Urease inhibitors: current advances, therapeutic potentials, and clinical challenges.

Συγγραφείς: Alzoubi OH; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Khamees A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.; Princess Basma Teaching Hospital, Ministry of Health, Irbid, Jordan., Alzu'bi MB; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Freihat SF; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Attar A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Abo Sameed H; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alzubi R; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alsamarah AA; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Yassin RY; Faculty of Pharmacy, Yarmouk University, Irbid, Jordan., Al-Shami K; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Al-Trad B; Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia., Al-Zoubi RM; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.; Department of Chemistry, Jordan University of Science and Technology, Irbid, Jordan.; Department of Biomedical Sciences, QU-Health, College of Health Sciences, Qatar University, Doha, Qatar., Al Zoubi MS; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Πηγή: Future medicinal chemistry [Future Med Chem] 2026 Jul; Vol. 18 (14), pp. 1907-1923. Date of Electronic Publication: 2026 Jun 15.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Urease*/antagonists & inhibitors , Urease*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Helicobacter Infections/drug therapy ; Humans ; Animals

Newly synthesized 2-cyclopentylidenehydrazinylthiazoles as potential therapeutic agents against peptic ulcer.

Συγγραφείς: Sehrish; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; Department of Chemistry, Jinnah University for Women, Karachi, Pakistan., Salar U; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Naz F; Department of Chemistry, Jinnah University for Women, Karachi, Pakistan., Ishaq A; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Naz F; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Iqbal J; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Khan KM; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Πηγή: Future medicinal chemistry [Future Med Chem] 2026 Apr; Vol. 18 (8), pp. 865-880. Date of Electronic Publication: 2026 Mar 12.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Urease*/antagonists & inhibitors , Urease*/metabolism , Thiazoles*/chemistry , Thiazoles*/pharmacology , Thiazoles*/chemical synthesis , Thiazoles*/therapeutic use , Peptic Ulcer*/drug therapy , Anti-Ulcer Agents*/chemistry , Anti-Ulcer Agents*/pharmacology , Anti-Ulcer Agents*/chemical synthesis , Anti-Ulcer Agents*/therapeutic use , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Structure-Activity Relationship ; Molecular Docking Simulation ; Humans ; Molecular Structure

Urease-driven nanomotors loaded with sorafenib for magnetically-guided accumulation and deep tissue penetration towards hepatocellular carcinoma therapy via ferroptosis induction.

Συγγραφείς: Hua C; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Lu Z; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Cui W; Postgraduate Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Ren W; The second Department of General Surgery, Second Hospital of Harbin, Harbin, Heilongjiang, 150056, China., Xu Y; Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Li J; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Zhao X; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Zhao S; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China., Kang P; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China. kang_pengcheng@126.com., Cui Y; Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China. yfcui7@163.com.

Πηγή: Mikrochimica acta [Mikrochim Acta] 2026 Jan 26; Vol. 193 (2), pp. 110. Date of Electronic Publication: 2026 Jan 26.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Sorafenib*/pharmacology , Sorafenib*/chemistry , Sorafenib*/therapeutic use , Sorafenib*/metabolism , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Urease*/metabolism , Urease*/chemistry , Ferroptosis*/drug effects, Silicon Dioxide/chemistry ; Drug Carriers/chemistry ; Magnetite Nanoparticles/chemistry ; Humans ; Animals ; Mice ; Drug Liberation ; Cell Line, Tumor

Droplet Digital PCR-Based Detection of Clarithromycin Resistance on Rapid Urease Test Samples Predicts Helicobacter pylori Eradication Success: A New Zealand Cohort Study.

Συγγραφείς: Inns SJ; University of Otago, Wellington, New Zealand.; Capital Coast and Hutt Valley, Health New Zealand Te Whatu Ora, Wellington, New Zealand., Sowerbutts S; University of Otago, Wellington, New Zealand., Yumnam B; Malaghan Institute of Medical Research, Wellington, New Zealand., Payne K; Malaghan Institute of Medical Research, Wellington, New Zealand., Wheller G; Malaghan Institute of Medical Research, Wellington, New Zealand., Camberis M; Malaghan Institute of Medical Research, Wellington, New Zealand., Mules T; University of Otago, Wellington, New Zealand.; Capital Coast and Hutt Valley, Health New Zealand Te Whatu Ora, Wellington, New Zealand.; Malaghan Institute of Medical Research, Wellington, New Zealand.

