn F., Herrmann M., Helming L., Gordon S., Jahnen-Dechent W. Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A. Circ Res. 2012;111(5):575-84. doi:10.1161/CIRCRESAHA.111.261479.; Köppert S., Büscher A., Babler A., Ghallab A., Buhl E.M., Latz E., Hengstler J.G., Smith E.R., Jahnen-Dechent W. Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity. Front Immunol. 2018;9:1991. doi:10.3389/fimmu.2018.01991.; Kutikhin A.G., Shishkova D.K., Velikanova E.A., Sinitsky M.Y., Sinitskaya A.V., Markova V.E. Endothelial Dysfunction in the Context of Blood-Brain Barrier Modeling. J Evol Biochem Physiol. 2022;58(3):781-806. doi:10.1134/S0022093022030139.; Shishkova D.K., Sinitskaya A.V., Sinitsky M.Yu., Matveeva V.G., Velikanova E.A., Markova V.E., Kutikhin A.G. Spontaneous endothelial-to-mesenchymal transition in human primary umbilical vein endothelial cells. Complex Issues of Cardiovascular Diseases. 2022;11(3):97-114. doi:10.17802/2306-1278-2022-11-3-97-114 (In Russian)]; Liberale L., Montecucco F., Tardif J.C, Libby P., Camici G.G. Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. Eur Heart J. 2020;41(31):2974-2982. doi:10.1093/eurheartj/ehz961.
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2Academic Journal
Authors: Daria K. Shishkova, Victoria E. Markova, Yulia O. Markova, Evgeniya A. Torgunakova, Egor A. Kondratiev, Yulia A. Dyleva, Anton G. Kutikhin, Дарья Кирилловна Шишкова, Виктория Евгеньевна Маркова, Юлия Олеговна Маркова, Евгения Александровна Торгунакова, Егор Андреевич Кондратьев, Юлия Александровна Дылева, Антон Геннадьевич Кутихин
Contributors: Исследование выполнено за счет гранта Российского научного фонда № 22-15-00107, https://rscf.ru/project/22-15-00107/.
Source: Complex Issues of Cardiovascular Diseases; Том 13, № 2 (2024); 60-71 ; Комплексные проблемы сердечно-сосудистых заболеваний; Том 13, № 2 (2024); 60-71 ; 2587-9537 ; 2306-1278
Subject Terms: Дисфункция эндотелия, Ionized calcium, Calciprotein monomers, Calciprotein particles, Albumin, Mineral stress, Endothelial dysfunction, Ионизированный кальций, Кальципротеиновые мономеры, Кальципротеиновые частицы, Альбумин, Минеральный стресс
File Description: application/pdf
Relation: https://www.nii-kpssz.com/jour/article/view/1396/891; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1396/1473; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1396/1474; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1396/1475; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1396/1488; https://www.nii-kpssz.com/jour/article/downloadSuppFile/1396/1489; Kutikhin A.G., Feenstra L., Kostyunin A.E., Yuzhalin A.E., Hillebrands J.L., Krenning G. Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology. Arterioscler Thromb Vasc Biol. 2021;41(5):1607-1624. doi:10.1161/ATVBAHA.120.315697.; Shishkova D.K., Velikanova E.A., Bogdanov L.A., Sinitsky M.Y., Kostyunin A.E., Tsepokina A.V., Gruzdeva O.V., Mironov A.V., Mukhamadiyarov R.A., Glushkova T.V., Krivkina E.O., Matveeva V.G., Hryachkova O.N., Markova V.E., Dyleva Y.A., Belik E.V., Frolov A.V., Shabaev A.R., Efimova O.S., Popova A.N., Malysheva V.Y., Kolmykov R.P., Sevostyanov O.G., Russakov