Πηγή: Helicobacter [Helicobacter] 2025 Sep-Oct; Vol. 30 (5), pp. e70075.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9605411 Publication Model: Print Cited Medium: Internet ISSN: 1523-5378 (Electronic) Linking ISSN: 10834389 NLM ISO Abbreviation: Helicobacter Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Clarithromycin*/pharmacology , Clarithromycin*/therapeutic use , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/diagnosis , Helicobacter pylori*/drug effects , Helicobacter pylori*/genetics , Helicobacter pylori*/enzymology , Helicobacter pylori*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Polymerase Chain Reaction*/methods , Urease*/analysis , Drug Resistance, Bacterial*, Humans ; New Zealand ; Female ; Male ; Middle Aged ; Aged ; Adult ; Cohort Studies ; Treatment Outcome

Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives.

Συγγραφείς: Agabo-Martínez A; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Gomez-Chang E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Hernández-Hipólito E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Estrada-Muñiz E; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Escobedo-Martínez C; Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato 36050, Mexico., Obregón-Mendoza MA; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Enríquez RG; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Vega L; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Romero I; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico.

Πηγή: Molecules (Basel, Switzerland) [Molecules] 2025 Sep 23; Vol. 30 (19). Date of Electronic Publication: 2025 Sep 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Curcumin*/analogs & derivatives , Curcumin*/chemistry , Curcumin*/pharmacology , Curcumin*/therapeutic use , Curcumin*/analogs & derivatives , Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Stomach Ulcer*/chemically induced , Stomach Ulcer*/pathology , Stomach Ulcer*/prevention & control , Protective Agents*/chemistry , Protective Agents*/pharmacology , Protective Agents*/therapeutic use, Metals/chemistry ; Ethanol/toxicity ; Urease/antagonists & inhibitors ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology ; Topoisomerase II Inhibitors/therapeutic use ; Biological Availability ; Microbial Sensitivity Tests ; Disease Models, Animal ; Toxicity Tests, Subacute ; Animals ; Mice ; Male

Preliminary assessment of the antioxidant, anti-inflammatory, antidiabetic, and anti-carcinogenic attributes of Australian red seaweeds

Additional Titles: Red seaweeds contain an assortment of valuable phytochemical; however, while their pharmaceutical and therapeutic potential has been previously recognized, many aspects of their bioactive properties remain underexplored, especially among the Australian species. An ultrasonic-assisted extraction method was used to obtain polyphenol-rich extracts from thirteen Australian red seaweeds. Antioxidant activity and anti-inflammatory potential, assessed through assays such as urease inhibition and nitric oxide scavenging, as well as anti-diabetic capacity through α-amylase and α-glucosidase inhibition, were evaluated. Rhodophyllis sp. demonstrated the greatest antioxidant capacity with relative antioxidant capacity index score of 1.43, while Crouania attenuata exhibited superior antidiabetic effects through α-glucosidase and α-amylase inhibition. Notable anti-inflammatory potential was observed in Plocamium and Asparagopsis samples, with A. armata excelling in protease inhibition. Moreover, LC-ESI-QTOF-MS/MS analysis of the extracts tentatively identified 26 polyphenols, indicating the rich bioactive profile of these marine resources. The in vitro assays and phenolic composition highlight the considerable biological potential of Australian Rhodophyta, emphasizing the need for further exploration of these red seaweeds as promising candidates for therapeutic and pharmaceutical applications.

Συγγραφείς: Ebrahimi, F, Subbiah, V, Agar, OT, Legione, AR, Ahmadi, F, Suleria, HAR

Όροι ευρετηρίου: Journal Article

Σύνδεσμος: https://hdl.handle.net/11343/365053

Diuretic and Anti-hyperuricemic Effects of Geranyl Acetate in Rats.

Συγγραφείς: Shah SN; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Younis W; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, , New York University Grossman School of Medicine, New York, USA., Junior AG; Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil., Manzoor W; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Malik MNH; Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan., Mushtaq MN; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Munir MU; Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, Brisbane, Australia., Bashir A; Riphah Institute of Pharmaceutical Sciences, Riphah International Univeristy, Lahore, Pakistan., Bibi S; Department of Biosciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Talha M; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan., Dos Reis Livero FA; Laboratory of Cardiometabolic Pharmacology, Federal University of Paraná, Curitiba, Brazil.; Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil.