D.M., Dolganyuk V.F., Gutakovsky A.K., Zhivodkov Y.A., Kozhukhov A.S., Brusina E.B., Ismagilov Z.R., Barbarash O.L., Yuzhalin A.E., Kutikhin A.G. Calciprotein Particles Link Disturbed Mineral Homeostasis with Cardiovascular Disease by Causing Endothelial Dysfunction and Vascular Inflammation. Int J Mol Sci. 2021;22(22):12458. doi:10.3390/ijms222212458.; Ronit A., Kirkegaard-Klitbo D.M., Dohlmann T.L., Lundgren J., Sabin C.A., Phillips A.N., Nordestgaard B.G., Afzal S. Plasma Albumin and Incident Cardiovascular Disease: Results From the CGPS and an Updated Meta-Analysis. Arterioscler Thromb Vasc Biol. 2020;40(2):473-482. doi:10.1161/ATVBAHA.119.313681.; Xie W.M., Ran L.S., Jiang J., Chen Y.S., Ji H.Y., Quan X.Q. Association between fetuin-A and prognosis of CAD: A systematic review and meta-analysis. Eur J Clin Invest. 2019;49(5):e13091. doi:10.1111/eci.13091.; Reid I.R., Gamble G.D., Bolland M.J. Circulating calcium concentrations, vascular disease and mortality: a systematic review. J Intern Med. 2016;279(6):524-40. doi:10.1111/joim.12464.; Kobylecki C.J., Nordestgaard B.G., Afzal S. Plasma Ionized Calcium and Risk of Cardiovascular Disease: 106 774 Individuals from the Copenhagen General Population Study. Clin Chem. 2021;67(1):265-275. doi:10.1093/clinchem/hvaa245.; Campos-Obando N., Lahousse L., Brusselle G., Stricker B.H., Hofman A., Franco O.H., Uitterlinden A.G., Zillikens M.C. Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men. Eur J Epidemiol. 2018;33(9):859-871. doi:10.1007/s10654-018-0407-7.; Кутихин А.Г. Патофизиологическая и клиническая значимость нарушений минерального гомеостаза в контексте развития сердечно-сосудистых заболеваний. Фундаментальная и клиническая медицина. 2021. Т. 6. № 2. С. 82-102. doi:10.23946/2500-0764-2021-6-1-82-102.; Bäck M., Aranyi T., Cancela M.L., Carracedo M., Conceição N., Leftheriotis G., Macrae V., Martin L., Nitschke Y., Pasch A., Quaglino D., Rutsch F., Shanahan C., Sorribas V., Szeri F., Valdivielso P., Vanakker O., Kempf H. Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet. Front Cardiovasc Med. 2019;5:196. doi:10.3389/fcvm.2018.00196.; Heiss A., Pipich V., Jahnen-Dechent W., Schwahn D. Fetuin-A is a mineral carrier protein: small angle neutron scattering provides new insight on Fetuin-A controlled calcification inhibition. Biophys J. 2010;99(12):3986-95. doi:10.1016/j.bpj.2010.10.030.; Koeppert S., Ghallab A., Peglow S., Winkler C.F., Graeber S., Büscher A., Hengstler J.G., Jahnen-Dechent W. Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers. Front Cell Dev Biol. 2021;9:633925. doi:10.3389/fcell.2021.633925.; Heiss A., Eckert T., Aretz A., Richtering W., van Dorp W., Schäfer C., Jahnen-Dechent W. Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 2008;283(21):14815-25. doi:10.1074/jbc.M709938200.; Jahnen-Dechent W., Schäfer C., Ketteler M., McKee M.D. Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med (Berl). 2008;86(4):379-89. doi:10.1007/s00109-007-0294-y.; Шишкова Д.К., Матвеева В.Г., Маркова В.Е., Хрячкова О.Н., Индукаева Е.В., Шабаев А.Р., Фролов А.В., Кутихин А.