Πηγή: Current medicinal chemistry [Curr Med Chem] 2026; Vol. 33 (8), pp. 1551-1567.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hyperuricemia*/drug therapy , Hyperuricemia*/metabolism , Diuretics*/pharmacology , Diuretics*/chemistry , Diuretics*/therapeutic use , Acetates*/pharmacology , Acetates*/chemistry , Acetates*/therapeutic use, Xanthine Oxidase/antagonists & inhibitors ; Xanthine Oxidase/metabolism ; Acetylcholinesterase/metabolism ; Urease/metabolism ; Urease/antagonists & inhibitors ; Animals ; Male ; Rats, Wistar ; Molecular Docking Simulation ; Rats

Urease inhibitory potential of pyridine-containing triazolothiadiazole and triazolothiadiazine scaffolds for the treatment of ulceration and kidney stone: in vitro screening, kinetics mechanism, and in silico computational analysis.

Συγγραφείς: Ullah S; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Halim SA; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Ibrar A; Department of Chemistry, Faculty of Natural Sciences, The University of Haripur, Haripur, Pakistan., Khan I; Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK., Ataya FS; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Fouad D; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, Egypt., Khan A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman., Al-Harrasi A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.

Πηγή: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Feb; Vol. 43 (3), pp. 1249-1258. Date of Electronic Publication: 2023 Dec 28.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Urease*/antagonists & inhibitors , Urease*/chemistry , Thiadiazoles*/chemistry , Thiadiazoles*/pharmacology , Pyridines*/chemistry , Pyridines*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use , Thiadiazines*/chemistry , Thiadiazines*/pharmacology , Ulcer*/drug therapy, Molecular Docking Simulation ; Kinetics ; Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Dynamics Simulation

Mechanistic insights into the inhibitory effect of epigallocatechin gallate on the production of virulence factors in Proteus mirabilis.

Συγγραφείς: Xue Z; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Chen H; College of Marine Sciences, Ningde Normal University, Ningde, China., Qi Y; Clinical Laboratory, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Zeng Q; Hospital Infection Management Department, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Yan G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China., Fang G; Department of Respiratory and Critical Care Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.

Πηγή: Medicine [Medicine (Baltimore)] 2026 Jan 02; Vol. 105 (1), pp. e46893.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Catechin*/analogs & derivatives , Catechin*/pharmacology , Catechin*/therapeutic use , Catechin*/analogs & derivatives , Catheter-Related Infections*/drug therapy , Catheter-Related Infections*/microbiology , Proteus Infections*/drug therapy , Proteus Infections*/microbiology , Proteus mirabilis*/drug effects , Proteus mirabilis*/genetics , Proteus mirabilis*/metabolism , Proteus mirabilis*/pathogenicity , Urinary Tract Infections*/drug therapy , Urinary Tract Infections*/microbiology , Virulence Factors*/antagonists & inhibitors , Virulence Factors*/biosynthesis, Biofilms/drug effects ; Biofilms/growth & development ; Gene Expression Regulation, Bacterial/drug effects ; Hemolysin Proteins/antagonists & inhibitors ; Hemolysin Proteins/biosynthesis ; Urease/antagonists & inhibitors ; Urease/biosynthesis ; Microbial Sensitivity Tests ; Humans

Kidney Stone Dissolution By Tetherless, Enzyme-Loaded, Soft Magnetic Miniature Robots.

Συγγραφείς: Khabbazian A; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Kwong L; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Lewis A; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Liu E; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Abdelrazec N; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Bakenecker AC; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Medical Engineering, Technical University of Darmstadt, Merckstr. 25, 64283, Darmstadt, Germany., Fontanals N; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Lopez G; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain., Sánchez S; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Catalan Institute for Research and Advanced Studies, ICREA, Barcelona, 08028, Spain., Lopez JM; Department of Urology, University of Barcelona Clinic Hospital, Barcelona, 08036, Spain., Carrillo B; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Farcas M; Farcas Lab, Department of Surgery, Division of Urology, St. Michael's Hospital, University of Toronto, Toronto, M5B 1W8, Canada., Kallweit C; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada., Yu ACH; Schlegel Research Institute for Aging and Department of Electrical and Computer Engineering, University of Waterloo, Ontario, N2J0E2, Canada.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada., Behrad Khamesee M; Department of Mechanical Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada., Magdanz V; Medical Microrobotics Lab, Department of Systems Design Engineering, University of Waterloo, Waterloo, N2L 3G1, Canada.; Institute for Bioengineering of Catalonia, Barcelona, 08028, Spain.; Waterloo Institute for Nanotechnology, Waterloo, N2L 3G1, Canada.

Πηγή: Advanced healthcare materials [Adv Healthc Mater] 2025 Sep; Vol. 14 (23), pp. e2403423. Date of Electronic Publication: 2025 Jul 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Kidney Calculi*/therapy , Urease*/therapeutic use , Robotics*, Wireless Technology ; Magnetics ; Urinary Tract ; Humans ; Models, Anatomic ; Printing, Three-Dimensional ; Ultrasonography

Multimodal anti-Helicobacter pylori effects of Lactobacillus casei HY001: Evidence from in vitro and in vivo studies.

Συγγραφείς: Lv Z; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Yu J; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang X; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang L; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhang C; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Liu X; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Chang Y; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Yin H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Wang W; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Zhao H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China., Li H; Harbin Pharmaceutical Group Bioengineering Co., LTD., Harbin, China.

Πηγή: PloS one [PLoS One] 2026 May 14; Vol. 21 (5), pp. e0349099. Date of Electronic Publication: 2026 May 14 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lacticaseibacillus casei*/physiology , Helicobacter pylori*/physiology , Helicobacter Infections*/microbiology , Helicobacter Infections*/therapy , Probiotics*/pharmacology , Probiotics*/therapeutic use, Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Urease/metabolism ; RNA, Ribosomal, 16S/genetics ; NF-kappa B/metabolism ; Animals ; Humans ; Mice ; Bacterial Adhesion ; Male ; Gastrointestinal Microbiome

Therapeutic potential of Cydonia oblonga extracts for anti-urease and antibacterial activities to cure urinary tract infections

Συγγραφείς: Sharif, Aneeqa ^a, Ali, Anser ^{a, ⁎⁎}, Amjad, Muhammad ^b, Ismatullah, Humaira ^c, Latief, Noreen ^d, Javaid, Binish ^e, Tariq, Muhammad ^{e, ⁎}, Yasin, Rabia ^e, Rafiq, Muhammad ^f

Πηγή: In Journal of Agriculture and Food Research March 2025 19

Combined therapeutic strategy through antioxidant and urease inhibitory activities of Algerian Crataegus monogyna ethanolic fraction: UAE extraction, RP-HPLC-PDA metabolite profiling, and molecular Insights

Συγγραφείς: Goudjil, Sabrina ^{a, ⁎}, Boussekine, Samira ^a, Goudjil, Sarra ^b, Goudjil, Hanane ^c, Kolaylı, Sevgi ^d, Kara, Yakup ^d, Zegheb, Nadjiba ^e

Πηγή: In South African Journal of Botany January 2026 188:207-218

Anti-biopassivated Reticular Micromotors for Bladder Cancer Therapy.

Συγγραφείς: Sun J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Chu R; Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan 250021, China., Wu X; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Yu Q; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Xiao W; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ao H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wang Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu T; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Ju H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Wu J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China., Lei J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Πηγή: Journal of the American Chemical Society [J Am Chem Soc] 2025 May 28; Vol. 147 (21), pp. 17936-17945. Date of Electronic Publication: 2025 May 16.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/pathology , Urease*/metabolism , Urease*/chemistry , Metal-Organic Frameworks*/chemistry , Metal-Organic Frameworks*/pharmacology , Metal-Organic Frameworks*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Urea/metabolism ; Urea/chemistry ; Humans ; Hydrogen Bonding ; Cell Line, Tumor

Multi-Targeting Carnosic Acid Kills Drug-Resistant Helicobacter pylori With Narrow-Spectrum Activity.

Συγγραφείς: Bai Y; NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan, China.; Helicobacter Pylori Research Center, Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China.; Institute of Dermatology, Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China., Huang H; NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan, China., Hang X; NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan, China., Hu S; Helicobacter Pylori Research Center, Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China., Tong Q; Helicobacter Pylori Research Center, Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China., Xu J; Helicobacter Pylori Research Center, Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China., Jia J; Laboratory of Pathogen Biology, State Key Laboratory of Cardiology and Research Center for Translational Medicine, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, China.; Key Laboratory of Pathogen-Host Interaction, School of Medicine, Tongji University, Shanghai, China., Bi H; NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan, China.; Helicobacter Pylori Research Center, Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China.

Πηγή: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Sep; Vol. 13 (50), pp. e76080. Date of Electronic Publication: 2026 Jun 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Abietanes*/pharmacology , Abietanes*/therapeutic use , Helicobacter pylori*/drug effects , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Drug Resistance, Multiple, Bacterial*/drug effects, Biofilms/drug effects ; Animals ; Mice ; Humans ; Disease Models, Animal ; Microbial Sensitivity Tests

Anti-inflammatory and urease inhibitory iridoid glycosides from Nyctanthes arbor-tristis Linn.

Συγγραφείς: Sana T; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Khan M; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Siddiqui BS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Pakistan Academy of Sciences, 3-Constitution Avenue, G-5/2, Islamabad, Pakistan. Electronic address: siddiqui_bina@yahoo.com., Baig TA; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Jabeen A; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Begum S; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Hadda TB; Laboratoire de Chimie des Matériaux, Facultédes Sciences, Université Mohammed Premier, 60000, Oujda, Morocco., Shah L; Hazara University, Mansehra, 21300, Pakistan.