Г. Количественная оценка исходной концентрации кальций-фосфатных бионов как скринингового маркера минерального гомеостаза крови у пациентов с сердечно-сосудистыми заболеваниями и у пациентов с хронической болезнью почек. Российский кардиологический журнал. 2022. Т. 27. № 12. С. 20-31. doi:10.15829/1560-4071-2022-5064.; Кутихин А.Г., Шишкова Д.К., Хрячкова О.Н., Фролов А.В., Шабаев А.Р., Загородников Н.И., Маркова В.Е., Богданов Л.А., Осяев Н.Ю., Индукаева Е.В., Груздева О.В. Закономерности формирования кальций-фосфатных бионов у пациентов с каротидным и коронарным атеросклерозом. Российский кардиологический журнал. 2020. Т. 25. № 12. С. 39-48. doi:10.15829/1560-4071-2020-3881; Harlacher E., Wollenhaupt J., Baaten C.C.F.M.J., Noels H. Impact of Uremic Toxins on Endothelial Dysfunction in Chronic Kidney Disease: A Systematic Review. Int J Mol Sci. 2022;23(1):531. doi:10.3390/ijms23010531.; Roumeliotis S., Mallamaci F., Zoccali C. Endothelial Dysfunction in Chronic Kidney Disease, from Biology to Clinical Outcomes: A 2020 Update. J Clin Med. 2020;9(8):2359. doi:10.3390/jcm9082359.; Shishkova D., Markova V., Sinitsky M., Tsepokina A., Velikanova E., Bogdanov L., Glushkova T., Kutikhin A. Calciprotein Particles Cause Endothelial Dysfunction under Flow. Int J Mol Sci. 2020;21(22):8802. doi:10.3390/ijms21228802.; Kutikhin A.G., Velikanova E.A., Mukhamadiyarov R.A., Glushkova T.V., Borisov V.V., Matveeva V.G., Antonova L.V., Filip'ev D.E., Golovkin A.S., Shishkova D.K., Burago A.Y., Frolov A.V., Dolgov V.Y., Efimova O.S., Popova A.N., Malysheva V.Y., Vladimirov A.A., Sozinov S.A., Ismagilov Z.R., Russakov D.M., Lomzov A.A., Pyshnyi D.V., Gutakovsky A.K., Zhivodkov Y.A., Demidov E.A., Peltek S.E., Dolganyuk V.F., Babich O.O., Grigoriev E.V., Brusina E.B., Barbarash O.L., Yuzhalin A.E. Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions. Sci Rep. 2016;6:27255. doi:10.1038/srep27255.; Feenstra L., Kutikhin A.G., Shishkova D.K., Buikema H., Zeper L.W., Bourgonje A.R., Krenning G., Hillebrands JL. Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism. Arterioscler Thromb Vasc Biol. 2023;43(3):443-455. doi:10.1161/ATVBAHA.122.318420.; Shishkova D., Lobov A., Zainullina B., Matveeva V., Markova V., Sinitskaya A., Velikanova E., Sinitsky M., Kanonykina A., Dyleva Y., Kutikhin A. Calciprotein Particles Cause Physiologically Significant Pro-Inflammatory Response in Endothelial Cells and Systemic Circulation. Int J Mol Sci. 2022;23(23):14941. doi:10.3390/ijms232314941.; Ferrucci L., Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15(9):505-522. doi:10.1038/s41569-018-0064-2.; Liberale L., Montecucco F., Tardif J.C., Libby P., Camici G.G. Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. Eur Heart J. 2020;41(31):2974-2982. doi:10.1093/eurheartj/ehz961.; Gu S.X., Tyagi T., Jain K., Gu V.W., Lee S.H., Hwa J.M., Kwan J.M., Krause D.S., Lee A.I., Halene S., Martin K.A., Chun H.J., Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nat Rev Cardiol. 2021;18(3):194-209. doi:10.1038/s41569-020-00469-1.; Heiss A., DuChesne A., Denecke B., Grötzinger J., Yamamoto K., Renné T., Jahnen-Dechent W. Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem. 2003;278(15):13333-41. doi:10.1074/jbc.M210868200.