Πηγή: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jan 30; Vol. 319 (Pt 3), pp. 117368. Date of Electronic Publication: 2023 Oct 30.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Plant Extracts*/therapeutic use , Urease*, Iridoid Glycosides/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Mice ; Animals ; Kinetics ; Molecular Docking Simulation ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha

Novel therapeutic approaches for phosphate regulation.

Συγγραφείς: Alzyood L; Department of Medicine, Nephrology Division, Montefiore Medical Center., Chen W; Department of Medicine, Nephrology Division, Montefiore Medical Center.; Department of Medicine, Nephrology Division, Albert Einstein College of Medicine.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine.; Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York, USA.

Πηγή: Current opinion in nephrology and hypertension [Curr Opin Nephrol Hypertens] 2026 Sep 01; Vol. 35 (5), pp. 491-497. Date of Electronic Publication: 2026 May 15.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9303753 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-6543 (Electronic) Linking ISSN: 10624821 NLM ISO Abbreviation: Curr Opin Nephrol Hypertens Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hyperphosphatemia*/drug therapy , Hyperphosphatemia*/blood , Hyperphosphatemia*/etiology , Phosphates*/blood , Renal Insufficiency, Chronic*/blood , Renal Insufficiency, Chronic*/complications , Renal Insufficiency, Chronic*/therapy , Chelating Agents*/therapeutic use , Chelating Agents*/adverse effects, Lanthanum/therapeutic use ; Biomarkers/blood ; Isoquinolines/therapeutic use ; Isoquinolines/adverse effects ; Intestinal Absorption/drug effects ; Humans ; Animals ; Treatment Outcome ; Sulfonamides

Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance.

Συγγραφείς: Zhang Z; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Lin J; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Dai X; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Li X; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Huang F; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Qin S; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Song E; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China. Electronic address: eqsong@swu.edu.cn., Tan W; The Key Laboratory of Zhejiang Province for Nucleic Acids, Hangzhou Institute of Medicine, Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.

Πηγή: Acta biomaterialia [Acta Biomater] 2025 Jul 01; Vol. 201, pp. 534-544. Date of Electronic Publication: 2025 Jun 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Theranostic Nanomedicine*/methods , Helicobacter pylori*/drug effects , Helicobacter Infections*/diagnostic imaging , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/therapy , Helicobacter Infections*/metabolism , Nanoparticles*/chemistry , Nanoparticles*/therapeutic use , Photoacoustic Techniques*, Hematoporphyrins/chemistry ; Hematoporphyrins/pharmacology ; Urease/metabolism ; Animals ; Mice ; Humans

The Unfinished Agenda in Helicobacter pylori Treatment: Resistance, Microbiome Effects, and Future Directions.

Συγγραφείς: Rokkas T; Gastroenterology Clinic, Henry Dunant Hospital, Athens, Greece; Medical School, European University of Cyprus, Nicosia, Cyprus and. Electronic address: sakkor@otenet.gr., Graham DY; Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas.

Πηγή: Gastroenterology [Gastroenterology] 2026 Aug; Vol. 171 (2), pp. 271-284. Date of Electronic Publication: 2026 Mar 27.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Helicobacter pylori*/drug effects , Helicobacter pylori*/pathogenicity , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/diagnosis , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/adverse effects , Anti-Bacterial Agents*/pharmacology , Gastrointestinal Microbiome*/drug effects , Drug Resistance, Bacterial*, Proton Pump Inhibitors/therapeutic use ; Probiotics/therapeutic use ; Humans ; Treatment Outcome

Phytochemicals as Natural Therapeutics Against Helicobacter pylori: A Comprehensive Review.

Συγγραφείς: Shah SAR; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan. ali.raza@imbb.uol.edu.pk., Jamil H; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Mustafa I; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Sharif S; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Zahid Z; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Yasir A; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Nayila I; Department of Pharmacy, The University of Lahore, Sargodha Campus, Sargodha, Pakistan.

Πηγή: Current microbiology [Curr Microbiol] 2026 Jul 23; Vol. 83 (9). Date of Electronic Publication: 2026 Jul 23.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Helicobacter pylori*/drug effects , Helicobacter pylori*/physiology , Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Phytochemicals*/chemistry , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/chemistry, Biofilms/drug effects ; Plants, Medicinal/chemistry ; Humans ; Drug Resistance, Bacterial